Author results

1N1S
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TRYPANOSOMA RANGELI SIALIDASE
Descriptor:Sialidase, SULFATE ION
Authors:Amaya, M.F., Buschiazzo, A., Nguyen, T., Alzari, P.M.
Deposit date:2002-10-20
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase
J.Mol.Biol., 325, 2003
1N1T
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TRYPANOSOMA RANGELI SIALIDASE IN COMPLEX WITH DANA AT 1.6 A
Descriptor:Sialidase, SULFATE ION, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID
Authors:Amaya, M.F., Buschiazzo, A., Nguyen, T., Alzari, P.M.
Deposit date:2002-10-20
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase
J.Mol.Biol., 325, 2003
1N1V
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TRYPANOSOMA RANGELI SIALIDASE IN COMPLEX WITH DANA
Descriptor:Sialidase, SULFATE ION, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID
Authors:Amaya, M.F., Buschiazzo, A., Nguyen, T., Alzari, P.M.
Deposit date:2002-10-21
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase
J.Mol.Biol., 325, 2003
1N1Y
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TRYPANOSOMA RANGELI SIALIDASE IN COMPLEX WITH SIALIC ACID
Descriptor:Sialidase, O-SIALIC ACID
Authors:Amaya, M.F., Buschiazzo, A., Nguyen, T., Alzari, P.M.
Deposit date:2002-10-21
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase
J.Mol.Biol., 325, 2003
5JNM
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CRYSTAL STRUCTURE OF MTLD FROM STAPHYLOCOCCUS AUREUS AT 1.7-ANGSTROM RESOLUTION
Descriptor:Mannitol-1-phosphate 5-dehydrogenase, SULFATE ION
Authors:Ta, H.M., Nguyen, T., Kim, T., Kim, K.K.
Deposit date:2016-04-30
Release date:2017-11-08
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Crystal structure of MtlD from Staphylococcus aureus at 1.7-Angstrom resolution
To Be Published
1C4R
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THE STRUCTURE OF THE LIGAND-BINDING DOMAIN OF NEUREXIN 1BETA: REGULATION OF LNS DOMAIN FUNCTION BY ALTERNATIVE SPLICING
Descriptor:NEUREXIN-I BETA
Authors:Rudenko, G., Nguyen, T., Chelliah, Y., Sudhof, T.C., Deisenhofer, J.
Deposit date:1999-09-28
Release date:2000-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing.
Cell(Cambridge,Mass.), 99, 1999
1KWD
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SOLUTION STRUCTURE OF THE CENTRAL CONSERVED REGION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT GLYCOPROTEIN G 187
Descriptor:MAJOR SURFACE GLYCOPROTEIN G
Authors:Sugawara, M., Czaplicki, J., Ferrage, J., Haeuw, J.F., Power, U.F., Corvaia, N., Nguyen, T., Beck, A., Milon, A.
Deposit date:2002-01-29
Release date:2003-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure-antigenicity relationship studies of the central conserved region of human respiratory syncytial virus protein G.
J.Pept.Res., 60, 2002
1KWE
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SOLUTION STRUCTURE OF THE CENTRAL CONSERVED REGION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT GLYCOPROTEIN G
Descriptor:MAJOR SURFACE GLYCOPROTEIN G
Authors:Sugawara, M., Czaplicki, J., Ferrage, J., Haeuw, J.F., Power, U.F., Corvaia, N., Nguyen, T., Beck, A., Milon, A.
Deposit date:2002-01-29
Release date:2003-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure-antigenicity relationship studies of the central conserved region of human respiratory syncytial virus protein G.
J.Pept.Res., 60, 2002
1S0I
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TRYPANOSOMA CRUZI TRANS-SIALIDASE IN COMPLEX WITH SIALYL-LACTOSE (MICHAELIS COMPLEX)
Descriptor:trans-sialidase, 5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2->3)-BETA-D-LYXO-HEXOPYRANOSYL-(1->4)HEXOPYRANOSE
Authors:Amaya, M.F., Watts, A.G., Damager, I., Wehenkel, A., Nguyen, T., Buschiazzo, A., Paris, G., Frasch, A.C., Withers, S.G., Alzari, P.M.
Deposit date:2003-12-31
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase.
