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3AFJ
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CRYSTAL STRUCTURE OF CELLVIBRIO GILVUS CELLOBIOSE PHOSPHORYLASE TRIPLE MUTANT
Descriptor:Cellobiose Phosphorylase, BETA-D-GLUCOSE, PHOSPHATE ION, ...
Authors:Hidaka, M., Ogawa, N., Fushinobu, S.
Deposit date:2010-03-04
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineering of cellobiose phosphorylase
To be Published
1A0A
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PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4/DNA COMPLEX
Descriptor:DNA (5'-D(*CP*TP*CP*AP*CP*AP*CP*GP*TP*GP*GP*GP*AP*CP*TP*AP*G )-3'), DNA (5'-D(*CP*TP*AP*GP*TP*CP*CP*CP*AP*CP*GP*TP*GP*TP*GP*AP*G )-3'), PROTEIN (PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4)
Authors:Shimizu, T., Toumoto, A., Ihara, K., Shimizu, M., Kyogoku, Y., Ogawa, N., Oshima, Y., Hakoshima, T.
Deposit date:1997-11-27
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition.
EMBO J., 16, 1997
1IXC
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CRYSTAL STRUCTURE OF CBNR, A LYSR FAMILY TRANSCRIPTIONAL REGULATOR
Descriptor:LysR-type regulatory protein
Authors:Muraoka, S., Okumura, R., Ogawa, N., Miyashita, K., Senda, T.
Deposit date:2002-06-18
Release date:2003-06-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Full-length LysR-type Transcriptional Regulator, CbnR: Unusual Combination of Two Subunit Forms and Molecular Bases for Causing and Changing DNA Bend
J.Mol.Biol., 328, 2003
1IZ1
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CRYSTAL STRUCTURE OF CBNR, A LYSR FAMILY TRANSCRIPTIONAL REGULATOR
Descriptor:LysR-type regulatory protein
Authors:Muraoka, S., Okumura, R., Ogawa, N., Miyashita, K., Senda, T.
Deposit date:2002-09-18
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of a Full-length LysR-type Transcriptional Regulator, CbnR: Unusual Combination of Two Subunit Forms and Molecular Bases for Causing and Changing DNA Bend
J.Mol.Biol., 328, 2003
3UMX
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CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH INHIBITOR (Z)-2-[(1H-INDOL-3-YL)METHYLENE]-7-(AZEPAN-1-YLMETHYL)-6-HYDROXYBENZOFURAN-3(2H)-ONE
Descriptor:Proto-oncogene serine/threonine-protein kinase pim-1, (2Z)-7-(azepan-1-ylmethyl)-6-hydroxy-2-(1H-indol-3-ylmethylidene)-1-benzofuran-3(2H)-one, SULFATE ION
Authors:Parker, L.J., Handa, N., Yokoyama, S.
Deposit date:2011-11-15
Release date:2012-08-08
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor
Acta Crystallogr.,Sect.F, 68, 2012
4ENX
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CRYSTAL STRUCTURE OF PIM-1 KINASE IN COMPLEX WITH INHIBITOR (2E,5Z)-2-(2-CHLOROPHENYLIMINO)-5-(4-HYDROXY-3-NITROBENZYLIDENE)THIAZOLIDIN-4-ONE
Descriptor:Serine/threonine-protein kinase pim-1, PHOSPHATE ION, (2Z,5Z)-2-[(2-chlorophenyl)imino]-5-(4-hydroxy-3-nitrobenzylidene)-1,3-thiazolidin-4-one
Authors:Parker, L.J., Handa, N., Yokoyama, S.
Deposit date:2012-04-13
Release date:2012-08-08
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor
Acta Crystallogr.,Sect.F, 68, 2012
4ENY
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CRYSTAL STRUCTURE OF PIM-1 KINASE IN COMPLEX WITH (2E,5Z)-2-(2-CHLOROPHENYLIMINO)-5-(4-HYDROXY-3-METHOXYBENZYLIDENE)THIAZOLIDIN-4-ONE
Descriptor:Serine/threonine-protein kinase pim-1, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Parker, L.J., Handa, N., Yokoyama, S.
