Author results

2H4U
  • Download 2h4u
  • View 2h4u
Molmil generated image of 2h4u
CRYSTAL STRUCTURE OF HUMAN THIOESTERASE SUPERFAMILY MEMBER 2 (CASP TARGET)
Descriptor:Thioesterase superfamily member 2
Authors:Ogg, D.J., Uppenberg, J., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Grasslund, S., Flodin, S., Hammerstrom, M., Hogbom, M., Holmberg-Schiavone, L., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Sundstrom, M., Thorsell, A.-G., Weigelt, J., Hallberg, M., Structural Genomics Consortium (SGC)
Deposit date:2006-05-25
Release date:2006-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of human thioesterase superfamily member 2
To be Published
2BW0
  • Download 2bw0
  • View 2bw0
Molmil generated image of 2bw0
CRYSTAL STRUCTURE OF THE HYDROLASE DOMAIN OF HUMAN 10-FORMYLTETRAHYDROFOLATE 2 DEHYDROGENASE
Descriptor:10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE, SULFATE ION
Authors:Ogg, D.J., Stenmark, P., Arrowsmith, C., Edwards, A., Ehn, M., Graslund, S., Hammarstrom, M., Hallberg, M., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A., Dobritzsch, D., Weigelt, J.
Deposit date:2005-07-07
Release date:2005-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the Hydrolase Domain of Human 10-Formyltetrahydrofolate Dehydrogenase and its Complex with a Substrate Analogue.
Acta Crystallogr.,Sect.D, 62, 2006
4IWV
  • Download 4iwv
  • View 4iwv
Molmil generated image of 4iwv
CRYSTALS STRUCTURE OF HUMAN GLUCOKINASE IN COMPLEX WITH SMALL MOLECULE ACTIVATOR
Descriptor:Glucokinase isoform 3, SODIUM ION, ALPHA-D-GLUCOSE, ...
Authors:Ogg, D.J., Hargreaves, D., Gerhardt, S., Flavell, L., McAlister, M.
Deposit date:2013-01-24
Release date:2013-04-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485
To be Published
6R0X
  • Download 6r0x
  • View 6r0x
Molmil generated image of 6r0x
THE EXTRACELLULAR DOMAIN OF G6B-B IN COMPLEX WITH FAB FRAGMENT AND DP12 HEPARIN OLIGOSACCHARIDE.
Descriptor:antibody fab fragment heavy chain, antibody fab fragment light chain, Megakaryocyte and platelet inhibitory receptor G6b, ...
Authors:Ogg, D.J., McMiken, H.J., Howard, T.D.
Deposit date:2019-03-13
Release date:2019-09-04
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B.
Elife, 8, 2019
2CFI
  • Download 2cfi
  • View 2cfi
Molmil generated image of 2cfi
THE HYDROLASE DOMAIN OF HUMAN 10-FTHFD IN COMPLEX WITH 6- FORMYLTETRAHYDROPTERIN
Descriptor:10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE, SULFATE ION, 6-FORMYLTETRAHYDROPTERIN
Authors:Kursula, P., Stenmark, P., Arrowsmith, C., Edwards, A., Ehn, M., Graslund, S., Hammarstrom, M., Hallberg, M., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Ogg, D.J., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A., Weigelt, J.
Deposit date:2006-02-21
Release date:2006-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of the Hydrolase Domain of Human 10-Formyltetrahydrofolate Dehydrogenase and its Complex with a Substrate Analogue.
Acta Crystallogr.,Sect.D, 62, 2006
4NMH
  • Download 4nmh
  • View 4nmh
Molmil generated image of 4nmh
11-BETA-HSD1 IN COMPLEX WITH A 3,3-DI-METHYL-AZETIDIN-2-ONE
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, (4S)-4-(2-methoxyphenyl)-3,3-dimethyl-1-[3-(methylsulfonyl)phenyl]azetidin-2-one, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:McCoull, W., Augustin, M., Blake, C., Ertan, A., Kilgour, E.K., Krapp, S., Moore, J.E., Newcombe, N.J., Packer, M.J., Rees, A., Revill, J., Scott, J.S., Selmi, N., Gerhardt, S., Ogg, D.J., Steinbacher, S., Whittamore, P.R.O.
Deposit date:2013-11-15
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD1)
TO BE PUBLISHED
4HFR
  • Download 4hfr
  • View 4hfr
Molmil generated image of 4hfr
HUMAN 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 IN COMPLEX WITH AN ORALLY BIOAVAILABLE ACIDIC INHIBITOR AZD4017.
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {(3S)-1-[5-(cyclohexylcarbamoyl)-6-(propylsulfanyl)pyridin-2-yl]piperidin-3-yl}acetic acid
Authors:Ogg, D.J., Gerhardt, S., Hargreaves, D.
Deposit date:2012-10-05
Release date:2012-10-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11 -Hydroxysteroid Dehydrogenase Type 1 (11 -HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)
J.Med.Chem., 55, 2012
4ZSL
  • Download 4zsl
  • View 4zsl
Molmil generated image of 4zsl
MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR
Descriptor:Mitogen-activated protein kinase 7, 3-amino-5-[(4-chlorophenyl)amino]-N-[(1S)-1-phenylethyl]-1H-1,2,4-triazole-1-carboxamide, GLYCEROL
Authors:Ogg, D.J., Tucker, J.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
6GQO
  • Download 6gqo
  • View 6gqo
Molmil generated image of 6gqo
CRYSTAL STRUCTURE OF HUMAN KDR (VEGFR2) KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 18)
Descriptor:Vascular endothelial growth factor receptor 2, 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide
Authors:Ogg, D.J., Schimpl, M., Hardy, C.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
4IXC
  • Download 4ixc
  • View 4ixc
Molmil generated image of 4ixc
CRYSTAL STRUCTURE OF HUMAN GLUCOKINASE IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR.
