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2FAF
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THE STRUCTURE OF CHICKEN MITOCHONDRIAL PEPCK.
Descriptor:Phosphoenolpyruvate carboxykinase, MANGANESE (II) ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Holyoak, T., Sullivan, S.M., Nowak, T.
Deposit date:2005-12-07
Release date:2006-06-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights into the Mechanism of PEPCK Catalysis
Biochemistry, 45, 2006
2FAH
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THE STRUCTURE OF MITOCHONDRIAL PEPCK, COMPLEX WITH MN AND GDP
Descriptor:Phosphoenolpyruvate carboxykinase, MANGANESE (II) ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Holyoak, T., Sullivan, S.M., Nowak, T.
Deposit date:2005-12-07
Release date:2006-06-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural Insights into the Mechanism of PEPCK Catalysis
Biochemistry, 45, 2006
2QZY
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THE STRUCTURE OF CHICKEN MITOCHONDRIAL PEPCK IN COMPLEX WITH PEP
Descriptor:Phosphoenolpyruvate carboxykinase [GTP], MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ...
Authors:Holyoak, T., Sullivan, S.M., Nowak, T.
Deposit date:2007-08-17
Release date:2007-09-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into the Mechanism of PEPCK Catalysis
Biochemistry, 45, 2006
1A3W
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PYRUVATE KINASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH FBP, PG, MN2+ AND K+
Descriptor:PYRUVATE KINASE, 2-PHOSPHOGLYCOLIC ACID, BETA-FRUCTOSE-1,6-DIPHOSPHATE, ...
Authors:Jurica, M.S., Mesecar, A., Heath, P.J., Shi, W., Nowak, T., Stoddard, B.L.
Deposit date:1998-01-26
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
Structure, 6, 1998
1A3X
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PYRUVATE KINASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH PG, MN2+ AND K+
Descriptor:PYRUVATE KINASE, 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, ...
Authors:Jurica, M.S., Mesecar, A., Heath, P.J., Shi, W., Nowak, T., Stoddard, B.L.
Deposit date:1998-01-26
Release date:1998-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
Structure, 6, 1998
4URU
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THE CRYSTAL STRUCTURE OF H-RAS AND SOS IN COMPLEX WITH LIGANDS
Descriptor:GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, 4-METHOXY-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE
Authors:Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Deposit date:2014-07-02
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URV
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THE CRYSTAL STRUCTURE OF H-RAS AND SOS IN COMPLEX WITH LIGANDS
Descriptor:GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, FORMIC ACID, ...
Authors:Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Deposit date:2014-07-02
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URW
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THE CRYSTAL STRUCTURE OF H-RAS AND SOS IN COMPLEX WITH LIGANDS
Descriptor:GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, 2-(2,6-DIMETHYLPHENYL)-4-(METHYLSULFANYL)-6-(PIPERAZIN-1-YL)-1,3,5-TRIAZINE
Authors:Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Deposit date:2014-07-02
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URX
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THE CRYSTAL STRUCTURE OF H-RAS AND SOS IN COMPLEX WITH LIGANDS
Descriptor:GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, 6-bromo-1H-indole, ...
Authors:Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Deposit date:2014-07-02
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URY
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THE CRYSTAL STRUCTURE OF H-RAS AND SOS IN COMPLEX WITH LIGANDS
Descriptor:GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, N-[(4-aminophenyl)sulfonyl]cyclopropanecarboxamide
Authors:Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Deposit date:2014-07-02
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4URZ
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THE CRYSTAL STRUCTURE OF H-RAS AND SOS IN COMPLEX WITH LIGANDS
Descriptor:GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, 1-[(4-aminophenyl)sulfonyl]piperidin-2-one
Authors:Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Deposit date:2014-07-02
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4US0
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THE CRYSTAL STRUCTURE OF H-RAS AND SOS IN COMPLEX WITH LIGANDS
Descriptor:GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, N-ETHYLMALEIMIDE
Authors:Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Deposit date:2014-07-02
Release date:2015-03-04
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4US1
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THE CRYSTAL STRUCTURE OF H-RAS AND SOS IN COMPLEX WITH LIGANDS
Descriptor:GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, (3S)-3-[3-(aminomethyl)phenyl]-1-ethylpyrrolidine-2,5-dione
Authors:Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Deposit date:2014-07-02
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4US2
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THE CRYSTAL STRUCTURE OF H-RAS AND SOS IN COMPLEX WITH LIGANDS
Descriptor:GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1, 3-[(3R)-1-ethyl-2,5-dioxopyrrolidin-3-yl]benzamide
Authors:Winter, J.J.G., Anderson, M., Blades, K., Brassington, C., Breeze, A.L., Chresta, C., Embrey, K., Fairley, G., Faulder, P., Finlay, M.R.V., Kettle, J.G., Nowak, T., Overman, R., Patel, S.J., Perkins, P., Spadola, L., Tart, J., Tucker, J., Wrigley, G.
