Author results

6ABU
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RAT XANTHINE OXIDOREDUCTASE, NAD BOUND FORM
Descriptor:Xanthine dehydrogenase/oxidase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIC ACID, ...
Authors:Okamoto, K., Kawaguchi, Y.
Deposit date:2018-07-24
Release date:2019-07-31
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Rat Xanthine oxidoreductase, NAD bound form
To Be Published
1V97
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CRYSTAL STRUCTURE OF BOVINE MILK XANTHINE DEHYDROGENASE FYX-051 BOUND FORM
Descriptor:Xanthine dehydrogenase, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Okamoto, K., Matsumoto, K., Hille, R., Eger, B.T., Pai, E.F., Nishino, T.
Deposit date:2004-01-21
Release date:2004-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition.
Proc.Natl.Acad.Sci.USA, 101, 2004
1N5X
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XANTHINE DEHYDROGENASE FROM BOVINE MILK WITH INHIBITOR TEI-6720 BOUND
Descriptor:Xanthine Dehydrogenase, FE2/S2 (INORGANIC) CLUSTER, PHOSPHONIC ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER, ...
Authors:Okamoto, K., Eger, B.T., Nishino, T., Kondo, S., Pai, E.F., Nishino, T.
Deposit date:2002-11-07
Release date:2003-03-18
Last modified:2013-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An Extremely Potent Inhibitor of Xanthine Oxidoreductase: Crystal Structure of the Enzyme-Inhibitor Complex and Mechanism of Inhibition
J.BIOL.CHEM., 278, 2003
3WZD
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KDR IN COMPLEX WITH LIGAND LENVATINIB
Descriptor:Vascular endothelial growth factor receptor 2, 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ...
Authors:Okamoto, K., Ikemori_Kawada, M., Inoue, A., Matsui, J.
Deposit date:2014-09-24
Release date:2015-05-27
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.
ACS MED.CHEM.LETT., 6, 2015
3WZE
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KDR IN COMPLEX WITH LIGAND SORAFENIB
Descriptor:Vascular endothelial growth factor receptor 2, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ACETATE ION, ...
Authors:Okamoto, K., Ikemori_Kawada, M., Inoue, A., Matsui, J.
Deposit date:2014-09-24
Release date:2015-05-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.
ACS MED.CHEM.LETT., 6, 2015
3AMZ
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BOVINE XANTHINE OXIDOREDUCTASE URATE BOUND FORM
Descriptor:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, CALCIUM ION, ...
Authors:Okamoto, K., Eger, B.T., Pai, E.F., Nishino, T.
Deposit date:2010-08-27
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase: Substrate Orientation and Structure of the Key Reaction Intermediate
J.Am.Chem.Soc., 132, 2010
3AN1
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CRYSTAL STRUCTURE OF RAT D428A MUTANT, URATE BOUND FORM
Descriptor:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, CALCIUM ION, ...
Authors:Okamoto, K., Kawaguchi, Y., Eger, B.T., Pai, E.F., Nishino, T.
Deposit date:2010-08-27
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase: Substrate Orientation and Structure of the Key Reaction Intermediate
J.Am.Chem.Soc., 132, 2010
6A7X
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RAT XANTHINE OXIDOREDUCTASE, D428A VARIANT, NAD BOUND FORM
Descriptor:Xanthine dehydrogenase/oxidase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIC ACID, ...
Authors:Okamoto, K., Kawaguchi, Y.
Deposit date:2018-07-05
Release date:2019-07-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Rat Xanthine oxidoreductase, D428A variant, NAD bound form
To Be Published
6AC1
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RAT XANTHINE OXIDOREDUCTASE, NADH BOUND FORM
Descriptor:Xanthine dehydrogenase/oxidase, URIC ACID, BICARBONATE ION, ...
Authors:Okamoto, K., Kawaguchi, Y.
