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6PBW
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BU of 6pbw by Molmil
Crystal structure of Fab667 complex
Descriptor: Fab667 heavy chain, Fab667 light chain, GLYCEROL, ...
Authors:Oyen, D, Wilson, I.A.
Deposit date:2019-06-14
Release date:2020-03-04
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.058 Å)
Cite:Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
6PBV
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BU of 6pbv by Molmil
Crystal structure of Fab668 complex
Descriptor: 1,2-ETHANEDIOL, Fab668 heavy chain, Fab668 light chain, ...
Authors:Oyen, D, Wilson, I.A.
Deposit date:2019-06-14
Release date:2020-03-04
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (1.566 Å)
Cite:Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
5W3Q
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BU of 5w3q by Molmil
L28F E.coli DHFR in complex with NADPH
Descriptor: CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oyen, D, Wright, P.E, Wilson, I.A.
Deposit date:2017-06-08
Release date:2017-08-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion.
J. Am. Chem. Soc., 139, 2017
3K74
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BU of 3k74 by Molmil
Disruption of protein dynamics by an allosteric effector antibody
Descriptor: Dihydrofolate reductase, Nanobody
Authors:Oyen, D, Srinivasan, V, Steyaert, J, Barlow, J.
Deposit date:2009-10-12
Release date:2010-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
J.Mol.Biol., 407, 2011
5CC9
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BU of 5cc9 by Molmil
L28F E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate
Descriptor: 5,10-DIDEAZATETRAHYDROFOLIC ACID, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oyen, D, Wright, P.E.
Deposit date:2015-07-01
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.199 Å)
Cite:Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
J.Am.Chem.Soc., 137, 2015
5CCC
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BU of 5ccc by Molmil
wild-type E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate
Descriptor: 5,10-DIDEAZATETRAHYDROFOLIC ACID, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oyen, D, Wright, P.E.
Deposit date:2015-07-01
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
J.Am.Chem.Soc., 137, 2015
4EIG
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BU of 4eig by Molmil
CA1698 camel antibody fragment in complex with DHFR
Descriptor: CA1698 camel antibody fragment, Dihydrofolate reductase
Authors:Oyen, D, Srinivasan, V.
Deposit date:2012-04-05
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4EIZ
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BU of 4eiz by Molmil
Structure of Nb113 bound to apoDHFR
Descriptor: Dihydrofolate reductase, Nb113 Camel antibody fragment
Authors:Oyen, D, Srinivasan, V.
Deposit date:2012-04-06
Release date:2013-04-24
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
6AXL
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BU of 6axl by Molmil
Crystal structure of Fab317 complex
Descriptor: Fab317 heavy chain, Fab317 light chains, Peptide ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-NH2
Authors:Oyen, D, Wilson, I.A.
Deposit date:2017-09-07
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6AXK
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BU of 6axk by Molmil
Crystal structure of Fab311 complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN, Fab311 heavy chain, ...
Authors:Oyen, D, Wilson, I.A.
Deposit date:2017-09-07
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4EJ1
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BU of 4ej1 by Molmil
Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex
Descriptor: Dihydrofolate reductase, FOLIC ACID, Nb113 camelid antibody fragment, ...
Authors:Oyen, D, Srinivasan, V.
Deposit date:2012-04-06
Release date:2013-04-24
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4FHB
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BU of 4fhb by Molmil
Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179)
Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Oyen, D.
Deposit date:2012-06-06
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4I1N
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BU of 4i1n by Molmil
R104A-ca1697 nanobody binding to the binary DHFR.folate complex
Descriptor: Dihydrofolate reductase, FOLIC ACID, Protein ca1697 (nanobody)
Authors:Oyen, D, Steyaert, J, Barlow, J.N.
Deposit date:2012-11-21
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.888 Å)
Cite:Exploring an alternative antibody interaction mechanism
To be Published
4I13
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BU of 4i13 by Molmil
Nanobody ca1697 binding to the DHFR.folate binary complex
Descriptor: Dihydrofolate reductase, FOLIC ACID, Protein ca1697 (nanobody)
Authors:Oyen, D, Steyaert, J, Barlow, J.N.
Deposit date:2012-11-19
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Exploring an alternative antibody interaction mechanism
To be Published
7RA7
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BU of 7ra7 by Molmil
Crystal structure of rabbit anti-HIV Fab 11A
Descriptor: 11A Fab heavy chain, 11A Fab light chain, PENTAETHYLENE GLYCOL, ...
Authors:Oyen, D, Wilson, I.A.
Deposit date:2021-06-30
Release date:2022-07-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Limited breadth of anti-HIV Env glycan hole antibodies is further hindered by strain-specific peptide interactions
To Be Published
6VSR
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BU of 6vsr by Molmil
Crystal structure of macaque anti-HIV-1 antibody RM20F
Descriptor: RM20F Fab Heavy Chain, RM20F Fab Light Chain, SULFATE ION
Authors:Oyen, D, Yuan, M, Wilson, I.A.
Deposit date:2020-02-11
Release date:2020-09-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.176 Å)
Cite:Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6BQB
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BU of 6bqb by Molmil
MGG4 Fab in complex with peptide
Descriptor: GLYCEROL, MGG4 Fab heavy chain, MGG4 Fab light chain, ...
Authors:Oyen, D, Tan, J, Lanzavecchia, A, Wilson, I.A.
Deposit date:2017-11-27
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Nat. Med., 24, 2018
6W05
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BU of 6w05 by Molmil
Crystal structure of Fab356 in complex with NPNA2 peptide from circumsporozoite protein
Descriptor: Fab356 heavy chain, Fab356 light chain, NPNA2 peptide
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-02-29
Release date:2020-07-29
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (2.516 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
6W00
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BU of 6w00 by Molmil
Crystal structure of Fab239 in complex with NPNA2 peptide from circumsporozoite protein
Descriptor: Fab239 heavy chain, Fab239 light chain, Immunoglobulin G-binding protein G, ...
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-02-28
Release date:2020-07-29
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (1.853 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
6WG1
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BU of 6wg1 by Molmil
Crystal structure of Fab399 in complex with NPNA6 peptide from circumsporozoite protein
Descriptor: Fab399 heavy chain, Fab399 light chain, NPNA6 peptide
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (2.086 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
6WFX
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BU of 6wfx by Molmil
Crystal structure of Fab395 in complex with NPNA2 peptide from circumsporozoite protein
Descriptor: Fab395 heavy chain, Fab395 light chain, NPNA2 peptide
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
6WG0
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BU of 6wg0 by Molmil
Crystal structure of Fab366 in complex with NPNA3 peptide from circumsporozoite protein
Descriptor: Fab366 heavy chain, Fab366 light chain, NPNA3 peptide
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
6WFW
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BU of 6wfw by Molmil
Crystal structure of Fab364 in complex with NPNA2 peptide from circumsporozoite protein
Descriptor: Fab364 heavy chain, Fab364 light chain, Immunoglobulin G-binding protein G, ...
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
6WG2
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BU of 6wg2 by Molmil
Crystal structure of Fab239 in complex with NPNA4 peptide from circumsporozoite protein
Descriptor: Fab239 heavy chain, Fab239 light chain, NPNA4 peptide
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (2.534 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
6WFZ
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BU of 6wfz by Molmil
Crystal structure of Fab399 in complex with NPNA3 peptide from circumsporozoite protein
Descriptor: Fab399 heavy chain, Fab399 light chain, NPNA3 peptide
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021

 

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