Author results

3TCP
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC569
Descriptor:Tyrosine-protein kinase Mer, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, CHLORIDE ION, ...
Authors:Liu, J., Yang, C., Simpson, C., DeRyckere, D., Van Deusen, A., Miley, M., Kireev, D.B., Norris-Drouin, J., Sather, S., Hunter, D., Patel, H.S., Janzen, W.P., Machius, M., Johnson, G., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2011-08-09
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS Med Chem Lett, 3, 2012
5K0K
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC2434
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3H)-one, ...
Authors:Wang, X., Liu, J., Zhang, W., Stashko, M.A., Nichols, J., DeRyckere, D., Miley, M.J., Norris-Drouin, J., Chen, Z., Machius, M., Wood, E., Graham, D.K., Earp, H.S., Graham, K., Kireev, D., Frye, S.V.
Deposit date:2016-05-17
Release date:2017-01-11
Method:X-RAY DIFFRACTION (2.545 Å)
Cite:Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
ACS Med Chem Lett, 7, 2016
5K0X
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC2541
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide
Authors:McIver, A.L., Zhang, W., Liu, Q., Jiang, X., Stashko, M.A., Nichols, J., Miley, M.J., Norris-Drouin, J., Machius, M., DeRyckere, D., Wood, E., Graham, D.K., Earp, H.S., Kireev, D., Frye, S.V., Wang, X.
Deposit date:2016-05-17
Release date:2017-02-22
Method:X-RAY DIFFRACTION (2.231 Å)
Cite:Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
ChemMedChem, 12, 2017
4M3Q
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1917
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Zhang, W., Zhang, D., Stashko, M.A., DeRyckere, D., Hunter, D., Kireev, D.B., Miley, M., Cummings, C., Lee, M., Norris-Drouin, J., Stewart, W.M., Sather, S., Zhou, Y., Kirkpatrick, G., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-06
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.718 Å)
Cite:Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors.
J.Med.Chem., 56, 2013
4MH7
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1896
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Zhang, W., McIver, A., Stashko, M.A., Deryckere, D., Branchford, B.R., Hunter, D., Kireev, D.B., Miley, M.J., Norris-Drouin, J., Stewart, W.M., Lee, M., Sather, S., Zhou, Y., DiPaola, J.A., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-29
Release date:2014-05-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013
4MHA
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1817
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, ...
Authors:Zhang, W., Mciver, A., Stashko, M.A., Deryckere, D., Branchford, B.R., Hunter, D., Kireev, D.B., Miley, D.B.M., Norris-Drouin, J., Stewart, W.M., Lee, M., Sather, S., Zhou, Y., Dipaola, J.A., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-29
Release date:2014-05-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013
6MEP
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC3437
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, cis-4-[(2-[(4-{[4-(1,3-dioxolan-2-yl)pyridin-2-yl]ethynyl}phenyl)amino]-5-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}pyrimidin-4-yl)amino]cyclohexan-1-ol, ...
Authors:Da, C., Zhang, D., Stashko, M.A., Cheng, A., Hunter, D., Norris-Drouin, J., Graves, L., Machius, M., Miley, M.J., DeRyckere, D., Earp, H.S., Graham, D.K., Frye, S.V., Wang, X., Kireev, D.
Deposit date:2018-09-06
Release date:2019-09-11
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.893 Å)
Cite:Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.
J.Am.Chem.Soc., 2019