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4BGD
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BU of 4bgd by Molmil
Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nguyen, T.H.D, Li, J, Nagai, K.
Deposit date:2013-03-25
Release date:2013-05-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of Brr2-Prp8 Interactions and Implications for U5 Snrnp Biogenesis and the Spliceosome Active Site
Structure, 21, 2013
5GAM
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BU of 5gam by Molmil
Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-02-03
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
7BG9
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BU of 7bg9 by Molmil
The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate
Descriptor: DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3'), Histone H2A, Histone H2B, ...
Authors:Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K.
Deposit date:2021-01-06
Release date:2021-04-28
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of human telomerase holoenzyme with bound telomeric DNA.
Nature, 593, 2021
7BGB
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BU of 7bgb by Molmil
The H/ACA RNP lobe of human telomerase
Descriptor: H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ...
Authors:Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K.
Deposit date:2021-01-06
Release date:2021-04-28
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Structure of human telomerase holoenzyme with bound telomeric DNA.
Nature, 593, 2021
5GAO
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BU of 5gao by Molmil
Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Descriptor: Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAN
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BU of 5gan by Molmil
The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom
Descriptor: 13 kDa ribonucleoprotein-associated protein, GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-processing factor 31, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5OF4
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BU of 5of4 by Molmil
The cryo-EM structure of human TFIIH
Descriptor: General transcription factor IIH subunit 2, General transcription factor IIH subunit 3, General transcription factor IIH subunit 4,p52,General transcription factor IIH subunit 4, ...
Authors:Greber, B.J, Nguyen, T.H.D, Fang, J, Afonine, P.V, Adams, P.D, Nogales, E.
Deposit date:2017-07-10
Release date:2017-09-13
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:The cryo-electron microscopy structure of human transcription factor IIH.
Nature, 549, 2017
8OX0
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BU of 8ox0 by Molmil
Structure of apo telomeric nucleosome
Descriptor: Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, Histone H3.1, ...
Authors:Hu, H, van Roon, A.M.M, Ghanim, G.E, Ahsan, B, Oluwole, A, Peak-Chew, S, Robinson, C.V, Nguyen, T.H.D.
Deposit date:2023-04-28
Release date:2023-08-30
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (2.52 Å)
Cite:Structural basis of telomeric nucleosome recognition by shelterin factor TRF1.
Sci Adv, 9, 2023
8OX1
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BU of 8ox1 by Molmil
Structure of TRF1core in complex with telomeric nucleosome
Descriptor: Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, Histone H3.1, ...
Authors:Hu, H, van Roon, A.M.M, Ghanim, G.E, Ahsan, B, Oluwole, A, Peak-Chew, S, Robinson, C.V, Nguyen, T.H.D.
Deposit date:2023-04-28
Release date:2023-08-30
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis of telomeric nucleosome recognition by shelterin factor TRF1.
Sci Adv, 9, 2023
8OUE
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BU of 8oue by Molmil
The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in a semi-closed conformation
Descriptor: H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ...
Authors:Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D.
Deposit date:2023-04-22
Release date:2024-01-31
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
Nat Commun, 15, 2024
8OUF
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BU of 8ouf by Molmil
The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in an open conformation
Descriptor: H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ...
Authors:Ghanim, G.E, Sekne, Z, van Roon, A.M.M, Balch, S, Nguyen, T.H.D.
Deposit date:2023-04-22
Release date:2024-01-31
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:2.7 angstrom cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
Nat Commun, 15, 2024
7QXB
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BU of 7qxb by Molmil
Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map)
Descriptor: Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ...
Authors:Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D.
Deposit date:2022-01-26
Release date:2022-03-02
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
7QXS
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BU of 7qxs by Molmil
Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains)
Descriptor: Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ...
Authors:Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D.
Deposit date:2022-01-27
Release date:2022-03-02
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
7QXA
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BU of 7qxa by Molmil
Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened)
Descriptor: Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ...
Authors:Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D.
Deposit date:2022-01-26
Release date:2022-03-02
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
8F2U
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BU of 8f2u by Molmil
Human CCC complex
Descriptor: COMM domain-containing protein 1, COMM domain-containing protein 10, COMM domain-containing protein 2, ...
