Author results

6B82
  • Download 6b82
  • View 6b82
Molmil generated image of 6b82
ZEBRA FISH CYP-450 17A1 MUTANT ABIRATERONE COMPLEX
Descriptor:Cytochrome P450, family 17, subfamily A, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-10-05
Release date:2017-12-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Inherent steroid 17 alpha ,20-lyase activity in defunct cytochrome P450 17A enzymes.
J. Biol. Chem., 293, 2018
5W20
  • Download 5w20
  • View 5w20
Molmil generated image of 5w20
CRYSTAL STRUCTURE OF INOSINE-SUBSTITUTED DUPLEX DNA
Descriptor:DNA (5'-D(*CP*CP*AP*IP*IP*CP*CP*TP*GP*G)-3'), MAGNESIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-06-05
Release date:2017-08-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Comparative analysis of inosine-substituted duplex DNA by circular dichroism and X-ray crystallography.
J. Biomol. Struct. Dyn., 36, 2018
5W1Z
  • Download 5w1z
  • View 5w1z
Molmil generated image of 5w1z
CRYSTAL STRUCTURE OF INOSINE-SUBSTITUTED DECAMER DUPLEX DNA (I4)
Descriptor:DNA (5'-D(*CP*CP*AP*IP*IP*CP*CP*(BRU)P*IP*I)-3'), MAGNESIUM ION, SODIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-06-05
Release date:2017-08-30
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Comparative analysis of inosine-substituted duplex DNA by circular dichroism and X-ray crystallography.
J. Biomol. Struct. Dyn., 36, 2018
5VBU
  • Download 5vbu
  • View 5vbu
Molmil generated image of 5vbu
CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 21A2 HYDROXYPROGESTERONE COMPLEX
Descriptor:Cytochrome P450 21-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (9beta)-17-hydroxypregn-4-ene-3,20-dione
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-30
Release date:2017-05-31
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.
J. Biol. Chem., 292, 2017
5VAJ
  • Download 5vaj
  • View 5vaj
Molmil generated image of 5vaj
BHRNASE H - AMIDE-RNA/DNA COMPLEX
Descriptor:RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*(URU)P*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), Ribonuclease H, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-27
Release date:2017-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs.
Nucleic Acids Res., 45, 2017
5V2H
  • Download 5v2h
  • View 5v2h
Molmil generated image of 5v2h
RNA OCTAMER CONTAINING GLYCOL NUCLEIC ACID, SGNT
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3'), COBALT HEXAMMINE(III), MAGNESIUM ION
Authors:Harp, J.M., Egli, M.
Deposit date:2017-03-04
Release date:2017-06-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.080013 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5V1L
  • Download 5v1l
  • View 5v1l
Molmil generated image of 5v1l
STRUCTURE OF S-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), STRONTIUM ION, SPERMINE
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-14
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5V1K
  • Download 5v1k
  • View 5v1k
Molmil generated image of 5v1k
STRUCTURE OF R-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-21
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
5SWM
  • Download 5swm
  • View 5swm
Molmil generated image of 5swm
BACILLUS HALODURANS RNASE H MUTANT D132N IN COMPLEX WITH 12-MER FRNA/DNA HYBRID
Descriptor:Ribonuclease H, RNA (12-MER), DNA (12-MER), ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2016-08-08
Release date:2016-09-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Limits of RNA 2'-OH Mimicry by Fluorine: Crystal Structure of Bacillus halodurans RNase H Bound to a 2'-FRNA:DNA Hybrid.
Biochemistry, 55, 2016
5DO5
  • Download 5do5
  • View 5do5
Molmil generated image of 5do5
CRYSTAL STRUCTURE OF 2'-FLUORO-RNA BEARING A PHOSPHORODITHIOATE
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(AF2)P*(2SG)P*CP*G)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2015-09-10
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of 2'-Fluoro-RNA bearing a phosphorodithioate
To Be Published
5DO4
  • Download 5do4
  • View 5do4
Molmil generated image of 5do4
THROMBIN-RNA APTAMER COMPLEX
Descriptor:Thrombin light chain, Thrombin heavy chain, RNA (25-MER), ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2015-09-10
Release date:2016-09-14
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
Nucleic Acids Res., 44, 2016
4Y8W
  • Download 4y8w
  • View 4y8w
Molmil generated image of 4y8w
CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 21A2 PROGESTERONE COMPLEX
Descriptor:Cytochrome P450 21-hydroxylase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Pallan, P.S., Lei, L., Egli, M.
