Author results

1BOO
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PVUII DNA METHYLTRANSFERASE (CYTOSINE-N4-SPECIFIC)
Descriptor:PROTEIN (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE PVU II), S-ADENOSYL-L-HOMOCYSTEINE
Authors:Gong, W., O'Gara, M., Blumenthal, R.M., Cheng, X.
Deposit date:1998-07-31
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment.
Nucleic Acids Res., 25, 1997
10MH
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TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET
Descriptor:DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), ...
Authors:Sheikhnejad, G., Brank, A., Christman, J.K., Goddard, A., Alvarez, E., Ford Junior, H., Marquez, V.E., Marasco, C.J., Sufrin, J.R., O'Gara, M., Cheng, X.
Deposit date:1998-08-10
Release date:1999-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine.
J.Mol.Biol., 285, 1999
1ROS
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CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4-(4-ETHOXY[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID
Descriptor:Macrophage metalloelastase, ZINC ION, CALCIUM ION, ...
Authors:Morales, R., Perrier, S., Florent, J.M., Beltra, J., Dufour, S., De Mendez, I., Manceau, P., Tertre, A., Moreau, F., Compere, D., Dublanchet, A.C., O'Gara, M.
Deposit date:2003-12-02
Release date:2004-12-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12.
J.Mol.Biol., 341, 2004
1UTT
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CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4-(4-ETHOXY[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID
Descriptor:MACROPHAGE METALLOELASTASE, ACETOHYDROXAMIC ACID, 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL) ETHYL-4-(4'-ETHOXY [1,1'-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID, ...
Authors:Morales, R., Perrier, S., Florent, J.M., Beltra, J., Dufour, S., De Mendez, I., Manceau, P., Tertre, A., Moreau, F., Compere, D., Dublanchet, A.C., O'Gara, M.
Deposit date:2003-12-10
Release date:2004-12-15
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12.
J. Mol. Biol., 341, 2004
1UTZ
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CRYSTAL STRUCTURE OF MMP-12 COMPLEXED TO (2R)-3-({[4-[(PYRIDIN-4-YL)PHENYL]-THIEN-2-YL}CARBOXAMIDO)(PHENYL)PROPANOIC ACID
Descriptor:MACROPHAGE METALLOELASTASE, (2R)-3-({[4-[(PYRIDIN-4-YL)PHENYL]-THIEN-2-YL}CARBOXAMIDO)(PHENYL)PROPANOIC ACID, ACETOHYDROXAMIC ACID, ...
Authors:Morales, R., Perrier, S., Florent, J.M., Beltra, J., Dufour, S., De Mendez, I., Manceau, P., Tertre, A., Moreau, F., Compere, D., Dublanchet, A.C., O'Gara, M.
Deposit date:2003-12-12
Release date:2004-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of Novel Non-Peptidic, Non-Zinc Chelating Inhibitors Bound to Mmp-12
J.Mol.Biol., 341, 2004
2HMY
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BINARY COMPLEX OF HHAI METHYLTRANSFERASE WITH ADOMET FORMED IN THE PRESENCE OF A SHORT NONPSECIFIC DNA OLIGONUCLEOTIDE
Descriptor:PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), S-ADENOSYLMETHIONINE
Authors:O'Gara, M., Zhang, X., Roberts, R.J., Cheng, X.
Deposit date:1999-02-08
Release date:1999-03-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide.
J.Mol.Biol., 287, 1999
2VNT
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UROKINASE-TYPE PLASMINOGEN ACTIVATOR INHIBITOR COMPLEX WITH A 1-(7- SULPHOAMIDOISOQUINOLINYL)GUANIDINE
Descriptor:UROKINASE-TYPE PLASMINOGEN ACTIVATOR, 1-({4-CHLORO-1-[(DIAMINOMETHYLIDENE)AMINO]ISOQUINOLIN-7-YL}SULFONYL)-D-PROLINE, SULFATE ION
Authors:Fish, P.V., Barber, C.G., Brown, D.G., Butt, R., Henry, B.T., Horne, V., Huggins, J.P., Mccleverty, D., Phillips, C., Webster, R., Dickinson, R.P., Collis, M.G., King, E., O'Gara, M., Mcintosh, F.
