Author results

5AGR
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCINE--TRNA LIGASE, METHIONINE, LEUCINE, ...
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-02
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGS
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCYL-TRNA SYNTHETASE, METHIONINE, 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-09
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGT
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-4-CHLORO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
分子名称:LEUCINE--TRNA LIGASE, METHIONINE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, ...
著者Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
登録日2015-02-03
公開日2016-03-02
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOG
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CRYSTAL STRUCTURE OF HTE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN COMPLEX WITH A POST-TRANSFER EDITING ANALOGUE OF NORVALINE (NV2AA)
分子名称:LEUCYL-TRNA SYNTHETASE, 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 1,2-ETHANEDIOL, ...
著者Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
登録日2015-11-20
公開日2016-08-03
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOL
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CRYSTAL STRUCTURE OF THE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN COMPLEX WITH A POST-TRANSFER EDITING ANALOGUE OF ISOEUCINE (ILE2AA)
分子名称:LEUCYL-TRNA SYNTHETASE, PHOSPHATE ION, 2'-(L-ISOLEUCYL)AMINO-2'-DEOXYADENOSINE
著者Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
登録日2015-11-24
公開日2016-08-03
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOM
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CRYSTAL STRUCTURE OF THE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN COMPLEX WITH THE ADDUCT AMP-AN6426
分子名称:LEUCYL-TRNA SYNTHETASE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, PHOSPHATE ION
著者Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
登録日2015-11-24
公開日2016-08-03
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FON
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CRYSTAL STRUCTURE OF THE CRYPTOSPORIDIUM MURIS CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN (APO STRUCTURE)
分子名称:LEUCYL-TRNA SYNTHETASE
著者Palencia, A., Liu, R.J., Lukarska, M., Gut, J., Bougdour, A., Touquet, B., Wang, E.D., Alley, M.R.K., Rosenthal, P.J., Hakimi, M.A., Cusack, S.
登録日2015-11-24
公開日2016-08-03
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
4AQ7
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND LEUCYL-ADENYLATE ANALOGUE IN THE AMINOACYLATION CONFORMATION
分子名称:LEUCINE--TRNA LIGASE, E. COLI TRNALEU UAA ISOACCEPTOR, ZINC ION, ...
著者Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.
登録日2012-04-13
公開日2012-06-13
最終更新日2012-10-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4ARC
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND LEUCINE IN THE EDITING CONFORMATION
分子名称:LEUCINE--TRNA LIGASE, TRNA-LEU5 (UAA ISOACCEPTOR), LEUCINE, ...
著者Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.
登録日2012-04-23
公開日2012-06-13
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4ARI
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN2679 IN THE EDITING CONFORMATION
分子名称:LEUCINE--TRNA LIGASE, TRNA-LEU5 (UAA ISOACEPTOR), GLYCEROL, ...
著者Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.
登録日2012-04-24
公開日2012-06-13
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
4AS1
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN2679 IN THE EDITING CONFORMATION
分子名称:LEUCINE--TRNA LIGASE, TRNA-LEU5 (UAA ISOACEPTOR), MAGNESIUM ION
著者Palencia, A., Crepin, T., Vu, M.T., Lincecum Jr, T.L., Martinis, S.A., Cusack, S.
登録日2012-04-27
公開日2012-06-13
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Structural Dynamics of the Aminoacylation and Proofreading Functional Cycle of Bacterial Leucyl-tRNA Synthetase
Nat.Struct.Mol.Biol., 19, 2012
2F0R
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CRYSTALLOGRAPHIC STRUCTURE OF HUMAN TSG101 UEV DOMAIN
分子名称:Tumor susceptibility gene 101 protein, SULFATE ION
著者Camara-Artigas, A., Luque, I., Palencia, A., Martinez, J.C., Mateo, P.L.
登録日2005-11-13
公開日2006-03-28
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Structure of human TSG101 UEV domain.
Acta Crystallogr.,Sect.D, 62, 2006
4CQN
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CRYSTAL STRUCTURE OF THE E.COLI LEURS-TRNA COMPLEX WITH THE NON- COGNATE ISOLEUCYL ADENYLATE ANALOGUE
分子名称:LEUCINE--TRNA LIGASE, ESCHERICHIA COLI TRNA-LEU UAA ISOACCEPTOR, ZINC ION, ...
著者Palencia, A., Cusack, S., Cvetesic, N., Haslaz, I., Gruic-Sovulj, I.
登録日2014-02-20
公開日2014-07-02
最終更新日2014-08-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Physiological Target for Leurs Translational Quality Control is Norvaline
Embo J., 33, 2014
5AH5
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF AGROBACTERIUM RADIOBACTER K84 AGNB2 LEURS-TRNA-LEUAMS
分子名称:LEUCINE--TRNA LIGASE, TRNA-LEU TAA ISOACCEPTOR, ZINC ION, ...
著者Palencia, A., Chopra, S., Virus, C., Schulwitz, S., Temple, B.R., Cusack, S., Reader, J.S.
登録日2015-02-05
公開日2016-02-17
最終更新日2016-10-19
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Characterization of Antibiotic Self-Immunity tRNA Synthetase in Plant Tumour Biocontrol Agent.
Nat.Commun., 7, 2016
5FO4
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CRYSTAL STRUCTURE OF THE P.FALCIPARUM CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN (SPACE GROUP P1)
分子名称:LEUCYL TRNA SYNTHASE
著者Palencia, A., Sonoiki, E., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V.S., Gut, J., Legac, J., Cooper, R., Alley, M.R.K., Freund, Y.R., DeRisi, J., Cusack, S., Rosenthal, P.J.