Structure, 12, 2004
1S0J
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TRYPANOSOMA CRUZI TRANS-SIALIDASE IN COMPLEX WITH MUNANA (MICHAELIS COMPLEX)
Descriptor:trans-sialidase, 4-METHYL-2-OXO-2H-CHROMEN-7-YL 5-(ACETYLAMINO)-3,5-DIDEOXY-L-ERYTHRO-NON-2-ULOPYRANOSIDONIC ACID
Authors:Amaya, M.F., Watts, A.G., Damager, I., Wehenkel, A., Nguyen, T., Buschiazzo, A., Paris, G., Frasch, A.C., Withers, S.G., Alzari, P.M.
Deposit date:2003-12-31
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase.
Structure, 12, 2004
1WCS
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A MUTANT OF TRYPANOSOMA RANGELI SIALIDASE DISPLAYING TRANS-SIALIDASE ACTIVITY
Descriptor:SIALIDASE
Authors:Paris, G., Ratier, L., Amaya, M.F., Nguyen, T., Alzari, P.M., Frasch, C.
Deposit date:2004-11-21
Release date:2004-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A Sialidase Mutant Displaying Trans-Sialidase Activity
J.Mol.Biol., 345, 2005
1YY6
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THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 COMPLEXED WITH AN EBNA1 PEPTIDE
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, Epstein-Barr nuclear antigen-1, SODIUM ION
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Holowaty, M., Shire, K., Nguyen, T., Zhang, R., Liao, J., Lee, W., Edwards, A.M., Arrowsmith, C.H., Frappier, L.
Deposit date:2005-02-23
Release date:2005-04-05
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol.Cell, 18, 2005
1YZE
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF USP7/HAUSP.
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Holowaty, M.N., Shire, K., Nguyen, T., Zhang, R.G., Liao, J., Lee, W., Edwards, A.M., Arrowsmith, C.H., Frappier, L.
Deposit date:2005-02-28
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol.Cell, 18, 2005
2AH2
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TRYPANOSOMA CRUZI TRANS-SIALIDASE IN COMPLEX WITH 2,3-DIFLUOROSIALIC ACID (COVALENT INTERMEDIATE)
Descriptor:trans-sialidase, CHLORIDE ION, 5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, ...
Authors:Amaya, M.F., Watts, A.G., Damager, I., Wehenkel, A., Nguyen, T., Buschiazzo, A., Paris, G., Frasch, A.C., Withers, S.G., Alzari, P.M.
Deposit date:2005-07-27
Release date:2005-08-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase
Structure, 12, 2004
2GFP
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STRUCTURE OF THE MULTIDRUG TRANSPORTER EMRD FROM ESCHERICHIA COLI
Descriptor:Multidrug resistance protein D
Authors:Yin, Y., He, X., Szewczyk, P., Nguyen, T., Chang, G.
Deposit date:2006-03-22
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the multidrug transporter EmrD from Escherichia coli
Science, 312, 2006
5K5S
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CRYSTAL STRUCTURE OF THE ACTIVE FORM OF HUMAN CALCIUM-SENSING RECEPTOR EXTRACELLULAR DOMAIN
Descriptor:Extracellular calcium-sensing receptor, TRYPTOPHAN, PHOSPHATE ION, ...
Authors:Geng, Y., Mosyak, L., Kurinov, I., Zuo, H., Sturchler, E., Cheng, T.C., Subramanyam, P., Brown, A.P., Brennan, S.C., Mun, H.-C., Bush, M., Chen, Y., Nguyen, T., Cao, B., Chang, D., Quick, M., Conigrave, A., Colecraft, H.M., McDonald, P., Fan, Q.R.
Deposit date:2016-05-23
Release date:2016-08-03
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016
5K5T
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CRYSTAL STRUCTURE OF THE INACTIVE FORM OF HUMAN CALCIUM-SENSING RECEPTOR EXTRACELLULAR DOMAIN
Descriptor:Extracellular calcium-sensing receptor, CALCIUM ION, SULFATE ION, ...
Authors:Geng, Y., Mosyak, L., Kurinov, I., Zuo, H., Sturchler, E., Cheng, T.C., Subramanyam, P., Brown, A.P., Brennan, S.C., Mun, H.-C., Bush, M., Chen, Y., Nguyen, T., Cao, B., Chang, D., Quick, M., Conigrave, A., Colecraft, H.M., McDonald, P., Fan, Q.R.
