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1URF
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BU of 1urf by Molmil
HR1b domain from PRK1
Descriptor: PROTEIN KINASE C-LIKE 1
Authors:Owen, D, Lowe, P.N, Nietlispach, D, Brosnan, C.E, Chirgadze, D.Y, Parker, P.J, Blundell, T.L, Mott, H.R.
Deposit date:2003-10-29
Release date:2003-11-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Molecular Dissection of the Interaction between the Small G Proteins Rac1 and Rhoa and Protein Kinase C-Related Kinase 1 (Prk1)
J.Biol.Chem., 278, 2003
1ZSG
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BU of 1zsg by Molmil
beta PIX-SH3 complexed with an atypical peptide from alpha-PAK
Descriptor: Rho guanine nucleotide exchange factor 7, Serine/threonine-protein kinase PAK 1
Authors:Mott, H.R, Nietlispach, D, Evetts, K.A, Owen, D.
Deposit date:2005-05-24
Release date:2005-08-30
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structural Analysis of the SH3 Domain of beta-PIX and Its Interaction with alpha-p21 Activated Kinase (PAK)
Biochemistry, 44, 2005
1CF4
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BU of 1cf4 by Molmil
CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN (ACTIVATED P21CDC42HS KINASE), ...
Authors:Mott, H.R, Owen, D, Nietlispach, D, Lowe, P.N, Lim, L, Laue, E.D.
Deposit date:1999-03-23
Release date:1999-06-18
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.
Nature, 399, 1999
1E0A
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BU of 1e0a by Molmil
Cdc42 complexed with the GTPase binding domain of p21 activated kinase
Descriptor: Cell division control protein 42 homolog, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Morreale, A, Venkatesan, M, Mott, H.R, Owen, D, Nietlispach, D, Lowe, P.N, Laue, E.D.
Deposit date:2000-03-16
Release date:2000-04-18
Last modified:2019-09-25
Method:SOLUTION NMR
Cite:Solution Structure of Cdc42 Bound to the Gtpase Binding Domian of Pak
Nat.Struct.Biol., 7, 2000
1UQV
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BU of 1uqv by Molmil
SAM domain from Ste50p
Descriptor: STE50 PROTEIN
Authors:Grimshaw, S.J, Mott, H.R, Stott, K.M, Nielsen, P.R, Evetts, K.A, Hopkins, L.J, Nietlispach, D, Owen, D.
Deposit date:2003-10-20
Release date:2003-10-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Sterile {Alpha} Motif (Sam) Domain of the Saccharomyces Cerevisiae Mitogen-Activated Protein Kinase Pathway-Modulating Protein Ste50 and Analysis of its Interaction with the Ste11 Sam
J.Biol.Chem., 279, 2004
8V1P
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BU of 8v1p by Molmil
CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH UBF9092
Descriptor: Glucose-induced degradation protein 4 homolog, N,N~2~-bis[(4-methoxyphenyl)methyl]glycinamide
Authors:Dong, C, Dong, A, Calabrese, M, Wang, F, Owen, D, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2023-11-21
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH UBF9092
To be published
7NQC
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BU of 7nqc by Molmil
Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane targeting motifs
Descriptor: CALCIUM ION, Calmodulin-1, PRO-ASN-GLY-LYS-LYS-LYS-ARG-LYS-SER-LEU-ALA-LYS-ARG-ILE-ARG-GLU-ARG-CMF, ...
Authors:Chamberlain, S.G, Owen, D, Mott, H.R.
Deposit date:2021-03-01
Release date:2021-09-22
Method:SOLUTION NMR
Cite:Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs.
Proc.Natl.Acad.Sci.USA, 118, 2021
6R28
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BU of 6r28 by Molmil
Structure of peptide P7, which binds Cdc42 and inhibits effector interactions.
Descriptor: peptide P7
Authors:Murphy, N.P, Mott, H.R, Owen, D.
Deposit date:2019-03-15
Release date:2020-01-29
Last modified:2024-03-06
Method:SOLUTION NMR
Cite:The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling.
J.Biol.Chem., 295, 2020
7SLZ
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BU of 7slz by Molmil
CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH BPF023596
Descriptor: Glucose-induced degradation protein 4 homolog, N-[(1s,4s)-4-(1H-benzimidazol-2-yl)cyclohexyl]-N~2~-[(1H-indol-2-yl)methyl]glycinamide
Authors:Song, X, Dong, A, Calabrese, M, Wang, F, Owen, D, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2021-10-25
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:CRYSTAL STRUCTURE OF GID4 IN COMPLEX WITH BPF023596
To Be Published
4E47
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BU of 4e47 by Molmil
SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine
Descriptor: (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, BETA-MERCAPTOETHANOL, Histone-lysine N-methyltransferase SETD7, ...
Authors:Walker, J.R, Ouyang, H, Dong, A, Fish, P, Cook, A, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2012-03-12
Release date:2012-03-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Setd7 in Complex with Inhibitor and SAM
To be Published
2MBG
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BU of 2mbg by Molmil
Rlip76 (gap-gbd)
Descriptor: RalA-binding protein 1
Authors:Rajasekar, K.V, Campbell, L.J, Nietlispach, D, Owen, D, Mott, H.R.
Deposit date:2013-07-30
Release date:2013-12-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the Membrane.
Structure, 21, 2013
2RMK
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BU of 2rmk by Molmil
Rac1/PRK1 Complex
Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1, ...
Authors:Modha, R, Campbell, L.J, Nietlispach, D, Buhecha, H.R, Owen, D, Mott, H.R.