登録日2015-11-18
公開日2016-06-22
最終更新日2016-08-10
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOC
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CRYSTAL STRUCTURE OF THE P.FALCIPARUM CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN (SPACE GROUP P21)
分子名称:LEUCYL-TRNA SYNTHETASE
著者Palencia, A., Sonoiki, E., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V.S., Gut, J., Legac, J., Cooper, R., Alley, M.R.K., Freund, Y.R., DeRisi, J., Cusack, S., Rosenthal, P.J.
登録日2015-11-19
公開日2016-06-22
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOD
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CRYSTAL STRUCTURE OF THE P.FALCIPARUM CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN (SPACE GROUP P1) CONTAINING DELETIONS OF INSERTIONS 1 AND 3
分子名称:LEUCYL-TRNA SYNTHETASE, 1,2-ETHANEDIOL
著者Palencia, A., Sonoiki, E., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V.S., Gut, J., Legac, J., Cooper, R., Alley, M.R.K., Freund, Y.R., DeRisi, J., Cusack, S., Rosenthal, P.J.
登録日2015-11-19
公開日2016-06-22
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5FOF
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CRYSTAL STRUCTURE OF THE P.KNOWLESI CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAIN
分子名称:LEUCYL-TRNA SYNTHETASE
著者Palencia, A., Sonoiki, E., Guo, D., Ahyong, V., Dong, C., Li, X., Hernandez, V.S., Gut, J., Legac, J., Cooper, R., Alley, M.R.K., Freund, Y.R., DeRisi, J., Cusack, S., Rosenthal, P.J.
登録日2015-11-19
公開日2016-06-22
最終更新日2016-08-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5OMW
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MUTANT T252A OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND LEUCYL-ADENYLATE ANALOGUE IN THE AMINOACYLATION CONFORMATION
分子名称:Leucine--tRNA ligase, L-leucyl-tRNA, ZINC ION, ...
著者Palencia, A., Cusack, S.
登録日2017-08-02
公開日2017-11-15
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
5ON2
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QUATERNARY COMPLEX OF MUTANT T252A OF E. COLI LEUCYL-TRNA SYNTHETASE WITH TRNA(LEU), LEUCYL-ADENYLATE ANALOGUE, AND POST-TRANSFER EDITING ANALOGUE OF NORVALINE IN THE AMINOACYLATION CONFORMATION
分子名称:Leucine--tRNA ligase, tRNA(leu), ZINC ION, ...
著者Palencia, A., Cusack, S.
登録日2017-08-02
公開日2017-11-15
最終更新日2017-12-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
5ON3
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QUATERNARY COMPLEX OF MUTANT T252A OF E. COLI LEUCYL-TRNA SYNTHETASE WITH TRNA(LEU), LEUCYL-ADENYLATE ANALOGUE, AND POST-TRANSFER EDITING ANALOGUE OF LEUCINE IN THE AMINOACYLATION CONFORMATION
分子名称:Leucine--tRNA ligase, tRNA(leu), ZINC ION, ...
著者Palencia, A., Cusack, S.
登録日2017-08-02
公開日2017-11-15
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
5ONH
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QUATERNARY COMPLEX OF WILD TYPE E. COLI LEUCYL-TRNA SYNTHETASE WITH TRNA(LEU), LEUCYL-ADENYLATE ANALOGUE, AND POST-TRANSFER EDITING ANALOGUE OF NORVALINE IN THE AMINOACYLATION CONFORMATION
分子名称:Leucine--tRNA ligase, L-leucyl-tRNA(Leu), ZINC ION, ...
著者Palencia, A., Cusack, S.
登録日2017-08-03
公開日2017-11-15
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
3ZGZ
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TERNARY COMPLEX OF E. COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND TOXIC MOIETY FROM AGROCIN 84 (TM84) IN AMINOACYLATION-LIKE CONFORMATION
分子名称:LEUCINE--TRNA LIGASE, TRNA-LEU UAA ISOACCEPTOR, ZINC ION, ...
著者Chopra, S., Palencia, A., Virus, C., Tripathy, A., Temple, B.R., Velazquez-Campoy, A., Cusack, S., Reader, J.S.
登録日2012-12-19
公開日2013-01-30
最終更新日2013-02-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Plant Tumour Biocontrol Agent Employs a tRNA-Dependent Mechanism to Inhibit Leucyl-tRNA Synthetase
Nat.Commun., 4, 2013
3ZJT
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TERNARY COMPLEX OF E.COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU)574 AND THE BENZOXABOROLE AN3017 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
3ZJU
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TERNARY COMPLEX OF E .COLI LEUCYL-TRNA SYNTHETASE, TRNA(LEU) AND THE BENZOXABOROLE AN3016 IN THE EDITING CONFORMATION
分子名称:LEUCYL-TRNA SYNTHETASE, TRNALEU5 UAA ISOACCEPTOR, MAGNESIUM ION
著者Cusack, S., Palencia, A., Crepin, T., Hernandez, V., Akama, T., Baker, S.J., Bu, W., Feng, L., Freund, Y.R., Liu, L., Meewan, M., Mohan, M., Mao, W., Rock, F.L., Sexton, H., Sheoran, A., Zhang, Y., Zhang, Y., Zhou, Y., Nieman, J.A., Anugula, M.R., Keramane, E.M., Savariraj, K., Reddy, D.S., Sharma, R., Subedi, R., Singh, R., OLeary, A., Simon, N.L., DeMarsh, P.L., Mushtaq, S., Warner, M., Livermore, D.M., Alley, M.R.K., Plattner, J.J.
登録日2013-01-18
公開日2013-04-17
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of a Novel Class of Boron-Based Antibacterials with Activity Against Gram-Negative Bacteria.
Antimicrob.Agents Chemother., 57, 2013
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