Author results

2IY9
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CRYSTAL STRUCTURE OF THE A-SUBUNIT OF THE AB5 TOXIN FROM E. COLI
Descriptor:SUBA
Authors:Paton, A.W., Beddoe, T., Thorpe, C.M., Whisstock, J.C., Wilce, M.C.J., Rossjohn, J., Talbot, U.M., Paton, J.C.
Deposit date:2006-07-13
Release date:2006-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ab5 Subtilase Cytotoxin Inactivates the Endoplasmic Reticulum Chaperone Bip
Nature, 443, 2006
3DWA
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CRYSTAL STRUCTURE OF THE B-SUBUNIT OF THE AB5 TOXIN FROM E. COLI
Descriptor:Subtilase cytotoxin, subunit B, PENTAETHYLENE GLYCOL
Authors:Byres, E., Paton, A.W., Paton, J.C., Lofling, J.C., Smith, D.F., Wilce, M.C.J., Talbot, U.M., Chong, D.C., Yu, H., Huang, S., Chen, X., Varki, N.M., Varki, A., Rossjohn, J., Beddoe, T.
Deposit date:2008-07-22
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.084 Å)
Cite:Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin
Nature, 456, 2008
3DWP
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CRYSTAL STRUCTURE OF THE B-SUBUNIT OF THE AB5 TOXIN FROM E. COLI WITH NEU5GC
Descriptor:Subtilase cytotoxin, subunit B, 3,5-dideoxy-5-[(hydroxyacetyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid, ...
Authors:Byres, E., Paton, A.W., Paton, J.C., Lofling, J.C., Smith, D.F., Wilce, M.C.J., Talbot, U.M., Chong, D.C., Yu, H., Huang, S., Chen, X., Varki, N.M., Varki, A., Rossjohn, J., Beddoe, T.
Deposit date:2008-07-22
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin
Nature, 456, 2008
3DWQ
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CRYSTAL STRUCTURE OF THE A-SUBUNIT OF THE AB5 TOXIN FROM E. COLI WITH NEU5GC-2,3GAL-1,3GLCNAC
Descriptor:Subtilase cytotoxin, subunit B, 3,5-dideoxy-5-[(hydroxyacetyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid, ...
Authors:Byres, E., Paton, A.W., Paton, J.C., Lofling, J.C., Smith, D.F., Wilce, M.C.J., Talbot, U.M., Chong, D.C., Yu, H., Huang, S., Chen, X., Varki, N.M., Varki, A., Rossjohn, J., Beddoe, T.
Deposit date:2008-07-22
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin
Nature, 456, 2008
4BWG
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STRUCTURAL BASIS OF SUBTILASE CYTOTOXIN SUBAB ASSEMBLY
Descriptor:SUBA, SUBTILASE CYTOTOXIN, SUBUNIT B, ...
Authors:Le Nours, J., Paton, A.W., Byres, E., Troy, S., Herdman, B.P., Johnson, M.D., Paton, J.C., Rossjohn, J., Beddoe, T.
Deposit date:2013-07-02
Release date:2013-08-14
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis of Subtilase Cytotoxin Subab Assembly.
J.Biol.Chem., 288, 2013
3ZK7
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CRYSTAL STRUCTURE OF PNEUMOCOCCAL SURFACE ANTIGEN PSAA IN THE METAL-FREE, OPEN STATE
Descriptor:MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Counago, R.M., Ween, M.P., Bajaj, M., Zuegg, J., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., McDevitt, C.A.
Deposit date:2013-01-22
Release date:2013-11-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Imperfect coordination chemistry facilitates metal ion release in the Psa permease.
Nat. Chem. Biol., 10, 2014
3ZK8
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CRYSTAL STRUCTURE OF PNEUMOCOCCAL SURFACE ANTIGEN PSAA E205Q IN THE METAL-FREE, OPEN STATE
Descriptor:MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Counago, R.M., Ween, M.P., Bajaj, M., Zuegg, J., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., McDevitt, C.A.
Deposit date:2013-01-22
Release date:2013-11-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Imperfect coordination chemistry facilitates metal ion release in the Psa permease.
