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3ED8
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BU of 3ed8 by Molmil
Application of the superfolder YFP bimolecular fluorescence complementation for studying protein-protein interactions in vitro
Descriptor: yellow fluorescence protein
Authors:Ottmann, C, Weyand, M.
Deposit date:2008-09-02
Release date:2009-01-20
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Applicability of superfolder YFP bimolecular fluorescence complementation in vitro.
Biol.Chem., 390, 2009
2O98
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BU of 2o98 by Molmil
Structure of the 14-3-3 / H+-ATPase plant complex
Descriptor: 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ...
Authors:Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C.
Deposit date:2006-12-13
Release date:2007-04-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy
Mol.Cell, 25, 2007
3E6Y
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BU of 3e6y by Molmil
Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A
Descriptor: 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ...
Authors:Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C.
Deposit date:2008-08-17
Release date:2009-03-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A
J.Mol.Biol., 386, 2009
2O02
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BU of 2o02 by Molmil
Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to pathogenesis
Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, ExoS (416-430) peptide
Authors:Ottmann, C, Yasmin, L, Weyand, M, Hauser, A.R, Wittinghofer, A, Hallberg, B.
Deposit date:2006-11-27
Release date:2007-11-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis
Embo J., 26, 2007
3GNU
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BU of 3gnu by Molmil
Toxin fold as basis for microbial attack and plant defense
Descriptor: 25 kDa protein elicitor, CHLORIDE ION, GUANIDINE
Authors:Ottmann, C, Luberacki, B, Kuefner, I, Koch, W, Brunner, F, Weyand, M, Mattinen, L, Pirhonen, M, Anderluh, G, Seitz, H.U, Nuernberger, T, Oecking, C.
Deposit date:2009-03-18
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A common toxin fold mediates microbial attack and plant defense
Proc.Natl.Acad.Sci.USA, 106, 2009
3GNZ
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BU of 3gnz by Molmil
Toxin fold for microbial attack and plant defense
Descriptor: 25 kDa protein elicitor, MAGNESIUM ION
Authors:Ottmann, C, Luberacki, B, Kuefner, I, Koch, W, Brunner, F, Weyand, M, Mattinen, L, Pirhonen, M, Anderluh, G, Seitz, H.U, Nuernberger, T, Oecking, C.
Deposit date:2009-03-18
Release date:2009-06-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A common toxin fold mediates microbial attack and plant defense
Proc.Natl.Acad.Sci.USA, 106, 2009
3IQU
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BU of 3iqu by Molmil
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer)
Descriptor: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ...
Authors:Ottmann, C, Weyand, M.
Deposit date:2009-08-21
Release date:2010-09-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol.Cell.Biol., 30, 2010
3IQJ
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BU of 3iqj by Molmil
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer)
Descriptor: 10-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Ottmann, C, Weyand, M.
Deposit date:2009-08-20
Release date:2010-09-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol.Cell.Biol., 30, 2010
3IQV
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BU of 3iqv by Molmil
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin
Descriptor: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ...
Authors:Ottmann, C, Weyand, M.
Deposit date:2009-08-21
Release date:2010-09-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol.Cell.Biol., 30, 2010
4FR3
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BU of 4fr3 by Molmil
Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H
Descriptor: (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, MAGNESIUM ION, ...
Authors:Ottmann, C, Anders, C, Schumacher, B.
Deposit date:2012-06-26
Release date:2013-05-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface.
Chem.Biol., 20, 2013
3O8I
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BU of 3o8i by Molmil
Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment
Descriptor: 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one
Authors:Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P.
Deposit date:2010-08-03
Release date:2010-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling
Mol.Cell.Biol., 30, 2010
5BTV
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BU of 5btv by Molmil
Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Ottmann, C, Schumacher, B, Bartel, M.
Deposit date:2015-06-03
Release date:2016-07-20
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
Faseb J., 29, 2015
4FJ3
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BU of 4fj3 by Molmil
14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide
Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase
Authors:Ottmann, C, Molzan, M.
Deposit date:2012-06-11
Release date:2012-09-05
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer
J.Mol.Biol., 423, 2012
3I6S
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BU of 3i6s by Molmil
Crystal Structure of the plant subtilisin-like protease SBT3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Subtilisin-like protease, alpha-L-fucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Rose, R, Ottmann, C.
