Author results

1GS0
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CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF MURINE POLY(ADP-RIBOSE) POLYMERASE-2
Descriptor:POLY (ADP-RIBOSE) POLYMERASE-2
Authors:Oliver, A.W., Roe, S.M., Pearl, L.H.
Deposit date:2001-12-19
Release date:2002-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Catalytic Fragment of Murine Poly(Adp-Ribose) Polymerase-2
Nucleic Acids Res., 32, 2004
1W4S
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CRYSTAL STRUCTURE OF THE PROXIMAL BAH DOMAIN OF POLYBROMO
Descriptor:POLYBROMO 1 PROTEIN, CHLORIDE ION
Authors:Oliver, A.W., Roe, S.M., Pearl, L.H.
Deposit date:2004-07-28
Release date:2005-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of the Proximal Bah Domain of the Polybromo Protein
Biochem.J., 389, 2005
2CN5
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CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH ADP
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Oliver, A.W., Pearl, L.H.
Deposit date:2006-05-18
Release date:2006-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange
Embo J., 25, 2006
2CN8
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CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH DEBROMOHYMENIALDISINE
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, MAGNESIUM ION, NITRATE ION, ...
Authors:Oliver, A.W., Pearl, L.H.
Deposit date:2006-05-18
Release date:2006-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange
Embo J., 25, 2006
2W18
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CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF HUMAN PALB2
Descriptor:PARTNER AND LOCALIZER OF BRCA2, GLYCEROL
Authors:Oliver, A.W., Pearl, L.H.
Deposit date:2008-10-15
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Recruitment of Brca2 by Palb2
Embo Rep., 10, 2009
3EU7
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CRYSTAL STRUCTURE OF A PALB2 / BRCA2 COMPLEX
Descriptor:Partner and localizer of BRCA2, 19meric peptide from Breast cancer type 2 susceptibility protein, GLYCEROL
Authors:Oliver, A.W., Pearl, L.H.
Deposit date:2008-10-09
Release date:2009-07-28
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for recruitment of BRCA2 by PALB2
Embo Rep., 10, 2009
2BRF
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CRYSTAL STRUCTURE OF THE FHA DOMAIN OF HUMAN POLYNUCLEOTIDE KINASE 3' PHOSPHATASE
Descriptor:BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, SULFATE ION
Authors:Oliver, A.W., Ali, A.A.E., Pearl, L.H.
Deposit date:2005-05-04
Release date:2005-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
Nucleic Acids Res., 37, 2009
2W3O
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CRYSTAL STRUCTURE OF THE HUMAN PNKP FHA DOMAIN IN COMPLEX WITH AN XRCC1-DERIVED PHOSPHOPEPTIDE
Descriptor:BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, DNA REPAIR PROTEIN XRCC1, CALCIUM ION
Authors:Oliver, A.W., Ali, A.A.E., Pearl, L.H.
Deposit date:2008-11-13
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
Nucleic Acids Res., 37, 2009
4U6A
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X-RAY CRYSTAL STRUCTURE OF HUMAN TNKS IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:Tankyrase-1, ZINC ION, 3-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)-5-methylisoquinolin-1(2H)-one, ...
Authors:Oliver, A.W.
Deposit date:2014-07-28
Release date:2015-07-08
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Design and discovery of 3-aryl-5-substituted-isoquinolin-1- ones as potent and selective tankyrase inhibitors
To be published
4UUH
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X-RAY CRYSTAL STRUCTURE OF HUMAN TNKS IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:TANKYRASE-1, ZINC ION, GLYCEROL, ...
Authors:Oliver, A.W., Rajasekaran, M.B., Pearl, L.H.
Deposit date:2014-07-28
Release date:2015-07-08
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1- Ones as Potent and Selective Tankyrase Inhibitors
Medchemcommm, 6, 2015
4UW1
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X-RAY CRYSTAL STRUCTURE OF HUMAN TNKS IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:TANKYRASE-1, ZINC ION, GLYCEROL, ...
