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1BGI
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BU of 1bgi by Molmil
ORTHORHOMBIC LYSOZYME CRYSTALLIZED AT HIGH TEMPERATURE (310K)
Descriptor: CHLORIDE ION, LYSOZYME
Authors:Oki, H, Matsuura, Y, Komatsu, H, Chernov, A.A.
Deposit date:1998-05-28
Release date:1998-10-28
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Refined structure of orthorhombic lysozyme crystallized at high temperature: correlation between morphology and intermolecular contacts.
Acta Crystallogr.,Sect.D, 55, 1999
7W63
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BU of 7w63 by Molmil
Crystal structure of minor pilin TcpB from Vibrio cholerae
Descriptor: SULFATE ION, Toxin-coregulated pilus biosynthesis protein B
Authors:Oki, H, Kawahara, K, Iimori, M, Imoto, Y, Maruno, T, Uchiyama, S, Muroga, Y, Yoshida, A, Yoshida, T, Ohkubo, T, Matsuda, S, Iida, T, Nakamura, S.
Deposit date:2021-12-01
Release date:2022-11-09
Last modified:2022-11-16
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural basis for the toxin-coregulated pilus-dependent secretion of Vibrio cholerae colonization factor.
Sci Adv, 8, 2022
7W65
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BU of 7w65 by Molmil
Crystal structure of minor pilin TcpB from Vibrio cholerae complexed with secreted protein TcpF
Descriptor: Toxin coregulated pilus biosynthesis protein F, Toxin-coregulated pilus biosynthesis protein B
Authors:Oki, H, Kawahara, K, Iimori, M, Imoto, Y, Maruno, T, Uchiyama, S, Muroga, Y, Yoshida, A, Yoshida, T, Ohkubo, T, Matsuda, S, Iida, T, Nakamura, S.
Deposit date:2021-12-01
Release date:2022-11-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (4.05 Å)
Cite:Structural basis for the toxin-coregulated pilus-dependent secretion of Vibrio cholerae colonization factor.
Sci Adv, 8, 2022
7W64
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BU of 7w64 by Molmil
Crystal structure of minor pilin TcpB from Vibrio cholerae complexed with N-terminal peptide fragment of TcpF
Descriptor: CALCIUM ION, CHLORIDE ION, PENTAETHYLENE GLYCOL, ...
Authors:Oki, H, Kawahara, K, Iimori, M, Imoto, Y, Maruno, T, Uchiyama, S, Muroga, Y, Yoshida, A, Yoshida, T, Ohkubo, T, Matsuda, S, Iida, T, Nakamura, S.
Deposit date:2021-12-01
Release date:2022-11-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the toxin-coregulated pilus-dependent secretion of Vibrio cholerae colonization factor.
Sci Adv, 8, 2022
5YQ0
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BU of 5yq0 by Molmil
Crystal structure of secreted protein CofJ from ETEC.
Descriptor: CALCIUM ION, CofJ
Authors:Oki, H, Kawahara, K, Maruno, T, Imai, T, Muroga, Y, Fukakusa, S, Iwashita, T, Kobayashi, Y, Matsuda, S, Kodama, T, Iida, T, Yoshida, T, Ohkubo, T, Nakamura, S.
Deposit date:2017-11-04
Release date:2018-06-27
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Interplay of a secreted protein with type IVb pilus for efficient enterotoxigenicEscherichia colicolonization
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YPZ
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BU of 5ypz by Molmil
Crystal structure of minor pilin CofB from CFA/III complexed with N-terminal peptide fragment of CofJ
Descriptor: CofB, CofJ
Authors:Oki, H, Kawahara, K, Maruno, T, Imai, T, Muroga, Y, Fukakusa, S, Iwashita, T, Kobayashi, Y, Matsuda, S, Kodama, T, Iida, T, Yoshida, T, Ohkubo, T, Nakamura, S.
Deposit date:2017-11-04
Release date:2018-06-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.521 Å)
Cite:Interplay of a secreted protein with type IVb pilus for efficient enterotoxigenicEscherichia colicolonization.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7XW8
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BU of 7xw8 by Molmil
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418 distomer, FAD-adduct
Descriptor: GLYCEROL, Lysine-specific histone demethylase 1A, MAGNESIUM ION, ...
