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2I5B
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THE CRYSTAL STRUCTURE OF AN ADP COMPLEX OF BACILLUS SUBTILIS PYRIDOXAL KINASE PROVIDES EVIDENCE FOR THE PARRALEL EMERGENCE OF ENZYME ACTIVITY DURING EVOLUTION
Descriptor:Phosphomethylpyrimidine kinase, ADENOSINE-5'-DIPHOSPHATE
Authors:Newman, J.A., Das, S.K., Sedelnikova, S.E., Rice, D.W.
Deposit date:2006-08-24
Release date:2006-09-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of an ADP Complex of Bacillus subtilis Pyridoxal Kinase Provides Evidence for the Parallel Emergence of Enzyme Activity During Evolution.
J.Mol.Biol., 363, 2006
3ZKC
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CRYSTAL STRUCTURE OF THE MASTER REGULATOR FOR BIOFILM FORMATION SINR IN COMPLEX WITH DNA.
Descriptor:HTH-TYPE TRANSCRIPTIONAL REGULATOR SINR, 5'-D(*AP*AP*AP*GP*TP*TP*CP*TP*CP*TP*TP*TP*AP*GP *AP*GP*AP*AP*CP*AP*AP)-3', 5'-D(*AP*TP*TP*GP*TP*TP*CP*TP*CP*TP*AP*AP*AP*GP *AP*GP*AP*AP*CP*TP*TP)-3'
Authors:Newman, J.A., Rodrigues, C., Lewis, R.J.
Deposit date:2013-01-22
Release date:2013-03-06
Last modified:2013-05-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular Basis of the Activity of Sinr, the Master Regulator of Biofilm Formation in Bacillus Subtilis.
J.Biol.Chem., 288, 2013
3ZQ4
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UNUSUAL, DUAL ENDO- AND EXO-NUCLEASE ACTIVITY IN THE DEGRADOSOME EXPLAINED BY CRYSTAL STRUCTURE ANALYSIS OF RNASE J1
Descriptor:RIBONUCLEASE J 1, ZINC ION, CALCIUM ION
Authors:Newman, J.A., Hewitt, L., Rodrigues, C., Solovyova, A., Harwood, C.R., Lewis, R.J.
Deposit date:2011-06-07
Release date:2011-09-14
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Unusual, Dual Endo- and Exonuclease Activity in the Degradosome Explained by Crystal Structure Analysis of Rnase J1.
Structure, 19, 2011
4A3R
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CRYSTAL STRUCTURE OF ENOLASE FROM BACILLUS SUBTILIS.
Descriptor:ENOLASE, CITRIC ACID, SODIUM ION
Authors:Newman, J.A., Hewitt, L., Rodrigues, C., Solovyova, A.S., Harwood, C.R., Lewis, R.J.
Deposit date:2011-10-04
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dissection of the Network of Interactions that Links RNA Processing with Glycolysis in the Bacillus Subtilis Degradosome.
J.Mol.Biol., 416, 2012
4A3S
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CRYSTAL STRUCTURE OF PFK FROM BACILLUS SUBTILIS
Descriptor:6-PHOSPHOFRUCTOKINASE
Authors:Newman, J.A., Hewitt, L., Rodrigues, C., Solovyova, A.S., Harwood, C.R., Lewis, R.J.
Deposit date:2011-10-04
Release date:2012-08-15
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dissection of the Network of Interactions that Links RNA Processing with Glycolysis in the Bacillus Subtilis Degradosome.
J.Mol.Biol., 416, 2012
4BQA
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CRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETS2 IN COMPLEX WITH DNA
Descriptor:PROTEIN C-ETS-2, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3'
Authors:Newman, J.A., Cooper, C.D.O., Krojer, T., Arrowsmith, C.H., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2013-05-30
Release date:2013-06-12
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights Into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2.
