Author results

1NZO
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THE CRYSTAL STRUCTURE OF WILD TYPE PENICILLIN-BINDING PROTEIN 5 FROM E. COLI
Descriptor:Penicillin-binding protein 5, BETA-MERCAPTOETHANOL
Authors:Nicholas, R.A., Krings, S., Tomberg, J., Nicola, G., Davies, C.
Deposit date:2003-02-19
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex.
J.Biol.Chem., 278, 2003
1NJ4
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CRYSTAL STRUCTURE OF A DEACYLATION-DEFECTIVE MUTANT OF PENICILLIN-BINDING PROTEIN 5 AT 1.9 A RESOLUTION
Descriptor:Penicillin-binding protein 5
Authors:Nicola, G., Nicholas, R.A., Davies, C.
Deposit date:2002-12-30
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex.
J.Biol.Chem., 278, 2003
1SDN
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CRYSTAL STRUCTURE OF A DEACYLATION-DEFECTIVE MUTANT OF PENICILLIN-BINDING PROTEIN 5 MODIFIED BY MERCURY
Descriptor:Penicillin-binding protein 5, MERCURY (II) ION
Authors:Nicola, G., Nicholas, R.A., Davies, C.
Deposit date:2004-02-13
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli.
Biochem.J., 392, 2005
1HD8
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CRYSTAL STRUCTURE OF A DEACYLATION-DEFECTIVE MUTANT OF PENICILLIN-BINDING PROTEIN 5 AT 2.3 A RESOLUTION
Descriptor:PENICILLIN-BINDING PROTEIN 5
Authors:Davies, C., White, S.W., Nicholas, R.A.
Deposit date:2000-11-11
Release date:2001-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of a Deacylation-Defective Mutant of Penicillin-Binding Protein 5 at 2.3-A Resolution
J.Biol.Chem., 276, 2001
1NZU
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WILD-TYPE PENICILLIN-BINDING PROTEIN 5 FROM E. COLI MODIFIED BY BETA-MERCAPTOETHANOL
Descriptor:Penicillin-binding protein 5, BETA-MERCAPTOETHANOL
Authors:Nicola, G., Nicholas, R.A., Davies, C.
Deposit date:2003-02-19
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli.
Biochem.J., 392, 2005
1Z6F
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI IN COMPLEX WITH A BORONIC ACID INHIBITOR
Descriptor:Penicillin-binding protein 5, N1-[(1R)-1-(DIHYDROXYBORYL)ETHYL]-N2-[(TERT-BUTOXYCARBONYL)-D-GAMMA-GLUTAMYL]-N6-[(BENZYLOXY)CARBONYL-L-LYSINAMIDE, GLYCEROL
Authors:Nicola, G., Peddi, S., Stefanova, M., Nicholas, R.A., Gutheil, W.G., Davies, C.
Deposit date:2005-03-22
Release date:2005-06-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Escherichia coli Penicillin-Binding Protein 5 Bound to a Tripeptide Boronic Acid Inhibitor: A Role for Ser-110 in Deacylation.
Biochemistry, 44, 2005
2G6G
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CRYSTAL STRUCTURE OF MLTA FROM NEISSERIA GONORRHOEAE
Descriptor:GNA33, SULFATE ION, GLYCEROL
Authors:Powell, A.J., Liu, Z.J., Nicholas, R.A., Davies, C.
Deposit date:2006-02-24
Release date:2006-05-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of the Lytic Transglycosylase MltA from N.gonorrhoeae and E.coli: Insights into Interdomain Movements and Substrate Binding.
J.Mol.Biol., 359, 2006
2GAE
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CRYSTAL STRUCTURE OF MLTA FROM E. COLI
Descriptor:Membrane-bound lytic murein transglycosylase A
Authors:Powell, A.J., Liu, Z.J., Nicholas, R.A., Davies, C.
Deposit date:2006-03-08
Release date:2006-05-09
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the Lytic Transglycosylase MltA from N.gonorrhoeae and E.coli: Insights into Interdomain Movements and Substrate Binding.
J.Mol.Biol., 359, 2006
2GK2
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CRYSTAL STRUCTURE OF THE N TERMINAL DOMAIN OF HUMAN CEACAM1
Descriptor:Carcinoembryonic antigen-related cell adhesion molecule 1, NICKEL (II) ION, GLYCEROL
Authors:Fedarovich, A., Tomberg, J., Nicholas, R.A., Davies, C.
Deposit date:2006-03-31
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae.
Acta Crystallogr.,Sect.D, 62, 2006
3EQU
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 2 FROM NEISSERIA GONORRHOEAE
Descriptor:Penicillin-binding protein 2, SULFATE ION, GLYCEROL
Authors:Powell, A.J., Deacon, A.M., Nicholas, R.A., Davies, C.
Deposit date:2008-10-01
Release date:2008-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance.
J.Biol.Chem., 284, 2009
3EQV
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 2 FROM NEISSERIA GONORRHOEAE CONTAINING FOUR MUTATIONS ASSOCIATED WITH PENICILLIN RESISTANCE
Descriptor:Penicillin-binding protein 2, SULFATE ION, GLYCEROL
Authors:Powell, A.J., Deacon, A.M., Nicholas, R.A., Davies, C.
