Author results

1CD2
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LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+
Descriptor:DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FOLIC ACID
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Blakley, R.L., Gangjee, A.
Deposit date:1999-03-05
Release date:2000-03-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
Biochemistry, 38, 1999
1HFP
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COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Blakley, R.L., Gangjee, A.
Deposit date:1997-11-04
Release date:1998-01-28
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-Cancer Drug Des., 13, 1998
1HFQ
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COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Blakley, R.L., Gangjee, A.
Deposit date:1997-11-04
Release date:1998-01-28
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-Cancer Drug Des., 13, 1998
1HFR
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COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Blakley, R.L., Gangjee, A.
Deposit date:1997-11-04
Release date:1998-01-28
Last modified:2013-12-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-Cancer Drug Des., 13, 1998
1S5I
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FAB (LNKB-2) OF MONOCLONAL ANTIBODY TO HUMAN INTERLEUKIN-2, CRYSTAL STRUCTURE
Descriptor:Fab-fragment of monoclonal antibody
Authors:Pletnev, V.Z., Goryacheva, E.A., Tsygannik, I.N., Nesmeyanov, V.A., Pletnev, S.V., Pangborn, W., Duax, W.
Deposit date:2004-01-21
Release date:2004-05-25
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:[A new crystal form of the Fab fragment of a monoclonal antibody to human interleukin-2: the three-dimensional structure at 2.7 A resolution].
Bioorg. Khim., 30
1BOZ
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STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4-DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS
Descriptor:PROTEIN (DIHYDROFOLATE REDUCTASE), NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE
Authors:Gangjee, A., Vidwans, A.P., Vasudevan, A., Queener, S.F., Kisliuk, R.L., Cody, V., Li, R., Galitsky, N., Luft, J.R., Pangborn, W.
Deposit date:1998-08-06
Release date:1998-08-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
J.Med.Chem., 41, 1998
1KGI
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RAT TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3,3',5,5'-TETRAIODOTHYROACETIC ACID (T4AC)
Descriptor:TRANSTHYRETIN, 3,3',5,5'-TETRAIODOTHYROACETIC ACID
Authors:Wojtczak, A., Neumann, P., Muziol, T., Cody, V., Luft, J.R., Pangborn, W.
Deposit date:2001-11-27
Release date:2002-11-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution.
Acta Biochim.Pol., 48, 2001
1KLK
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CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH
Descriptor:Dihydrofolate reductase, [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Rosowsky, A., Queener, S.F.
Deposit date:2001-12-12
Release date:2002-12-12
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH.
Acta Crystallogr.,Sect.D, 58, 2002
1OHJ
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HUMAN DIHYDROFOLATE REDUCTASE, MONOCLINIC (P21) CRYSTAL FORM
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W.
Deposit date:1997-09-17
Release date:1998-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.
Biochemistry, 36, 1997
1OHK
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HUMAN DIHYDROFOLATE REDUCTASE, ORTHORHOMBIC (P21 21 21) CRYSTAL FORM
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W.
Deposit date:1997-09-17
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.
Biochemistry, 36, 1997
2BQP
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THE STRUCTURE OF THE PEA LECTIN-D-GLUCOPYRANOSE COMPLEX
Descriptor:PROTEIN (PEA LECTIN), ALPHA-D-GLUCOSE, CALCIUM ION, ...
Authors:Ruzeinikov, S.N., Mikhailova Yu, I., Tsygannik, I.N., Pangborn, W., Duax, W., Pletnev, V.Z.
Deposit date:1998-12-08
Release date:1998-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Structure of Pea Lectin-D-Glucopyranose Complex at a 1.9 A Resolution
RUSS.J.BIOORGANIC CHEM., 23, 1997
1DLR
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METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W.
Deposit date:1995-01-25
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers.
J.Biol.Chem., 270, 1995
1DLS
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METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W.
Deposit date:1995-01-25
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers.
J.Biol.Chem., 270, 1995
1G66
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ACETYLXYLAN ESTERASE AT 0.90 ANGSTROM RESOLUTION
Descriptor:ACETYL XYLAN ESTERASE II, SULFATE ION, GLYCEROL
Authors:Ghosh, D., Sawicki, M., Lala, P., Erman, M., Pangborn, W., Eyzaguirre, J., Gutierrez, R., Jornvall, H., Thiel, D.J.
Deposit date:2000-11-03
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Multiple conformations of catalytic serine and histidine in acetylxylan esterase at 0.90 A.
J.Biol.Chem., 276, 2001
1LY3
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ANALYSIS OF QUINAZOLINE AND PYRIDOPYRIMIDINE N9-C10 REVERSED BRIDGE ANTIFOLATES IN COMPLEX WITH NADP+ AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-6-[N-(2',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]QUINAZOLINE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Queener, S.F., Gangjee, A.
