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5K0K
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC2434
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3H)-one, ...
Authors:Wang, X., Liu, J., Zhang, W., Stashko, M.A., Nichols, J., DeRyckere, D., Miley, M.J., Norris-Drouin, J., Chen, Z., Machius, M., Wood, E., Graham, D.K., Earp, H.S., Graham, K., Kireev, D., Frye, S.V.
Deposit date:2016-05-17
Release date:2017-01-11
Method:X-RAY DIFFRACTION (2.545 Å)
Cite:Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
ACS Med Chem Lett, 7, 2016
1P8D
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X-RAY CRYSTAL STRUCTURE OF LXR LIGAND BINDING DOMAIN WITH 24(S),25-EPOXYCHOLESTEROL
Descriptor:Oxysterols receptor LXR-beta, nuclear receptor coactivator 1 isoform 3, 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL
Authors:Williams, S., Bledsoe, R.K., Collins, J.L., Boggs, S., Lambert, M.H., Miller, A.B., Moore, J., McKee, D.D., Moore, L., Nichols, J., Parks, D., Watson, M., Wisely, B., Willson, T.M.
Deposit date:2003-05-06
Release date:2003-07-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
J.Biol.Chem., 278, 2003
5K0X
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC2541
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, (7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide
Authors:McIver, A.L., Zhang, W., Liu, Q., Jiang, X., Stashko, M.A., Nichols, J., Miley, M.J., Norris-Drouin, J., Machius, M., DeRyckere, D., Wood, E., Graham, D.K., Earp, H.S., Kireev, D., Frye, S.V., Wang, X.
Deposit date:2016-05-17
Release date:2017-02-22
Method:X-RAY DIFFRACTION (2.231 Å)
Cite:Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
ChemMedChem, 12, 2017
1G8L
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI MOEA
Descriptor:MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN, GLYCEROL
Authors:Xiang, S., Nichols, J., Rajagopalan, K.V., Schindelin, H.
Deposit date:2000-11-17
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
Structure, 9, 2001
1G8R
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MOEA
Descriptor:MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN, GLYCEROL
Authors:Xiang, S., Nichols, J., Rajagopalan, K.V., Schindelin, H.
Deposit date:2000-11-20
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
Structure, 9, 2001
3PUH
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COCAINE ESTERASE, WILD-TYPE BIOLOGICALLY ACTIVE DIMER
Descriptor:Cocaine esterase, GLYCEROL, SULFATE ION
Authors:Nance, M.R., Tesmer, J.J.G.
Deposit date:2010-12-04
Release date:2011-09-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
3PUI
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COCAINE ESTERASE WITH MUTATIONS G4C, S10C
Descriptor:Cocaine esterase, CHLORIDE ION, SODIUM ION
Authors:Nance, M.R., Tesmer, J.J.G.
Deposit date:2010-12-04
Release date:2011-09-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
4Z0V
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THE STRUCTURE OF HUMAN PDE12 RESIDUES 161-609
Descriptor:2',5'-phosphodiesterase 12, MAGNESIUM ION, GLYCEROL
Authors:Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.
Deposit date:2015-03-26
Release date:2015-06-17
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
4Z2B
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THE STRUCTURE OF HUMAN PDE12 RESIDUES 161-609 IN COMPLEX WITH GSK3036342A
Descriptor:2',5'-phosphodiesterase 12, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.
Deposit date:2015-03-29
Release date:2015-06-17
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015