Deposit date:2018-07-24
Release date:2019-07-31
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Rat Xanthine oxidoreductase, D428A variant, NAD bound form
To Be Published
6AD4
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RAT XANTHINE OXIDOREDUCTASE, D428A VARIANT, NADH BOUND FORM
Descriptor:Xanthine dehydrogenase/oxidase, URIC ACID, BICARBONATE ION, ...
Authors:Okamoto, K., Kawaguchi, Y.
Deposit date:2018-07-30
Release date:2019-07-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Rat Xanthine oxidoreductase, D428A variant, NAD bound form
To Be Published
6ADJ
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RAT XANTHINE OXIDOREDUCTASE, D428E VARIANT
Descriptor:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, CALCIUM ION, ...
Authors:Okamoto, K., Kawaguchi, Y.
Deposit date:2018-08-01
Release date:2019-08-07
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Rat Xanthine oxidoreductase, D428A variant, NAD bound form
To Be Published
3BDJ
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CRYSTAL STRUCTURE OF BOVINE MILK XANTHINE DEHYDROGENASE WITH A COVALENTLY BOUND OXIPURINOL INHIBITOR
Descriptor:Xanthine dehydrogenase/oxidase, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Eger, B.T., Okamoto, K., Nishino, T., Pai, E.F., Nishino, T.
Deposit date:2007-11-14
Release date:2008-11-25
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.
Nucleosides Nucleotides Nucleic Acids, 27, 2008
2Z5E
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CRYSTAL STRUCTURE OF PROTEASOME ASSEMBLING CHAPERONE 3
Descriptor:Proteasome Assembling Chaperone 3
Authors:Okamoto, K., Kurimoto, E., Sakata, E., Suzuki, A., Yamane, T., Hirano, Y., Murata, S., Tanaka, K., Kato, K.
Deposit date:2007-07-06
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes
Nat.Struct.Mol.Biol., 15, 2008
4YRW
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RAT XANTHINE OXIDOREDUCTASE, C-TERMINAL DELETION PROTEIN VARIANT
Descriptor:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, BICARBONATE ION, ...
Authors:Okamoto, K.
Deposit date:2015-03-16
Release date:2015-04-29
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase
Febs J., 282, 2015
2Z5B
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CRYSTAL STRUCTURE OF A NOVEL CHAPERONE COMPLEX FOR YEAST 20S PROTEASOME ASSEMBLY
Descriptor:Protein YPL144W, Uncharacterized protein YLR021W
Authors:Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano, Y., Murata, S., Kato, K., Yamane, T., Tanaka, K.
Deposit date:2007-07-03
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes
Nat.Struct.Mol.Biol., 15, 2008
2Z5C
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CRYSTAL STRUCTURE OF A NOVEL CHAPERONE COMPLEX FOR YEAST 20S PROTEASOME ASSEMBLY
Descriptor:Protein YPL144W, Uncharacterized protein YLR021W, Proteasome component PUP2
Authors:Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano, Y., Murata, S., Kato, K., Yamane, T., Tanaka, K.
Deposit date:2007-07-03
Release date:2008-01-22
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes
Nat.Struct.Mol.Biol., 15, 2008
6JPT
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CRYSTAL STRUCTURE OF HUMAN PAC3 HOMODIMER (TRIGONAL FORM)
Descriptor:Proteasome assembly chaperone 3, THIOCYANATE ION, POTASSIUM ION
Authors:Satoh, T., Yagi-Utsumi, M., Okamoto, K., Kurimoto, E., Tanaka, K., Kato, K.
Deposit date:2019-03-27
Release date:2019-05-29
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Molecular and Structural Basis of the Proteasome alpha Subunit Assembly Mechanism Mediated by the Proteasome-Assembling Chaperone PAC3-PAC4 Heterodimer.
Int J Mol Sci, 20, 2019
2E1Q
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CRYSTAL STRUCTURE OF HUMAN XANTHINE OXIDOREDUCTASE MUTANT, GLU803VAL
Descriptor:Xanthine dehydrogenase/oxidase, BICARBONATE ION, CALCIUM ION, ...
Authors:Yamaguchi, Y., Matsumura, T., Ichida, K., Okamoto, K., Nishino, T.
