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4QF1
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CRYSTAL STRUCTURE OF UNLIGANDED CH59UA, THE INFERRED UNMUTATED ANCESTOR OF THE RV144 ANTI-HIV ANTIBODY LINEAGE PRODUCING CH59
Descriptor:CH59UA Fab fragment of heavy chain, Inferred unmutated ancestor (UA) of anti-HIV antibody CH59, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Wiehe, K., Easterhoff, D., Luo, K., Nicely, N.I., Bradley, T., Jaeger, F.H., Dennison, S.M., Zhang, R., Lloyd, K.E., Stolarchuk, C., Parks, R., Sutherland, L.L., Scearce, R.M., Morris, L., Kaewkungwal, J., Nitayaphan, S., Pitisuttithum, P., Rerks-Ngarm, S., Michael, N., Kim, J., Kelsoe, G., Montefiori, D.C., Tomaras, G., Bonsignori, M., Santra, S., Kepler, T.B., Alam, S.M., Moody, M.A., Liao, H.-X., Haynes, B.F.
Deposit date:2014-05-19
Release date:2015-02-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Antibody Light-Chain-Restricted Recognition of the Site of Immune Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved.
Immunity, 41, 2014
5DD0
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CRYSTAL STRUCTURES IN AN ANTI-HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES
Descriptor:ANTI-HIV ANTIBODY DH570 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570 FAB HEAVY LIGHT, oligo peptide
Authors:Zhang, R., Verkoczy, L., Wiehe, K., Alam, S.M., Nicely, N.I., Santra, S., Bradley, T., Pemble, C., Gao, F., Montefiori, D.C., Bouton-Verville, H., Kelsoe, G., Parks, R., Foulger, A., Tomaras, G., Keple, T.B., Moody, M.A., Liao, H.-X., Haynes, B.F.
Deposit date:2015-08-24
Release date:2016-05-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.488 Å)
Cite:Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.
Sci Transl Med, 8, 2016
5DD1
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CRYSTAL STRUCTURES IN AN ANTI-HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES
Descriptor:ANTI-HIV ANTIBODY DH570 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570 FAB LIGHT CHAIN
Authors:Zhang, R., Verkoczy, L., Wiehe, K., Alam, S.M., Nicely, N.I., Santra, S., Bradley, T., Pemble, C., Gao, F., Montefiori, D.C., Bouton-Verville, H., Kelsoe, G., Parks, R., Foulger, A., Tomaras, G., Keple, T.B., Moody, M.A., Liao, H.-X., Haynes, B.F.
Deposit date:2015-08-24
Release date:2016-05-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.597 Å)
Cite:Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.
Sci Transl Med, 8, 2016
5CY5
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CRYSTAL STRUCTURE OF THE T33-51H DESIGNED SELF-ASSEMBLING PROTEIN TETRAHEDRON
Descriptor:T33-51H-B, T33-51H-A
Authors:Cannon, K.A., Cascio, D., Park, R., Boyken, S., King, N., Yeates, T.O.
Deposit date:2015-07-30
Release date:2016-08-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the T33-51H designed self-assembling protein tetrahedron
to be published
5VL4
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ACCIDENTAL MINIMUM CONTACT CRYSTAL LATTICE FORMED BY A REDESIGNED PROTEIN OLIGOMER
Descriptor:T33-53H-B
Authors:Cannon, K.A., Cascio, D., Sawaya, M.R., Park, R., Boyken, S., King, N., Yeates, T.
Deposit date:2017-04-24
Release date:2018-05-23
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Accidental minimum contact crystal lattice formed by a redesigned protein oligomer
to be published
5IIE
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STRUCTURE OF THE UNLIGANDED ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3
Descriptor:antibody DH501 FabH chain, antibody DH501 light chain
Authors:Nicely, N.I., Haynes, B.F.
Deposit date:2016-03-01
Release date:2017-03-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:HIV Envelope vaccination elicits asparagine 332 glycan-dependent antibodies that resemble broadly neutralizing antibody precursors
Cell Rep, 2017
5T4Z
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STRUCTURE OF THE ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3 WITH FREE MAN9 GLYCAN
Descriptor:antibody DH501 Fab heavy chain, antibody DH501 Fab light chain, ALPHA-D-MANNOSE, ...
