Author results

1L9A
  • Download 1l9a
  • View 1l9a
Molmil generated image of 1l9a
CRYSTAL STRUCTURE OF SRP19 IN COMPLEX WITH THE S DOMAIN OF SIGNAL RECOGNITION PARTICLE RNA
Descriptor:signal recognition particle RNA S domain, SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN, MAGNESIUM ION, ...
Authors:Oubridge, C., Kuglstatter, A., Jovine, L., Nagai, K.
Deposit date:2002-03-22
Release date:2002-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle.
Mol.Cell, 9, 2002
1URN
  • Download 1urn
  • View 1urn
Molmil generated image of 1urn
U1A MUTANT/RNA COMPLEX + GLYCEROL
Descriptor:RNA (5'-R(*AP*AP*UP*CP*CP*AP*UP*UP*GP*CP*AP*CP*UP*CP*CP*GP*G P*AP*UP*UP*U)-3'), PROTEIN (U1A), CHLORIDE ION, ...
Authors:Oubridge, C., Ito, N., Evans, P.R., Teo, C.-H., Nagai, K.
Deposit date:1995-01-04
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.
Nature, 372, 1994
4PKD
  • Download 4pkd
  • View 4pkd
Molmil generated image of 4pkd
U1-70K IN COMPLEX WITH U1 SNRNA STEM-LOOPS 1 AND U1-A RRM IN COMPLEX WITH STEM-LOOP 2
Descriptor:U1 snRNA stem-loops 1 and 2 (55-MER), U1 small nuclear ribonucleoprotein A,U1 small nuclear ribonucleoprotein 70 kDa, MAGNESIUM ION, ...
Authors:Oubridge, C., Kondo, Y., van Roon, A.M., Nagai, K.
Deposit date:2014-05-14
Release date:2014-12-31
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
Elife, 4, 2015
3CW1
  • Download 3cw1
  • View 3cw1
Molmil generated image of 3cw1
CRYSTAL STRUCTURE OF HUMAN SPLICEOSOMAL U1 SNRNP
Descriptor:U1 snRNA, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein-associated proteins B and B, ...
Authors:Pomeranz Krummel, D.A., Oubridge, C., Leung, A.K., Li, J., Nagai, K.
Deposit date:2008-04-21
Release date:2009-03-24
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (5.493 Å)
Cite:Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
Nature, 458, 2009
5MPS
  • Download 5mps
  • View 5mps
Molmil generated image of 5mps
STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION
Descriptor:Yeast UBC4 gene for ubiquitin-conjugating enzyme, UBC4 gene exon, U2 snRNA, ...
Authors:Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K.
Deposit date:2016-12-18
Release date:2017-01-18
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
5MQ0
  • Download 5mq0
  • View 5mq0
Molmil generated image of 5mq0
STRUCTURE OF A SPLICEOSOME REMODELED FOR EXON LIGATION
Descriptor:Yeast UBC4 gene for ubiquitin-conjugating enzyme, 5'-EXON OF UBC4 PRE-MRNA, S.cerevisiae chromosome II reading frame ORF YBR230c, ...
Authors:Fica, S.M., Oubridge, C., Galej, W.P., Wilkinson, M.E., Newman, A.J., Bai, X.-C., Nagai, K.
Deposit date:2016-12-19
Release date:2017-01-18
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
1DUH
  • Download 1duh
  • View 1duh
Molmil generated image of 1duh
CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN IV OF E. COLI 4.5S RNA
Descriptor:4.5S RNA DOMAIN IV, LUTETIUM (III) ION, MAGNESIUM ION, ...
Authors:Jovine, L., Hainzl, T., Oubridge, C., Scott, W.G., Li, J., Sixma, T.K., Wonacott, A., Skarzynski, T., Nagai, K.
Deposit date:2000-01-17
Release date:2000-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA.
Structure Fold.Des., 8, 2000
2VRD
  • Download 2vrd
  • View 2vrd
Molmil generated image of 2vrd
THE STRUCTURE OF THE ZINC FINGER FROM THE HUMAN SPLICEOSOMAL PROTEIN U1C
Descriptor:U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C, ZINC ION
Authors:Muto, Y., Pomeranz-Krummel, D., Oubridge, C., Hernandez, H., Robinson, C., Neuhaus, D., Nagai, K.