Deposit date:2006-10-27
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate
J.Biochem.(Tokyo), 141, 2007
3AM9
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COMPLEX OF BOVINE XANTHINE DEHYDROGENASE AND TRIHYDROXY FYX-051
Descriptor:Xanthine dehydrogenase/oxidase, FE2/S2 (INORGANIC) CLUSTER, CALCIUM ION, ...
Authors:Matsumoto, K., Okamoto, K., Ashizawa, N., Matsumura, T., Kusano, T., Nishino, T.
Deposit date:2010-08-18
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:FYX-051: A Novel and Potent Hybrid-Type Inhibitor of Xanthine Oxidoreductase
J.Pharmacol.Exp.Ther., 336, 2011
2E3T
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CRYSTAL STRUCTURE OF RAT XANTHINE OXIDOREDUCTASE MUTANT (W335A AND F336L)
Descriptor:Xanthine dehydrogenase/oxidase, BICARBONATE ION, PHOSPHATE ION, ...
Authors:Asai, R., Nishino, T., Matsumura, T., Okamoto, K., Pai, E.F., Nishino, T.
Deposit date:2006-11-28
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase
J.Biochem.(Tokyo), 141, 2007
2Z9S
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CRYSTAL STRUCTURE ANALYSIS OF RAT HBP23/PEROXIREDOXIN I, CYS52SER MUTANT
Descriptor:Peroxiredoxin-1
Authors:Matsumura, T., Okamoto, K., Nishino, T., Abe, Y.
Deposit date:2007-09-25
Release date:2007-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Dimer-Oligomer Interconversion of Wild-type and Mutant Rat 2-Cys Peroxiredoxin: DISULFIDE FORMATION AT DIMER-DIMER INTERFACES IS NOT ESSENTIAL FOR DECAMERIZATION
J.Biol.Chem., 283, 2008
1FIQ
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CRYSTAL STRUCTURE OF XANTHINE OXIDASE FROM BOVINE MILK
Descriptor:XANTHINE OXIDASE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Enroth, C., Eger, B.T., Okamoto, K., Nishino, T., Nishino, T., Pai, E.F.
Deposit date:2000-08-04
Release date:2000-10-04
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FO4
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CRYSTAL STRUCTURE OF XANTHINE DEHYDROGENASE ISOLATED FROM BOVINE MILK
Descriptor:XANTHINE DEHYDROGENASE, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Enroth, C., Eger, B.T., Okamoto, K., Nishino, T., Nishino, T., Pai, E.F.
Deposit date:2000-08-24
Release date:2000-10-25
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion.
Proc.Natl.Acad.Sci.USA, 97, 2000
1VDV
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BOVINE MILK XANTHINE DEHYDROGENASE Y-700 BOUND FORM
Descriptor:Xanthine dehydrogenase/oxidase, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Fukunari, A., Okamoto, K., Nishino, T., Eger, B.T., Pai, E.F., Kamezawa, M., Yamada, I., Kato, N.
Deposit date:2004-03-25
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid]: a potent xanthine oxidoreductase inhibitor with hepatic excretion
J.Pharmacol.Exp.Ther., 311, 2004
1WYG
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CRYSTAL STRUCTURE OF A RAT XANTHINE DEHYDROGENASE TRIPLE MUTANT (C535A, C992R AND C1324S)
Descriptor:Xanthine dehydrogenase/oxidase, PHOSPHATE ION, CALCIUM ION, ...
Authors:Nishino, T., Okamoto, K., Kawaguchi, Y., Hori, H., Matsumura, T., Eger, B.T., Pai, E.F., Nishino, T.
Deposit date:2005-02-14
Release date:2005-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase: IDENTIFICATION OF THE TWO CYSTEINE DISULFIDE BONDS AND CRYSTAL STRUCTURE OF A NON-CONVERTIBLE RAT LIVER XANTHINE DEHYDROGENASE MUTANT
J.Biol.Chem., 280, 2005
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