Author results

5ML9
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COCRYSTAL STRUCTURE OF FC GAMMA RECEPTOR IIIA INTERACTING WITH AFFIMER F4, A SPECIFIC BINDING PROTEIN WHICH BLOCKS IGG BINDING TO THE RECEPTOR.
Descriptor:Low affinity immunoglobulin gamma Fc region receptor III-A, Affimer F4 with specificity for Fc gamma receptor IIIa, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Robinson, J.I., Tomlinson, D.C., Baxter, E.W., Owen, R.L., Thomsen, M., Win, S.J., Nettleship, J.E., Tiede, C., Foster, R.J., Waterhouse, M.P., Harris, S.A., Owens, R.J., Fishwick, C.W.G., Goldman, A., McPherson, M.J., Morgan, A.W.
Deposit date:2016-12-06
Release date:2017-12-13
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5MN2
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COCRYSTAL STRUCTURE OF FC GAMMA RECEPTOR IIIA INTERACTING WITH AFFIMER G3, A SPECIFIC BINDING PROTEIN WHICH BLOCKS IGG BINDING TO THE RECEPTOR.
Descriptor:Low affinity immunoglobulin gamma Fc region receptor III-A, Affimer G3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Robinson, J.I., Owen, R.L., Tomlinson, D.C., Baxter, E.W., Nettleship, J.E., Waterhouse, M.P., Harris, S.A., Owens, R.J., McPherson, M.J., Morgan, A.W., Tiede, C., Goldman, A., Thomsen, M.
Deposit date:2016-12-12
Release date:2017-12-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4N6T
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ADHIRON: A STABLE AND VERSATILE PEPTIDE DISPLAY SCAFFOLD - FULL LENGTH ADHIRON
Descriptor:Adhiron
Authors:Mcpherson, M., Tomlinson, D., Owen, R.L., Nettleship, J.E., Owens, R.J.
Deposit date:2013-10-14
Release date:2014-04-09
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications.
Protein Eng.Des.Sel., 27, 2014
4N6U
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ADHIRON: A STABLE AND VERSATILE PEPTIDE DISPLAY SCAFFOLD - TRUNCATED ADHIRON
Descriptor:Adhiron
Authors:Mcpherson, M., Tomlinson, D., Owen, R.L., Nettleship, J.E., Owens, R.J.
Deposit date:2013-10-14
Release date:2014-04-09
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications.
Protein Eng.Des.Sel., 27, 2014
2Y7Q
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THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI
Descriptor:HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA, IG EPSILON CHAIN C REGION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Davies, A.M., Holdom, M.D., Nettleship, J.E., Beavil, A.J., Owens, R.J., Sutton, B.J.
Deposit date:2011-02-01
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri
Nat.Struct.Mol.Biol., 18, 2011
1O0V
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THE CRYSTAL STRUCTURE OF IGE FC REVEALS AN ASYMMETRICALLY BENT CONFORMATION
Descriptor:Immunoglobulin heavy chain epsilon-1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Wan, T., Beavil, R.L., Fabiane, S.M., Beavil, A.J., Sohi, M.K., Keown, M., Young, R.J., Henry, A.J., Owens, R.J., Gould, H.J., Sutton, B.J.
Deposit date:2002-09-06
Release date:2002-09-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of IgE Fc reveals an asymmetrically bent conformation
NAT.IMMUNOL., 3, 2002
2BRY
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CRYSTAL STRUCTURE OF THE NATIVE MONOOXYGENASE DOMAIN OF MICAL AT 1.45 A RESOLUTION
Descriptor:NEDD9 INTERACTING PROTEIN WITH CALPONIN HOMOLOGY AND LIM DOMAINS, CHLORIDE ION, GLYCEROL, ...
