Author results

2QBX
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EPHB2/SNEW ANTAGONISTIC PEPTIDE COMPLEX
Descriptor:Ephrin type-B receptor 2, antagonistic peptide, SULFATE ION
Authors:Chrencik, J.E., Brooun, A., Recht, M.I., Nicola, G., Pasquale, E.B., Kuhn, P., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-06-18
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.
J.Biol.Chem., 282, 2007
5JR2
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CRYSTAL STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH APYD3 PEPTIDE INHIBITOR
Descriptor:Ephrin type-A receptor 4, APYd3 peptide, HEXANE-1,6-DIOL, ...
Authors:Lechtenberg, B.C., Olson, E.J., Pasquale, E.B., Dawson, P.E., Riedl, S.J.
Deposit date:2016-05-05
Release date:2016-07-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability.
Acs Med.Chem.Lett., 7, 2016
6NJZ
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EPHA2 LBD IN COMPLEX WITH YSA-GSGSK-BIO PEPTIDE
Descriptor:Ephrin type-A receptor 2, YSA-GSGSK-bio peptide, GLYCEROL, ...
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling.
J.Biol.Chem., 2019
6NK0
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EPHA2 LBD IN COMPLEX WITH BA-WLA-YAM PEPTIDE
Descriptor:Ephrin type-A receptor 2, bA-WLA-Yam, GLYCEROL, ...
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling.
J.Biol.Chem., 2019
6NK1
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EPHA2 LBD IN COMPLEX WITH BA-WLA-YRPKBIO PEPTIDE
Descriptor:Ephrin type-A receptor 2, bA-WLA-YRPKbio, ACETATE ION, ...
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling.
J.Biol.Chem., 2019
6NK2
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EPHA2 LBD IN COMPLEX WITH BA-WLA-YRPK BIO PEPTIDE
Descriptor:Ephrin type-A receptor 2, bA-WLA-YPRKbio peptide, DI(HYDROXYETHYL)ETHER
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling.
J.Biol.Chem., 2019
6NKP
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EPHA2 LBD IN COMPLEX WITH BA-WLA-YSKBIO PEPTIDE
Descriptor:Ephrin type-A receptor 2, bA-WLA-YSKbio peptide, BIOTIN
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-07
Release date:2019-05-01
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.033 Å)
Cite:Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling.
J.Biol.Chem., 2019
3GXU
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CRYSTAL STRUCTURE OF EPH RECEPTOR AND EPHRIN COMPLEX
Descriptor:Ephrin type-A receptor 4, Ephrin-B2
Authors:Qin, H.N., Song, J.X.
Deposit date:2009-04-03
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of the EphA4-ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity
J.Biol.Chem., 2009
2BBA
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CRYSTAL STRUCTURE AND THERMODYNAMIC CHARACTERIZATION OF THE EPHB4 RECEPTOR IN COMPLEX WITH AN EPHRIN-B2 ANTAGONIST PEPTIDE REVEALS THE DETERMINANTS FOR RECEPTOR SPECIFICITY.
Descriptor:Ephrin type-B receptor 4, Agonist peptide, SULFATE ION
Authors:Chrencik, J.E., Kuhn, P., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2005-10-17
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity.
Structure, 14, 2006
2GJY
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NMR SOLUTION STRUCTURE OF TENSIN1 PTB DOMAIN
Descriptor:Tensin
Authors:Leone, M., Pellecchia, M.
Deposit date:2006-03-31
Release date:2007-04-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies.
Biopolymers, 89, 2007
3CKH
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CRYSTAL STRUCTURE OF EPH A4 RECEPTOR
Descriptor:Ephrin type-A receptor 4
Authors:Shi, J.H., Song, J.X.
Deposit date:2008-03-15
Release date:2008-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor
J.Biol.Chem., 283, 2008
3T6A
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STRUCTURE OF THE C-TERMINAL DOMAIN OF BCAR3
Descriptor:Breast cancer anti-estrogen resistance protein 3, (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, UNKNOWN ATOM OR ION
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2011-07-28
Release date:2011-11-23
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.
Nat.Struct.Mol.Biol., 18, 2011
3T6G
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STRUCTURE OF THE COMPLEX BETWEEN NSP3 (SHEP1) AND P130CAS
Descriptor:SH2 domain-containing protein 3C, Breast cancer anti-estrogen resistance protein 1, ACETATE ION
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2011-07-28
Release date:2011-11-23
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.
Nat.Struct.Mol.Biol., 18, 2011
4IZ5
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STRUCTURE OF THE COMPLEX BETWEEN ERK2 PHOSPHOMIMETIC MUTANT AND PEA-15
Descriptor:Mitogen-activated protein kinase 1, Astrocytic phosphoprotein PEA-15, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2013-01-29
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Nat Commun, 4, 2013
4IZ7
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STRUCTURE OF NON-PHOSPHORYLATED ERK2 BOUND TO THE PEA-15 DEATH EFFECTOR DOMAIN
Descriptor:Mitogen-activated protein kinase 1, Astrocytic phosphoprotein PEA-15, SODIUM ION
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2013-01-29
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Nat Commun, 4, 2013
4IZA
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STRUCTURE OF DUALLY PHOSPHORYLATED ERK2 BOUND TO THE PEA-15 DEATH EFFECTOR DOMAIN
Descriptor:Mitogen-activated protein kinase 1, Astrocytic phosphoprotein PEA-15
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2013-01-29
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Nat Commun, 4, 2013
4L0P
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STRUCTURE OF THE HUMAN EPHA3 RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH EPHRIN-A5
Descriptor:Ephrin type-A receptor 3, Ephrin-A5, SULFATE ION, ...
Authors:Forse, G.J., Kolatkar, A.R., Kuhn, P.
Deposit date:2013-05-31
Release date:2014-06-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5.
Plos One, 10, 2015
4W4Z
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STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH PEPTIDE
Descriptor:Ephrin type-A receptor 4, APY-bAla8.am peptide, HEXANE-1,6-DIOL, ...
Authors:Lechtenberg, B.C., Mace, P.D., Riedl, S.J.
Deposit date:2014-08-15
Release date:2014-10-08
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
4W50
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STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH PEPTIDE
Descriptor:Ephrin type-A receptor 4, APY peptide, 1,3-BUTANEDIOL, ...
Authors:Lechtenberg, B.C., Mace, P.D., Riedl, S.J.
Deposit date:2014-08-16
Release date:2014-10-08
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
5V60
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PHOSPHO-ERK2 BOUND TO AMP-PCP
Descriptor:Mitogen-activated protein kinase 1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, GLYCEROL, ...
Authors:Lechtenberg, B.C., Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
5V61
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PHOSPHO-ERK2 BOUND TO BIVALENT INHIBITOR SBP2
Descriptor:Mitogen-activated protein kinase 1, Ribosomal protein S6 kinase alpha-1,Protein Tat, GLYCEROL, ...
Authors:Lechtenberg, B.C., Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
5V62
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PHOSPHO-ERK2 BOUND TO BIVALENT INHIBITOR SBP3
Descriptor:Mitogen-activated protein kinase 1, Ribosomal protein S6 kinase alpha-1, GLYCEROL, ...
Authors:Lechtenberg, B.C., Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017