6J10
| Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly | Descriptor: | 6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one, Capsid protein | Authors: | Park, S, Jin, M.S, Cho, Y, Kang, J, Kim, S, Park, M, Park, H, Kim, J, Park, S, Hwang, J, Kim, Y, Kim, Y.J. | Deposit date: | 2018-12-27 | Release date: | 2019-04-17 | Last modified: | 2019-05-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly. Nat Commun, 10, 2019
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8DS7
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4GKF
| Crystal structure and characterization of Cmr5 protein from Pyrococcus furiosus | Descriptor: | CRISPR system Cmr subunit Cmr5 | Authors: | Park, J, Sun, J, Park, S, Hwang, H, Park, M, Shin, M.S. | Deposit date: | 2012-08-11 | Release date: | 2013-01-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of Cmr5 from Pyrococcus furiosus and its functional implications Febs Lett., 587, 2013
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8G8N
| CTLA4 Fab with peptide | Descriptor: | CYS-PRO-GLY-LYS-GLY-LEU-PRO-SER-CYS, Fab heavy chain, Fab light chain | Authors: | Williams, J.C. | Deposit date: | 2023-02-18 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer. J Immunother Cancer, 11, 2023
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8G2M
| The tumor activated anti-CTLA-4 monoclonal antibody XTX101 demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer | Descriptor: | CITRIC ACID, Heavy chain of humanized IgG, Light chain of humanized IgG, ... | Authors: | Williams, J.C, Williams, J.C. | Deposit date: | 2023-02-05 | Release date: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer. J Immunother Cancer, 11, 2023
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8GUY
| human insulin receptor bound with two insulin molecules | Descriptor: | Insulin A chain, Insulin, isoform 2, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-09-14 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures Nat Commun, 13, 2022
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4R3Z
| Crystal structure of human ArgRS-GlnRS-AIMP1 complex | Descriptor: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Arginine--tRNA ligase, cytoplasmic, ... | Authors: | Fu, Y, Kim, Y, Cho, Y. | Deposit date: | 2014-08-18 | Release date: | 2014-10-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (4.033 Å) | Cite: | Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation Proc.Natl.Acad.Sci.USA, 111, 2014
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7YQ4
| human insulin receptor bound with A62 DNA aptamer and insulin - locally refined | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures Nat Commun, 13, 2022
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7YQ6
| human insulin receptor bound with A62 DNA aptamer | Descriptor: | IR-A62 aptamer, Isoform Short of Insulin receptor | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures Nat Commun, 13, 2022
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7YQ5
| human insulin receptor bound with A62 DNA aptamer and insulin | Descriptor: | IR-A62 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures Nat Commun, 13, 2022
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7YQ3
| human insulin receptor bound with A43 DNA aptamer and insulin | Descriptor: | IR-A43 aptamer, Insulin A chain, Insulin, ... | Authors: | Kim, J, Yunn, N, Ryu, S, Cho, Y. | Deposit date: | 2022-08-05 | Release date: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures Nat Commun, 13, 2022
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1SSL
| Solution structure of the PSI domain from the Met receptor | Descriptor: | Hepatocyte growth factor receptor | Authors: | Kozlov, G, Perreault, A, Schrag, J.D, Cygler, M, Gehring, K, Ekiel, I. | Deposit date: | 2004-03-24 | Release date: | 2004-10-12 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Insights into function of PSI domains from structure of the Met receptor PSI domain. Biochem.Biophys.Res.Commun., 321, 2004
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4YZU
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4Z0K
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4K86
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4K88
| Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form) | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Proline--tRNA ligase, ZINC ION | Authors: | Hwang, K.Y, Son, J.H, Lee, E.H. | Deposit date: | 2013-04-18 | Release date: | 2013-10-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.619 Å) | Cite: | Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. Acta Crystallogr.,Sect.D, 69, 2013
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4K87
| Crystal structure of human prolyl-tRNA synthetase (substrate bound form) | Descriptor: | ADENOSINE, PROLINE, Proline--tRNA ligase, ... | Authors: | Hwang, K.Y, Son, J.H, Lee, E.H. | Deposit date: | 2013-04-18 | Release date: | 2013-10-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. Acta Crystallogr.,Sect.D, 69, 2013
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4QIQ
| Crystal structure of D-xylose-proton symporter | Descriptor: | D-xylose-proton symporter, ZINC ION | Authors: | Wisedchaisri, G, Park, M, Iadanza, M.G, Zheng, H, Gonen, T. | Deposit date: | 2014-06-01 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE. Nat Commun, 5, 2014
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7UZA
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7UZ7
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7UZ5
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7UZ4
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7UZ9
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7UZB
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7UZ6
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