Deposit date:2007-10-25
Release date:2007-11-13
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:The Rac1 Polybasic Region Is Required for Interaction with Its Effector PRK1
J.Biol.Chem., 283, 2008
5FRG
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BU of 5frg by Molmil
The NMR Structure of the Cdc42-interacting region of TOCA1
Descriptor: FORMIN-BINDING PROTEIN 1-LIKE
Authors:Watson, J.R, Nietlispach, D, Owen, D, Mott, H.R.
Deposit date:2015-12-17
Release date:2016-05-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Investigation of the Interaction between Cdc42 and its Effector Toca1: Handover of Cdc42 to the Actin Regulator N-Wasp is Facilitated by Differential Binding Affinities.
J.Biol.Chem., 291, 2016
2K9A
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BU of 2k9a by Molmil
The Solution Structure of the Arl2 Effector, BART
Descriptor: ADP-ribosylation factor-like protein 2-binding protein
Authors:Bailey, L.K, Campbell, L.J, Evetts, K.A, Littlefield, K, Rajendra, E, Nietlispach, D, Owen, D, Mott, H.R.
Deposit date:2008-10-06
Release date:2008-11-11
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:The Structure of Binder of Arl2 (BART) Reveals a Novel G Protein Binding Domain: IMPLICATIONS FOR FUNCTION.
J.Biol.Chem., 284, 2009
2KE5
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BU of 2ke5 by Molmil
Solution structure and dynamics of the small GTPase Ralb in its active conformation: significance for effector protein binding
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Ral-B
Authors:Fenwick, R, Prasannan, S, Campbell, L.J, Nietlispach, D, Evetts, K.A, Camonis, J, Mott, H.R, Owen, D.
Deposit date:2009-01-23
Release date:2009-02-17
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding
Biochemistry, 48, 2009
2KWH
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BU of 2kwh by Molmil
Ral binding domain of RLIP76 (RalBP1)
Descriptor: RalA-binding protein 1
Authors:Fenwick, R.B, Campbell, L.J, Rajasekar, K, Prasannan, S, Nietlispach, D, Camonis, J, Owen, D, Mott, H.R.
Deposit date:2010-04-12
Release date:2010-09-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction
Structure, 18, 2010
2KWI
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BU of 2kwi by Molmil
RalB-RLIP76 (RalBP1) complex
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RalA-binding protein 1, ...
Authors:Fenwick, R.B, Campbell, L.J, Rajasekar, K, Prasannan, S, Nietlispach, D, Camonis, J, Owen, D, Mott, H.R.
Deposit date:2010-04-12
Release date:2010-09-01
Last modified:2021-10-06
Method:SOLUTION NMR
Cite:The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction
Structure, 18, 2010
1HK6
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BU of 1hk6 by Molmil
Ral binding domain from Sec5
Descriptor: EXOCYST COMPLEX COMPONENT SEC5
Authors:Mott, H.R, Nietlispach, D, Hopkins, L.J, Mirey, G, Camonis, J.H, Owen, D.
Deposit date:2003-03-05
Release date:2003-03-13
Last modified:2018-03-28
Method:SOLUTION NMR
Cite:Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site.
J. Biol. Chem., 278, 2003
4JDS
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BU of 4jds by Molmil
SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
Descriptor: Histone-lysine N-methyltransferase SETD7, N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, S-ADENOSYLMETHIONINE, ...
Authors:Dong, A, Wu, H, Zeng, H, Park, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2013-02-25
Release date:2013-03-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
to be published
6ZRN
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BU of 6zrn by Molmil
Crystal structure of the RLIP76 Ral binding domain mutant (E427S/L429M/Q433L/K440R) in complex with RalB-GMPPNP
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Hurd, C, Brear, P, Revell, J, Ross, S, Mott, H, Owen, D.
Deposit date:2020-07-13
Release date:2020-11-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.482 Å)
Cite:Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
J.Biol.Chem., 296, 2020
5E7D
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BU of 5e7d by Molmil
Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand
Descriptor: (2E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one, 1,2-ETHANEDIOL, Protein polybromo-1
Authors:Filippakopoulos, P, Picaud, S, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Owen, D, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2015-10-12
Release date:2016-10-12
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand
To Be Published
6ZQT
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BU of 6zqt by Molmil
Crystal structure of the RLIP76 Ral binding domain mutant (E427H/Q433L/K440R) in complex with RalB-GMPPNP
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Hurd, C, Brear, P, Revell, J, Ross, S, Mott, H, Owen, D.
Deposit date:2020-07-10
Release date:2020-11-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
J.Biol.Chem., 296, 2020
1AP7
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BU of 1ap7 by Molmil
P19-INK4D FROM MOUSE, NMR, 20 STRUCTURES
Descriptor: P19-INK4D
Authors:Archer, S.J, Luh, F.Y, Domaille, P.J, Smith, B.O, Laue, E.D.
Deposit date:1997-07-25
Release date:1998-09-16
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of the cyclin-dependent kinase inhibitor p19Ink4d.
Nature, 389, 1997
1AM4
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BU of 1am4 by Molmil
COMPLEX BETWEEN CDC42HS.GMPPNP AND P50 RHOGAP (H. SAPIENS)
Descriptor: CDC42HS, MAGNESIUM ION, P50-RHOGAP, ...
Authors:Rittinger, K, Walker, P, Gamblin, S.J, Smerdon, S.J.
Deposit date:1997-06-22
Release date:1998-07-15
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Nature, 388, 1997
5JJZ
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BU of 5jjz by Molmil
Chromo domain of human Chromodomain Protein, Y-Like 2
Descriptor: Chromodomain Y-like protein 2, LYS-LYS-LYS-ALA-ARG-MLY-SER-ALA-GLY-ALA-ALA-LYS-TYR
Authors:DONG, A, DOMBROVSKI, L, LOPPNAU, P, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, MIN, J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2016-04-25
Release date:2016-05-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of CDYL2 domain of human CDYL2 protein
to be published

 

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