Author results

1L8J
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CRYSTAL STRUCTURE OF THE ENDOTHELIAL PROTEIN C RECEPTOR AND BOUND PHOSPHOLIPID MOLECULE
Descriptor:Endothelial protein C receptor, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Oganesyan, V., Oganesyan, N., Terzyan, S., Dongfeng, Q., Dauter, Z., Esmon, N.L., Esmon, C.T.
Deposit date:2002-03-20
Release date:2002-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the endothelial protein C receptor and a bound phospholipid.
J.Biol.Chem., 277, 2002
1LQV
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CRYSTAL STRUCTURE OF THE ENDOTHELIAL PROTEIN C RECEPTOR WITH PHOSPHOLIPID IN THE GROOVE IN COMPLEX WITH GLA DOMAIN OF PROTEIN C.
Descriptor:Endothelial protein C receptor, Vitamin-K dependent protein C, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Oganesyan, V., Oganesyan, N., Terzyan, S., Dongfeng, Q., Dauter, Z., Esmon, N.L., Esmon, C.T.
Deposit date:2002-05-13
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of the endothelial protein C receptor and a bound phospholipid.
J.Biol.Chem., 277, 2002
1T72
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CRYSTAL STRUCTURE OF PHOSPHATE TRANSPORT SYSTEM PROTEIN PHOU FROM AQUIFEX AEOLICUS
Descriptor:Phosphate transport system protein phoU homolog
Authors:Oganesyan, V., Kim, S.-H., Oganesyan, N., Jancarik, J., Adams, P.D., Kim, R., Berkeley Structural Genomics Center (BSGC)
Deposit date:2004-05-07
Release date:2004-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the "PhoU-like" phosphate uptake regulator from Aquifex aeolicus.
J.Bacteriol., 187, 2005
1T8B
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CRYSTAL STRUCTURE OF REFOLDED PHOU-LIKE PROTEIN (GI 2983430) FROM AQUIFEX AEOLICUS
Descriptor:Phosphate transport system protein phoU homolog
Authors:Oganesyan, V., Kim, S.-H., Oganesyan, N., Jancarik, J., Adams, P.D., Kim, R., Berkeley Structural Genomics Center (BSGC)
Deposit date:2004-05-11
Release date:2004-12-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Crystal structure of the "PhoU-like" phosphate uptake regulator from Aquifex aeolicus.
J.Bacteriol., 187, 2005
1OZ9
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CRYSTAL STRUCTURE OF AQ_1354, A HYPOTHETICAL PROTEIN FROM AQUIFEX AEOLICUS
Descriptor:Hypothetical protein AQ_1354
Authors:Oganesyan, V., Busso, D., Brandsen, J., Chen, S., Jancarik, J., Kim, R., Kim, S.H., Berkeley Structural Genomics Center (BSGC)
Deposit date:2003-04-08
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.894 Å)
Cite:Structure of the hypothetical protein AQ_1354 from Aquifex aeolicus.
Acta Crystallogr.,Sect.D, 59, 2003
1S7O
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CRYSTAL STRUCTURE OF PUTATIVE DNA BINDING PROTEIN SP_1288 FROM STREPTOCOCCUS PYGENES
Descriptor:Hypothetical UPF0122 protein SPy1201/SpyM3_0842/SPs1042/spyM18_1152
Authors:Oganesyan, V., Pufan, R., DeGiovanni, A., Yokota, H., Kim, R., Kim, S.-H., Berkeley Structural Genomics Center (BSGC)
Deposit date:2004-01-29
Release date:2004-06-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structure of the putative DNA-binding protein SP_1288 from Streptococcus pyogenes.
Acta Crystallogr.,Sect.D, 60, 2004
1T75
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI BETA CARBONIC ANHYDRASE
Descriptor:Protein yadF, ZINC ION
Authors:Oganesyan, V., Kim, S.-H., Kim, R., Jancarik, J., Berkeley Structural Genomics Center (BSGC)
Deposit date:2004-05-07
Release date:2004-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Escherichia coli beta carbonic anhydrase
TO BE PUBLISHED
2HEK
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CRYSTAL STRUCTURE OF O67745, A HYPOTHETICAL PROTEIN FROM AQUIFEX AEOLICUS AT 2.0 A RESOLUTION.
