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1KEY
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BU of 1key by Molmil
Crystal Structure of Mouse Testis/Brain RNA-binding Protein (TB-RBP)
Descriptor: translin
Authors:Pascal, J.M, Hart, P.J, Hecht, N.B, Robertus, J.D.
Deposit date:2001-11-19
Release date:2002-07-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structure of TB-RBP, a Novel RNA-binding and Regulating Protein
J.Mol.Biol., 319, 2002
1X9N
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BU of 1x9n by Molmil
Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA
Descriptor: 5'-phosphorylated DNA, ADENOSINE MONOPHOSPHATE, DNA ligase I, ...
Authors:Pascal, J.M, O'Brien, P.J, Tomkinson, A.E, Ellenberger, T.
Deposit date:2004-08-23
Release date:2004-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human DNA ligase I completely encircles and partially unwinds nicked DNA.
Nature, 432, 2004
1HWP
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BU of 1hwp by Molmil
EBULIN COMPLEXED WITH PTEROIC ACID, TRIGONAL CRYSTAL FORM
Descriptor: EBULIN, PTEROIC ACID, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ...
Authors:Pascal, J.M, Day, P.J, Monzingo, A.F, Ernst, S.R, Robertus, J.D.
Deposit date:2001-01-09
Release date:2001-01-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.
Proteins, 43, 2001
1HWM
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BU of 1hwm by Molmil
EBULIN,ORTHORHOMBIC CRYSTAL FORM MODEL
Descriptor: EBULIN, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose
Authors:Pascal, J.M, Day, P.J, Monzingo, A.F, Ernst, S.R, Robertus, J.D.
Deposit date:2001-01-09
Release date:2001-01-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.
Proteins, 43, 2001
1HWN
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BU of 1hwn by Molmil
EBULIN COMPLEXED WITH GALACTOSE, TRIGONAL CRYSTAL FORM
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EBULIN, beta-D-galactopyranose
Authors:Pascal, J.M, Day, P.J, Monzingo, A.F, Ernst, S.R, Robertus, J.D.
Deposit date:2001-01-09
Release date:2001-01-24
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.
Proteins, 43, 2001
1HWO
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BU of 1hwo by Molmil
EBULIN COMPLEXED WITH LACTOSE, TRIGONAL CRYSTAL FORM
Descriptor: EBULIN, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Pascal, J.M, Day, P.J, Monzingo, A.F, Ernst, S.R, Robertus, J.D.
Deposit date:2001-01-09
Release date:2001-01-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.
Proteins, 43, 2001
2HII
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BU of 2hii by Molmil
heterotrimeric PCNA sliding clamp
Descriptor: PCNA1 (SSO0397), PCNA2 (SSO1047), PCNA3 (SSO0405)
Authors:Pascal, J.M, Tsodikov, O.V, Ellenberger, T.
Deposit date:2006-06-29
Release date:2006-11-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
2HIK
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BU of 2hik by Molmil
heterotrimeric PCNA sliding clamp
Descriptor: PCNA1 (SSO0397), PCNA2 (SSO1047), PCNA3 (SSO0405)
Authors:Pascal, J.M, Tsodikov, O.V, Ellenberger, T.
Deposit date:2006-06-29
Release date:2006-11-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
2HIV
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BU of 2hiv by Molmil
ATP-dependent DNA ligase from S. solfataricus
Descriptor: Thermostable DNA ligase
Authors:Pascal, J.M, Ellenberger, T.
Deposit date:2006-06-29
Release date:2006-11-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
2HIX
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BU of 2hix by Molmil
ATP dependent DNA ligase from S. solfataricus bound to ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Thermostable DNA ligase
Authors:Pascal, J.M, Ellenberger, T.
Deposit date:2006-06-29
Release date:2006-11-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:A Flexible Interface between DNA Ligase and PCNA Supports Conformational Switching and Efficient Ligation of DNA.
Mol.Cell, 24, 2006
5KNI
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BU of 5kni by Molmil
Crystal Structure of the wild-type SAM domain of human Tankyrase-1
Descriptor: Tankyrase-1
Authors:Pascal, J.M, McCauley, M, Langelier, M.F, Riccio, A.A.
Deposit date:2016-06-28
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Tankyrase Sterile alpha Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.
Structure, 24, 2016
6BHV
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BU of 6bhv by Molmil
Human PARP-1 bound to NAD+ analog benzamide adenine dinucleotide (BAD)
Descriptor: Poly [ADP-ribose] polymerase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name)
Authors:Pascal, J.M, Langelier, M.F.
Deposit date:2017-10-31
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:NAD+analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains.
Nat Commun, 9, 2018
4OQA
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BU of 4oqa by Molmil
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide
Descriptor: (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide, DNA (26-MER), Poly [ADP-ribose] polymerase 1, ...
Authors:Pascal, J.M, Steffen, J.D.