Deposit date:2008-03-31
Release date:2008-04-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure and Biochemical Properties of the Human Spliceosomal Protein U1C
J.Mol.Biol., 341, 2004
1MFQ
  • Download 1mfq
  • View 1mfq
Molmil generated image of 1mfq
CRYSTAL STRUCTURE ANALYSIS OF A TERNARY S-DOMAIN COMPLEX OF HUMAN SIGNAL RECOGNITION PARTICLE
Descriptor:7S RNA of human SRP, signal recognition particle 19kDa protein, signal recognition particle 54kDa protein, ...
Authors:Kuglstatter, A., Oubridge, C., Nagai, K.
Deposit date:2002-08-13
Release date:2002-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Induced structural changes of 7SL RNA during the assembly of human signal recognition particle
Nat.Struct.Biol., 9, 2002
3KL4
  • Download 3kl4
  • View 3kl4
Molmil generated image of 3kl4
RECOGNITION OF A SIGNAL PEPTIDE BY THE SIGNAL RECOGNITION PARTICLE
Descriptor:Signal recognition 54 kDa protein, Signal peptide of yeast dipeptidyl aminopeptidase B
Authors:Janda, C.Y., Nagai, K., Li, J., Oubridge, C.
Deposit date:2009-11-06
Release date:2010-03-31
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Recognition of a signal peptide by the signal recognition particle.
Nature, 465, 2010
3ZEF
  • Download 3zef
  • View 3zef
Molmil generated image of 3zef
CRYSTAL STRUCTURE OF PRP8:AAR2 COMPLEX: SECOND CRYSTAL FORM AT 3.1 ANGSTROM RESOLUTION
Descriptor:A1 CISTRON-SPLICING FACTOR AAR2, PRE-MRNA-SPLICING FACTOR 8
Authors:Galej, W.P., Oubridge, C., Newman, A.J., Nagai, K.
Deposit date:2012-12-05
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of Prp8 Reveals Active Site Cavity of the Spliceosome
Nature, 493, 2013
4I43
  • Download 4i43
  • View 4i43
Molmil generated image of 4i43
CRYSTAL STRUCTURE OF PRP8:AAR2 COMPLEX
Descriptor:A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8
Authors:Galej, W.P., Oubridge, C., Newman, A.J., Nagai, K.
Deposit date:2012-11-27
Release date:2013-01-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Prp8 reveals active site cavity of the spliceosome.
Nature, 493, 2013
4PJO
  • Download 4pjo
  • View 4pjo
Molmil generated image of 4pjo
MINIMAL U1 SNRNP
Descriptor:Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein-associated proteins B and B', Small nuclear ribonucleoprotein Sm D1, ...
Authors:Kondo, Y., Oubridge, C., van Roon, A.M., Nagai, K.
Deposit date:2014-05-12
Release date:2014-12-31
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
Elife, 4, 2015
5GAM
  • Download 5gam
  • View 5gam
Molmil generated image of 5gam
FOOT REGION OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP
Descriptor:U5 snRNA, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ...
Authors:Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K.
Deposit date:2015-12-15
Release date:2016-02-03
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
5GAN
  • Download 5gan
  • View 5gan
Molmil generated image of 5gan
THE OVERALL STRUCTURE OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP AT 3.7 ANGSTROM
Descriptor:U4 snRNA, U6 snRNA, Pre-mRNA-splicing factor 8, ...
Authors:Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAO
  • Download 5gao
  • View 5gao
Molmil generated image of 5gao
HEAD REGION OF THE YEAST SPLICEOSOMAL U4/U6.U5 TRI-SNRNP
Descriptor:Small nuclear ribonucleoprotein-associated protein B, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, ...
Authors:Nguyen, T.H.D., Galej, W.P., Bai, X.C., Oubridge, C., Scheres, S.H.W., Newman, A.J., Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAP
  • Download 5gap
  • View 5gap
Molmil generated image of 5gap
BODY REGION OF THE U4/U6.U5 TRI-SNRNP
Descriptor:U4 snRNA, 5' region, nucleotides 1-67, ...
