Author results

1Q1U
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CRYSTAL STRUCTURE OF HUMAN FHF1B (FGF12B)
Descriptor:fibroblast growth factor homologous factor 1, SULFATE ION
Authors:Olsen, S.K., Garbi, M., Zampieri, N., Eliseenkova, A.V., Ornitz, D.M., Goldfarb, M., Mohammadi, M.
Deposit date:2003-07-22
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs
J.Biol.Chem., 278, 2003
1RY7
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CRYSTAL STRUCTURE OF THE 3 IG FORM OF FGFR3C IN COMPLEX WITH FGF1
Descriptor:Heparin-binding growth factor 1, Fibroblast growth factor receptor 3
Authors:Olsen, S.K., Ibrahimi, O.A., Raucci, A., Zhang, F., Eliseenkova, A.V., Yayon, A., Basilico, C., Linhardt, R.J., Schlessinger, J., Mohammadi, M.
Deposit date:2003-12-19
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Proc.Natl.Acad.Sci.Usa, 101, 2004
2PSM
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CRYSTAL STRUCTURE OF INTERLEUKIN 15 IN COMPLEX WITH INTERLEUKIN 15 RECEPTOR ALPHA
Descriptor:Interleukin-15, Interleukin-15 receptor alpha chain, BENZAMIDINE
Authors:Olsen, S.K., Murayama, K., Kishishita, S., Kukimoto-Niino, M., Terada, T., Shirouzu, M., Ota, N., Kanagawa, O., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-07
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Crystal Structure of the Interleukin-15{middle dot}Interleukin-15 Receptor {alpha} Complex: INSIGHTS INTO TRANS AND CIS PRESENTATION
J.Biol.Chem., 282, 2007
4II2
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CRYSTAL STRUCTURE OF UBIQUITIN ACTIVATING ENZYME 1 (UBA1) IN COMPLEX WITH THE UB E2 UBC4, UBIQUITIN, AND ATP/MG
Descriptor:Ubiquitin-activating enzyme E1 1, Ubiquitin-60S ribosomal protein L40, Ubiquitin-conjugating enzyme E2 4, ...
Authors:Olsen, S.K., Lima, C.D.
Deposit date:2012-12-19
Release date:2013-02-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
Mol.Cell, 49, 2013
4II3
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CRYSTAL STRUCTURE OF S. POMBE UBIQUITIN ACTIVATING ENZYME 1 (UBA1) IN COMPLEX WITH UBIQUITIN AND ATP/MG
Descriptor:Ubiquitin-activating enzyme E1 1, Ubiquitin-60S ribosomal protein L40, MAGNESIUM ION, ...
Authors:Olsen, S.K., Lima, C.D.
Deposit date:2012-12-19
Release date:2013-02-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
Mol.Cell, 49, 2013
2FDB
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CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR (FGF)8B IN COMPLEX WITH FGF RECEPTOR (FGFR) 2C
Descriptor:fibroblast growth factor 8 isoform B, Fibroblast growth factor receptor 2
Authors:Mohammadi, M., Olsen, S.K.
Deposit date:2005-12-13
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain
Genes Dev., 20, 2006
5KNL
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CRYSTAL STRUCTURE OF S. POMBE UBIQUITIN E1 (UBA1) IN COMPLEX WITH UBC15 AND UBIQUITIN
Descriptor:Ubiquitin-activating enzyme E1 1, Ubiquitin, Ubiquitin-conjugating enzyme E2 15, ...
Authors:Olsen, S.K., Lv, Z., Yuan, L., Williams, K.
Deposit date:2016-06-28
Release date:2017-02-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
Mol. Cell, 65, 2017
5IZ2
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CRYSTAL STRUCTURE OF THE N. CLAVIPES SPIDROIN NTD AT PH 6.5
Descriptor:Major ampullate spidroin 1A, Major ampullate spidroin 1A (Partial C-terminus)
Authors:Atkison, J.H., Olsen, S.K.
Deposit date:2016-03-24
Release date:2016-07-27
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal Structure of the Nephila clavipes Major Ampullate Spidroin 1A N-terminal Domain Reveals Plasticity at the Dimer Interface.
J.Biol.Chem., 291, 2016
5TTE
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CRYSTAL STRUCTURE OF AN RBR E3 UBIQUITIN LIGASE IN COMPLEX WITH AN E2-UB THIOESTER INTERMEDIATE MIMIC
Descriptor:E3 ubiquitin-protein ligase ARIH1, Ubiquitin-conjugating enzyme E2 L3, ubiquitin, ...
Authors:Yuan, L., Lv, Z., Olsen, S.K.
