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4ZZ7
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CRYSTAL STRUCTURE OF METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (DDDC) FROM OCEANIMONAS DOUDOROFFII
分子名称:Methylmalonate-semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Do, H., Lee, C.W., Lee, S.G., Kang, H., Park, C.M., Kim, H.J., Park, H., Park, H., Lee, J.H.
登録日2015-05-22
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure and modeling of the tetrahedral intermediate state of methylmalonate-semialdehyde dehydrogenase (MMSDH) from Oceanimonas doudoroffii.
J. Microbiol., 54, 2016
2O1Y
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-X, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-29
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O21
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-2, 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-29
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O22
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-2, N-[(4-{[1,1-dimethyl-2-(phenylthio)ethyl]amino}-3-nitrophenyl)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-29
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2F
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-2, 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-29
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2M
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-X, 4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-30
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2N
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
分子名称:Apoptosis regulator Bcl-X, 4-[4-(BIPHENYL-2-YLMETHYL)PIPERAZIN-1-YL]-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE
著者Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
登録日2006-11-30
公開日2007-02-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
3V9B
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1-[1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4-YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE
分子名称:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, N-(3-{1-[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)acetamide, ZINC ION
著者Kim, H.T., Chang, H.J.
登録日2011-12-25
公開日2012-01-18
最終更新日2013-06-26
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Stereoselective synthesis of novel pyrazole derivatives using tert-butansulfonamide as a chiral auxiliary
Org.Biomol.Chem., 10, 2012
3OW6
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CRYSTAL STRUCTURE OF HSP90 WITH N-ARYL-BENZIMIDAZOLONE I
分子名称:Heat shock protein HSP 90-alpha, 1-(2,4-dihydroxyphenyl)-1,3-dihydro-2H-benzimidazol-2-one
著者Park, C.H.
登録日2010-09-17
公開日2011-09-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3OWB
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CRYSTAL STRUCTURE OF HSP90 WITH VER-49009
分子名称:Heat shock protein HSP 90-alpha, 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
著者Park, C.H.
登録日2010-09-17
公開日2011-09-21
最終更新日2011-10-19
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3OWD
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CRYSTAL STRUCTURE OF HSP90 WITH N-ARYL-BENZIMIDAZOLONE II
分子名称:Heat shock protein HSP 90-alpha, N-{[1-(5-chloro-2,4-dihydroxyphenyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]methyl}naphthalene-1-sulfonamide
著者Park, C.H.
登録日2010-09-17
公開日2011-09-21
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
4LVT
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BCL_2-NAVITOCLAX (ABT-263) COMPLEX
分子名称:Apoptosis regulator Bcl-2, 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide
著者Park, C.H.
登録日2013-07-26
公開日2013-08-14
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
NAT.MED. (N.Y.), 19, 2013
4LXD
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BCL_2-NAVITOCLAX ANALOG (WITHOUT THIOPHENYL) COMPLEX
分子名称:Apoptosis regulator Bcl-2, 4-(4-{[4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylamino)phenyl]sulfonyl}benzamide
著者Park, C.H.
登録日2013-07-29
公開日2013-08-14
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
NAT.MED. (N.Y.), 19, 2013
4MAN
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BCL_2-NAVITOCLAX ANALOG (WITH INDOLE) COMPLEX
分子名称:Apoptosis regulator Bcl-2, 4-[4-({4'-chloro-3-[2-(dimethylamino)ethoxy]biphenyl-2-yl}methyl)piperazin-1-yl]-2-(1H-indol-5-yloxy)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)benzamide
著者Park, C.H.
登録日2013-08-16
公開日2014-01-29
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
NAT.MED. (N.Y.), 19, 2013
4Y46
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PYRIDOPYRIMIDINONE DERIVATIVES AS POTENT AND SELECTIVE C-JUN N-TERMINAL KINASE (JNK) INHIBITORS
分子名称:Mitogen-activated protein kinase 10, 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea
著者Park, H.
