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4FFF
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CRYSTAL STRUCTURE OF LEVAN FRUCTOTRANSFERASE FROM ARTHROBACTER UREAFACIENS
Descriptor:Levan fructotransferase
Authors:Park, J., Rhee, S.
Deposit date:2012-06-01
Release date:2012-07-18
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural and functional basis for substrate specificity and catalysis of levan fructotransferase.
J.Biol.Chem., 287, 2012
4FFG
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CRYSTAL STRUCTURE OF LEVAN FRUCTOTRANSFERASE FROM ARTHROBACTER UREAFACIENS IN COMPLEX WITH DFA-IV
Descriptor:Levan fructotransferase, 6-O-beta-D-fructofuranosyl-beta-D-fructofuranose, (1R,4R,5S,6S,7R,10R,11S,12S)-1,7-bis(hydroxymethyl)-2,8,13,14-tetraoxatricyclo[8.2.1.1~4,7~]tetradecane-5,6,11,12-tetrol
Authors:Park, J., Rhee, S.
Deposit date:2012-06-01
Release date:2012-07-18
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional basis for substrate specificity and catalysis of levan fructotransferase.
J.Biol.Chem., 287, 2012
4FFH
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CRYSTAL STRUCTURE OF LEVAN FRUCTOTRANSFERASE D54N MUTANT FROM ARTHROBACTER UREAFACIENS IN COMPLEX WITH SUCROSE
Descriptor:Levan fructotransferase, SUCROSE
Authors:Park, J., Rhee, S.
Deposit date:2012-06-01
Release date:2012-07-18
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional basis for substrate specificity and catalysis of levan fructotransferase.
J.Biol.Chem., 287, 2012
4FFI
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CRYSTAL STRUCTURE OF LEVAN FRUCTOTRANSFERASE D54N MUTANT FROM ARTHROBACTER UREAFACIENS IN COMPLEX WITH LEVANBIOSE
Descriptor:Levan fructotransferase, 6-O-beta-D-fructofuranosyl-beta-D-fructofuranose, beta-D-fructofuranosyl-(2->6)-beta-D-fructofuranosyl-(2->6)-beta-D-fructofuranose
Authors:Park, J., Rhee, S.
Deposit date:2012-06-01
Release date:2012-07-18
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional basis for substrate specificity and catalysis of levan fructotransferase.
J.Biol.Chem., 287, 2012
4GO6
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CRYSTAL STRUCTURE OF HCF-1 SELF-ASSOCIATION SEQUENCE 1
Descriptor:HCF N-terminal chain 1, HCF C-terminal chain 1, SULFATE ION
Authors:Park, J., Lammers, F., Herr, W., Song, J.
Deposit date:2012-08-18
Release date:2012-10-17
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:HCF-1 self-association via an interdigitated Fn3 structure facilitates transcriptional regulatory complex formation
Proc.Natl.Acad.Sci.USA, 109, 2012
5BYC
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CRYSTAL STRUCTURE OF HUMAN RIBOKINASE IN C2 SPACEGROUP
Descriptor:Ribokinase, SODIUM ION
Authors:Park, J., Chakrabarti, J., Singh, B., Gupta, R.S., Junop, M.S.
Deposit date:2015-06-10
Release date:2016-06-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of unliganded human ribokinase in C2 spacegroup
To Be Published
5BYD
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CRYSTAL STRUCTURE OF HUMAN RIBOKINASE IN P21 SPACEGROUP
Descriptor:Ribokinase, SODIUM ION, POTASSIUM ION
Authors:Park, J., Chakrabarti, J., Singh, B., Gupta, R.S., Junop, M.S.
Deposit date:2015-06-10
Release date:2016-06-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human ribokinase in P21 spacegroup
To Be Published
5BYE
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CRYSTAL STRUCTURE OF HUMAN RIBOKINASE IN P212121 SPACEGROUP
Descriptor:Ribokinase, SODIUM ION, CHLORIDE ION
Authors:Park, J., Chakrabarti, J., Singh, B., Gupta, R.S., Junop, M.S.
Deposit date:2015-06-10
Release date:2016-06-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of human ribokinase in P212121 spacegroup
To Be Published
5BYF
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CRYSTAL STRUCTURE OF HUMAN RIBOKINASE IN COMPLEX WITH AMP
Descriptor:Ribokinase, ADENOSINE MONOPHOSPHATE, SODIUM ION, ...
Authors:Park, J., Chakrabarti, J., Singh, B., Gupta, R.S., Junop, M.S.
Deposit date:2015-06-10
Release date:2016-06-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human ribokinase in complex with AMP
To Be Published
5C3Y
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STRUCTURE OF HUMAN RIBOKINASE CRYSTALLIZED WITH AMPPNP
Descriptor:Ribokinase, AMP PHOSPHORAMIDATE, SODIUM ION
Authors:Park, J., Chakrabarti, J., Singh, B., Gupta, R.S., Junop, M.S.
Deposit date:2015-06-17
Release date:2016-06-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of human ribokinase crystallized with AMPPNP
To Be Published
5C3Z
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CRYSTAL STRUCTURE OF HUMAN RIBOKINASE IN COMPLEX WITH AMPPCP IN C2 SPACEGROUP
Descriptor:Ribokinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SODIUM ION, ...