Deposit date:2008-10-01
Release date:2008-10-21
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance.
J.Biol.Chem., 284, 2009
3MZD
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STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI: CLOXACILLIN ACYL-ENZYME COMPLEX
Descriptor:D-alanyl-D-alanine carboxypeptidase dacA, (2R,4S)-2-[(1S)-1-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, GLYCEROL
Authors:Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C.
Deposit date:2010-05-12
Release date:2011-03-16
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
3MZE
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STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E.COLI: CEFOXITIN ACYL-ENZYME COMPLEX
Descriptor:D-alanyl-D-alanine carboxypeptidase dacA, (2R)-5-[(carbamoyloxy)methyl]-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, GLYCEROL
Authors:Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C.
Deposit date:2010-05-12
Release date:2011-03-16
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
3MZF
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STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI: IMIPENEM ACYL-ENZYME COMPLEX
Descriptor:D-alanyl-D-alanine carboxypeptidase dacA, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, GLYCEROL
Authors:Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C.
Deposit date:2010-05-12
Release date:2011-03-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
2G5D
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CRYSTAL STRUCTURE OF MLTA FROM NEISSERIA GONORRHOEAE MONOCLINIC FORM
Descriptor:GNA33
Authors:Davies, C.
Deposit date:2006-02-22
Release date:2006-03-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of the Lytic Transglycosylase MltA from N.gonorrhoeae and E.coli: Insights into Interdomain Movements and Substrate Binding.
J.Mol.Biol., 359, 2006
3LO7
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CRYSTAL STRUCTURE OF PBPA FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Penicillin-binding protein A
Authors:Fedarovich, A., Davies, C.
Deposit date:2010-02-03
Release date:2010-03-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis.
J.Mol.Biol., 398, 2010
3P3C
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CRYSTAL STRUCTURE OF THE AQUIFEX AEOLICUS LPXC/LPC-009 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, ...
Authors:Lee, C.-J., Zhou, P.
Deposit date:2010-10-04
Release date:2011-01-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
Chem.Biol., 18, 2011
3P3E
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CRYSTAL STRUCTURE OF THE PSEUDOMONAS AERUGINOSA LPXC/LPC-009 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, ...
Authors:Lee, C.-J., Zhou, P.
Deposit date:2010-10-04
Release date:2011-01-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
Chem.Biol., 18, 2011
3P3G
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CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI LPXC/LPC-009 COMPLEX
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, ...
Authors:Lee, C.-J., Zhou, P.
Deposit date:2010-10-04
Release date:2011-01-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
Chem.Biol., 18, 2011
3UN7
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CRYSTAL STRUCTURE OF PBPA FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Penicillin-binding protein A
Authors:Fedarovich, A., Davies, C.
Deposit date:2011-11-15
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418, 2012
3UPN
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STRUCTURE OF PENICILLIN-BINDING PROTEIN A FROM M. TUBERCULOSIS: IMIPENEM ACYL-ENZYME COMPLEX
Descriptor:Penicillin-binding protein A, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
Authors:Davies, C., Fedorovich, A.
Deposit date:2011-11-18
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418, 2012
3UPO
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STRUCTURE OF PENICILLIN-BINDING PROTEIN A FROM M. TUBERCULOSIS: PENICILLIN G ACYL-ENZYME COMPLEX
Descriptor:Penicillin-binding protein A, OPEN FORM - PENICILLIN G
Authors:Davies, C., Fedorovich, A.
Deposit date:2011-11-18
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418, 2012
3UPP
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STRUCTURE OF PENICILLIN-BINDING PROTEIN A FROM M. TUBERCULOSIS: CEFTRIXAONE ACYL-ENZYME COMPLEX
Descriptor:Penicillin-binding protein A, CEFOTAXIME, C3' cleaved, ...
Authors:Davies, C., Fedorovich, A.
Deposit date:2011-11-18
Release date:2012-10-24
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418, 2012
4U3T
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CRYSTAL STRUCTURE OF THE TRANSPEPTIDASE DOMAIN OF NEISSERIA GONORRHOEAE PENICILLIN-BINDING PROTEIN 2 DERIVED FROM THE PENICILLIN-RESISTANT STRAIN 6140
Descriptor:Penicillin-binding protein 2
Authors:Fedarovich, A., Davies, C.
Deposit date:2014-07-22
Release date:2014-12-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Effect of the Asp345a Insertion in Penicillin-Binding Protein 2 from Penicillin-Resistant Strains of Neisseria gonorrhoeae.
Biochemistry, 53, 2014
5KSH
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 2 FROM NEISSERIA GONORRHOEAE CONTAINING AN A501T MUTATION ASSOCIATED WITH CEPHALOSPORIN RESISTANCE
Descriptor:Penicillin-binding protein 2, GLYCEROL, SULFATE ION
Authors:Fedarovich, A., Davies, C.
Deposit date:2016-07-08
Release date:2017-03-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness.
Biochemistry, 56, 2017