Authors:Healy, M.D, McNally, K.E, Butkovic, R, Chilton, M, Kato, K, Sacharz, J, McConville, C, Moody, E.R.R, Shaw, S, Planelles-Herrero, V.J, Kadapalakere, S.Y, Ross, J, Borucu, U, Palmer, C.S, Chen, K, Croll, T.I, Hall, R.J, Caruana, N.J, Ghai, R, Nguyen, T.H.D, Heesom, K.J, Saitoh, S, Berger, I, Berger-Schaffitzel, C, Williams, T.A, Stroud, D.A, Derivery, E, Collins, B.M, Cullen, P.J.
Deposit date:2022-11-08
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Cell, 186, 2023
8F2R
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BU of 8f2r by Molmil
Human CCC complex
Descriptor: COMM domain-containing protein 1, COMM domain-containing protein 10, COMM domain-containing protein 2, ...
Authors:Healy, M.D, McNally, K.E, Butkovic, R, Chilton, M, Kato, K, Sacharz, J, McConville, C, Moody, E.R.R, Shaw, S, Planelles-Herrero, V.J, Kadapalakere, S.Y, Ross, J, Borucu, U, Palmer, C.S, Chen, K, Croll, T.I, Hall, R.J, Caruana, N.J, Ghai, R, Nguyen, T.H.D, Heesom, K.J, Saitoh, S, Berger, I, Berger-Schaffitzel, C, Williams, T.A, Stroud, D.A, Derivery, E, Collins, B.M, Cullen, P.J.
Deposit date:2022-11-08
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Cell, 186, 2023
5GAP
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BU of 5gap by Molmil
Body region of the U4/U6.U5 tri-snRNP
Descriptor: 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-processing factor 31, Pre-mRNA-splicing factor 6, ...
Authors:Nguyen, T.H.D, Galej, W.P, Oubridge, C, Bai, X.C, Newman, A, Scheres, S, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5W5Y
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BU of 5w5y by Molmil
RNA polymerase I Initial Transcribing Complex
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Han, Y, He, Y.
Deposit date:2017-06-16
Release date:2017-07-26
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
5W66
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BU of 5w66 by Molmil
RNA polymerase I Initial Transcribing Complex State 3
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Han, Y, He, Y.
Deposit date:2017-06-16
Release date:2017-07-26
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
5W65
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BU of 5w65 by Molmil
RNA polymerase I Initial Transcribing Complex State 2
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Han, Y, He, Y.
Deposit date:2017-06-16
Release date:2017-08-02
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
5W64
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BU of 5w64 by Molmil
RNA Polymerase I Initial Transcribing Complex State 1
Descriptor: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ...
Authors:Han, Y, He, Y.
Deposit date:2017-06-16
Release date:2017-07-26
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Elife, 6, 2017
8ESD
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BU of 8esd by Molmil
Crystal structure of COMMD7-COMMD9-COMMD5-COMMD10 tetramer
Descriptor: COMM domain-containing protein 10, COMM domain-containing protein 5, COMM domain-containing protein 7, ...
Authors:Healy, M.D, Collins, B.M.
Deposit date:2022-10-13
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Cell, 186, 2023
8ESE
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BU of 8ese by Molmil
Crystal structure of human Vps29 bound to a peptide from Vps35L
Descriptor: VPS35 endosomal protein-sorting factor-like, Vacuolar protein sorting-associated protein 29
Authors:Healy, M.D, Collins, B.M.
Deposit date:2022-10-13
Release date:2023-05-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Cell, 186, 2023
6O9M
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BU of 6o9m by Molmil
Structure of the human apo TFIIH
Descriptor: CDK-activating kinase assembly factor MAT1, General transcription factor IIH subunit 1, General transcription factor IIH subunit 2, ...
Authors:Yan, C.L, Dodd, T, He, Y, Tainer, J.A, Tsutakawa, S.E, Ivanov, I.
Deposit date:2019-03-14
Release date:2019-05-29
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Nat.Struct.Mol.Biol., 26, 2019

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