Deposit date:2008-02-07
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective Urokinase-Type Plasminogen Activator (Upa) Inhibitors 4. 1-(7-Sulphonamidoisoquinolinyl) Guanidines
J.Med.Chem., 50, 2007
3MHT
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TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH UNMODIFIED DNA AND ADOHCY
Descriptor:DNA (5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE (E.C.2.1.1.73)), ...
Authors:O'Gara, M., Klimasauskas, S., Roberts, R.J., Cheng, X.
Deposit date:1996-07-24
Release date:1997-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes.
J.Mol.Biol., 261, 1996
7MHT
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CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX
Descriptor:5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', 5'-D(P*CP*CP*AP*TP*GP*AP*GP*CP*TP*GP*AP*C)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ...
Authors:O'Gara, M., Horton, J.R., Roberts, R.J., Cheng, X.
Deposit date:1998-08-05
Release date:1998-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base.
Nat.Struct.Biol., 5, 1998
8MHT
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CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX
Descriptor:5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', 5'-D(P*CP*CP*AP*TP*GP*UP*GP*CP*TP*GP*AP*C)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ...
Authors:O'Gara, M., Horton, J.R., Roberts, R.J., Cheng, X.
Deposit date:1998-08-06
Release date:1998-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base.
Nat.Struct.Biol., 5, 1998
9MHT
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CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX
Descriptor:5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ...
Authors:O'Gara, M., Horton, J.R., Roberts, R.J., Cheng, X.
Deposit date:1998-08-07
Release date:1998-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base.
Nat.Struct.Biol., 5, 1998
5MHT
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TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH HEMIMETHYLATED DNA AND ADOHCY
Descriptor:DNA (5'-D(*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (HHAI METHYLTRANSFERASE), ...
Authors:Cheng, X.
Deposit date:1996-10-22
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase.
J.Mol.Biol., 263, 1996
4MHT
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TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH NATIVE DNA AND ADOHCY
Descriptor:DNA (5'-D(*GP*AP*TP*AP*GP*(5CM)P*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*TP*AP*GP*(5CM)P*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE (E.C.2.1.1.73)), ...
Authors:Cheng, X.
Deposit date:1996-07-24
Release date:1997-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes.
J.Mol.Biol., 261, 1996
1AQI
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STRUCTURE OF ADENINE-N6-DNA-METHYLTRANSFERASE TAQI
Descriptor:ADENINE-N6-DNA-METHYLTRANSFERASE TAQI, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Schluckebier, G., Saenger, W.
Deposit date:1996-07-25
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI.
J.Mol.Biol., 265, 1997
1AQJ
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STRUCTURE OF ADENINE-N6-DNA-METHYLTRANSFERASE TAQI
Descriptor:ADENINE-N6-DNA-METHYLTRANSFERASE TAQI, SINEFUNGIN
Authors:Schluckebier, G., Saenger, W.
Deposit date:1996-07-25
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI.
J.Mol.Biol., 265, 1997
2ADM
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ADENINE-N6-DNA-METHYLTRANSFERASE TAQI
Descriptor:ADENINE-N6-DNA-METHYLTRANSFERASE TAQI, S-ADENOSYLMETHIONINE
Authors:Schluckebier, G., Saenger, W.
Deposit date:1996-07-15
Release date:1997-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI.
J.Mol.Biol., 265, 1997
3DNG
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A NON-ZINC CHELATING INHIBITOR
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Pochetti, G., Montanari, R., Mazza, F.
Deposit date:2008-07-02
Release date:2009-03-03
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8)
J.Med.Chem., 52, 2009
3DPE
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A NON-ZINC CHELATING INHIBITOR
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Pochetti, G., Montanari, R., Mazza, F.
Deposit date:2008-07-08
Release date:2009-03-03
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8)
J.Med.Chem., 52, 2009
3DPF
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A NON-ZINC CHELATING INHIBITOR
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Pochetti, G., Montanari, R., Mazza, F.
Deposit date:2008-07-08
Release date:2009-03-03
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8)
J.Med.Chem., 52, 2009