Authors:Siebold, C., Berrow, N., Walter, T.S., Harlos, K., Owens, R.J., Terman, J.R., Stuart, D.I., Kolodkin, A.L., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2005-05-13
Release date:2005-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:High-Resolution Structure of the Catalytic Region of Mical (Molecule Interacting with Casl), a Multidomain Flavoenzyme-Signaling Molecule.
Proc.Natl.Acad.Sci.USA, 102, 2005
2C4C
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CRYSTAL STRUCTURE OF THE NADPH-TREATED MONOOXYGENASE DOMAIN OF MICAL
Descriptor:NEDD9-INTERACTING PROTEIN WITH CALPONIN HOMOLOGY AND LIM DOMAINS, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION
Authors:Siebold, C., Berrow, N., Walter, T.S., Harlos, K., Owens, R.J., Terman, J.R., Stuart, D.I., Kolodkin, A.L., Pasterkamp, R.J., Jones, E.Y.
Deposit date:2005-10-18
Release date:2005-10-26
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:High-Resolution Structure of the Catalytic Region of Mical (Molecule Interacting with Casl), a Multidomain Flavoenzyme-Signaling Molecule.
Proc.Natl.Acad.Sci.USA, 102, 2005
2PX2
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH (MONOCLINIC FORM 1)
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PX4
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH (MONOCLINIC FORM 2)
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], CHLORIDE ION, SULFATE ION, ...
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PX5
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH (ORTHORHOMBIC CRYSTAL FORM)
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PX8
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH AND 7M-GTP
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, TRIPHOSPHATE, ...
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PXA
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAH AND GTPG
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], GUANOSINE-5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2PXC
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CRYSTAL STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS NS5 2'-O METHYLTRANSFERASE DOMAIN IN COMPLEX WITH SAM AND GTPA
Descriptor:Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], S-ADENOSYLMETHIONINE, GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE
Authors:Assenberg, R., Ren, J., Verma, A., Walter, T.S., Alderton, D., Hurrelbrink, R.J., Fuller, S.D., Owens, R.J., Stuart, D.I., Grimes, J.M., Oxford Protein Production Facility (OPPF)
Deposit date:2007-05-14
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
2W2S
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STRUCTURE OF THE LAGOS BAT VIRUS MATRIX PROTEIN
Descriptor:MATRIX PROTEIN
Authors:Graham, S.C., Assenberg, R., Delmas, O., Verma, A., Gholami, A., Talbi, C., Owens, R.J., Stuart, D.I., Grimes, J.M., Bourhy, H.
Deposit date:2008-11-03
Release date:2009-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Rhabdovirus Matrix Protein Structures Reveal a Novel Mode of Self-Association.
Plos Pathog., 4, 2008
3HHF
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STRUCTURE OF CRGA REGULATORY DOMAIN, A LYSR-TYPE TRANSCRIPTIONAL REGULATOR FROM NEISSERIA MENINGITIDIS.
Descriptor:Transcriptional regulator, LysR family, CHLORIDE ION
Authors:Sainsbury, S., Ren, J., Owens, R.J., Stuart, D.I., Oxford Protein Production Facility (OPPF)
Deposit date:2009-05-15
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators
Nucleic Acids Res., 37, 2009
3HHG
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STRUCTURE OF CRGA, A LYSR-TYPE TRANSCRIPTIONAL REGULATOR FROM NEISSERIA MENINGITIDIS.
Descriptor:Transcriptional regulator, LysR family
Authors:Sainsbury, S., Ren, J., Owens, R.J., Stuart, D.I., Oxford Protein Production Facility (OPPF)
Deposit date:2009-05-15
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators
Nucleic Acids Res., 37, 2009
2A0J
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CRYSTAL STRUCTURE OF NITROGEN REGULATORY PROTEIN IIA-NTR FROM NEISSERIA MENINGITIDIS
Descriptor:PTS system, nitrogen regulatory IIA protein
Authors:Ren, J., Sainsbury, S., Berrow, N.S., Alderton, D., Nettleship, J.E., Stammers, D.K., Saunders, N.J., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2005-06-16
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of nitrogen regulatory protein IIANtr from Neisseria meningitidis
Bmc Struct.Biol., 5, 2005
2GW8
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STRUCTURE OF THE PII SIGNAL TRANSDUCTION PROTEIN OF NEISSERIA MENINGITIDIS AT 1.85 RESOLUTION
Descriptor:PII signal transduction protein
Authors:Nichols, C.E., Sainsbury, S., Berrow, N.S., Alderton, D., Stammers, D.K., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2006-05-04
Release date:2006-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the P(II) signal transduction protein of Neisseria meningitidis at 1.85 A resolution.