Authors:Oliver, A.W., Rajasekaran, M.B., Pearl, L.H.
Deposit date:2014-08-08
Release date:2015-07-08
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors
Medchemcommm, 6, 2015
2WTC
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CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, 4-[2-AMINO-5-(4-HYDROXY-3-METHOXYPHENYL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION
Authors:Hilton, S., Naud, S., Caldwell, J.J., Boxall, K., Burns, S., Anderson, V.E., Antoni, L., Allen, C.E., Pearl, L.H., Oliver, A.W., Aherne, G.W., Garrett, M.D., Collins, I.
Deposit date:2009-09-15
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
2WTD
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CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, 4-[2-AMINO-5-(1,3-BENZODIOXOL-4-YL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION, ...
Authors:Hilton, S., Naud, S., Caldwell, J.J., Boxall, K., Burns, S., Anderson, V.E., Antoni, L., Allen, C.E., Pearl, L.H., Oliver, A.W., Aherne, G.W., Garrett, M.D., Collins, I.
Deposit date:2009-09-15
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
2WTI
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CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
Descriptor:CHECKPOINT KINASE 2, 4-[2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION, ...
Authors:Hilton, S., Naud, S., Caldwell, J.J., Boxall, K., Burns, S., Anderson, V.E., Antoni, L., Allen, C.E., Pearl, L.H., Oliver, A.W., Aherne, G.W., Garrett, M.D., Collins, I.
Deposit date:2009-09-16
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
2WTJ
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CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
Descriptor:CHECKPOINT KINASE 2, 2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)-N-[2-(DIMETHYLAMINO)ETHYL]PYRIDINE-3-CARBOXAMIDE, NITRATE ION, ...
Authors:Hilton, S., Naud, S., Caldwell, J.J., Boxall, K., Burns, S., Anderson, V.E., Antoni, L., Allen, C.E., Pearl, L.H., Oliver, A.W., Aherne, G.W., Garrett, M.D., Collins, I.
Deposit date:2009-09-16
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
2XBJ
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CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, 4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL)PYRROLIDIN-3-YL]AMINO}-6,7-DIMETHOXYQUINAZOLIN-2-YL)PHENOL, MAGNESIUM ION, ...
Authors:Anderson, V.E., Walton, M.I., Eve, P.D., Caldwell, J.J., Pearl, L.H., Oliver, A.W., Collins, I., Garrett, M.D.
Deposit date:2010-04-12
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Based Design of Potent and Selective 2-(Quinazolin-2-Yl)Phenol Inhibitors of Checkpoint Kinase 2.
J.Med.Chem., 54, 2011
2XM8
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CO-CRYSTAL STRUCTURE OF A SMALL MOLECULE INHIBITOR BOUND TO THE KINASE DOMAIN OF CHK2
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, 2-{4-[(3S)-PYRROLIDIN-3-YLAMINO]QUINAZOLIN-2-YL}PHENOL
Authors:Caldwell, J.J., Welsh, E.J., Matijssen, C., Anderson, V.E., Antoni, L., Boxall, K., Urban, F., Hayes, A., Raynaud, F.I., Rigoreau, L.J., Raynham, T., Aherne, G.W., Pearl, L.H., Oliver, A.W., Garrett, M.D., Collins, I.
Deposit date:2010-07-26
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure-Based Design of Potent and Selective 2-(Quinazolin-2-Yl)Phenol Inhibitors of Checkpoint Kinase 2.
J.Med.Chem., 54, 2011
2XM9
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STRUCTURE OF A SMALL MOLECULE INHIBITOR WITH THE KINASE DOMAIN OF CHK2
Descriptor:SERINE/THREONINE-PROTEIN KINASE CHK2, 4-(1H-pyrazol-5-yl)-2-{4-[(3S)-pyrrolidin-3-ylamino]quinazolin-2-yl}phenol, NITRATE ION
Authors:Caldwell, J.J., Welsh, E.J., Matijssen, C., Anderson, V.E., Antoni, L., Boxall, K., Urban, F., Hayes, A., Raynaud, F.I., Rigoreau, L.J., Raynham, T., Aherne, G.W., Pearl, L.H., Oliver, A.W., Garrett, M.D., Collins, I.
