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4R3R
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BU of 4r3r by Molmil
Crystal structures of EGFR in complex with Mig6
Descriptor: Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1'
Authors:Park, E, Kim, N, Yi, Z, Cho, A, Kim, K, Ficarro, S.B, Park, A, Park, W.Y, Murray, B, Meyerson, M, Beroukim, R, Marto, J.A, Cho, J, Eck, M.J.
Deposit date:2014-08-17
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
4R3P
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BU of 4r3p by Molmil
Crystal structures of EGFR in complex with Mig6
Descriptor: Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1
Authors:Park, E, Kim, N, Yi, Z, Cho, A, Kim, K, Ficarro, S.B, Park, A, Park, W.Y, Murray, B, Meyerson, M, Beroukim, R, Marto, J.A, Cho, J, Eck, M.J.
Deposit date:2014-08-17
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.905 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
8DSW
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BU of 8dsw by Molmil
Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant
Descriptor: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Park, E, Eck, M.J.
Deposit date:2022-07-23
Release date:2023-09-27
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural basis for oncogenic activation of the epidermal growth factor receptor by the InsFQEA exon 20 insertion
To Be Published
6COY
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BU of 6coy by Molmil
Human CLC-1 chloride ion channel, transmembrane domain
Descriptor: CHLORIDE ION, Chloride channel protein 1
Authors:Park, E, MacKinnon, R.
Deposit date:2018-03-13
Release date:2018-06-13
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structure of the CLC-1 chloride channel fromHomo sapiens.
Elife, 7, 2018
6COZ
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BU of 6coz by Molmil
Human CLC-1 chloride ion channel, C-terminal cytosolic domain
Descriptor: Chloride channel protein 1
Authors:Park, E, MacKinnon, R.
Deposit date:2018-03-13
Release date:2018-06-13
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structure of the CLC-1 chloride channel fromHomo sapiens.
Elife, 7, 2018
6Q0J
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BU of 6q0j by Molmil
Structure of a MAPK pathway complex
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Park, E, Rawson, S, Jeon, H, Eck, M.J.
Deposit date:2019-08-01
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6Q0K
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BU of 6q0k by Molmil
Structure of a MAPK pathway complex
Descriptor: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf
Authors:Park, E, Rawson, S, Jeon, H, Eck, M.J.
Deposit date:2019-08-01
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6Q0T
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BU of 6q0t by Molmil
Structure of a MAPK pathway complex
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Park, E, Rawson, S, Jeon, H, Eck, M.J.
Deposit date:2019-08-02
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
5TQQ
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BU of 5tqq by Molmil
Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1) conformation
Descriptor: Chloride channel protein, Monoclonal antibody, Fab fragment, ...
Authors:Park, E, MacKinnon, R.
Deposit date:2016-10-24
Release date:2017-01-04
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
5TR1
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BU of 5tr1 by Molmil
Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation
Descriptor: CHOLESTEROL HEMISUCCINATE, Chloride channel protein, Monoclonal antibody, ...
Authors:Park, E, MacKinnon, R.
Deposit date:2016-10-25
Release date:2017-01-11
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
6NYB
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BU of 6nyb by Molmil
Structure of a MAPK pathway complex
Descriptor: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Park, E, Rawson, S, Li, K, Jeon, H, Eck, M.J.
Deposit date:2019-02-11
Release date:2019-10-09
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
4V4N
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BU of 4v4n by Molmil
Structure of the Methanococcus jannaschii ribosome-SecYEBeta channel complex
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein L7AE, ...
Authors:Menetret, J.F, Park, E, Gumbart, J.C, Ludtke, S.J, Li, W, Whynot, A, Rapoport, T.A, Akey, C.W.
Deposit date:2013-06-17
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Structure of the SecY channel during initiation of protein translocation.
Nature, 506, 2013
8TQM
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BU of 8tqm by Molmil
Cryo-EM structure of E3 ubiquitin ligase Doa10 from Saccharomyces cerevisiae
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ERAD-associated E3 ubiquitin-protein ligase DOA10, ...
Authors:Park, E, Itskanov, S.I.
Deposit date:2023-08-07
Release date:2024-03-13
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10.
Nat Commun, 15, 2024
4ZJV
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BU of 4zjv by Molmil
crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
Descriptor: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor
Authors:Eck, M.J, Park, E, Lee, B.
Deposit date:2015-04-29
Release date:2015-08-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
8DNW
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BU of 8dnw by Molmil
Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2)
Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO3
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BU of 8do3 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I
Descriptor: N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DNY
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BU of 8dny by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by decatransin
Descriptor: Decatransin peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DNV
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BU of 8dnv by Molmil
Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1)
Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DNX
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BU of 8dnx by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by cotransin
Descriptor: Cotransin analogue peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO1
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BU of 8do1 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin F
Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO2
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BU of 8do2 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA)
Descriptor: 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DO0
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BU of 8do0 by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by mycolactone
Descriptor: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
8DNZ
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BU of 8dnz by Molmil
Cryo-EM structure of the human Sec61 complex inhibited by apratoxin F
Descriptor: Apratoxin F peptide inhibitor, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ...
Authors:Park, E, Itskanov, S.
Deposit date:2022-07-12
Release date:2023-05-24
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:A common mechanism of Sec61 translocon inhibition by small molecules.
Nat.Chem.Biol., 19, 2023
6XMP
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BU of 6xmp by Molmil
Structure of P5A-ATPase Spf1, Apo form
Descriptor: DODECYL-BETA-D-MALTOSIDE, P5A-type ATPase
Authors:Park, E, Sim, S.I.
Deposit date:2020-06-30
Release date:2020-09-23
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.
Science, 369, 2020
6XMT
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BU of 6xmt by Molmil
Structure of P5A-ATPase Spf1, BeF3-bound form
Descriptor: BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, P5A-type ATPase
Authors:Park, E, Sim, S.I.
Deposit date:2020-06-30
Release date:2020-09-23
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.
Science, 369, 2020

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