Deposit date:2014-07-02
Release date:2015-03-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
J.Med.Chem., 58, 2015
4UTN
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH SUCCINYLATED CPS1-PEPTIDE
Descriptor:NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL, SUCCINYL-CPS1-PEPTIDE, ...
Authors:Pannek, M., Gertz, M., Steegborn, C.
Deposit date:2014-07-21
Release date:2014-08-20
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
Angew.Chem.Int.Ed.Engl., 53, 2014
4UTR
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH GLUTARYLATED CPS1-PEPTIDE
Descriptor:NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL, GLUTARYL-CPS1 PEPTIDE, ...
Authors:Pannek, M., Gertz, M., Steegborn, C.
Deposit date:2014-07-22
Release date:2014-08-20
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
Angew.Chem.Int.Ed.Engl., 53, 2014
4UTV
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH 3-PHENYL- SUCCINYLATED CPS1-PEPTIDE
Descriptor:NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL, CARBAMOYLPHOSPHATE SYNTHETASE I, ...
Authors:Pannek, M., Gertz, M., Steegborn, C.
Deposit date:2014-07-23
Release date:2014-08-20
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
Angew.Chem.Int.Ed.Engl., 53, 2014
4UTX
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH 3-NITRO- PROPIONYLATED CPS1-PEPTIDE
Descriptor:NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL, CARBAMOYLPHOSPHATE SYNTHETASE I, ...
Authors:Pannek, M., Gertz, M., Steegborn, C.
Deposit date:2014-07-23
Release date:2014-08-20
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
Angew.Chem.Int.Ed.Engl., 53, 2014
4UTZ
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH ADIPOYLATED CPS1-PEPTIDE
Descriptor:SIRTUIN 5, CARBAMOYLPHOSPHATE SYNTHETASE I, ZINC ION, ...
Authors:Pannek, M., Gertz, M., Steegborn, C.
Deposit date:2014-07-24
Release date:2014-08-20
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
Angew.Chem.Int.Ed.Engl., 53, 2014
4UU7
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH 3-METHYL- SUCCINYLATED CPS1-PEPTIDE
Descriptor:NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL, CARBAMOYLPHOSPHATE SYNTHETASE I, ...
Authors:Pannek, M., Gertz, M., Steegborn, C.
Deposit date:2014-07-24
Release date:2014-08-20
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
Angew.Chem.Int.Ed.Engl., 53, 2014
4UU8
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH 3,3-DIMETHYL- SUCCINYLATED CPS1-PEPTIDE
Descriptor:NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL, CARBAMOYLPHOSPHATE SYNTHETASE I, ...
Authors:Pannek, M., Gertz, M., Steegborn, C.
Deposit date:2014-07-24
Release date:2014-08-20
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
Angew.Chem.Int.Ed.Engl., 53, 2014
4UUA
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH 3S-Z-AMINO- SUCCINYLATED CPS1-PEPTIDE
Descriptor:NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL, CARBAMOYLPHOSPHATE SYNTHETASE I, ...
Authors:Pannek, M., Gertz, M., Steegborn, C.
Deposit date:2014-07-25
Release date:2014-08-20
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
Angew.Chem.Int.Ed.Engl., 53, 2014
4UUB
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH 2R-BUTYL- SUCCINYLATED CPS1-PEPTIDE
Descriptor:NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL, CARBAMOYLPHOSPHATE SYNTHETASE I, ...
Authors:Pannek, M., Gertz, M., Steegborn, C.
Deposit date:2014-07-25
Release date:2014-08-20
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors.
Angew.Chem.Int.Ed.Engl., 53, 2014
5G55
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3-QUINOLINE CARBOXAMIDES INHIBITORS OF PI3K
Descriptor:PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 6-cyano-4-[[(1R)-1-(4-methylphenyl)ethyl]amino]quinoline-3-carboxamide, SULFATE ION
Authors:Edman, K., Phillips, C.
Deposit date:2016-05-20
Release date:2016-08-03
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (Atm) Kinase.
J.Med.Chem., 59, 2016
6FKY
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CRYSTAL STRUCTURE OF ZEBRAFISH SIRTUIN 5 IN COMPLEX WITH 3-(BENZYLTHIO)SUCCINYL-CPS1 PEPTIDE
Descriptor:NAD-dependent protein deacylase sirtuin-5, mitochondrial, 3(R)-(phenylthio)succinyl-CPS1 peptide, ...
Authors:Pannek, M., Steegborn, C.
Deposit date:2018-01-25
Release date:2018-03-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Potent and Selective Inhibitors of Human Sirtuin 5.
J. Med. Chem., 61, 2018
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