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2J5X
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BU of 2j5x by Molmil
STRUCTURE OF THE SMALL G PROTEIN ARF6 IN COMPLEX WITH GTPGAMMAS
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADP-RIBOSYLATION FACTOR 6, MAGNESIUM ION
Authors:Pasqualato, S, Menetrey, J, Franco, M, Cherfils, J.
Deposit date:2006-09-20
Release date:2006-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structural Gdp-GTP Cycle of Human Arf6.
Embo Rep., 2, 2001
1OIX
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BU of 1oix by Molmil
X-ray structure of the small G protein Rab11a in complex with GDP and Pi
Descriptor: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pasqualato, S, Senic-Matuglia, F, Renault, L, Goud, B, Salamero, J, Cherfils, J.
Deposit date:2003-06-26
Release date:2005-01-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystallographic Evidence for Substrate-Assisted GTP Hydrolysis by a Small GTP Binding Protein
Structure, 13, 2005
1OIW
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BU of 1oiw by Molmil
X-ray structure of the small G protein Rab11a in complex with GTPgammaS
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, RAS-RELATED PROTEIN RAB-11A
Authors:Pasqualato, S, Senic-Matuglia, F, Renault, L, Goud, B, Salamero, J, Cherfils, J.
Deposit date:2003-06-26
Release date:2004-01-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Structural Gdp/GTP Cycle of Rab11 Reveals a Novel Interface Involved in the Dynamics of Recycling Endosomes
J.Biol.Chem., 279, 2004
1OIV
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BU of 1oiv by Molmil
X-ray structure of the small G protein Rab11a in complex with GDP
Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, RAS-RELATED PROTEIN RAB-11A, ...
Authors:Pasqualato, S, Senic-Matuglia, F, Renault, L, Goud, B, Salamero, J, Cherfils, J.
Deposit date:2003-06-26
Release date:2004-01-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The Structural Gdp/GTP Cycle of Rab11 Reveals a Novel Interface Involved in the Dynamics of Recycling Endosomes
J.Biol.Chem., 279, 2004
6TE1
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BU of 6te1 by Molmil
Structure of the KDM1A/CoREST complex with the inhibitor 2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol
Descriptor: 5-[4-cyclobutyl-1-[2-(4-piperidin-4-yloxyphenoxy)ethyl]imidazol-2-yl]-4-methyl-thieno[3,2-b]pyrrole, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Pasqualato, S, Cecatiello, V.
Deposit date:2019-11-11
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.
Acs Med.Chem.Lett., 11, 2020
6HC2
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BU of 6hc2 by Molmil
Crystal structure of NuMA/LGN hetero-hexamers
Descriptor: G-protein-signaling modulator 2, Nuclear mitotic apparatus protein 1
Authors:Pasqualato, S, Culurgioni, S, Foadi, J, Alfieri, A, Mapelli, M.
Deposit date:2018-08-13
Release date:2019-05-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.31 Å)
Cite:Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions.
Nat Commun, 10, 2019
1E7Z
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BU of 1e7z by Molmil
Crystal structure of the EMAP2/RNA binding domain of the p43 protein from human aminoacyl-tRNA synthetase complex
Descriptor: ENDOTHELIAL-MONOCYTE ACTIVATING POLYPEPTIDE II, MERCURY (II) ION
Authors:Pasqualato, S, Kerjan, P, Renault, L, Menetrey, J, Mirande, M, Cherfils, J.
Deposit date:2000-09-13
Release date:2000-11-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the Emapii Domain of Human Aminoacyl-tRNA Synthetase Complex Reveals Evolutionary Dimeric Mimicry
Embo J., 20, 2001
4WAU
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BU of 4wau by Molmil
Crystal structure of CENP-M solved by native-SAD phasing
Descriptor: Centromere protein M
Authors:Weinert, T, Basilico, F, Cecatiello, V, Pasqualato, S, Wang, M.
Deposit date:2014-09-01
Release date:2014-12-10
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
6QJA
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BU of 6qja by Molmil
Organizational principles of the NuMA-Dynein interaction interface and implications for mitotic spindle functions
Descriptor: CHLORIDE ION, MAGNESIUM ION, Nuclear mitotic apparatus protein 1
Authors:Renna, C, Rizzelli, F, Carminati, M, Gaddoni, C, Pirovano, L, Cecatiello, V, Pasqualato, S, Mapelli, M.
Deposit date:2019-01-23
Release date:2020-02-05
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Organizational Principles of the NuMA-Dynein Interaction Interface and Implications for Mitotic Spindle Functions.
Structure, 28, 2020
1FL0
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BU of 1fl0 by Molmil
CRYSTAL STRUCTURE OF THE EMAP2/RNA-BINDING DOMAIN OF THE P43 PROTEIN FROM HUMAN AMINOACYL-TRNA SYNTHETASE COMPLEX
Descriptor: ENDOTHELIAL-MONOCYTE ACTIVATING POLYPEPTIDE II
Authors:Renault, L, Kerjan, P, Pasqualato, S, Menetrey, J, Robinson, J.-C, Kawaguchi, S, Vassylyev, D.G, Yokoyama, S, Mirande, M, Cherfils, J.
Deposit date:2000-08-11
Release date:2000-12-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry.
EMBO J., 20, 2001
1KU1
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BU of 1ku1 by Molmil
Crystal Structure of the Sec7 Domain of Yeast GEA2
Descriptor: ARF guanine-nucleotide exchange factor 2
Authors:Renault, L, Christova, P, Guibert, B, Pasqualato, S, Cherfils, J.
Deposit date:2002-01-20
Release date:2002-03-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mechanism of domain closure of Sec7 domains and role in BFA sensitivity.