Deposit date:2002-06-06
Release date:2002-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
Acta Crystallogr.,Sect.D, 58, 2002
1LY4
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ANALYSIS OF QUINAZOLINE AND PYRIDO[2,3D]PYRIMIDINE N9-C10 REVERSED BRIDGE ANTIFOLATES IN COMPLEX WITH NADP+ AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE
Descriptor:DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Queener, S.F., Gangjee, A.
Deposit date:2002-06-06
Release date:2002-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
Acta Crystallogr.,Sect.D, 58, 2002
1BQP
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THE STRUCTURE OF THE PEA LECTIN-D-MANNOPYRANOSE COMPLEX
Descriptor:PROTEIN (LECTIN), CALCIUM ION, MANGANESE (II) ION, ...
Authors:Ruzeinikov, S.N., Mikhailova, I.Y., Tsygannik, I.N., Pangborn, W., Duax, W., Pletnev, V.Z.
Deposit date:1998-08-17
Release date:1998-08-26
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structure of the Pea Lectin-D-Mannopyranose Complex at a 2.1 A Resolution
RUSS.J.BIOORGANIC CHEM., 24, 1998
1BEN
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INSULIN COMPLEXED WITH 4-HYDROXYBENZAMIDE
Descriptor:HUMAN INSULIN, ZINC ION, 4-HYDROXYBENZAMIDE, ...
Authors:Smith, G.D., Ciszak, E., Pangborn, W.
Deposit date:1996-02-15
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A novel complex of a phenolic derivative with insulin: structural features related to the T-->R transition.
Protein Sci., 5, 1996
1BS9
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ACETYLXYLAN ESTERASE FROM P. PURPUROGENUM REFINED AT 1.10 ANGSTROMS
Descriptor:ACETYL XYLAN ESTERASE, SULFATE ION
Authors:Ghosh, D., Erman, M., Sawicki, M.W., Lala, P., Weeks, D.R., Li, N., Pangborn, W., Thiel, D.J., Jornvall, H., Eyzaguirre, J.
Deposit date:1998-09-01
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Determination of a protein structure by iodination: the structure of iodinated acetylxylan esterase.
Acta Crystallogr.,Sect.D, 55, 1999
1DAJ
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COMPARISON OF TERNARY COMPLEXES OF PNEUMOCYSTIS CARINII AND WILD TYPE HUMAN DIHYDROFOLATE REDUCTASE WITH COENZYME NADPH AND A NOVEL CLASSICAL ANTITUMOR FURO[2,3D]PYRIMIDINE ANTIFOLATE
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE
Authors:Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Gangjee, A., Devraj, R., Queener, S.F., Blakley, R.L.
Deposit date:1997-07-29
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate.
Acta Crystallogr.,Sect.D, 53, 1997
1KGJ
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RAT TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3',5'-DIBROMOFLAVONE (EMD21388)
Descriptor:TRANSTHYRETIN, 6,4'-DIHYDROXY-3-METHYL-3',5'-DIBROMOFLAVONE
Authors:Wojtczak, A., Neumann, P., Muziol, T., Cody, V., Luft, J.R., Pangborn, W.
Deposit date:2001-11-27
Release date:2002-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Comparison of binding interactions of dibromoflavonoids with transthyretin.
Acta Biochim.Pol., 48, 2001
1KP6
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USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT
Descriptor:PROTEIN (TOXIN), SULFATE ION
Authors:Li, N., Erman, M., Pangborn, W., Duax, W.L., Park, C.-M., Bruenn, J., Ghosh, D.
Deposit date:1999-05-28
Release date:1999-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore.
J.Biol.Chem., 274, 1999
1P49
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STRUCTURE OF HUMAN PLACENTAL ESTRONE/DHEA SULFATASE
Descriptor:STERYL-SULFATASE, B-OCTYLGLUCOSIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hernandez-Guzman, F.G., Higashiyama, T., Pangborn, W., Osawa, Y., Ghosh, D.
Deposit date:2003-04-21
Release date:2003-08-12
Last modified:2015-12-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association
J.Biol.Chem., 278, 2003
1PD8
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ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5-METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYLANILINO)METHYL]PYRIDO[2,3-D]PYRIMIDINE
Authors:Cody, V., Luft, J.R., Pangborn, W., Gangjee, A.
Deposit date:2003-05-19
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.
Acta Crystallogr.,Sect.D, 59, 2003
1PD9
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ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5-METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE
Descriptor:Dihydrofolate reductase, SULFATE ION, 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYLANILINO)METHYL]PYRIDO[2,3-D]PYRIMIDINE
Authors:Cody, V., Luft, J.R., Pangborn, W., Gangjee, A.
Deposit date:2003-05-19
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.
Acta Crystallogr.,Sect.D, 59, 2003
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