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1PHK
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BU of 1phk by Molmil
TWO STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHORYLASE, KINASE: AN ACTIVE PROTEIN KINASE COMPLEXED WITH NUCLEOTIDE, SUBSTRATE-ANALOGUE AND PRODUCT
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PHOSPHORYLASE KINASE
Authors:Owen, D.J, Noble, M.E.M, Garman, E.F, Papageorgiou, A.C, Johnson, L.N.
Deposit date:1996-03-15
Release date:1996-08-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product.
Structure, 3, 1995
1HES
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BU of 1hes by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH P-selectin INTERNALIZATION PEPTIDE SHLGTYGVFTNAA
Descriptor: CLATHRIN COAT ASSEMBLY PROTEIN AP50, P-SELECTIN PEPTIDE
Authors:Owen, D.J, Evans, P.R, Green, S.A.
Deposit date:2000-11-24
Release date:2001-05-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Third Specificity-Determining Site in Mu 2 Adaptin for Sequences Upstream of Yxx Phi Sorting Motifs
Traffic, 2, 2001
1BB9
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BU of 1bb9 by Molmil
CRYSTAL STRUCTURE OF THE SH3 DOMAIN FROM RAT AMPHIPHYSIN 2
Descriptor: AMPHIPHYSIN 2
Authors:Owen, D.J, Mcmahon, H.T, Evans, P.R.
Deposit date:1998-04-29
Release date:1998-06-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation.
EMBO J., 17, 1998
1B9K
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BU of 1b9k by Molmil
ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2
Descriptor: PROTEIN (ALPHA-ADAPTIN APPENDAGE DOMAIN)
Authors:Owen, D.J, Evans, P.R.
Deposit date:1999-02-11
Release date:1999-07-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain.
Cell(Cambridge,Mass.), 97, 1999
1BXX
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BU of 1bxx by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH TGN38 INTERNALIZATION PEPTIDE DYQRLN
Descriptor: PROTEIN (AP50), PROTEIN (TGN38 PEPTIDE)
Authors:Owen, D.J, Evans, P.R.
Deposit date:1998-10-08
Release date:1998-11-25
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A structural explanation for the recognition of tyrosine-based endocytotic signals.
Science, 282, 1998
1BW8
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BU of 1bw8 by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM
Descriptor: PROTEIN (INTERNALIZATION SIGNAL FROM EGFR), PROTEIN (MU2 ADAPTIN SUBUNIT)
Authors:Owen, D.J, Evans, P.R.
Deposit date:1998-09-30
Release date:1998-11-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A structural explanation for the recognition of tyrosine-based endocytotic signals.
Science, 282, 1998
1E42
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BU of 1e42 by Molmil
Beta2-adaptin appendage domain, from clathrin adaptor AP2
Descriptor: AP-2 COMPLEX SUBUNIT BETA, CHLORIDE ION, DITHIANE DIOL, ...
Authors:Owen, D.J, Evans, P.R, McMahon, H.T.
Deposit date:2000-06-27
Release date:2000-08-21
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structure and Function of the Beta2-Adaptin Appendage Domain
Embo J., 19, 2000
1E6I
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BU of 1e6i by Molmil
Bromodomain from GCN5 complexed with acetylated H4 peptide
Descriptor: HISTONE H4, TRANSCRIPTIONAL ACTIVATOR GCN5
Authors:Owen, D.J, Travers, A.A, Evans, P.R.
Deposit date:2000-08-18
Release date:2000-11-24
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Structural Basis for the Recognition of Acetylated Histone H4 by the Bromodomain of Histone Acetyltransferase Gcn5P
Embo J., 19, 2000
5C7Z
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BU of 5c7z by Molmil
AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide
Descriptor: AP-2 complex subunit mu, Integrin alpha-4
Authors:Owen, D.J, Evans, P.R, Wilson, T.A.