Acta Crystallogr.,Sect.F, 62, 2006
2JCB
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THE CRYSTAL STRUCTURE OF 5-FORMYL-TETRAHYDROFOLATE CYCLOLIGASE FROM BACILLUS ANTHRACIS (BA4489)
Descriptor:5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE FAMILY PROTEIN, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, ...
Authors:Meier, C., Carter, L.G., Winter, G., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2006-12-21
Release date:2007-02-20
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of 5-Formyltetrahydrofolate Cyclo-Ligase from Bacillus Anthracis (Ba4489).
Acta Crystallogr.,Sect.F, 63, 2007
2JJX
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THE CRYSTAL STRUCTURE OF UMP KINASE FROM BACILLUS ANTHRACIS (BA1797)
Descriptor:URIDYLATE KINASE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Meier, C., Carter, L.G., Mancini, E.J., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2008-04-23
Release date:2008-07-29
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:The Crystal Structure of Ump Kinase from Bacillus Anthracis (Ba1797) Reveals an Allosteric Nucleotide-Binding Site.
J.Mol.Biol., 381, 2008
2P5V
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CRYSTAL STRUCTURE OF TRANSCRIPTIONAL REGULATOR NMB0573 FROM NEISSERIA MENINGITIDIS
Descriptor:Transcriptional regulator, LRP/AsnC family, CALCIUM ION, ...
Authors:Ren, J., Sainsbury, S., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2007-03-16
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:The Structure and Transcriptional Analysis of a Global Regulator from Neisseria meningitidis.
J.Biol.Chem., 282, 2007
2P6S
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CRYSTAL STRUCTURE OF TRANSCRIPTIONAL REGULATOR NMB0573/L-MET COMPLEX FROM NEISSERIA MENINGITIDIS
Descriptor:Transcriptional regulator, LRP/AsnC family, METHIONINE, ...
Authors:Ren, J., Sainsbury, S., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2007-03-19
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure and Transcriptional Analysis of a Global Regulator from Neisseria meningitidis.
J.Biol.Chem., 282, 2007
2P6T
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CRYSTAL STRUCTURE OF TRANSCRIPTIONAL REGULATOR NMB0573 AND L-LEUCINE COMPLEX FROM NEISSERIA MENINGITIDIS
Descriptor:Transcriptional regulator, LRP/AsnC family, LEUCINE, ...
Authors:Ren, J., Sainsbury, S., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2007-03-19
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Structure and Transcriptional Analysis of a Global Regulator from Neisseria meningitidis.
J.Biol.Chem., 282, 2007
2UVD
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THE CRYSTAL STRUCTURE OF A 3-OXOACYL-(ACYL CARRIER PROTEIN) REDUCTASE FROM BACILLUS ANTHRACIS (BA3989)
Descriptor:3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE
Authors:Zaccai, N.R., Carter, L.G., Berrow, N.S., Sainsbury, S., Nettleship, J.E., Walter, T.S., Harlos, K., Owens, R.J., Wilson, K.S., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2007-03-09
Release date:2007-04-17
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of a 3-Oxoacyl-(Acylcarrier Protein) Reductase (Ba3989) from Bacillus Anthracis at 2.4-A Resolution.
Proteins: Struct., Funct., Bioinf., 70, 2008