Authors:Nguyen, T.H.D., Galej, W.P., Oubridge, C., Bai, X.C., Newman, A., Scheres, S., Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5LJ3
  • Download 5lj3
  • View 5lj3
Molmil generated image of 5lj3
STRUCTURE OF THE CORE OF THE YEAST SPLICEOSOME IMMEDIATELY AFTER BRANCHING
Descriptor:U5 snRNA (small nuclear RNA), Exon 1 (5' exon) of UBC4 pre-mRNA, Intron of UBC4 pre-mRNA, ...
Authors:Galej, W.P., Wilkinson, M.F., Fica, S.M., Oubridge, C., Newman, A.J., Nagai, K.
Deposit date:2016-07-17
Release date:2016-08-03
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the spliceosome immediately after branching.
Nature, 537, 2016
5LJ5
  • Download 5lj5
  • View 5lj5
Molmil generated image of 5lj5
OVERALL STRUCTURE OF THE YEAST SPLICEOSOME IMMEDIATELY AFTER BRANCHING.
Descriptor:U5 snRNA (small nuclear RNA), Exon 1 (5' exon) of UBC4 pre-mRNA, Intron of UBC4 pre-mRNA, ...
Authors:Galej, W.P., Wilkinson, M.F., Fica, S.M., Oubridge, C., Newman, A.J., Nagai, K.
Deposit date:2016-07-17
Release date:2016-08-31
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the spliceosome immediately after branching.
Nature, 537, 2016
5LSB
  • Download 5lsb
  • View 5lsb
Molmil generated image of 5lsb
CRYSTAL STRUCTURE OF YEAST HSH49P IN COMPLEX WITH CUS1P BINDING DOMAIN.
Descriptor:Protein HSH49, Cold sensitive U2 snRNA suppressor 1
Authors:van Roon, A.M., Obayashi, E., Sposito, B., Oubridge, C., Nagai, K.
Deposit date:2016-08-24
Release date:2017-04-12
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain.
RNA, 23, 2017
5LSL
  • Download 5lsl
  • View 5lsl
Molmil generated image of 5lsl
CRYSTAL STRUCTURE OF YEAST HSH49P IN COMPLEX WITH CUS1P BINDING DOMAIN.
Descriptor:Protein HSH49, Cold sensitive U2 snRNA suppressor 1
Authors:van Roon, A.M., Obayashi, E., Sposito, B., Oubridge, C., Nagai, K.
Deposit date:2016-09-02
Release date:2017-04-12
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain.
RNA, 23, 2017
6QDV
  • Download 6qdv
  • View 6qdv
Molmil generated image of 6qdv
HUMAN POST-CATALYTIC P COMPLEX SPLICEOSOME
Descriptor:U2 snRNA, U5 snRNA, U6 snRNA, ...
Authors:Fica, S.M., Oubridge, C., Wilkinson, M.E., Newman, A.J., Nagai, K.
Deposit date:2019-01-03
Release date:2019-02-20
Last modified:2019-02-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
Science, 363, 2019
4WZJ
  • Download 4wzj
  • View 4wzj
Molmil generated image of 4wzj
SPLICEOSOMAL U4 SNRNP CORE DOMAIN
Descriptor:Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein-associated proteins B and B', Small nuclear ribonucleoprotein Sm D1, ...
Authors:Leung, A.K.W., Nagai, K., Li, J.
Deposit date:2014-11-19
Release date:2015-01-14
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
Nature, 473, 2011
1FHT
  • Download 1fht
  • View 1fht
Molmil generated image of 1fht
RNA-BINDING DOMAIN OF THE U1A SPLICEOSOMAL PROTEIN U1A117, NMR, 43 STRUCTURES
Descriptor:U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
Authors:Allain, F.H.-T., Gubser, C.C., Howe, P.W.A., Nagai, K., Neuhaus, D., Varani, G.
Deposit date:1996-02-21
Release date:1996-07-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.
J.Mol.Biol., 257, 1996
1OIA
  • Download 1oia
  • View 1oia
Molmil generated image of 1oia
U1A RNP DOMAIN 1-95
Descriptor:U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
Authors:Nagai, K., Evans, P.R.
Deposit date:2003-06-12
Release date:2003-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the RNA-Binding Domain of the U1 Small Nuclear Ribonucleoprotein A
Nature, 348, 1990
<12>