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3I9J
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH A SUBSTRATE ANALOG AND A PRODUCT NICOTINAMIDE
Descriptor:ADP-ribosyl cyclase, Nicotinamide 2-fluoro-adenine dinucleotide, [(2R,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ...
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9K
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH SUBSTRATE NAD
Descriptor:ADP-ribosyl cyclase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9L
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH N1-CIDPR
Descriptor:ADP-ribosyl cyclase, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9M
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CRYSTAL STRUCTURE OF HUMAN CD38 COMPLEXED WITH AN ANALOG ARA-2'F-ADPR
Descriptor:ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9N
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CRYSTAL STRUCTURE OF HUMAN CD38 COMPLEXED WITH AN ANALOG RIBO-2'F-ADP RIBOSE
Descriptor:ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Liu, Q., Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B., Oppenheimer, N., Lin, H., Potter, B.V.L., Lee, H.C., Hao, Q.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J.Biol.Chem., 284, 2009
3I9O
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH RIBO-2'F-ADP RIBOSE
Descriptor:ADP-ribosyl cyclase, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Graeff, R., Liu, Q., Kriksunov, I.A., Kotaka, M., Oppenheimer, N., Hao, Q., Lee, H.C.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38
J.Biol.Chem., 284, 2009
3GH3
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STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM OF CD38: EVIDENCE FOR A CONFORMATIONALLY FLEXIBLE COVALENT ENZYME-SUBSTRATE COMPLEX.
Descriptor:Ecto-NAD+ glycohydrolase (CD38 molecule), N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
Authors:Egea, P.F., Muller-Steffner, H., Stroud, R.M., Kellenberger, E., Oppenheimer, N., Schuber, F.
Deposit date:2009-03-02
Release date:2010-03-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
Plos One, 7, 2012
3GC6
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STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM OF CD38: EVIDENCE FOR A CONFORMATIONALLY FLEXIBLE COVALENT ENZYME-SUBSTRATE COMPLEX.
Descriptor:Ecto-NAD+ glycohydrolase (CD38 molecule), SULFATE ION, N-ACETYL-D-GLUCOSAMINE
Authors:Egea, P.F., Muller-Steffner, H., Stroud, R.M., Oppenheimer, N., Kellenberger, E., Schuber, F.
Deposit date:2009-02-21
Release date:2010-03-02
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.
Plos One, 7, 2012