Deposit date:2014-02-07
Release date:2014-07-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
J.Med.Chem., 57, 2014
4OPX
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BU of 4opx by Molmil
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide
Descriptor: (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide, DNA (26-MER), Poly [ADP-ribose] polymerase 1, ...
Authors:Pascal, J.M, Steffen, J.D.
Deposit date:2014-02-06
Release date:2014-07-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.314 Å)
Cite:Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
J.Med.Chem., 57, 2014
4OQB
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BU of 4oqb by Molmil
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-{4-[2-(morpholin-4-yl)ethoxy]benzylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide
Descriptor: (2Z)-2-{4-[2-(morpholin-4-yl)ethoxy]benzylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide, DNA (26-MER), Poly [ADP-ribose] polymerase 1, ...
Authors:Pascal, J.M, Steffen, J.D.
Deposit date:2014-02-07
Release date:2014-07-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.362 Å)
Cite:Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
J.Med.Chem., 57, 2014
2RIQ
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BU of 2riq by Molmil
Crystal Structure of the Third Zinc-binding domain of human PARP-1
Descriptor: ETHANOL, GLYCEROL, Poly [ADP-ribose] polymerase 1, ...
Authors:Pascal, J.M, Langelier, M.F, Servent, K.M.
Deposit date:2007-10-12
Release date:2008-01-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Third Zinc-binding Domain of Human Poly(ADP-ribose) Polymerase-1 Coordinates DNA-dependent Enzyme Activation.
J.Biol.Chem., 283, 2008
3OD8
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BU of 3od8 by Molmil
Human PARP-1 zinc finger 1 (Zn1) bound to DNA
Descriptor: 5'-D(*CP*CP*CP*AP*AP*GP*CP*GP*GP*C)-3', 5'-D(*GP*CP*CP*GP*CP*TP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ...
Authors:Pascal, J.M, Langelier, M.-F.
Deposit date:2010-08-11
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
3ODA
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BU of 3oda by Molmil
Human PARP-1 zinc finger 1 (Zn1) bound to DNA
Descriptor: 5'-D(*GP*CP*CP*TP*GP*CP*AP*GP*GP*C)-3', Poly [ADP-ribose] polymerase 1, ZINC ION
Authors:Pascal, J.M, Langelier, M.-F.
Deposit date:2010-08-11
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
3ODE
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BU of 3ode by Molmil
Human PARP-1 zinc finger 2 (Zn2) bound to DNA
Descriptor: 5'-D(*CP*CP*CP*AP*AP*GP*CP*G)-3', 5'-D(*CP*GP*CP*TP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ...
Authors:Pascal, J.M, Langelier, M.-F.
Deposit date:2010-08-11
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
3ODC
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BU of 3odc by Molmil
Human PARP-1 zinc finger 2 (Zn2) bound to DNA
Descriptor: 5'-D(*CP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*G)-3', Poly [ADP-ribose] polymerase 1, ...
Authors:Pascal, J.M, Langelier, M.-F.
Deposit date:2010-08-11
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY.
J.Biol.Chem., 286, 2011
4QNH
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BU of 4qnh by Molmil
Calcium-calmodulin (T79D) complexed with the calmodulin binding domain from a small conductance potassium channel SK2-a
Descriptor: CALCIUM ION, Calmodulin, SULFATE ION, ...
Authors:Zhang, M, Pascal, J.M, Logothetis, D.E, Zhang, J.F.
Deposit date:2014-06-17
Release date:2014-08-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.
Nat.Chem.Biol., 10, 2014
5JHQ
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BU of 5jhq by Molmil
ARCs 1-3 of human Tankyrase-1 bound to a peptide derived from IRAP
Descriptor: Peptide derived from insulin-responsive aminopeptidase (IRAP), Tankyrase-1
Authors:Eisemann, T, Pascal, J.M.
Deposit date:2016-04-21
Release date:2016-09-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
Structure, 24, 2016
3SJQ
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BU of 3sjq by Molmil
Crystal structure of a small conductance potassium channel splice variant complexed with calcium-calmodulin
Descriptor: 1-phenylurea, CALCIUM ION, Calmodulin, ...
Authors:Zhang, M, Pascal, J.M, Zhang, J.-F.
Deposit date:2011-06-21
Release date:2012-05-30
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for calmodulin as a dynamic calcium sensor.
Structure, 20, 2012
8SX1
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BU of 8sx1 by Molmil
PARP4 catalytic domain
Descriptor: Protein mono-ADP-ribosyltransferase PARP4
Authors:Frigon, L, Pascal, J.M.
Deposit date:2023-05-19
Release date:2023-11-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.
Nucleic Acids Res., 51, 2023
8SWY
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BU of 8swy by Molmil
PARP4 ART domain bound to NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, Protein mono-ADP-ribosyltransferase PARP4
Authors:Frigon, L, Pascal, J.M.
Deposit date:2023-05-19
Release date:2023-11-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.
Nucleic Acids Res., 51, 2023

 

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