Deposit date:2016-11-03
Release date:2017-08-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.
Nat Commun, 8, 2017
5UM6
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CRYSTAL STRUCTURE OF S. POMBE UBA1 IN A CLOSED CONFORMATION
Descriptor:Ubiquitin-activating enzyme E1 1, SULFATE ION, N-(2-{[(4-chlorophenyl)methyl]disulfanyl}ethyl)decan-1-amine, ...
Authors:Lv, Z., Yuan, L., Aldana-Masangkay, G., Atkison, J.H., Chen, Y., Olsen, S.K.
Deposit date:2017-01-26
Release date:2017-06-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.
J. Biol. Chem., 292, 2017
6CWY
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CRYSTAL STRUCTURE OF SUMO E1 IN COMPLEX WITH AN ALLOSTERIC INHIBITOR
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, GLYCEROL, ...
Authors:Lv, Z., Yuan, L., Atkison, J.H., Williams, K.M., Olsen, S.K.
Deposit date:2018-04-01
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.462 Å)
Cite:Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
6CWZ
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CRYSTAL STRUCTURE OF APO SUMO E1
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ZINC ION
Authors:Lv, Z., Yuan, L., Atkison, J.H., Williams, K.M., Olsen, S.K.
Deposit date:2018-04-01
Release date:2019-01-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
6DC6
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CRYSTAL STRUCTURE OF HUMAN UBIQUITIN ACTIVATING ENZYME E1 (UBA1) IN COMPLEX WITH UBIQUITIN
Descriptor:Ubiquitin-like modifier-activating enzyme 1, Ubiquitin, MAGNESIUM ION, ...
Authors:Lv, Z., Yuan, L., Williams, K.M., Atkison, J.H., Olsen, S.K.
Deposit date:2018-05-04
Release date:2018-10-10
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity.
J. Biol. Chem., 293, 2018
3KYC
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HUMAN SUMO E1 COMPLEX WITH A SUMO1-AMP MIMIC
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, Small ubiquitin-related modifier 1, ...
Authors:Lima, C.D.
Deposit date:2009-12-05
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Active site remodelling accompanies thioester bond formation in the SUMO E1.
Nature, 463, 2010
3KYD
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HUMAN SUMO E1~SUMO1-AMP TETRAHEDRAL INTERMEDIATE MIMIC
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, Small ubiquitin-related modifier 1, ...
Authors:Lima, C.D.
Deposit date:2009-12-05
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Active site remodelling accompanies thioester bond formation in the SUMO E1.
Nature, 463, 2010
2P23
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CRYSTAL STRUCTURE OF HUMAN FGF19
Descriptor:Fibroblast growth factor 19
Authors:Mohammadi, M.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
2P39
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CRYSTAL STRUCTURE OF HUMAN FGF23
Descriptor:Fibroblast growth factor 23, SUCROSE OCTASULFATE
Authors:Mohammadi, M.
Deposit date:2007-03-08
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Mol.Cell.Biol., 27, 2007
3F1R
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CRYSTAL STRUCTURE OF FGF20 DIMER
Descriptor:Fibroblast growth factor 20, SULFATE ION
Authors:Kalinina, J., Mohammadi, M.
Deposit date:2008-10-28
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix
Mol.Cell.Biol., 29, 2009
3OJ2
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CRYSTAL STRUCTURE OF FGF1 COMPLEXED WITH THE ECTODOMAIN OF FGFR2B HARBORING THE A172F PFEIFFER SYNDROME MUTATION
Descriptor:Heparin-binding growth factor 1, Fibroblast growth factor receptor 2, SULFATE ION
Authors:Beenken, A., Mohammadi, M.
Deposit date:2010-08-20
Release date:2011-08-31
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
3OJM
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CRYSTAL STRUCTURE OF FGF1 COMPLEXED WITH THE ECTODOMAIN OF FGFR2B HARBORING P253R APERT MUTATION
Descriptor:Heparin-binding growth factor 1, Fibroblast growth factor receptor 2, SULFATE ION
Authors:Beenken, A., Mohammadi, M.
Deposit date:2010-08-23
Release date:2011-08-31
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012
3OJV
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CRYSTAL STRUCTURE OF FGF1 COMPLEXED WITH THE ECTODOMAIN OF FGFR1C EXHIBITING AN ORDERED LIGAND SPECIFICITY-DETERMINING BETAC'-BETAE LOOP
Descriptor:Heparin-binding growth factor 1, Basic fibroblast growth factor receptor 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, ...
Authors:Beenken, A., Mohammadi, M.
Deposit date:2010-08-23
Release date:2011-12-28
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.
J.Biol.Chem., 287, 2012