Deposit date:2015-06-25
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide
To Be Published
6RH6
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BU of 6rh6 by Molmil
Solution structure and 1H, 13C and 15N chemical shift assignments for the complex of NECAP1 PHear domain with phosphorylated AP2 mu2 148-163
Descriptor: AP-2 complex subunit mu, Adaptin ear-binding coat-associated protein 1
Authors:Owen, D.J, Neuhaus, D, Yang, J.-C, Herrmann, T.
Deposit date:2019-04-18
Release date:2019-09-04
Method:SOLUTION NMR
Cite:Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Dev.Cell, 50, 2019
6RH5
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BU of 6rh5 by Molmil
Solution structure and 1H, 13C and 15N chemical shift assignments for NECAP1 PHear domain
Descriptor: Adaptin ear-binding coat-associated protein 1
Authors:Owen, D.J, Neuhaus, D, Yang, J.-C, Herrmann, T.
Deposit date:2019-04-18
Release date:2019-09-04
Method:SOLUTION NMR
Cite:Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Dev.Cell, 50, 2019
6TL0
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BU of 6tl0 by Molmil
Solution structure and 1H, 13C and 15N chemical shift assignments for the complex of VPS29 with VARP 687-747
Descriptor: Ankyrin repeat domain-containing protein 27, Vacuolar protein sorting-associated protein 29, ZINC ION
Authors:Owen, D.J, Neuhaus, D, Yang, J.-C, Crawley-Snowdon, H.
Deposit date:2019-11-29
Release date:2020-10-21
Method:SOLUTION NMR
Cite:Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29.
Nat Commun, 11, 2020
5FPI
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BU of 5fpi by Molmil
Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4 internalisation peptide QYKSILQE
Descriptor: AP-2 COMPLEX SUBUNIT MU, INTEGRIN ALPHA-4 SUBUNIT
Authors:Owen, D.J, Evans, P.R, Ivaska, J.
Deposit date:2015-11-30
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Selective Integrin Endocytosis is Driven by Alpha Chain:Ap2 Interactions
Nat.Struct.Mol.Biol., 23, 2016
2R51
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BU of 2r51 by Molmil
Crystal Structure of mouse Vps26B
Descriptor: Vacuolar protein sorting-associated protein 26B
Authors:Owen, D.J, Teasdale, R.D, Collins, B.M.
Deposit date:2007-09-02
Release date:2008-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Vps26B and mapping of its interaction with the retromer protein complex.
Traffic, 9, 2008
2VGL
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BU of 2vgl by Molmil
AP2 CLATHRIN ADAPTOR CORE
Descriptor: ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT, AP-2 COMPLEX SUBUNIT BETA-1, ...
Authors:Owen, D.J, Collins, B.M, McCoy, A.J, Evans, P.R.
Deposit date:2007-11-14
Release date:2007-12-25
Last modified:2020-10-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Architecture and Functional Model of the Endocytic Ap2 Complex
Cell(Cambridge,Mass.), 109, 2002
2V8S
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BU of 2v8s by Molmil
VTI1B HABC DOMAIN - EPSINR ENTH DOMAIN COMPLEX
Descriptor: CLATHRIN INTERACTOR 1, GLYCEROL, VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B
Authors:Owen, D.J, McCoy, A.J, Collins, B.M, Miller, S.E.
Deposit date:2007-08-14
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A Snare-Adaptor Interaction is a New Mode of Cargo Recognition in Clathrin Coated Vesicles
Nature, 450, 2007
2JKT
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BU of 2jkt by Molmil
AP2 CLATHRIN ADAPTOR CORE with CD4 Dileucine peptide RM(phosphoS) EIKRLLSE Q to E mutant
Descriptor: AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2 COMPLEX SUBUNIT BETA-1, AP-2 COMPLEX SUBUNIT MU-1, ...
Authors:Owen, D.J, McCoy, A.J, Kelly, B.T, Evans, P.R.
Deposit date:2008-08-29
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:A Structural Explanation for the Binding of Endocytic Dileucine Motifs by the Ap2 Complex.