Authors:Oki, H.
Deposit date:2022-05-26
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.
Eur.J.Med.Chem., 239, 2022
5AXQ
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BU of 5axq by Molmil
Crystal structure of the catalytic domain of PDE10A complexed with highly potent and brain-penetrant PDE10A Inhibitor with 2-oxindole scaffold
Descriptor: 1-(cyclopropylmethyl)-4-fluoranyl-5-[5-methoxy-4-oxidanylidene-3-(2-phenylpyrazol-3-yl)pyridazin-1-yl]-3,3-dimethyl-indol-2-one, 3-[3-fluoranyl-4-[5-methoxy-4-oxidanylidene-3-(2-phenylpyrazol-3-yl)pyridazin-1-yl]phenyl]-1,3-oxazolidin-2-one, MAGNESIUM ION, ...
Authors:Oki, H, Zama, Y.
Deposit date:2015-07-31
Release date:2015-11-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
Bioorg.Med.Chem., 23, 2015
5AXP
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BU of 5axp by Molmil
Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
Descriptor: 3-[3-fluoranyl-4-[5-methoxy-4-oxidanylidene-3-(2-phenylpyrazol-3-yl)pyridazin-1-yl]phenyl]-1,3-oxazolidin-2-one, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H, Zama, Y.
Deposit date:2015-07-31
Release date:2015-11-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
Bioorg.Med.Chem., 23, 2015
5B4O
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BU of 5b4o by Molmil
Crystal structure of Macrophage Migration Inhibitory Factor in complex with BTZO-14
Descriptor: 1,2-ETHANEDIOL, 2-pyridin-3-yl-1,3-benzothiazin-4-one, Macrophage migration inhibitory factor, ...
Authors:Oki, H, Igaki, S, Moriya, Y, Hayano, Y, Habuka, N.
Deposit date:2016-04-07
Release date:2016-04-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression
Chem. Biol., 17, 2010
5B5O
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BU of 5b5o by Molmil
Crystal structure of the catalytic domain of MMP-13 complexed with N-phenyl-4-((4H-1,2,4-triazol-3-ylsulfanyl)methyl)-1,3-thiazol-2-amine
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Collagenase 3, ...
Authors:Oki, H, Tanaka, Y.
Deposit date:2016-05-13
Release date:2017-01-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
J. Med. Chem., 60, 2017
5B5P
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BU of 5b5p by Molmil
Crystal structure of the catalytic domain of MMP-13 complexed with 4-oxo-N-(3-(2-(1H-1,2,4-triazol-3-ylsulfanyl)ethoxy)benzyl)-3,4-dihydroquinazoline-2-carboxamide
Descriptor: 4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-ylsulfanyl)ethoxy]benzyl}-3,4-dihydroquinazoline-2-carboxamide, CALCIUM ION, Collagenase 3, ...
Authors:Oki, H, Tanaka, Y.
Deposit date:2016-05-13
Release date:2017-01-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
J. Med. Chem., 60, 2017
7E0G
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BU of 7e0g by Molmil
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418, FAD-adduct
Descriptor: GLYCEROL, IMIDAZOLE, Lysine-specific histone demethylase 1A, ...
Authors:Oki, H.
Deposit date:2021-01-28
Release date:2021-03-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models.
Sci Adv, 7, 2021
5B4L
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BU of 5b4l by Molmil
Crystal structure of the catalytic domain of human PDE10A complexed with 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
Descriptor: 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H, Zama, Y.
Deposit date:2016-04-05
Release date:2016-06-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket
Bioorg.Med.Chem., 24, 2016
5B4K
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BU of 5b4k by Molmil
Crystal structure of the catalytic domain of human PDE10A complexed with N-(4-((5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-1H-benzimidazol-2-amine
Descriptor: MAGNESIUM ION, N-(4-((5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-1H-benzimidazol-2-amine, ZINC ION, ...
Authors:Oki, H, Zama, Y.
