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An unexpected mode of small molecule DNA binding provides the structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A
Descriptor:	(1R,1'R,2S,2'S,3R,3'R,5aR,10aR,11a'S)-2'-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-2,2'-diethyl-11,11 '-dihydrazinyl-6,6',9,9'-tetrahydroxy-4,4',5,5',10,10'-hexaoxo-1,1'-bis{[2,4,6-trideoxy-4-(dimethylamino)-beta-L-arabino -hexopyranosyl]oxy}[2,2',3,3',4,4',5,5',5a,8,10,10',10a,11a'-tetradecahydro-1H,1'H-[3,3'-bibenzo[b]fluorene]]-2-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside, DNA (5'-D(GPCPTPAPTPAPGPC)-3')
Authors:	Woo, C.M, Li, Z, Paulson, E, Herzon, S.B.
Deposit date:	2015-11-07
Release date:	2016-06-01
Last modified:	2021-11-03
Method:	SOLUTION NMR
Cite:	Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A. Proc.Natl.Acad.Sci.USA, 113, 2016