3RIK
 
 | | The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease | | Descriptor: | (3S,4R,5R,6S)-1-(2-hydroxyethyl)azepane-3,4,5,6-tetrol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, ... | | Authors: | Orwig, S.D, Lieberman, R.L. | | Deposit date: | 2011-04-13 | | Release date: | 2012-03-14 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease
Biochemistry, 50, 2011
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3RIL
 | | The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease | | Descriptor: | (3S,4R,5R,6S)-azepane-3,4,5,6-tetrol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glucosylceramidase, ... | | Authors: | Orwig, S.D, Lieberman, R.L. | | Deposit date: | 2011-04-13 | | Release date: | 2012-03-14 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease
Biochemistry, 50, 2011
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4WXQ
 | | Crystal Structure of the Myocilin Olfactomedin Domain | | Descriptor: | CALCIUM ION, HEXAETHYLENE GLYCOL, Myocilin, ... | | Authors: | Orwig, S.D, Turnage, K.C, Donegan, R.K, Lieberman, R.L. | | Deposit date: | 2014-11-14 | | Release date: | 2015-04-01 | | Last modified: | 2017-09-06 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural basis for misfolding in myocilin-associated glaucoma.
Hum.Mol.Genet., 24, 2015
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4WXU
 | | Crystal Structure of the Selenomthionine Incorporated Myocilin Olfactomedin Domain E396D Variant. | | Descriptor: | CALCIUM ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | Donegan, R.K, Freeman, D.M, Lieberman, R.L. | | Deposit date: | 2014-11-14 | | Release date: | 2015-04-01 | | Method: | X-RAY DIFFRACTION (2.092 Å) | | Cite: | Structural basis for misfolding in myocilin-associated glaucoma.
Hum.Mol.Genet., 24, 2015
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4WXS
 | | Crystal Structure of the E396D SNP Variant of the Myocilin Olfactomedin Domain | | Descriptor: | CALCIUM ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | Donegan, R.K, Freeman, D.M, Lieberman, R.L. | | Deposit date: | 2014-11-14 | | Release date: | 2015-04-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for misfolding in myocilin-associated glaucoma.
Hum.Mol.Genet., 24, 2015
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