Author results

3SKJ
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STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF AN AGONISTIC ANTI-HUMAN EPHA2 MONOCLONAL ANTIBODY
Descriptor:Antibody, light chain, heavy chain, ...
Authors:Oganesyan, V.Y., Wu, H., Dall'Acqua, W.F.
Deposit date:2011-06-22
Release date:2011-08-31
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody.
J.Mol.Biol., 413, 2011
4QXG
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ANTIGEN BINDING FRAGMENT OF AN ANTI IFNAR1 ANTIBODY
Descriptor:Fab, heavy chain, IgG1, ...
Authors:Oganesyan, V.Y., Dall'Acqua, W.F.
Deposit date:2014-07-20
Release date:2015-02-25
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-alpha receptor 1 antibody.
MAbs, 7, 2015
4U6V
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MECHANISMS OF NEUTRALIZATION OF A HUMAN ANTI-ALPHA TOXIN ANTIBODY
Descriptor:Fab, antigen binding fragment, heavy chain, ...
Authors:Oganesyan, V.Y., Peng, L., Damschroder, M.M., Cheng, L., Sadowska, A., Tkaczyk, C., Sellman, B., Wu, H., Dall'Acqua, W.F.
Deposit date:2014-07-29
Release date:2014-09-17
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody.
J.Biol.Chem., 289, 2014
4UB0
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NEW DESIGN FOR MONOVALENT BISPECIFIC IGG THROUGH CYSTEINE ENGINEERING OF THE CH1-CL INTERFACE
Descriptor:IgG1, heavy chain, light chain
Authors:Oganesyan, V.Y., Dall'Acqua, W.F.
Deposit date:2014-08-11
Release date:2015-07-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Improving target cell specificity using a novel monovalent bispecific IgG design.
Mabs, 7, 2015
4ZNE
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IGG1 FC-FCGAMMARI ECD COMPLEX
Descriptor:High affinity immunoglobulin gamma Fc receptor I, Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Oganesyan, V.Y., Dall'Acqua, W.F.
Deposit date:2015-05-04
Release date:2015-11-11
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural insights into the interaction of human IgG1 with Fc gamma RI: no direct role of glycans in binding.
Acta Crystallogr.,Sect.D, 71, 2015
5HVW
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MONOMERIC IGG4 FC
Descriptor:Ig gamma-4 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Oganesyan, V.Y., Shan, L., Dall'Acqua, W.F.
Deposit date:2016-01-28
Release date:2016-08-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Generation and Characterization of an IgG4 Monomeric Fc Platform.
Plos One, 11, 2016
6ATT
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39S FAB BOUND TO HER2 ECD
Descriptor:Receptor tyrosine-protein kinase erbB-2, Antibody 39S Fab heavy chain, Antibody 39S Fab light chain, ...
Authors:Oganesyan, V.Y., Dall'Acqua, W.F.
Deposit date:2017-08-29
Release date:2018-04-25
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody.
J. Biol. Chem., 293, 2018
6BWV
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CRYSTAL STRUCTURE OF THE 4-1BB/4-1BBL COMPLEX
Descriptor:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, DI(HYDROXYETHYL)ETHER
Authors:Oganesyan, V., Gilbreth, R.N., Baca, M.
Deposit date:2017-12-15
Release date:2018-05-09
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human 4-1BB/4-1BBL complex.
J. Biol. Chem., 293, 2018