Deposit date:2015-02-16
Release date:2015-04-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
J.Biol.Chem., 290, 2015
4RC0
  • Download 4rc0
  • View 4rc0
Molmil generated image of 4rc0
X-RAY STRUCTURE OF RNA CONTAINING GUANOSINE PHOSPHORODITHIOATE
Descriptor:5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(A2M)P*(2SG)P*CP*G)-3'
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4RBZ
  • Download 4rbz
  • View 4rbz
Molmil generated image of 4rbz
X-RAY STRUCTURE OF RNA CONTAINING ADENOSINE PHOSPHORODITHIOATE
Descriptor:5'-R(*CP*GP*CP*GP*(A2M)P*(ADS)P*UP*UP*AP*GP*CP*G)-3'
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4RBY
  • Download 4rby
  • View 4rby
Molmil generated image of 4rby
FIRST X-RAY STRUCTURE OF RNA CONTAINING GUANOSINE PHOSPHORODITHIOATE
Descriptor:5'-R(*CP*GP*CP*(2SG)P*AP*AP*UP*UP*AP*GP*CP*G)-3', STRONTIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4R21
  • Download 4r21
  • View 4r21
Molmil generated image of 4r21
ZEBRA FISH CYTOCHROME P450 17A2 WITH PROGESTERONE
Descriptor:Cytochrome P450 family 17 polypeptide 2, PROTOPORPHYRIN IX CONTAINING FE, PROGESTERONE
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4R20
  • Download 4r20
  • View 4r20
Molmil generated image of 4r20
ZEBRA FISH CYTOCHROME P450 17A2 WITH ABIRATERONE
Descriptor:Cytochrome P450 family 17 polypeptide 2, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4R1Z
  • Download 4r1z
  • View 4r1z
Molmil generated image of 4r1z
ZEBRA FISH CYTOCHROME P450 17A1 WITH ABIRATERONE
Descriptor:Cyp17a1 protein, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4QC7
  • Download 4qc7
  • View 4qc7
Molmil generated image of 4qc7
DODECAMER STRUCTURE OF 5-FORMYLCYTOSINE CONTAINING DNA
Descriptor:short DNA strands
Authors:Szulik, M.W., Pallan, P., Egli, M., Stone, M.P.
Deposit date:2014-05-09
Release date:2015-02-11
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Biochemistry, 54, 2015
4PWM
  • Download 4pwm
  • View 4pwm
Molmil generated image of 4pwm
CRYSTAL STRUCTURE OF DICKERSON DREW DODECAMER WITH 5-CARBOXYCYTOSINE
Descriptor:5'-[CGCGAATT(5CC)GCG]-3'
Authors:Szulik, M.W., Pallan, P., Banerjee, S., Voehler, M., Egli, M., Stone, M.P.
Deposit date:2014-03-20
Release date:2015-02-11
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Biochemistry, 54, 2015
4OPK
  • Download 4opk
  • View 4opk
Molmil generated image of 4opk
BH-RNASEH:2'-SME-DNA COMPLEX
Descriptor:Ribonuclease H, 5'-D(*CP*GP*CP*GP*AP*AP*(USM)P*TP*CP*GP*CP*G)-3', GLYCEROL
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-02-05
Release date:2015-02-11
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.539 Å)
Cite:Generating Crystallographic Models of DNA Dodecamers from Structures of RNase H:DNA Complexes.
Methods Mol.Biol., 1320
4OPJ
  • Download 4opj
  • View 4opj
Molmil generated image of 4opj
BH-RNASEH:TCDA-DNA COMPLEX
Descriptor:5'-D(*CP*GP*CP*GP*AP*(TCY)P*TP*TP*CP*GP*CP*G)-3', Ribonuclease H, GLYCEROL
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-02-05
Release date:2015-02-11
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (1.541 Å)
Cite:Generating Crystallographic Models of DNA Dodecamers from Structures of RNase H:DNA Complexes.
Methods Mol.Biol., 1320
4O41
  • Download 4o41
  • View 4o41
Molmil generated image of 4o41
AMIDE LINKED RNA
Descriptor:AMIDE LINKED RNA, STRONTIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2013-12-18
Release date:2014-07-09
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.
Nucleic Acids Res., 42, 2014
4I9V
  • Download 4i9v
  • View 4i9v
Molmil generated image of 4i9v
THE ATOMIC STRUCTURE OF 5-HYDROXYMETHYL 2'-DEOXYCITIDINE BASE PAIRED WITH 2'-DEOXYGUANOSINE IN DICKERSON DREW DODECAMER
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(5HC)P*GP*CP*G)-3'), MAGNESIUM ION, SPERMINE (FULLY PROTONATED FORM)
Authors:Nocek, B., Szulik, M.W., Joachimiak, A., Stone, M.P.
Deposit date:2012-12-05
Release date:2013-11-20
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Biochemistry, 54, 2015
4HUG
  • Download 4hug
  • View 4hug
Molmil generated image of 4hug
STRUCTURE OF 5-CHLOROURACIL MODIFIED A:U BASE PAIRS
Descriptor:Ribonuclease H, DNA (5'-D(*CP*GP*CP*GP*AP*AP*(UCL)P*(UCL)P*CP*GP*CP*G)-3'), MAGNESIUM ION, ...
Authors:Patra, A., Egli, M.
Deposit date:2012-11-02
Release date:2012-12-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs.
Nucleic Acids Res., 41, 2013