Author results

2RCW
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PARP COMPLEXED WITH A620223
分子名称:Poly [ADP-ribose] polymerase 1, trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium
著者Park, C.H.
登録日2007-09-20
公開日2008-09-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献PARP complexed with A620223
To be Published
2RD6
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PARP COMPLEXED WITH A861695
分子名称:Poly [ADP-ribose] polymerase 1, (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium
著者Park, C.H.
登録日2007-09-21
公開日2008-09-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献PARP complexed with A861695
To be Published
3GN7
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PARP COMPLEXED WITH A861696
分子名称:Poly [ADP-ribose] polymerase 1, 2-[(2S)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide
著者Park, C.H.
登録日2009-03-16
公開日2010-03-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献PARP complexed with A861696
To be Published
5UEO
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BRD4_BD2_A-1395017
分子名称:Bromodomain-containing protein 4, N-[4-(2,4-difluorophenoxy)-3-(1-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)phenyl]ethanesulfonamide
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Complex structure of BRD4_BD2_A-1395017
To Be Published
5UEP
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BRD4_BD2_A-581577
分子名称:Bromodomain-containing protein 4, ethyl 3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Complex structure of BRD4_BD2_A-581577
To Be Published
5UEQ
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BRD4_BD2_A-1390146
分子名称:Bromodomain-containing protein 4, N-[3-(7-methyl-1-oxo-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-5-yl)-4-phenoxyphenyl]ethanesulfonamide
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Complex structure of BRD4_BD2_A-1390146
To Be Published
5UER
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BRD4_BD2_A-1359930
分子名称:Bromodomain-containing protein 4, N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)-4-phenoxyphenyl]methanesulfonamide
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Complex structure of BRD4_BD2_A-1359930
To Be Published
5UES
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BRD4_BD2_A-1344772
分子名称:Bromodomain-containing protein 4, 5-[2-(4-chlorophenoxy)phenyl]-2-methyl-1H-pyrrole-3-carboxamide
著者Park, C.H.
登録日2017-01-03
公開日2017-06-28
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Complex structure of BRD4_BD2_A-1344772
To Be Published
5UET
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BRD4_BD2_A-1308586
分子名称:Bromodomain-containing protein 4, 2-methyl-5-phenyl-1H-pyrrole-3-carboxamide
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Complex structure of BRD4_BD2_A-1308586
To Be Published
5UEV
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BRD4_BD2_A-556343
分子名称:Bromodomain-containing protein 4, 1-[5-(2-aminophenyl)-2-methyl-1H-pyrrol-3-yl]ethan-1-one
著者Park, C.H.
登録日2017-01-03
公開日2017-06-14
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Complex structure of BRD4_BD2_A-556343
To Be Published
5UVS
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BRD4_BD2_A-1406537
分子名称:Bromodomain-containing protein 4, 4-{2-[(cyclopropylmethyl)amino]-5-(ethylsulfonyl)phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one
著者Park, C.H.
登録日2017-02-20
公開日2017-06-21
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Complex structure of BRD4_BD2_A-1406537
To Be Published
5UVT
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BRD4_BD2_A-1454056
分子名称:Bromodomain-containing protein 4, 7-(cyclopropylmethyl)-2-methyl-10-[(propan-2-yl)sulfonyl]-2,4,6,7-tetrahydro-3H-2,4,7-triazadibenzo[cd,f]azulen-3-one
著者Park, C.H.
登録日2017-02-20
公開日2017-06-21
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Complex structure of BRD4_BD2_A-1454056
To Be Published
5UVU
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BRD4_BD2_A-1461028
分子名称:Bromodomain-containing protein 4, 7-(cyclopropylmethyl)-2-methyl-10-[(methylsulfonyl)methyl]-2,4,6,7-tetrahydro-3H-2,4,7-triazadibenzo[cd,f]azulen-3-one
著者Park, C.H.
登録日2017-02-20
公開日2017-06-21
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Complex structure of BRD4_BD2_A-1461028
To Be Published
5UVV
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BRD4 BROMODOMAIN 2 WITH A-1457066
分子名称:Bromodomain-containing protein 4, 7-(cyclopropylmethyl)-10-(ethylsulfonyl)-2-methyl-2,4,6,7-tetrahydro-3H-2,4,7-triazadibenzo[cd,f]azulen-3-one
著者Park, C.H.
登録日2017-02-20
公開日2017-06-21
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献BRD4 Bromodomain 2 with A-1457066
To Be Published
5UVW
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BRD4_BROMODOMAIN1-A1376855
分子名称:Bromodomain-containing protein 4, N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide, SULFATE ION
著者Park, C.H.
登録日2017-02-20
公開日2017-06-21
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献BRD4_Bromodomain1-A1376855
To Be Published
5UVX
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BRD4 BROMODOMAIN 2 WITH A-1359643
分子名称:Bromodomain-containing protein 4, N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]methanesulfonamide
著者Park, C.H.
登録日2017-02-20
公開日2017-06-21
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献BRD4 Bromodomain 2 with A-1359643
To Be Published
5UVY
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BRD4 BROMODOMAIN 2 WITH A-1349391
分子名称:Bromodomain-containing protein 4, 6-methyl-4-(2-phenoxyphenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one
著者Park, C.H.
登録日2017-02-20
公開日2017-06-14
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献BRD4 Bromodomain 2 with A-1349391
To Be Published
5UVZ
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BRD4 BROMODOMAIN 2 WITH A-1354689
分子名称:Bromodomain-containing protein 4, 3-methyl-5-(2-phenoxyphenyl)pyridin-2(1H)-one
著者Park, C.H.
登録日2017-02-20
公開日2017-06-14
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献BRD4 Bromodomain 2 with A-1354689
To Be Published
1YW7
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H-METAP2 COMPLEXED WITH A444148
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID
著者Park, C.H.
登録日2005-02-17
公開日2006-02-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW8
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H-METAP2 COMPLEXED WITH A751277
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
著者Park, C.H.
登録日2005-02-17
公開日2006-02-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW9
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H-METAP2 COMPLEXED WITH A849519
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
著者Park, C.H.
登録日2005-02-17
公開日2006-02-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
3OW6
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CRYSTAL STRUCTURE OF HSP90 WITH N-ARYL-BENZIMIDAZOLONE I
分子名称:Heat shock protein HSP 90-alpha, 1-(2,4-dihydroxyphenyl)-1,3-dihydro-2H-benzimidazol-2-one
著者Park, C.H.
登録日2010-09-17
公開日2011-09-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3OWB
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CRYSTAL STRUCTURE OF HSP90 WITH VER-49009
分子名称:Heat shock protein HSP 90-alpha, 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
著者Park, C.H.
登録日2010-09-17
公開日2011-09-21
最終更新日2011-10-19
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3OWD
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CRYSTAL STRUCTURE OF HSP90 WITH N-ARYL-BENZIMIDAZOLONE II
分子名称:Heat shock protein HSP 90-alpha, N-{[1-(5-chloro-2,4-dihydroxyphenyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]methyl}naphthalene-1-sulfonamide
著者Park, C.H.
登録日2010-09-17
公開日2011-09-21
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
4LVT
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BCL_2-NAVITOCLAX (ABT-263) COMPLEX
分子名称:Apoptosis regulator Bcl-2, 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide
著者Park, C.H.
登録日2013-07-26
公開日2013-08-14
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
NAT.MED. (N.Y.), 19, 2013