Biochemistry, 41, 2002
4BE8
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BU of 4be8 by Molmil
NEDD4 HECT A889F structure
Descriptor: E3 UBIQUITIN-PROTEIN LIGASE NEDD4
Authors:Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S.
Deposit date:2013-03-06
Release date:2013-05-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.996 Å)
Cite:Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming
Nat.Struct.Mol.Biol., 20, 2013
4BBN
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BU of 4bbn by Molmil
NEDD4 HECT-Ub:Ub complex
Descriptor: E3 UBIQUITIN-PROTEIN LIGASE NEDD4, POLYUBIQUITIN-B
Authors:Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S.
Deposit date:2012-09-27
Release date:2013-05-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming
Nat.Struct.Mol.Biol., 20, 2013
3IZ0
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BU of 3iz0 by Molmil
Human Ndc80 Bonsai Decorated Microtubule
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Alushin, G.M, Ramey, V.H, Pasqualato, S, Ball, D.A, Grigorieff, N, Musacchio, A, Nogales, E.
Deposit date:2010-08-09
Release date:2010-10-13
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (8.6 Å)
Cite:The Ndc80 kinetochore complex forms oligomeric arrays along microtubules.
Nature, 467, 2010
6ZT0
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BU of 6zt0 by Molmil
Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex
Descriptor: 1,2-ETHANEDIOL, Protein eiger, Protein grindelwald
Authors:Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M.
Deposit date:2020-07-17
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
6ZSY
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BU of 6zsy by Molmil
Crystal structure of the Grindelwald extracellular domain complex
Descriptor: Protein grindelwald
Authors:Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M.
Deposit date:2020-07-17
Release date:2021-03-31
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (0.926 Å)
Cite:Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
6ZSZ
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BU of 6zsz by Molmil
Crystal structure of the Grindelwald extracellular domain complex
Descriptor: Protein grindelwald
Authors:Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M.
Deposit date:2020-07-17
Release date:2021-03-31
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
2XBB
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BU of 2xbb by Molmil
Nedd4 HECT:Ub complex
Descriptor: E3 UBIQUITIN-PROTEIN LIGASE NEDD4, GLYCEROL, UBIQUITIN
Authors:Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S.
Deposit date:2010-04-08
Release date:2011-03-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
2XBF
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BU of 2xbf by Molmil
Nedd4 HECT structure
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE NEDD4
Authors:Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S.
Deposit date:2010-04-09
Release date:2011-03-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
5FJK
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BU of 5fjk by Molmil
Crystal structure of human JMJD2C catalytic domain in complex 6-ethyl- 5-methyl-7-oxo-4,7-dihydropyrazolo(1,5-a)pyrimidine-3-carbonitrile
Descriptor: 1,2-ETHANEDIOL, 6-ethyl-5-methyl-7-oxidanylidene-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, CHLORIDE ION, ...
Authors:Cecatiello, V, Pasqualato, S.
Deposit date:2015-10-09
Release date:2015-10-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal Structures of Human Jmjd2C Catalytic Domain Bound to Inhibitors
To be Published
5FJH
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BU of 5fjh by Molmil
Crystal structure of human JMJD2C catalytic domain in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino) -2-oxoethyl)amino)methyl)isonicotinic acid
Descriptor: 1,2-ETHANEDIOL, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, CHLORIDE ION, ...
Authors:Cecatiello, V, Pasqualato, S.
Deposit date:2015-10-09
Release date:2015-10-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Human Jmjd2C Catalytic Domain Bound to Inhibitors
To be Published
2VE7
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BU of 2ve7 by Molmil
Crystal structure of a bonsai version of the human Ndc80 complex
Descriptor: GLYCEROL, KINETOCHORE PROTEIN HEC1, KINETOCHORE PROTEIN SPC25, ...
Authors:Ciferri, C, Pasqualato, S, Dos Reis, G, Screpanti, E, Maiolica, A, Polka, J, De Luca, J.G, De Wulf, P, Salek, M, Rappsilber, J, Moores, C.A, Salmon, E.D, Musacchio, A.
Deposit date:2007-10-17
Release date:2008-05-13
Last modified:2022-05-04
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex
Cell(Cambridge,Mass.), 133, 2008
4NFA
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BU of 4nfa by Molmil
Structure of the C-terminal doamin of Knl1
Descriptor: CHLORIDE ION, GLYCEROL, Protein CASC5
Authors:Petrovic, A, Mosalaganti, S, Keller, J, Mattiuzzo, M, Overlack, K, Wohlgemuth, S, Pasqualato, S, Raunser, S, Musacchio, A.
Deposit date:2013-10-31
Release date:2014-03-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization.
Mol.Cell, 53, 2014
4NF9
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BU of 4nf9 by Molmil
Structure of the Knl1/Nsl1 complex
Descriptor: CHLORIDE ION, Kinetochore-associated protein NSL1 homolog, Protein CASC5
Authors:Petrovic, A, Mosalaganti, S, Keller, J, Mattiuzzo, M, Overlack, K, Wohlgemuth, S, Pasqualato, S, Raunser, S, Musacchio, A.
Deposit date:2013-10-31
Release date:2014-03-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization.
Mol.Cell, 53, 2014
4P0T
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BU of 4p0t by Molmil
Crystal structure of human centromere protein M
Descriptor: Centromere protein M, GLYCEROL
Authors:Basilico, F, Pasqualato, S, Musacchio, A.
Deposit date:2014-02-22
Release date:2014-07-09
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (1.493 Å)
Cite:The pseudo GTPase CENP-M drives human kinetochore assembly.
Elife, 3, 2014

 

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