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2Z71
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STRUCTURE OF TRUNCATED MUTANT CYS1GLY OF PENICILLIN V ACYLASE FROM BACILLUS SPHAERICUS CO-CRYSTALLIZED WITH PENICILLIN V
Descriptor:Penicillin acylase, (2S,5R,6R)-3,3-DIMETHYL-7-OXO-6-(2-PHENOXYACETAMIDO)-4-THIA-1- AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID
Authors:Pathak, M.C., Brannigan, J., Dodson, G.G., Suresh, C.G.
Deposit date:2007-08-10
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Studies on the catalysis and post translational processing of penicillin V acylase
To be published
2QUY
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TRUNCATED MUTANT ASN175ALA OF PENICILLIN V ACYLASE FROM BACILLUS SPHAERICUS
Descriptor:Penicillin acylase, CHLORIDE ION
Authors:Pathak, M.C., Brannigan, J., Dodson, G.G., Suresh, C.G.
Deposit date:2007-08-07
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Auto-proteolytic processing of Penicillin V Acylase is simpler than of other related Ntn hydrolases
To be Published
3MJI
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ACTIVATION OF CATALYTIC CYSTEINE WITHOUT A BASE IN A MUTANT PENICILLIN ACYLASE PRECURSOR
Descriptor:Penicillin acylase
Authors:Pathak, M.C., Suresh, C.G., Dodson, G.G., Murshudov, G.N.
Deposit date:2010-04-12
Release date:2011-07-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Activation of catalytic cysteine without a base in a Mutant Penicillin Acylase Precursor
To be Published
4M8Z
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CRYSTAL STRUCTURE OF SFH3, A PHOSPHATIDYLINOSITOL TRANSFER PROTEIN THAT INTEGRATES PHOSPHOINOSITIDE SIGNALING WITH LIPID DROPLET METABOLISM
Descriptor:Phosphatidylinositol transfer protein PDR16
Authors:Ortlund, E.O., Pathak, M.C.
Deposit date:2013-08-14
Release date:2014-09-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.928 Å)
Cite:A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis.
Mol Biol Cell, 25, 2014
4GAH
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HUMAN ACYL-COA THIOESTERASES 4 IN COMPLEX WITH UNDECAN-2-ONE-COA INHIBITOR
Descriptor:Thioesterase superfamily member 4, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-[(2R)-2-oxidanylundecyl]sulfanylethylamino]propyl]amino]butyl] hydrogen phosphate
Authors:Lim, K., Pathak, M.C., Herzberg, O.
Deposit date:2012-07-25
Release date:2012-08-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.
Biochemistry, 51, 2012
4IS8
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DIVERGENT SEQUENCE TUNES LIGAND SENSITIVITY IN PHOSPHOLIPID-REGULATED HORMONE RECEPTORS
Descriptor:Nuclear receptor subfamily 5 group A member 2
Authors:Musille, P.M., Pathak, M.C., Ortlund, E.A.
Deposit date:2013-01-16
Release date:2013-06-12
Last modified:2013-07-31
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Divergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone Receptors.
J.Biol.Chem., 288, 2013
4DOR
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HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, IN ITS APO STATE BOUND TO A FRAGMENT OF HUMAN SHP BOX1
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor subfamily 0 group B member 2, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE
Authors:Musille, P.M., Ortlund, E.A.
Deposit date:2012-02-10
Release date:2012-04-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
Nat.Struct.Mol.Biol., 19, 2012
4DOS
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HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, BOUND TO DLPC AND A FRAGMENT OF TIF-2
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, PENTAETHYLENE GLYCOL, ...
Authors:Musille, P.M., Ortlund, E.A.
Deposit date:2012-02-10
Release date:2012-04-18
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
Nat.Struct.Mol.Biol., 19, 2012
5W75
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CRYSTAL STRUCTURE OF RECONSTRUCTED BACTERIAL ELONGATION FACTOR NODE 168
Descriptor:Elongation factor Tu, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ortlund, E.A.
Deposit date:2017-06-19
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.
Structure, 26, 2018
5W76
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CRYSTAL STRUCTURE OF RECONSTRUCTED BACTERIAL ELONGATION FACTOR NODE 168
Descriptor:Ancestral Elogation Factor N153, MAGNESIUM ION, SULFATE ION, ...
Authors:Ortlund, E.A.
Deposit date:2017-06-19
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.152 Å)
Cite:Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.
Structure, 26, 2018
5W7Q
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CRYSTAL STRUCTURE OF RECONSTRUCTED BACTERIAL ELONGATION FACTOR NODE 168
Descriptor:Consensus Elongation Factor, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Ortlund, E.A.
Deposit date:2017-06-20
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.
Structure, 26, 2018