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3DNI
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BU of 3dni by Molmil
CRYSTALLOGRAPHIC REFINEMENT AND STRUCTURE OF DNASE I AT 2 ANGSTROMS RESOLUTION
Descriptor: CALCIUM ION, DEOXYRIBONUCLEASE I, alpha-D-galactopyranose-(1-6)-beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Oefner, C, Suck, D.
Deposit date:1992-08-20
Release date:1994-01-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic refinement and structure of DNase I at 2 A resolution.
J.Mol.Biol., 192, 1986
2QPJ
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BU of 2qpj by Molmil
Human NEP complexed with a bifunctional NEP/DPP IV inhibitor
Descriptor: (2S)-2-({(2S)-3-[(R)-[(1R)-1-({(4S)-4-amino-5-[(2S)-2-cyanopyrrolidin-1-yl]-5-oxopentanoyl}amino)ethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}amino)propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Neprilysin, ...
Authors:Oefner, C, Dale, G.E.
Deposit date:2007-07-24
Release date:2007-11-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.
Acta Crystallogr.,Sect.D, 63, 2007
3FRE
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BU of 3fre by Molmil
S. aureus DHFR complexed with NADPH and TMP
Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM
Authors:Oefner, C, Dale-Glenn, E.
Deposit date:2009-01-08
Release date:2010-01-12
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
J.Antimicrob.Chemother., 63, 2009
3FY8
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BU of 3fy8 by Molmil
Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101
Descriptor: 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oefner, C, Dale, G.E.
Deposit date:2009-01-22
Release date:2009-08-04
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus
Acta Crystallogr.,Sect.D, 65, 2009
1FR1
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BU of 1fr1 by Molmil
REFINED CRYSTAL STRUCTURE OF BETA-LACTAMASE FROM CITROBACTER FREUNDII INDICATES A MECHANISM FOR BETA-LACTAM HYDROLYSIS
Descriptor: BETA-LACTAMASE
Authors:Oefner, C, D'Arcy, A, Daly, J.J, Winkler, F.K.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Refined crystal structure of beta-lactamase from Citrobacter freundii indicates a mechanism for beta-lactam hydrolysis.
Nature, 343, 1990
1FR6
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BU of 1fr6 by Molmil
REFINED CRYSTAL STRUCTURE OF BETA-LACTAMASE FROM CITROBACTER FREUNDII INDICATES A MECHANISM FOR BETA-LACTAM HYDROLYSIS
Descriptor: 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, BETA-LACTAMASE
Authors:Oefner, C, D'Arcy, A, Daly, J.J, Winkler, F.K.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined crystal structure of beta-lactamase from Citrobacter freundii indicates a mechanism for beta-lactam hydrolysis.
Nature, 343, 1990
3FRD
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BU of 3frd by Molmil
S. aureus DHFR complexed with NADPH and folate
Descriptor: DIHYDROFOLIC ACID, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oefner, C, Dale-Glenn, E.
Deposit date:2009-01-08
Release date:2010-01-12
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
J.Antimicrob.Chemother., 63, 2009
3FRA
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BU of 3fra by Molmil
Staphylococcus aureus F98Y DHFR complexed with iclaprim
Descriptor: 5-{[(2S)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl}pyrimidine-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oefner, C, Dale-Glenn, E.
Deposit date:2009-01-08
Release date:2010-01-12
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
J.Antimicrob.Chemother., 63, 2009
3FY9
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BU of 3fy9 by Molmil
Staph. aureus DHFR F98Y complexed with AR-102
Descriptor: 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oefner, C.
Deposit date:2009-01-22
Release date:2009-08-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus
Acta Crystallogr.,Sect.D, 65, 2009
3FYW
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BU of 3fyw by Molmil
Staph. aureus DHFR complexed with NADPH and AR-101
Descriptor: 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oefner, C.
Deposit date:2009-01-23
Release date:2009-08-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus
Acta Crystallogr.,Sect.D, 65, 2009
3FRB
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BU of 3frb by Molmil
S. aureus F98Y DHFR complexed with TMP
Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM
Authors:Oefner, C, Dale-Glenn, E.
Deposit date:2009-01-08
Release date:2010-01-12
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
J.Antimicrob.Chemother., 63, 2009
3FRF
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BU of 3frf by Molmil
S. aureus DHFR complexed with NADPH and iclaprim
Descriptor: 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oefner, C, Dale-Glenn, E.
Deposit date:2009-01-08
Release date:2010-01-12
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
J.Antimicrob.Chemother., 63, 2009
3FYV
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BU of 3fyv by Molmil
Staph. aureus DHFR complexed with NADPH and AR-102
Descriptor: 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oefner, C.