Nat. Chem. Biol., 10, 2014
3ZK9
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CRYSTAL STRUCTURE OF PNEUMOCOCCAL SURFACE ANTIGEN PSAA D280N IN THE METAL-FREE, OPEN STATE
Descriptor:MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Counago, R.M., Ween, M.P., Bajaj, M., Zuegg, J., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., McDevitt, C.A.
Deposit date:2013-01-22
Release date:2013-11-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Imperfect coordination chemistry facilitates metal ion release in the Psa permease.
Nat. Chem. Biol., 10, 2014
3ZKA
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CRYSTAL STRUCTURE OF PNEUMOCOCCAL SURFACE ANTIGEN PSAA D280N IN THE METAL-BOUND, OPEN STATE
Descriptor:MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN, MANGANESE (II) ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Counago, R.M., Ween, M.P., Bajaj, M., Zuegg, J., Cooper, M.A., McEwan, A.G., Paton, J.C., Kobe, B., McDevitt, C.A.
Deposit date:2013-01-22
Release date:2013-11-06
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Imperfect coordination chemistry facilitates metal ion release in the Psa permease.
Nat. Chem. Biol., 10, 2014
1PSZ
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PNEUMOCOCCAL SURFACE ANTIGEN PSAA
Descriptor:PROTEIN (SURFACE ANTIGEN PSAA), ZINC ION
Authors:Lawrence, M.C., Pilling, P.A., Epa, V.C., Berry, A.M., Ogunniyi, A.D., Paton, J.C.
Deposit date:1998-10-13
Release date:2000-04-19
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein.
Structure, 6, 1998
2YA0
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CATALYTIC MODULE OF THE MULTI-MODULAR GLYCOGEN-DEGRADING PNEUMOCOCCAL VIRULENCE FACTOR SPUA
Descriptor:PUTATIVE ALKALINE AMYLOPULLULANASE, CALCIUM ION, GLYCEROL, ...
Authors:Lammerts van Bueren, A., Ficko-Blean, E., Pluvinage, B., Hehemann, J.H., Higgins, M.A., Deng, L., Ogunniyi, A.D., Stroeher, U.H., Warry, N.E., Burke, R.D., Czjzek, M., Paton, J.C., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-17
Release date:2011-04-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor.
Structure, 19, 2011
2YA1
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PRODUCT COMPLEX OF A MULTI-MODULAR GLYCOGEN-DEGRADING PNEUMOCOCCAL VIRULENCE FACTOR SPUA
Descriptor:PUTATIVE ALKALINE AMYLOPULLULANASE, BETA-D-GLUCOSE, ALPHA-D-GLUCOSE, ...
Authors:Lammerts van Bueren, A., Ficko-Blean, E., Pluvinage, B., Hehemann, J.H., Higgins, M.A., Deng, L., Ogunniyi, A.D., Stroeher, U.H., Warry, N.E., Burke, R.D., Czjzek, M., Paton, J.C., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-17
Release date:2011-04-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor.
Structure, 19, 2011
2YA2
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CATALYTIC MODULE OF THE MULTI-MODULAR GLYCOGEN-DEGRADING PNEUMOCOCCAL VIRULENCE FACTOR SPUA IN COMPLEX WITH AN INHIBITOR.
Descriptor:PUTATIVE ALKALINE AMYLOPULLULANASE, 1-DEOXYNOJIRIMYCIN, ALPHA-D-GLUCOSE, ...
Authors:Lammerts van Bueren, A., Ficko-Blean, E., Pluvinage, B., Hehemann, J.H., Higgins, M.A., Deng, L., Ogunniyi, A.D., Stroeher, U.H., Warry, N.E., Burke, R.D., Czjzek, M., Paton, J.C., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-17
Release date:2011-04-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor.
Structure, 19, 2011
3ZTT
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CRYSTAL STRUCTURE OF PNEUMOCOCCAL SURFACE ANTIGEN PSAA WITH MANGANESE
Descriptor:MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN, MANGANESE (II) ION
Authors:McDevitt, C.A., Ogunniyi, A.D., Valkov, E., Lawrence, M.C., Kobe, B., McEwan, A.G., Paton, J.C.
Deposit date:2011-07-12
Release date:2011-12-07
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A molecular mechanism for bacterial susceptibility to zinc.