Deposit date:2010-07-26
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design of Potent and Selective 2-(Quinazolin-2-Yl)Phenol Inhibitors of Checkpoint Kinase 2.
J.Med.Chem., 54, 2011
2XNH
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STRUCTURE AND FUNCTION OF THE RAD9-BINDING REGION OF THE DNA DAMAGE CHECKPOINT ADAPTOR TOPBP1
Descriptor:DNA TOPOISOMERASE 2-BINDING PROTEIN 1, IODIDE ION
Authors:Rappas, M., Oliver, A.W., Pearl, L.H.
Deposit date:2010-08-02
Release date:2010-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
2XNK
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STRUCTURE AND FUNCTION OF THE RAD9-BINDING REGION OF THE DNA DAMAGE CHECKPOINT ADAPTOR TOPBP1
Descriptor:DNA TOPOISOMERASE 2-BINDING PROTEIN 1, GLYCEROL
Authors:Rappas, M., Oliver, A.W., Pearl, L.H.
Deposit date:2010-08-03
Release date:2010-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
3ZVL
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THE STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY MAMMALIAN POLYNUCLEOTIDE KINASE 3' PHOSPHATASE
Descriptor:BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, GLYCEROL, MAGNESIUM ION, ...
Authors:Garces, F., Pearl, L.H., Oliver, A.W.
Deposit date:2011-07-25
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3' Phosphatase.
Mol.Cell, 44, 2011
3ZVM
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THE STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY MAMMALIAN POLYNUCLEOTIDE KINASE 3' PHOSPHATASE
Descriptor:BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, 5'-D(*GP*TP*CP*AP*CP)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Garces, F., Pearl, L.H., Oliver, A.W.
Deposit date:2011-07-25
Release date:2011-11-16
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.
Mol. Cell, 44, 2011
3ZVN
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THE STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION BY MAMMALIAN POLYNUCLEOTIDE KINASE 3' PHOSPHATASE
Descriptor:BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, 5'-D(*GP*TP*CP*AP*CP)-3', MANGANESE (II) ION, ...
Authors:Garces, F., Pearl, L.H., Oliver, A.W.
Deposit date:2011-07-25
Release date:2011-11-16
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.
Mol. Cell, 44, 2011
4AV1
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CRYSTAL STRUCTURE OF THE HUMAN PARP-1 DNA BINDING DOMAIN IN COMPLEX WITH DNA
Descriptor:POLY [ADP-RIBOSE] POLYMERASE 1, 5'-D(*AP*AP*GP*TP*GP*TP*TP*GP*CP*AP*TP*TP)-3', 5'-D(*TP*AP*AP*TP*GP*CP*AP*AP*CP*AP*CP*TP)-3', ...
Authors:Ali, A.A.E., Timinszky, G., Arribas-Bosacoma, R., Kozlowski, M., Hassa, P.O., Hassler, M., Ladurner, A.G., Pearl, L.H., Oliver, A.W.
Deposit date:2012-05-23
Release date:2012-06-13
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks
Nat.Struct.Mol.Biol., 19, 2012
4BA9
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THE STRUCTURAL BASIS FOR THE COORDINATION OF Y-FAMILY TRANSLESION DNA POLYMERASES BY REV1
Descriptor:DNA POLYMERASE KAPPA, DNA REPAIR PROTEIN REV1, MAGNESIUM ION, ...
Authors:Grummitt, C.G., Kilkenny, M.L., Frey, A., Roe, S.M., Oliver, A.W., Sale, J.E., Pearl, L.H.
Deposit date:2012-09-12
Release date:2013-09-25
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:The Structural Basis for the Coordination of Y- Family Translesion DNA Polymerases by Rev1
To be Published
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