Deposit date:2009-01-23
Release date:2009-08-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus
Acta Crystallogr.,Sect.D, 65, 2009
2G2O
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BU of 2g2o by Molmil
Structure of E.coli FabD complexed with sulfate
Descriptor: Malonyl CoA-acyl carrier protein transacylase, SULFATE ION
Authors:Oefner, C.
Deposit date:2006-02-16
Release date:2006-05-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
Acta Crystallogr.,Sect.D, 62, 2006
2G1H
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BU of 2g1h by Molmil
Structure of E.coli FabD complexed with glycerol
Descriptor: GLYCEROL, Malonyl CoA-acyl carrier protein transacylase
Authors:Oefner, C.
Deposit date:2006-02-14
Release date:2006-05-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
Acta Crystallogr.,Sect.D, 62, 2006
2G2Y
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BU of 2g2y by Molmil
Structure of E.coli FabD complexed with malonate
Descriptor: MALONATE ION, Malonyl CoA-acyl carrier protein transacylase
Authors:Oefner, C.
Deposit date:2006-02-17
Release date:2006-05-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
Acta Crystallogr.,Sect.D, 62, 2006
1DMT
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BU of 1dmt by Molmil
STRUCTURE OF HUMAN NEUTRAL ENDOPEPTIDASE COMPLEXED WITH PHOSPHORAMIDON
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, ...
Authors:Oefner, C, D'Arcy, A, Hennig, M, Winkler, F.K, Dale, G.E.
Deposit date:1999-12-15
Release date:2000-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.
J.Mol.Biol., 296, 2000
1DRF
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BU of 1drf by Molmil
CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
Descriptor: DIHYDROFOLATE REDUCTASE, FOLIC ACID, SULFATE ION
Authors:Oefner, C, D'Arcy, A, Winkler, F.K.
Deposit date:1990-08-09
Release date:1992-01-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human dihydrofolate reductase complexed with folate.
Eur.J.Biochem., 174, 1988
1PFQ
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BU of 1pfq by Molmil
crystal structure of human apo dipeptidyl peptidase IV / CD26
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase IV soluble form
Authors:Oefner, C, D'Arcy, A, Mac Sweeney, A, Pierau, S, Gardiner, R, Dale, G.E.
Deposit date:2003-05-27
Release date:2003-07-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Acta Crystallogr.,Sect.D, 59, 2003
1PDG
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BU of 1pdg by Molmil
CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB
Descriptor: PLATELET-DERIVED GROWTH FACTOR BB
Authors:Oefner, C, Darcy, A.D, Winkler, F.K, Eggimann, B, Hosnag, M.
Deposit date:1992-07-14
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human platelet-derived growth factor BB.
EMBO J., 11, 1992
1R1I
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BU of 1r1i by Molmil
STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Neprilysin, ZINC ION, ...
Authors:Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E.
Deposit date:2003-09-24
Release date:2004-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis of neprilysin with various specific and potent inhibitors.
Acta Crystallogr.,Sect.D, 60, 2004
1R1H
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BU of 1r1h by Molmil
STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE, Neprilysin, ...
Authors:Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E.
Deposit date:2003-09-24
Release date:2004-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural analysis of neprilysin with various specific and potent inhibitors.
Acta Crystallogr.,Sect.D, 60, 2004
1R1J
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BU of 1r1j by Molmil
STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC AND POTENT INHIBITORS
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-(3-PHENYL-2-SULFANYLPROPANOYL)PHENYLALANYLALANINE, Neprilysin, ...
Authors:Oefner, C, Roques, B.P, Fournie-Zaluski, M.C, Dale, G.E.
Deposit date:2003-09-24
Release date:2004-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural analysis of neprilysin with various specific and potent inhibitors.
Acta Crystallogr.,Sect.D, 60, 2004
1AD4
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BU of 1ad4 by Molmil
DIHYDROPTEROATE SYNTHETASE COMPLEXED WITH OH-CH2-PTERIN-PYROPHOSPHATE FROM STAPHYLOCOCCUS AUREUS
Descriptor: 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, DIHYDROPTEROATE SYNTHETASE, MANGANESE (II) ION, ...
Authors:Oefner, C, Kostrewa, D.
Deposit date:1997-02-20
Release date:1998-04-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
J.Mol.Biol., 268, 1997
3DWB
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BU of 3dwb by Molmil
structure of human ECE-1 complexed with phosphoramidon
Descriptor: 5-(2-hydroxyethyl)nonane-1,9-diol, Endothelin-converting enzyme 1, N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, ...
Authors:Oefner, C.
Deposit date:2008-07-22
Release date:2008-11-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structure of human endothelin-converting enzyme I complexed with phosphoramidon
J.Mol.Biol., 385, 2009

 

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