Descriptor:Hypothetical protein, PHOSPHATE ION, ZINC ION, ...
Authors:Oganesyan, V., Jancarik, J., Adams, P.D., Kim, R., Kim, S.H., Berkeley Structural Genomics Center (BSGC)
Deposit date:2006-06-21
Release date:2006-07-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus.
Acta Crystallogr.,Sect.F, 63, 2007
2QL1
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STRUCTURAL CHARACTERIZATION OF A MUTATED, ADCC-ENHANCED HUMAN FC FRAGMENT
Descriptor:IGHM protein, ZINC ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Oganesyan, V., Wu, H., Dall'Acqua, W.F.
Deposit date:2007-07-12
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.534 Å)
Cite:Structural characterization of a mutated, ADCC-enhanced human Fc fragment
Mol.Immunol., 45, 2008
3C2S
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STRUCTURAL CHARACTERIZATION OF A HUMAN FC FRAGMENT ENGINEERED FOR LACK OF EFFECTOR FUNCTIONS
Descriptor:IGHM protein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Oganesyan, V., Wu, H., Dall'Acqua, W.F.
Deposit date:2008-01-25
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural characterization of a human Fc fragment engineered for lack of effector functions.
Acta Crystallogr.,Sect.D, 64, 2008
3FJT
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CRYSTAL STRUCTURE OF A HUMAN FC FRAGMENT ENGINEERED FOR EXTENDED SERUM HALF-LIFE
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Oganesyan, V., Wu, H., Dall'Acqua, W.F.
Deposit date:2008-12-15
Release date:2009-03-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of a human Fc fragment engineered for extended serum half-life.
Mol.Immunol., 46, 2009
4N0F
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HUMAN FCRN COMPLEXED WITH HUMAN SERUM ALBUMIN
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, Serum albumin
Authors:Oganesyan, V., Wu, H., Dall'Acqua, W.F.
Deposit date:2013-10-01
Release date:2014-02-05
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms.
J.Biol.Chem., 289, 2014
4N0U
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TERNARY COMPLEX BETWEEN NEONATAL FC RECEPTOR, SERUM ALBUMIN AND FC
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, Serum albumin, ...
Authors:Oganesyan, V., Wu, H., Dall'Acqua, W.F.
Deposit date:2013-10-02
Release date:2014-02-05
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms.
J.Biol.Chem., 289, 2014
4YPG
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STRUCTURAL INSIGHTS INTO THE NEUTRALIZATION PROPERTIES OF A HUMAN ANTI-INTERFERON MONOCLONAL ANTIBODY
Descriptor:Sifalimumab light chain, Sifalimumab heavy chain, Interferon alpha-2, ...
Authors:Oganesyan, V., Dall'Acqua, W.F.
Deposit date:2015-03-12
Release date:2015-05-06
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab.
J.Biol.Chem., 290, 2015
1EUE
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RAT OUTER MITOCHONDRIAL MEMBRANE CYTOCHROME B5
Descriptor:CYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE
Authors:Oganesyan, V., Zhang, X.
Deposit date:2000-04-19
Release date:2001-04-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Modulation of redox potential in electron transfer proteins: effects of complex formation on the active site microenvironment of cytochrome b5.
FARADAY DISC.CHEM.SOC, 116, 2001
6BRB
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NOVEL NON-ANTIBODY PROTEIN SCAFFOLD TARGETING CD40L
Descriptor:CD40 ligand, Tn3-like, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Oganesyan, V., Baca, M., Thisted, T., Grinberg, L., Wu, H., Dall'Acqua, W.F.
