Author results

2UZT
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PKA STRUCTURES OF AKT, INDAZOLE-PYRIDINE INHIBITORS
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, ...
Authors:Zhu, G.D., Gandhi, V.B., Gong, J., Thomas, S., Woods, K.W., Song, X., Li, T., Diebold, R.B., Luo, Y., Liu, X., Guan, R., Klinghofer, V., Johnson, E.F., Bouska, J., Olson, A., Marsh, K.C., Stoll, V.S., Mamo, M., Polakowski, J., Campbell, T.J., Penning, T.D., Li, Q., Rosenberg, S.H., Giranda, V.L.
Deposit date:2007-05-01
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension.
J.Med.Chem., 50, 2007
2UZU
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PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, ...
Authors:Zhu, G.D., Gandhi, V.B., Gong, J., Thomas, S., Woods, K.W., Song, X., Li, T., Diebold, R.B., Luo, Y., Liu, X., Guan, R., Klinghofer, V., Johnson, E.F., Bouska, J., Olson, A., Marsh, K.C., Stoll, V.S., Mamo, M., Polakowski, J., Campbell, T.J., Penning, T.D., Li, Q., Rosenberg, S.H., Giranda, V.L.
Deposit date:2007-05-01
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension.
J.Med.Chem., 50, 2007
2UZV
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PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS
Descriptor:CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA,, CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, ...
Authors:Zhu, G.D., Gandhi, V.B., Gong, J., Thomas, S., Woods, K.W., Song, X., Li, T., Diebold, R.B., Luo, Y., Liu, X., Guan, R., Klinghofer, V., Johnson, E.F., Bouska, J., Olson, A., Marsh, K.C., Stoll, V.S., Mamo, M., Polakowski, J., Campbell, T.J., Penning, T.D., Li, Q., Rosenberg, S.H., Giranda, V.L.
Deposit date:2007-05-01
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension.
J.Med.Chem., 50, 2007
2UZW
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PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, ...
Authors:Zhu, G.D., Gandhi, V.B., Gong, J., Thomas, S., Woods, K.W., Song, X., Li, T., Diebold, R.B., Luo, Y., Liu, X., Guan, R., Klinghofer, V., Johnson, E.F., Bouska, J., Olson, A., Marsh, K.C., Stoll, V.S., Mamo, M., Polakowski, J., Campbell, T.J., Penning, T.D., Li, Q., Rosenberg, S.H., Giranda, V.L.
Deposit date:2007-05-01
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension.
J.Med.Chem., 50, 2007
2MJG
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SOLUTION STRUCTURE OF C-TERMINAL ABRB
Descriptor:Transition state regulatory protein AbrB
Authors:Olson, A.L., Tucker, A.T., Thompson, R.J., Cavanagh, J.
Deposit date:2014-01-08
Release date:2014-11-26
Method:SOLUTION NMR
Cite:Structure of Full Length AbrB from Bacillus Subtilis
To be Published
3TLH
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
Descriptor:PROTEIN (PROTEASE), benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-03
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
5FIV
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
Descriptor:RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-02
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
6FIV
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
Descriptor:RETROPEPSIN, SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-02
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
2FIV
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CRYSTAL STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH A SUBSTRATE
Descriptor:FELINE IMMUNODEFICIENCY VIRUS PROTEASE, ACE-ALN-VAL-STA-GLU-ALN-NH2, SULFATE ION
Authors:Schalk-Hihi, C., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1997-07-21
Release date:1997-11-12
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry, 36, 1997
3FIV
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CRYSTAL STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH A SUBSTRATE
Descriptor:FELINE IMMUNODEFICIENCY VIRUS PROTEASE, ACE-ALN-VAL-LEU-ALA-GLU-ALN-NH2, SULFATE ION
Authors:Schalk-Hihi, C., Lubkowski, J., Zdanov, A., Wlodawer, A., Gustchina, A.
Deposit date:1997-07-09
Release date:1997-11-12
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry, 36, 1997
5VCK
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HIV PROTEASE (PR) WITH TL-3 IN THE ACTIVE SITE AND (Z)-N-(THIAZOL-2-YL)-N'-TOSYLCARBAMIMIDATE IN THE EXOSITE
Descriptor:Protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, 4-methyl-N-(thiazol-2-ylcarbamoyl)benzenesulfonamide
Authors:Tiefenbrunn, T., Stout, C.D.
Deposit date:2017-03-31
Release date:2018-04-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Fragment-based campaign for the identification of potential exosite binders of HIV-1 Protease
to be published
5VEA
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HIV PROTEASE (PR) WITH TL-3 IN ACTIVE SITE AND 4-METHYLBENZENE-1,2-DIAMINE IN EXOSITE
Descriptor:HIV-1 protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, 4-methylbenzene-1,2-diamine, ...
Authors:Stout, C.D.
Deposit date:2017-04-04
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fragment-based campaign for the identification of potential exosite binders of HIV-1 Protease
to be published
5VJ3
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HIV PROTEASE (PR) IN OPEN FORM WITH MG2+ IN ACTIVE SITE AND HIVE-9 IN EYE SITE
Descriptor:Protease, 4-methyl-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}carbamoyl)benzene-1-sulfonamide, MAGNESIUM ION
Authors:Tiefenbrunn, T., Stout, C.D.
Deposit date:2017-04-18
Release date:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fragment-based campaign for the identification of potential exosite binders of HIV-1 Protease
to be published
5W5W
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HIV PROTEASE (PR) IN OPEN FORM WITH MG2+ IN ACTIVE SITE AND HIVE-9 IN EYE SITE
Descriptor:HIV-1 protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, 4-methyl-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}carbamoyl)benzene-1-sulfonamide, ...
Authors:Tiefenbrunn, T., Stout, C.D.
Deposit date:2017-06-15
Release date:2018-06-20
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Fragment-based campaign for the identification of potential exosite binders of HIV-1 Protease
to be published
1VJI
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GENE PRODUCT OF AT1G76680 FROM ARABIDOPSIS THALIANA
Descriptor:12-oxophytodienoate reductase (OPR1), FLAVIN MONONUCLEOTIDE
Authors:Wesenberg, G.E., Smith, D.W., Phillips Jr., G.N., Johnson, K.A., Bingman, C.A., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2004-02-24
Release date:2004-03-16
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:X-ray structure of Arabidopsis At1g77680, 12-oxophytodienoate reductase isoform 1.
Proteins, 61, 2005