Authors:Nicely, N.I., Haynes, B.F.
Deposit date:2016-08-30
Release date:2017-03-08
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:HIV Envelope vaccination elicits asparagine 332 glycan-dependent antibodies that resemble broadly neutralizing antibody precursors
Cell Rep, 2017
4ZK7
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CRYSTAL STRUCTURE OF RESCUED TWO-COMPONENT SELF-ASSEMBLING TETRAHEDRAL CAGE T33-31
Descriptor:Chorismate mutase, Divalent-cation tolerance protein CutA
Authors:Liu, Y., Cascio, D., Sawaya, M.R., Bale, J., Collazo, M.J., Park, R., King, N., Baker, D., Yeates, T.
Deposit date:2015-04-30
Release date:2015-07-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression.
Protein Sci., 24, 2015
4JAM
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTI-HIV-1 ANTIBODY CH103
Descriptor:ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN of CH103, ANTIGEN BINDING FRAGMENT OF LIGHT CHAIN of CH103, SULFATE ION, ...
Authors:Zhou, T., Moquin, S., Zheng, A., Srivatsan, S., Kwong, P.D.
Deposit date:2013-02-18
Release date:2013-04-03
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Nature, 496, 2013
4JAN
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CH103 IN COMPLEX WITH HIV-1 GP120
Descriptor:ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN of CH103, ANTIGEN BINDING FRAGMENT OF LIGHT CHAIN of CH103, ...
Authors:Zhou, T., Moquin, S., Zheng, A., Srivatsan, S., Kwong, P.D.
Deposit date:2013-02-18
Release date:2013-04-03
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Nature, 496, 2013
5DD3
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CRYSTAL STRUCTURES IN AN ANTI-HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES
Descriptor:ANTI-HIV ANTIBODY DH570.4 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570.4 FAB LIGHT CHAIN
Authors:Nicely, N.I., Pemble IV, C.W., Haynes, B.F.
Deposit date:2015-08-24
Release date:2016-05-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.797 Å)
Cite:Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.
Sci Transl Med, 8, 2016
5DD5
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CRYSTAL STRUCTURES IN AN ANTI-HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES
Descriptor:ANTI-HIV ANTIBODY DH570.9 FAB HEAVY CHAIN
Authors:Nicely, N.I., Pemble IV, C.W., Haynes, B.F.
Deposit date:2015-08-24
Release date:2016-05-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.
Sci Transl Med, 8, 2016
5DD6
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CRYSTAL STRUCTURES IN AN ANTI-HIV ANTIBODY LINEAGE FROM IMMUNIZATION OF RHESUS MACAQUES
Descriptor:ANTI-HIV ANTIBODY DH570.mut58 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570.mut58 FAB LIGHT CHAIN
Authors:Nicely, N.I., Pemble IV, C.W., Haynes, B.F.
Deposit date:2015-08-24
Release date:2016-05-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.
Sci Transl Med, 8, 2016
5F6H
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CRYSTAL STRUCTURE OF TIER 2 NEUTRALIZING ANTIBODY DH427 FROM A RHESUS MACAQUE
Descriptor:DH427 Antibody Light Chain, DH427 Antibody Heavy Chain
Authors:Fera, D., Harrison, S.C.
Deposit date:2015-12-06
Release date:2016-01-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
5F6I
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CRYSTAL STRUCTURE OF TIER 2 NEUTRALIZING ANTIBODY DH428 FROM A RHESUS MACAQUE
Descriptor:DH428 Antibody Heavy Chain, DH428 Antibody Light Chain
Authors:Fera, D., Harrison, S.C.
Deposit date:2015-12-06
Release date:2016-01-13
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
5F6J
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CRYSTAL STRUCTURE OF TIER 2 NEUTRALIZING ANTIBODY DH427 FROM A RHESUS MACAQUE IN COMPLEX WITH HIV-1 GP120 CORE
Descriptor:ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, DH427 Antibody Light Chain, DH427 Antibody Heavy Chain
Authors:Fera, D., Harrison, S.C.