Nature, 456, 2008
2JKR
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BU of 2jkr by Molmil
AP2 CLATHRIN ADAPTOR CORE with Dileucine peptide RM(phosphoS)QIKRLLSE
Descriptor: AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2 COMPLEX SUBUNIT BETA-1, AP-2 COMPLEX SUBUNIT MU-1, ...
Authors:Owen, D.J, McCoy, A.J, Kelly, B.T, Evans, P.R.
Deposit date:2008-08-29
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:A Structural Explanation for the Binding of Endocytic Dileucine Motifs by the Ap2 Complex.
Nature, 456, 2008
4UQI
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BU of 4uqi by Molmil
AP2 controls clathrin polymerization with a membrane-activated switch
Descriptor: AP-2 COMPLEX SUBUNIT ALPHA-2, AP-2 COMPLEX SUBUNIT BETA, AP-2 COMPLEX SUBUNIT MU, ...
Authors:Kelly, B.T, Graham, S.C, Liska, N, Dannhauser, P.N, Hoening, S, Ungewickell, E.J, Owen, D.J.
Deposit date:2014-06-23
Release date:2014-07-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Clathrin Adaptors. Ap2 Controls Clathrin Polymerization with a Membrane-Activated Switch.
Science, 345, 2014
1QL6
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BU of 1ql6 by Molmil
THE CATALYTIC MECHANISM OF PHOSPHORYLASE KINASE PROBED BY MUTATIONAL STUDIES
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PHOSPHORYLASE KINASE, ...
Authors:Skamnaki, V.T, Owen, D.J, Noble, M.E.M, Lowe, E.D, Oikonomakos, N.G, Johnson, L.N.
Deposit date:1999-08-24
Release date:1999-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies.
Biochemistry, 38, 1999
2BP5
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BU of 2bp5 by Molmil
MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH NON-CANONICAL INTERNALIZATION PEPTIDE VEDYEQGLSG
Descriptor: CLATHRIN COAT ASSEMBLY PROTEIN AP50, P2X PURINOCEPTOR 4
Authors:Royle, S.J, Evans, P.R, Owen, D.J, Murrell-Lagnado, R.D.
Deposit date:2005-04-18
Release date:2005-07-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Non-Canonical Yxxg-Phi Endocytic Motifs: Recognition by Ap2 and Preferential Utilization in P2X4 Receptors.
J.Cell.Sci, 118, 2005
2G30
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BU of 2g30 by Molmil
beta appendage of AP2 complexed with ARH peptide
Descriptor: 16-mer peptide from Low density lipoprotein receptor adapter protein 1, AP-2 complex subunit beta-1, peptide sequence AAF
Authors:Edeling, M.A, Collins, B.M, Traub, L.M, Owen, D.J.
Deposit date:2006-02-17
Release date:2006-03-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular Switches Involving the AP-2 beta2 Appendage Regulate Endocytic Cargo Selection and Clathrin Coat Assembly
Dev.Cell, 10, 2006
7BLN
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BU of 7bln by Molmil
VPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins
Descriptor: Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35
Authors:Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J.
Deposit date:2021-01-18
Release date:2021-02-10
Last modified:2021-04-07
Method:ELECTRON MICROSCOPY (8.9 Å)
Cite:Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.
Sci Adv, 7, 2021
7BLR
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BU of 7blr by Molmil
Vps35/Vps29 arch of fungal membrane-assembled retromer:Vps5 (SNX-BAR) complex.
Descriptor: Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35
Authors:Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J.
Deposit date:2021-01-18
Release date:2021-02-10
Last modified:2021-04-07
Method:ELECTRON MICROSCOPY (9.3 Å)
Cite:Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.
Sci Adv, 7, 2021
7BLP
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BU of 7blp by Molmil
Vps35/Vps29 arch of fungal membrane-assembled retromer:Grd19 complex
Descriptor: Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35
Authors:Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J.
Deposit date:2021-01-18
Release date:2021-02-10
Last modified:2021-04-07
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.
Sci Adv, 7, 2021

 

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