Authors:Park, J., Chakrabarti, J., Singh, B., Gupta, R.S., Junop, M.S.
Deposit date:2015-06-17
Release date:2016-06-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human ribokinase in complex with AMPPCP in C2 spacegroup
To Be Published
5C40
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CRYSTAL STRUCTURE OF HUMAN RIBOKINASE IN COMPLEX WITH AMPPCP IN P21 SPACEGROUP
Descriptor:Ribokinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SODIUM ION, ...
Authors:Park, J., Chakrabarti, J., Singh, B., Gupta, R.S., Junop, M.S.
Deposit date:2015-06-17
Release date:2016-06-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of human ribokinase in complex with AMPPCP in P21 spacegroup
To Be Published
5C41
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CRYSTAL STRUCTURE OF HUMAN RIBOKINASE IN COMPLEX WITH AMPPCP IN P21 SPACEGROUP AND WITH 4 PROTOMERS
Descriptor:Ribokinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SODIUM ION, ...
Authors:Park, J., Chakrabarti, J., Singh, B., Gupta, R.S., Junop, M.S.
Deposit date:2015-06-17
Release date:2016-06-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human ribokinase in complex with AMPPCP in P21 spacegroup and with 4 protomers
To Be Published
5JUZ
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR CL-06-057
Descriptor:Farnesyl pyrophosphate synthase, CHLORIDE ION, [(R)-(2,3-dihydro-1-benzofuran-5-yl){[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl]phosphonic acid
Authors:Park, J., Magder, A., Leung, C.Y., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2016-05-10
Release date:2017-03-15
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
J. Med. Chem., 60, 2017
5JV0
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR CL-08-038
Descriptor:Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-2-(3-fluorophenyl)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}ethyl]phosphonic acid
Authors:Park, J., Leung, C.Y., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2016-05-10
Release date:2017-03-15
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
J. Med. Chem., 60, 2017
5JV1
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR CL-08-066
Descriptor:Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid
Authors:Park, J., Leung, C.Y., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2016-05-10
Release date:2017-03-15
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
J. Med. Chem., 60, 2017
5JV2
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR MIT-01-055
Descriptor:Farnesyl pyrophosphate synthase, PHOSPHATE ION, CHLORIDE ION, ...
Authors:Park, J., Magder, A., Tsakos, M., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2016-05-10
Release date:2017-03-15
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
J. Med. Chem., 60, 2017
5KSX
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR AM-02-072
Descriptor:Farnesyl pyrophosphate synthase, PHOSPHATE ION, [[(2~{S})-2-[[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoyl]amino]phosphonic acid
Authors:Park, J., Matralis, A., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2016-07-10
Release date:2017-03-15
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.
J. Med. Chem., 60, 2017
4H5C
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CRYSTAL STRUCTURE OF HUMAN FPPS IN TERNARY COMPLEX WITH YS0470 AND INORGANIC PHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), PHOSPHATE ION, ...
Authors:Park, J., Lin, Y.-S., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2012-09-18
Release date:2012-12-26
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
Bmc Struct.Biol., 12, 2012
4H5D
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CRYSTAL STRUCTURE OF HUMAN FPPS IN TERNARY COMPLEX WITH YS0470 AND INORGANIC PYROPHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), PYROPHOSPHATE 2-, ...
Authors:Park, J., Lin, Y.-S., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2012-09-18
Release date:2012-12-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
Bmc Struct.Biol., 12, 2012
4H5E
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CRYSTAL STRUCTURE OF HUMAN FPPS IN TERNARY COMPLEX WITH YS0470 AND ISOPENTENYL PYROPHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), ISOPENTYL PYROPHOSPHATE, ...
Authors:Park, J., Lin, Y.-S., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2012-09-18
Release date:2012-12-26
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
Bmc Struct.Biol., 12, 2012
4LFV
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH YS0470 AND TWO MOLECULES OF INORGANIC PHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), PHOSPHATE ION, ...
Authors:Park, J., Lin, Y.-S., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2013-06-27
Release date:2014-03-12
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate.
Acta Crystallogr F Struct Biol Commun, 70, 2014
4NFI
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH MAGNESIUM AND JDS05120
Descriptor:Farnesyl pyrophosphate synthase, [({5-[4-(cyclopropyloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid), MAGNESIUM ION
Authors:Park, J., De Schutter, J.W., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2013-10-31
Release date:2014-12-31
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
PLoS ONE, 12, 2017
4NFJ
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH MAGNESIUM, JDS05120, AND SULFATE
Descriptor:Farnesyl pyrophosphate synthase, [({5-[4-(cyclopropyloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid), MAGNESIUM ION, ...
Authors:Park, J., De Schutter, J.W., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2013-10-31
Release date:2014-12-31
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
PLoS ONE, 12, 2017
4NFK
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH NICKEL, JDS05120, AND SULFATE
Descriptor:Farnesyl pyrophosphate synthase, NICKEL (II) ION, [({5-[4-(cyclopropyloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid), ...
Authors:Park, J., De schutter, J.W., Tsantrizos, Y.S., Berghuis, A.M.
Deposit date:2013-10-31
Release date:2014-12-31
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
PLoS ONE, 12, 2017