Deposit date:2016-05-23
Release date:2016-08-03
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016
3NAX
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PDK1 IN COMPLEX WITH INHIBITOR MP7
Descriptor:3-phosphoinositide-dependent protein kinase 1, 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide
Authors:Yan, Y., Munshi, S.K., Allison, T.
Deposit date:2010-06-02
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
J.Biol.Chem., 286, 2011
3NAY
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PDK1 IN COMPLEX WITH INHIBITOR MP6
Descriptor:3-phosphoinositide-dependent protein kinase 1, 4-(2-cyclopropylethylidene)-9-(1H-pyrazol-4-yl)-6-{[(1R)-1,2,2-trimethylpropyl]amino}benzo[c][1,6]naphthyridin-1(4H)-one
Authors:Yan, Y., Munshi, S.K., Allison, T.
Deposit date:2010-06-02
Release date:2010-11-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Selective inhibition of PDK1 using an allosteric kinase inhibitor and RNAi impairs cancer cell migration and anchorage-independent growth of primary tumor lines
J.Biol.Chem., 2010
4DUS
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STRUCTURE OF BACE-1 (BETA-SECRETASE) IN COMPLEX WITH N-((2S,3R)-1-(4-FLUOROPHENYL)-3-HYDROXY-4-((6'-NEOPENTYL-3',4'-DIHYDROSPIRO[CYCLOBUTANE-1,2'-PYRANO[2,3-B]PYRIDIN]-4'-YL)AMINO)BUTAN-2-YL)ACETAMIDE
Descriptor:Beta-secretase 1, IODIDE ION, GLYCEROL, ...
Authors:Sickmier, E.A.
Deposit date:2012-02-22
Release date:2012-10-10
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of beta-Secretase.
ACS Med Chem Lett, 3, 2012
4FS4
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STRUCTURE OF BACE BOUND TO (S)-4-(3'-METHOXY-[1,1'-BIPHENYL]-3-YL)-1,4-DIMETHYL-6-OXOTETRAHYDROPYRIMIDIN-2(1H)-IMINIUM
Descriptor:Beta-secretase 1, (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one, L(+)-TARTARIC ACID
Authors:Strickland, C., Stamford, A.
Deposit date:2012-06-26
Release date:2012-10-10
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of beta-Secretase.
ACS Med Chem Lett, 3, 2012
2LBH
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SOLUTION STRUCTURE OF THE DIMERIC FORM OF A UNLIGANDED BOVINE NEUROPHYSIN, MINIMIZED AVERAGE STRUCTURE
Descriptor:Neurophysin 1
Authors:Lee, H., Naik, M., Nguyen, T., Bracken, C., Breslow, E.
Deposit date:2011-03-31
Release date:2012-04-04
Method:SOLUTION NMR
Cite:Structural Basis of the Dimerization-Induced Increase in Neurophysin-Hormone Affinity: Interplay of Inter-Domain and Inter-Subunit Interactions
To be Published
2LBN
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(REVISED) SOLUTION STRUCTURE OF THE MONOMERIC FORM OF A MUTANT UNLIGANDED BOVINE NEUROPHYSIN, 20 STRUCTURES
Descriptor:Neurophysin 1
Authors:Lee, H., Nguyen, T., Bracken, C., Breslow, E.
Deposit date:2011-04-01
Release date:2012-04-04
Method:SOLUTION NMR
Cite:Structural Basis of the Dimerization-Induced Increase in Neurophysin-Hormone Affinity: Interplay of Inter-Domain and Inter-Subunit Interactions
To be Published
3MJW
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PI3 KINASE GAMMA WITH A BENZOFURANONE INHIBITOR
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, (2Z)-4,6-dihydroxy-2-[(8-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)methylidene]-1-benzofuran-3(2H)-one
Authors:Bard, J., Svenson, K.
Deposit date:2010-04-13
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer.
Bioorg.Med.Chem.Lett., 20, 2010
4KG9
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CRYSTAL STRUCTURE OF USP7-NTD WITH MCM-BP
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, Mini-chromosome maintenance complex-binding protein
Authors:Saridakis, V., Luthra, N.
Deposit date:2013-04-29
Release date:2013-11-13
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A role for USP7 in DNA replication.
Mol.Cell.Biol., 34, 2014
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