登録日2015-02-10
公開日2015-05-06
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
4Y5H
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PYRIDOPYRIMIDINONE DERIVATIVES AS POTENT AND SELECTIVE C-JUN N-TERMINAL KINASE (JNK) INHIBITORS
分子名称:Mitogen-activated protein kinase 10, 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea
著者Park, H.
登録日2015-02-11
公開日2015-05-06
実験手法X-RAY DIFFRACTION (2.055 Å)
主引用文献Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
1I3C
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RESPONSE REGULATOR FOR CYANOBACTERIAL PHYTOCHROME, RCP1
分子名称:RESPONSE REGULATOR RCP1, SULFATE ION
著者Im, Y.J., Rho, S.-H., Park, C.-M., Yang, S.-S., Kang, J.-G., Lee, J.Y., Song, P.-S., Eom, S.H.
登録日2001-02-14
公開日2002-03-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a cyanobacterial phytochrome response regulator.
Protein Sci., 11, 2002
1JLK
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CRYSTAL STRUCTURE OF THE MN(2+)-BOUND FORM OF RESPONSE REGULATOR RCP1
分子名称:Response regulator RCP1, SULFATE ION, MANGANESE (II) ION
著者Im, Y.J., Rho, S.-H., Park, C.-M., Yang, S.-S., Kang, J.-G., Lee, J.Y., Song, P.-S., Eom, S.H.
登録日2001-07-16
公開日2002-03-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of a cyanobacterial phytochrome response regulator.
Protein Sci., 11, 2002
1KP6
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USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT
分子名称:PROTEIN (TOXIN), SULFATE ION
著者Li, N., Erman, M., Pangborn, W., Duax, W.L., Park, C.-M., Bruenn, J., Ghosh, D.
登録日1999-05-28
公開日1999-07-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore.
J.Biol.Chem., 274, 1999
2QI2
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CRYSTAL STRUCTURE OF THE THERMOPLASMA ACIDOPHILUM PELOTA PROTEIN
分子名称:Cell division protein pelota related protein
著者Lee, H.H., Kim, Y.S., Kim, K.H., Heo, I.H., Kim, S.K., Kim, O., Suh, S.W.
登録日2007-07-03
公開日2007-10-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural and functional insights into dom34, a key component of no-go mRNA decay
Mol.Cell, 27, 2007
4YSB
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CRYSTAL STRUCTURE OF ETHE1 FROM MYXOCOCCUS XANTHUS
分子名称:Metallo-beta-lactamase family protein, FE (III) ION
著者Sattler, S.A., Wang, X., DeHan, P.J., Xun, L., Kang, C.
登録日2015-03-17
公開日2015-06-24
最終更新日2015-08-12
実験手法X-RAY DIFFRACTION (2.5015 Å)
主引用文献Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily.
J.Biol.Chem., 290, 2015
4YSK
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CRYSTAL STRUCTURE OF APO-FORM SDOA FROM PSEUDOMONAS PUTIDA
分子名称:Beta-lactamase domain protein, FE (III) ION
著者Sattler, S.A., Wang, X., DeHan, P.J., Xun, L., Kang, C.
登録日2015-03-17
公開日2015-06-24
最終更新日2015-08-12
実験手法X-RAY DIFFRACTION (2.466 Å)
主引用文献Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily.
J.Biol.Chem., 290, 2015
4YSL
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CRYSTAL STRUCTURE OF SDOA FROM PSEUDOMONAS PUTIDA IN COMPLEX WITH GLUTATHIONE
分子名称:Beta-lactamase domain protein, FE (III) ION, GLUTATHIONE
著者Sattler, S.A., Wang, X., DeHan, P.J., Xun, L., Kang, C.
登録日2015-03-17
公開日2015-06-24
最終更新日2015-08-12
実験手法X-RAY DIFFRACTION (1.4618 Å)
主引用文献Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily.
J.Biol.Chem., 290, 2015