Deposit date:2015-12-06
Release date:2016-01-13
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (6.63 Å)
Cite:Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
5KG9
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CRYSTAL STRUCTURE OF THE GP120 V2 ANTIBODY RE505-22 FAB FROM IGH- AND IGK-HUMANIZED MOUSE
Descriptor:Antibody RE505-22 Fab heavy chain, Antibody RE505-22 Fab light chain
Authors:Nicely, N.I.
Deposit date:2016-06-13
Release date:2017-01-25
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.
J. Immunol., 198, 2017
5UKN
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STRUCTURE OF UNLIGANDED ANTI-GP120 CD4BS ANTIBODY DH522UCA FAB
Descriptor:DH522UCA Fab fragment heavy chain, DH522UCA Fab fragment light chain, CHLORIDE ION
Authors:Nicely, N.I.
Deposit date:2017-01-23
Release date:2017-12-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
Nat Commun, 8, 2017
5UKO
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STRUCTURE OF UNLIGANDED ANTI-GP120 CD4BS ANTIBODY DH522IA FAB
Descriptor:DH522IA Fab fragment heavy chain, DH522IA Fab fragment light chain
Authors:Nicely, N.I.
Deposit date:2017-01-23
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
Nat Commun, 8, 2017
5UKP
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STRUCTURE OF UNLIGANDED ANTI-GP120 CD4BS ANTIBODY DH522.1 FAB
Descriptor:DH522.1 Fab fragment heavy chain, DH522.1 Fab fragment light chain
Authors:Nicely, N.I.
Deposit date:2017-01-23
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
Nat Commun, 8, 2017
5UKQ
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STRUCTURE OF UNLIGANDED ANTI-GP120 CD4BS ANTIBODY DH522.2 FAB
Descriptor:DH522.2 Fab fragment heavy chain, DH522.2 Fab fragment light chain, GLYCEROL
Authors:Nicely, N.I.
Deposit date:2017-01-23
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
Nat Commun, 8, 2017
5UKR
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STRUCTURE OF UNLIGANDED ANTI-GP120 CD4BS ANTIBODY DH522.2 FAB IN COMPLEX WITH A GP120 CORE
Descriptor:DH522.2 Fab fragment heavy chain, DH522.2 Fab fragment light chain, Chimeric B.YU2 gp120 core derived from HIV-1 Env, ...
Authors:Nicely, N.I.
Deposit date:2017-01-23
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.712 Å)
Cite:Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
Nat Commun, 8, 2017
4DQO
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CRYSTAL STRUCTURE OF PG16 FAB IN COMPLEX WITH V1V2 REGION FROM HIV-1 STRAIN ZM109
Descriptor:PG16 Fab Heavy Chain, PG16 Fab Light Chain, 1FD6-V1V2 scaffold ZM109 HIV-1 strain, ...
Authors:Pancera, M., McLellan, J.S., Kwong, P.D.
Deposit date:2012-02-16
Release date:2013-03-06
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.438 Å)
Cite:Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.
Nat.Struct.Mol.Biol., 20, 2013
5IQ7
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CRYSTAL STRUCTURE OF 10E8-S74W FAB IN COMPLEX WITH AN HIV-1 GP41 PEPTIDE.
Descriptor:10E8-S74W Heavy Chain, 10E8-S74W Light Chain, gp41 MPER peptide
Authors:Ofek, G., Kwon, Y.D., Caruso, W., Kwong, P.D.
Deposit date:2016-03-10
Release date:2016-04-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.2869 Å)
Cite:Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
J.Virol., 90, 2016
5IQ9
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CRYSTAL STRUCTURE OF 10E8V4 FAB IN COMPLEX WITH AN HIV-1 GP41 PEPTIDE.
Descriptor:10E8v4 Heavy Chain, 10E8v4 Light Chain, gp41 MPER peptide
Authors:Ofek, G., Kwon, Y.D., Caruso, W., Kwong, P.D.
Deposit date:2016-03-10
Release date:2016-04-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
J.Virol., 90, 2016
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