PLoS Pathog., 7, 2011
6CSL
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PNEUMOCOCCAL PHTD PROTEIN 269-339 FRAGMENT WITH BOUND ZN(II)
Descriptor:Histidine triad protein D, ZINC ION
Authors:Luo, Z., Pederick, V.G., Paton, J.C., McDevitt, C.A., Kobe, B.
Deposit date:2018-03-20
Release date:2018-06-13
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.921 Å)
Cite:Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae.
FEBS Lett., 592, 2018
4L63
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APO FORM OF AB5 HOLOTOXIN
Descriptor:ECXA, ECXB, ZINC ION, ...
Authors:Littler, D.R., Ng, N.M., Rossjohn, J., Beddoe, T.
Deposit date:2013-06-11
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:EcxAB Is a Founding Member of a New Family of Metalloprotease AB5 Toxins with a Hybrid Cholera-like B Subunit.
Structure, 21, 2013
4L6T
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GM1 BOUND FORM OF THE ECX AB5 HOLOTOXIN
Descriptor:ECXA, ECXB, ZINC ION, ...
Authors:Littler, D.R., Ng, N.M., Rossjohn, J., Beddoe, T.
Deposit date:2013-06-12
Release date:2013-11-06
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:EcxAB Is a Founding Member of a New Family of Metalloprotease AB5 Toxins with a Hybrid Cholera-like B Subunit.
Structure, 21, 2013
4Z9C
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ECPLTAB OXIDIZED
Descriptor:Pertussis toxin-like subunit ArtA, Subtilase cytotoxin subunit B-like protein, PHOSPHATE ION
Authors:Littler, D.R., Johnson, M.D., Summers, R.J., Schembri, M.A., Rossjohn, J., Beddoe, T.
Deposit date:2015-04-10
Release date:2016-10-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
4Z9D
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ECPLTA
Descriptor:Pertussis toxin-like subunit ArtA, SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Littler, D.R., Johnson, M.D., Summers, R.J., Schembri, M.A., Rossjohn, J., Beddoe, T.
Deposit date:2015-04-10
Release date:2016-10-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G proteins.
J. Biol. Chem., 2017
4UTO
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CRYSTAL STRUCTURE OF PNEUMOCOCCAL SURFACE ANTIGEN PSAA D280N IN THE CD-BOUND, OPEN STATE
Descriptor:MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN, CADMIUM ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Luo, Z., Counago, R.M., Maher, M., Kobe, B.
Deposit date:2014-07-22
Release date:2015-03-11
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.
Nat Commun, 6, 2015
4UTP
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CRYSTAL STRUCTURE OF PNEUMOCOCCAL SURFACE ANTIGEN PSAA IN THE CD- BOUND, CLOSED STATE
Descriptor:MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN, CADMIUM ION
Authors:Luo, Z., Counago, R.M., Maher, M., Kobe, B.
Deposit date:2014-07-22
Release date:2014-08-13
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.
Nat Commun, 6, 2015
5A69
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GH20C, BETA-HEXOSAMINIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH GAL-PUGNAC
Descriptor:N-ACETYL-BETA-D-GLUCOSAMINIDASE, [(Z)-[(3R,4R,5R,6R)-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-ylidene]amino] N-phenylcarbamate
Authors:Cid, M., Robb, C.S., Higgins, M.A., Boraston, A.B.
Deposit date:2015-06-24
Release date:2015-09-23
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
5A6A
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GH20C, BETA-HEXOSAMINIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH NGT
Descriptor:N-ACETYL-BETA-D-GLUCOSAMINIDASE, 1,2-ETHANEDIOL, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL
Authors:Cid, M., Robb, C.S., Higgins, M.A., Boraston, A.B.
Deposit date:2015-06-24
Release date:2015-09-23
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
5A6B
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GH20C, BETA-HEXOSAMINIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH PUGNAC
Descriptor:N-ACETYL-BETA-D-GLUCOSAMINIDASE, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, MAGNESIUM ION
Authors:Cid, M., Robb, C.S., Higgins, M.A., Boraston, A.B.
Deposit date:2015-06-24
Release date:2015-09-23
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
5A6J
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GH20C, BETA-HEXOSAMINIDASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:N-ACETYL-BETA-D-GLUCOSAMINIDASE, 1,2-ETHANEDIOL
Authors:Cid, M., Robb, C.S., Higgins, M.A., Boraston, A.B.
Deposit date:2015-06-26
Release date:2015-09-23
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
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