Deposit date:2012-04-13
Release date:2012-08-08
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor
Acta Crystallogr.,Sect.F, 68, 2012
4LL5
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CRYSTAL STRUCTURE OF PIM-1 IN COMPLEX WITH THE FLUORESCENT COMPOUND SKF86002
Descriptor:Serine/threonine-protein kinase pim-1, 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, GLYCEROL, ...
Authors:Parker, L.J., Tanaka, A., Handa, N., Honda, K., Tomabechi, Y., Shirouzu, M., Yokoyama, S.
Deposit date:2013-07-09
Release date:2014-02-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002
Acta Crystallogr.,Sect.D, 70, 2014
4LM5
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CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH 2-{4-[(3-AMINOPROPYL)AMINO]QUINAZOLIN-2-YL}PHENOL (RESULTING FROM DISPLACEMENT OF SKF86002)
Descriptor:Serine/threonine-protein kinase pim-1, 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol, GLYCEROL
Authors:Parker, L.J., Tanaka, A., Handa, N., Honda, K., Tomabechi, Y., Shirouzu, M., Yokoyama, S.
Deposit date:2013-07-10
Release date:2014-02-12
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002
Acta Crystallogr.,Sect.D, 70, 2014
4LMU
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CRYSTAL STRUCTURE OF PIM1 IN COMPLEX WITH THE INHIBITOR QUERCETIN (RESULTING FROM DISPLACEMENT OF SKF86002)
Descriptor:Serine/threonine-protein kinase pim-1, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, GLYCEROL
Authors:Parker, L.J., Tanaka, A., Handa, N., Honda, K., Tomabechi, Y., Shirouzu, M., Yokoyama, S.
Deposit date:2013-07-11
Release date:2014-02-12
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002
Acta Crystallogr.,Sect.D, 70, 2014
4LUD
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CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH THE FLUORESCENT COMPOUND SKF86002
Descriptor:Tyrosine-protein kinase HCK, CALCIUM ION, 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, ...
Authors:Parker, L.J., Tanaka, A., Handa, N., Honda, K., Tomabechi, Y., Shirouzu, M., Yokoyama, S.
Deposit date:2013-07-25
Release date:2014-02-12
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002
Acta Crystallogr.,Sect.D, 70, 2014
4LUE
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CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH 7-[TRANS-4-(4-METHYLPIPERAZIN-1-YL)CYCLOHEXYL]-5-(4-PHENOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE (RESULTING FROM DISPLACEMENT OF SKF86002)
Descriptor:Tyrosine-protein kinase HCK, CALCIUM ION, 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ...
Authors:Parker, L.J., Tanaka, A., Handa, N., Honda, K., Tomabechi, Y., Shirouzu, M., Yokoyama, S.
Deposit date:2013-07-25
Release date:2014-02-12
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002
Acta Crystallogr.,Sect.D, 70, 2014
3UIX
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CRYSTAL STRUCTURE OF PIM1 KINASE IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:Proto-oncogene serine/threonine-protein kinase pim-1, 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol, CHLORIDE ION, ...
Authors:Parker, L.J.
Deposit date:2011-11-06
Release date:2012-04-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A novel pim-1 kinase inhibitor targeting residues that bind the substrate Peptide.
J.Mol.Biol., 417, 2012
5XXP
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CRYSTAL STRUCTURE OF CBNR_DBD-DNA COMPLEX
Descriptor:LysR-type regulatory protein, DNA (25-MER)
Authors:Senda, T., Senda, M.
Deposit date:2017-07-04
Release date:2018-01-17
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the DNA-binding domain of the LysR-type transcriptional regulator CbnR in complex with a DNA fragment of the recognition-binding site in the promoter region
FEBS J., 285, 2018
5YWX
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CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE IN COMPLEX WITH F092
Descriptor:Hematopoietic prostaglandin D synthase, GLUTATHIONE, N-[4-(2-oxopyrrolidin-1-yl)phenyl]-2-(pyridin-2-yl)pyrimidine-5-carboxamide, ...
Authors:Kamo, M., Furubayashi, N., Inaka, K., Aritake, K., Omura, A., Tanaka, A.
Deposit date:2017-11-30
Release date:2018-09-05
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies.
Bioorg. Med. Chem., 26, 2018