Deposit date:2017-11-30
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:MEDI4920, a novel non-antibody protein scaffold targeting CD40L, inhibits humoral immune activation in animal models and healthy subjects
To be Published
6CYF
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PCRV FRAGMENT WITH BOUND FAB
Descriptor:Type III secretion system protein, IgG1 antibody, kappa light chain, ...
Authors:Oganesyan, V.
Deposit date:2018-04-05
Release date:2018-08-01
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates.
J. Infect. Dis., 218, 2018
3CFW
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L-SELECTIN LECTIN AND EGF DOMAINS
Descriptor:L-selectin, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Mehta, P., Oganesyan, V., Terzyan, S., Mather, T., McEver, R.P.
Deposit date:2008-03-04
Release date:2008-03-18
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.
J.Biol.Chem., 292, 2017
4U6V
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MECHANISMS OF NEUTRALIZATION OF A HUMAN ANTI-ALPHA TOXIN ANTIBODY
Descriptor:Fab, antigen binding fragment, heavy chain, ...
Authors:Oganesyan, V.Y., Peng, L., Damschroder, M.M., Cheng, L., Sadowska, A., Tkaczyk, C., Sellman, B., Wu, H., Dall'Acqua, W.F.
Deposit date:2014-07-29
Release date:2014-09-17
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody.
J.Biol.Chem., 289, 2014
4ZNE
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IGG1 FC-FCGAMMARI ECD COMPLEX
Descriptor:High affinity immunoglobulin gamma Fc receptor I, Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Oganesyan, V.Y., Dall'Acqua, W.F.
Deposit date:2015-05-04
Release date:2015-11-11
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural insights into the interaction of human IgG1 with Fc gamma RI: no direct role of glycans in binding.
Acta Crystallogr.,Sect.D, 71, 2015
6ATT
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39S FAB BOUND TO HER2 ECD
Descriptor:Receptor tyrosine-protein kinase erbB-2, Antibody 39S Fab heavy chain, Antibody 39S Fab light chain, ...
Authors:Oganesyan, V.Y., Dall'Acqua, W.F.
Deposit date:2017-08-29
Release date:2018-04-25
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody.
J. Biol. Chem., 293, 2018
6BWV
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CRYSTAL STRUCTURE OF THE 4-1BB/4-1BBL COMPLEX
Descriptor:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, DI(HYDROXYETHYL)ETHER
Authors:Oganesyan, V., Gilbreth, R.N., Baca, M.
Deposit date:2017-12-15
Release date:2018-05-09
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human 4-1BB/4-1BBL complex.
J. Biol. Chem., 293, 2018
1JFD
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STRUCTURE OF INORGANIC PYROPHOSPHATASE
Descriptor:INORGANIC PYROPHOSPHATASE, SULFATE ION
Authors:Oganesyan, V., Avaeva, S.M., Huber, R., Harutyunyan, E.H.
Deposit date:1997-05-31
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Escherichia coli inorganic pyrophosphatase complexed with SO4(2-). Ligand-induced molecular asymmetry.
FEBS Lett., 410, 1997
1MJW
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STRUCTURE OF INORGANIC PYROPHOSPHATASE MUTANT D42N
Descriptor:INORGANIC PYROPHOSPHATASE, SULFATE ION
Authors:Oganesyan, V., Harutyunyan, E.H., Avaeva, S.M., Samygina, V.R., Huber, R.
Deposit date:1997-02-08
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Three-dimensional structures of mutant forms of E. coli inorganic pyrophosphatase with Asp-->Asn single substitution in positions 42, 65, 70, and 97.
Biochemistry Mosc., 63, 1998
1MJX
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STRUCTURE OF INORGANIC PYROPHOSPHATASE MUTANT D65N
Descriptor:INORGANIC PYROPHOSPHATASE, SULFATE ION
Authors:Oganesyan, V., Harutyunyan, E.H., Avaeva, S.M., Huber, R.
Deposit date:1997-02-08
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Three-dimensional structures of mutant forms of E. coli inorganic pyrophosphatase with Asp-->Asn single substitution in positions 42, 65, 70, and 97.
Biochemistry Mosc., 63, 1998
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