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2XTT
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BU of 2xtt by Molmil
Bovine trypsin in complex with evolutionary enhanced Schistocerca gregaria protease inhibitor 1 (SGPI-1-P02)
Descriptor: ACETATE ION, CALCIUM ION, CATIONIC TRYPSIN, ...
Authors:Wahlgren, W.Y, Pal, G, Kardos, J, Porrogi, P, Szenthe, B, Patthy, A, Graf, L, Katona, G.
Deposit date:2010-10-12
Release date:2010-11-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (0.93 Å)
Cite:The catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease action.
J.Biol.Chem., 286, 2011
2XQQ
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BU of 2xqq by Molmil
Human dynein light chain (DYNLL2) in complex with an in vitro evolved peptide (Ac-SRGTQTE).
Descriptor: ACETATE ION, DYNEIN LIGHT CHAIN 2, CYTOPLASMIC, ...
Authors:Rapali, P, Radnai, L, Suveges, D, Hetenyi, C, Harmat, V, Tolgyesi, F, Wahlgren, W.Y, Katona, G, Nyitray, L, Pal, G.
Deposit date:2010-09-07
Release date:2011-05-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Directed Evolution Reveals the Binding Motif Preference of the Lc8/Dynll Hub Protein and Predicts Large Numbers of Novel Binders in the Human Proteome
Plos One, 6, 2011
3P8M
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BU of 3p8m by Molmil
Human dynein light chain (DYNLL2) in complex with an in vitro evolved peptide dimerized by leucine zipper
Descriptor: Dynein light chain 2, General control protein GCN4
Authors:Rapali, P, Radnai, L, Suveges, D, Hetenyi, C, Harmat, V, Tolgyesi, F, Wahlgren, W.Y, Katona, G, Nyitray, L, Pal, G.
Deposit date:2010-10-14
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome.
Plos One, 6, 2011
3TVJ
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BU of 3tvj by Molmil
Catalytic fragment of MASP-2 in complex with its specific inhibitor developed by directed evolution on SGCI scaffold
Descriptor: Mannan-binding lectin serine protease 2 A chain, Mannan-binding lectin serine protease 2 B chain, Protease inhibitor SGPI-2, ...
Authors:Heja, D, Harmat, V, Dobo, J, Szasz, R, Kekesi, K.A, Zavodszky, P, Gal, P, Pal, G.
Deposit date:2011-09-20
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2.
J.Biol.Chem., 287, 2012
4DJZ
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BU of 4djz by Molmil
Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold
Descriptor: Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain, Protease inhibitor SGPI-2
Authors:Heja, D, Harmat, V, Fodor, K, Wilmanns, M, Dobo, J, Kekesi, K.A, Zavodszky, P, Gal, P, Pal, G.
Deposit date:2012-02-03
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2.
J.Biol.Chem., 287, 2012
7PQN
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BU of 7pqn by Molmil
Catalytic fragment of MASP-2 in complex with ecotin
Descriptor: Ecotin, GLYCEROL, Mannan-binding lectin serine protease 2 A chain, ...
Authors:Harmat, V, Fodor, K, Heja, D.
Deposit date:2021-09-17
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.400015 Å)
Cite:Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
J.Biol.Chem., 298, 2022
7PQO
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BU of 7pqo by Molmil
Catalytic fragment of MASP-1 in complex with P1 site mutant ecotin
Descriptor: Ecotin, GLYCEROL, Mannan-binding lectin serine protease 1, ...
Authors:Harmat, V, Fodor, K, Heja, D.
Deposit date:2021-09-17
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.39 Å)
Cite:Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
J.Biol.Chem., 298, 2022
7ARX
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BU of 7arx by Molmil
Crystal structure of the catalytic fragment of masp-1 in complex with SFMI1
Descriptor: DI(HYDROXYETHYL)ETHER, Mannan-binding lectin serine protease 1, SFMI1 - Sunflower MASP1 inhibitor
Authors:Durvanger, Z, Harmat, V, Dobo, J, Megyeri, M.
Deposit date:2020-10-26
Release date:2021-11-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides.
Acs Chem.Biol., 17, 2022
2B59
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BU of 2b59 by Molmil
The type II cohesin dockerin complex
Descriptor: CALCIUM ION, COG1196: Chromosome segregation ATPases, Cellulosomal scaffolding protein A
Authors:Adams, J.J, Smith, S.P, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2005-09-27
Release date:2005-10-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Mechanism of bacterial cell-surface attachment revealed by the structure of cellulosomal type II cohesin-dockerin complex.
Proc.Natl.Acad.Sci.Usa, 103, 2006
4IGD
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BU of 4igd by Molmil
Crystal structure of the zymogen catalytic region of Human MASP-1
Descriptor: GLYCEROL, Mannan-binding lectin serine protease 1
Authors:Harmat, V, Megyeri, M, Vegh, A, Dobo, J.
Deposit date:2012-12-17
Release date:2013-02-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway
J.Biol.Chem., 288, 2013

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