Descriptor:Glucokinase isoform 3, SODIUM ION, ALPHA-D-GLUCOSE, ...
Authors:Ogg, D.J., Hargreaves, D., Gerhardt, S.
Deposit date:2013-01-25
Release date:2013-04-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Matched triplicate design sets in the optimisation of glucokinase activators maximising medicinal chemistry information content
To be Published
4P38
  • Download 4p38
  • View 4p38
Molmil generated image of 4p38
HUMAN 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 IN COMPLEX WITH AZD8329
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid, ...
Authors:Ogg, D., Hargreaves, D., Gerhardt, S.
Deposit date:2014-03-06
Release date:2014-04-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Novel acidic 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).
J.Med.Chem., 55, 2012
4ZSG
  • Download 4zsg
  • View 4zsg
Molmil generated image of 4zsg
MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR
Descriptor:Mitogen-activated protein kinase 7, GLYCEROL, 3-amino-5-[(4-chlorophenyl)amino]-N-(propan-2-yl)-1H-1,2,4-triazole-1-carboxamide
Authors:Tucker, J., Ogg, D.J.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
4ZSJ
  • Download 4zsj
  • View 4zsj
Molmil generated image of 4zsj
MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR
Descriptor:Mitogen-activated protein kinase 7, GLYCEROL, 3-amino-5-[(4-chloro-3-methylphenyl)amino]-N-(propan-2-yl)-1H-1,2,4-triazole-1-carboxamide
Authors:Tucker, J., Ogg, D.J.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
6GQJ
  • Download 6gqj
  • View 6gqj
Molmil generated image of 6gqj
CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 18)
Descriptor:Mast/stem cell growth factor receptor Kit, 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQK
  • Download 6gqk
  • View 6gqk
Molmil generated image of 6gqk
CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 23)
Descriptor:Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQL
  • Download 6gql
  • View 6gql
Molmil generated image of 6gql
CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 35)
Descriptor:Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQM
  • Download 6gqm
  • View 6gqm
Molmil generated image of 6gqm
CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR, AZD3229
Descriptor:Mast/stem cell growth factor receptor Kit, ~{N}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide, CHLORIDE ION
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQP
  • Download 6gqp
  • View 6gqp
Molmil generated image of 6gqp
CRYSTAL STRUCTURE OF HUMAN KDR (VEGFR2) KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 23)
Descriptor:Vascular endothelial growth factor receptor 2, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide
Authors:Hardy, C.J., Schimpl, M., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQQ
  • Download 6gqq
  • View 6gqq
Molmil generated image of 6gqq
CRYSTAL STRUCTURE OF HUMAN KDR (VEGFR2) KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 35)
Descriptor:Vascular endothelial growth factor receptor 2, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
4AA7
  • Download 4aa7
  • View 4aa7
Molmil generated image of 4aa7
E.COLI GLMU IN COMPLEX WITH AN ANTIBACTERIAL INHIBITOR
Descriptor:BIFUNCTIONAL PROTEIN GLMU, N-(2,4-dimethoxy-5-{[(2R)-2-methyl-2,3-dihydro-1H-indol-1-yl]sulfonyl}phenyl)acetamide, SULFATE ION
Authors:Otterbein, L., Breed, J., Ogg, D.J.
Deposit date:2011-11-30
Release date:2012-08-15
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitors of Acetyltransferase Domain of N-Acetylglucosamine-1-Phosphate-Uridyltransferase/ Glucosamine-1-Phosphate-Acetyltransferase (Glmu). Part 1: Hit to Lead Evaluation of a Novel Arylsulfonamide Series.
Bioorg.Med.Chem.Lett., 22, 2012
4AAW
  • Download 4aaw
  • View 4aaw
Molmil generated image of 4aaw
S.PNEUMONIAE GLMU IN COMPLEX WITH AN ANTIBACTERIAL INHIBITOR
Descriptor:BIFUNCTIONAL PROTEIN GLMU, 4-{[1-(2-{[({5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl}sulfonyl)amino]methyl}phenyl)piperidin-4-yl]methoxy}-4-oxobutanoic acid, SULFATE ION
Authors:Otterbein, L., Breed, J., Ogg, D.J.
Deposit date:2011-12-05
Release date:2012-02-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitors of Acetyltransferase Domain of N-Acetylglucosamine-1-Phosphate-Uridyltransferase/ Glucosamine-1-Phosphate-Acetyltransferase (Glmu). Part 1: Hit to Lead Evaluation of a Novel Arylsulfonamide Series.
Bioorg.Med.Chem.Lett., 22, 2012
4AC3
  • Download 4ac3
  • View 4ac3
Molmil generated image of 4ac3
S.PNEUMONIAE GLMU IN COMPLEX WITH AN ANTIBACTERIAL INHIBITOR
Descriptor:BIFUNCTIONAL PROTEIN GLMU, N-{2,4-DIMETHOXY-5-[(2-PIPERIDIN-1-YLBENZYL)sulfamoyl]phenyl}acetamide, SULFATE ION
Authors:Otterbein, L., Breed, J., Ogg, D.J.
Deposit date:2011-12-12
Release date:2012-02-15
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibitors of Acetyltransferase Domain of N-Acetylglucosamine-1-Phosphate-Uridyltransferase/ Glucosamine-1-Phosphate-Acetyltransferase (Glmu). Part 1: Hit to Lead Evaluation of a Novel Arylsulfonamide Series.
Bioorg.Med.Chem.Lett., 22, 2012