Deposit date:2009-07-07
Release date:2010-01-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3.
Proc.Natl.Acad.Sci.USA, 106, 2009
6SLV
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BU of 6slv by Molmil
Fragment AZ-013 binding at the p53pT387/14-3-3 sigma interface
Descriptor: 14-3-3 protein sigma, 4-(methylamino)-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ...
Authors:Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P.
Deposit date:2019-08-20
Release date:2020-06-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
6SLX
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BU of 6slx by Molmil
Fragment AZ-010 binding at the TAZpS89/14-3-3 sigma interface
Descriptor: 14-3-3 protein sigma, TAZpS89, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]propanamide
Authors:Ottmann, C, Wolter, M, Guillory, X, Genet, S, Somsen, B, Leysen, S, Castaldi, P.
Deposit date:2019-08-20
Release date:2020-06-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.800045 Å)
Cite:Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
6SLW
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BU of 6slw by Molmil
Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface
Descriptor: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, WW domain-containing transcription regulator protein 1
Authors:Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P.
Deposit date:2019-08-20
Release date:2020-06-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
3I74
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BU of 3i74 by Molmil
Crystal Structure of the plant subtilisin-like protease SBT3 in complex with a chloromethylketone inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-PHE-GLU-LYS-ALA chloromethylketone INHIBITOR, Subtilisin-like protease, ...
Authors:Rose, R, Ottmann, C.
Deposit date:2009-07-08
Release date:2010-01-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3.
Proc.Natl.Acad.Sci.USA, 106, 2009
3M51
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BU of 3m51 by Molmil
Structure of the 14-3-3/PMA2 complex stabilized by Pyrrolidone1
Descriptor: 14-3-3-like protein C, 2-hydroxy-5-[(5S)-3-hydroxy-5-(4-nitrophenyl)-2-oxo-4-(phenylcarbonyl)-2,5-dihydro-1H-pyrrol-1-yl]benzoic acid, N.plumbaginifolia H+-translocating ATPase mRNA
Authors:Ottmann, C, Rose, R, Waldmann, H.
Deposit date:2010-03-12
Release date:2010-05-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions
Angew.Chem.Int.Ed.Engl., 49, 2010
3M50
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BU of 3m50 by Molmil
Structure of the 14-3-3/PMA2 complex stabilized by Epibestatin
Descriptor: 14-3-3-like protein C, N-[(2R,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, N.plumbaginifolia H+-translocating ATPase mRNA
Authors:Ottmann, C, Rose, R, Waldmann, H.
Deposit date:2010-03-12
Release date:2010-05-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions
Angew.Chem.Int.Ed.Engl., 49, 2010
6QZR
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BU of 6qzr by Molmil
14-3-3 sigma in complex with FOXO1 pT24 peptide
Descriptor: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Forkhead box protein O1, ...
Authors:Ottmann, C, Wolter, M, Lau, R.A.
Deposit date:2019-03-12
Release date:2019-07-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
J.Biol.Chem., 294, 2019
6QZS
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BU of 6qzs by Molmil
14-3-3 sigma in complex with FOXO1 pS256 peptide
Descriptor: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FOXO1 pS256 site, ...
Authors:Ottmann, C, Wolter, M, Lau, R.A.
Deposit date:2019-03-12
Release date:2019-07-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
J.Biol.Chem., 294, 2019
6YGJ
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BU of 6ygj by Molmil
small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction
Descriptor: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, [2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid
Authors:Ottmann, C, Visser, E.J.
Deposit date:2020-03-27
Release date:2020-09-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions.
Nat Commun, 11, 2020
6YE9
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BU of 6ye9 by Molmil
Small-molecule inhibitor of 14-3-3 protein-protein interactions
Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, [2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic acid
Authors:Ottmann, C, Visser, E.J.
Deposit date:2020-03-24
Release date:2021-03-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based conversion of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions
To Be Published
8C30
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BU of 8c30 by Molmil
Crystal structure of 14-3-3 in complex with PyrinpS242 and a protein/peptide interface fragment
Descriptor: 14-3-3 protein sigma, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CALCIUM ION, ...
Authors:Lau, R, Ottmann, C.
Deposit date:2022-12-23
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:14-3-3/Pyrin complex
To Be Published

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