Deposit date:2016-04-05
Release date:2016-06-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket
Bioorg.Med.Chem., 24, 2016
3WV2
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BU of 3wv2 by Molmil
Crystal structure of the catalytic domain of MMP-13 complexed with N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide
Descriptor: CALCIUM ION, Collagenase 3, N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide, ...
Authors:Oki, H, Tanaka, Y.
Deposit date:2014-05-12
Release date:2014-09-24
Last modified:2022-08-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1′′ binding site.
Bioorg.Med.Chem., 22, 2014
3WV3
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BU of 3wv3 by Molmil
Crystal structure of the catalytic domain of MMP-13 complexed with N-(3-methoxybenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Collagenase 3, ...
Authors:Oki, H, Tanaka, Y.
Deposit date:2014-05-12
Release date:2014-09-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1′′ binding site.
Bioorg.Med.Chem., 22, 2014
3WV1
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BU of 3wv1 by Molmil
Crystal structure of the catalytic domain of MMP-13 complexed with 4-(2-((6-fluoro-2-((3-methoxybenzyl)carbamoyl)-4-oxo-3,4-dihydroquinazolin-5-yl)oxy)ethyl)benzoic acid
Descriptor: 4-[2-({6-fluoro-2-[(3-methoxybenzyl)carbamoyl]-4-oxo-3,4-dihydroquinazolin-5-yl}oxy)ethyl]benzoic acid, CALCIUM ION, Collagenase 3, ...
Authors:Oki, H, Tanaka, Y.
Deposit date:2014-05-12
Release date:2015-05-20
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach
J.Med.Chem., 57, 2014
3VO3
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BU of 3vo3 by Molmil
Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative
Descriptor: 1,2-ETHANEDIOL, N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide, Vascular endothelial growth factor receptor 2
Authors:Oki, H, Okada, K.
Deposit date:2012-01-19
Release date:2013-03-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
Bioorg.Med.Chem., 21, 2013
3WYM
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BU of 3wym by Molmil
Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
Descriptor: 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H, Hayano, Y.
Deposit date:2014-09-01
Release date:2014-11-19
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.
J.Med.Chem., 57, 2014
3WYK
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BU of 3wyk by Molmil
Crystal structure of the catalytic domain of PDE10A complexed with 3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one
Descriptor: 3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H, Hayano, Y.
Deposit date:2014-09-01
Release date:2014-11-19
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.
J.Med.Chem., 57, 2014
3WYL
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BU of 3wyl by Molmil
Crystal structure of the catalytic domain of PDE10A complexed with 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one
Descriptor: 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H, Hayano, Y.
Deposit date:2014-09-01
Release date:2014-11-19
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.
J.Med.Chem., 57, 2014
5XKM
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BU of 5xkm by Molmil
Crystal structure of human phosphodiesterase 2A in complex with 6-methyl-N-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Descriptor: 6-methyl-N-[(1R)-1-[4-(trifluoromethyloxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, MAGNESIUM ION, ZINC ION, ...
Authors:Oki, H, Kondo, M, Snell, G, Lane, W.
Deposit date:2017-05-08
Release date:2017-08-16
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.
J. Med. Chem., 60, 2017
3VNT
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BU of 3vnt by Molmil
Crystal Structure of the Kinase domain of Human VEGFR2 with a [1,3]thiazolo[5,4-b]pyridine derivative
Descriptor: 1,2-ETHANEDIOL, 2-chloro-3-(1-cyanocyclopropyl)-N-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide, Vascular endothelial growth factor receptor 2
Authors:Oki, H.
Deposit date:2012-01-17
Release date:2012-04-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds
J.Med.Chem., 55, 2012
4U4P
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BU of 4u4p by Molmil
Crystal structure of the human condensin SMC hinge domain heterodimer with short coiled coils
Descriptor: Structural maintenance of chromosomes protein 2, Structural maintenance of chromosomes protein 4
Authors:Uchiyama, S, Kawahara, K, Hosokawa, Y, Fukakusa, S, Oki, H, Nakamura, S, Noda, M, Takino, R, Miyahara, Y, Maruno, T, Kobayashi, Y, Ohkubo, T, Fukui, K.
Deposit date:2014-07-24
Release date:2015-08-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural basis for dimer information and DNA recognition of human SMC proteins
to be published

 

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