J.Biol.Chem., 290, 2015
4CDG
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CRYSTAL STRUCTURE OF THE BLOOM'S SYNDROME HELICASE BLM IN COMPLEX WITH NANOBODY
Descriptor:BLOOM SYNDROME PROTEIN, NANOBODY, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Newman, J.A., Savitsky, P., Allerston, C.K., Pike, A.C.W., Pardon, E., Steyaert, J., Arrowsmith, C.H., von Delft, F., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2013-10-31
Release date:2013-11-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes.
Nucleic Acids Res., 43, 2015
4CGZ
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CRYSTAL STRUCTURE OF THE BLOOM'S SYNDROME HELICASE BLM IN COMPLEX WITH DNA
Descriptor:BLOOM'S SYNDROME HELICASE, 5'-D(*AP*GP*CP*GP*TP*CP*GP*AP*GP*AP*TP*CP)-3', 5'-D(*GP*AP*TP*CP*TP*CP*GP*AP*CP*GP*CP*TP*CP*DT *CP*CP*CP)-3', ...
Authors:Newman, J.A., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2013-11-27
Release date:2013-12-11
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes.
Nucleic Acids Res., 43, 2015
4CVO
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CRYSTAL STRUCTURE OF THE N-TERMINAL COLIED-COIL DOMAIN OF HUMAN DNA EXCISION REPAIR PROTEIN ERCC-6
Descriptor:DNA EXCISION REPAIR PROTEIN ERCC-6, MAGNESIUM ION
Authors:Newman, J.A., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2014-03-28
Release date:2014-04-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the N-Terminal Colied-Coil Domain of Human DNA Excision Repair Protein Ercc-6
To be Published
4MHV
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CRYSTAL STRUCTURE OF THE PNT DOMAIN OF HUMAN ETS2
Descriptor:Protein C-ets-2, CALCIUM ION, GLYCEROL, ...
Authors:Newman, J.A., Cooper, C.D.O., Krojer, T., Shrestha, L., Burgess-brown, N., Arrowsmith, C.H., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2013-08-30
Release date:2013-09-25
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the PNT domain of human ETS2
To be Published
4V0P
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CRYSTAL STRUCTURE OF THE MAGE HOMOLOGY DOMAIN OF HUMAN MAGE-A3
Descriptor:MELANOMA-ASSOCIATED ANTIGEN 3
Authors:Newman, J.A., Aitkenhead, H., Cooper, C.D.O., Pinkas, D.M., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2014-09-17
Release date:2014-10-01
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
Plos One, 11, 2016
5A9F
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CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF HUMAN DNA POLYMERASE THETA IN COMPLEX WITH ADP
Descriptor:DNA POLYMERASE THETA, ADENOSINE-5'-DIPHOSPHATE, POTASSIUM ION, ...
Authors:Newman, J.A., Cooper, C.D.O., Aitkenhead, H., Pinkas, D.M., Kupinska, K., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2015-07-21
Release date:2015-12-16
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
5A9J
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CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF HUMAN DNA POLYMERASE THETA, APO-FORM
Descriptor:DNA POLYMERASE THETA
Authors:Newman, J.A., Cooper, C.D.O., Aitkenhead, H., Pinkas, D.M., Kupinska, K., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2015-07-21
Release date:2015-12-16
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
5AGA
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CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF HUMAN DNA POLYMERASE THETA IN COMPLEX WITH AMPPNP
Descriptor:DNA POLYMERASE THETA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, CITRATE ANION, ...
Authors:Newman, J.A., Cooper, C.D.O., Aitkenhead, H., Pinkas, D.M., Kupinska, K., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2015-01-29
Release date:2015-02-25
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
5HVQ
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ALTERNATIVE MODEL OF THE MAGE-G1 NSE-1 COMPLEX
Descriptor:Melanoma-associated antigen G1, Non-structural maintenance of chromosomes element 1 homolog, ZINC ION
Authors:Newman, J.A., Cooper, C.D.O., Roos, A.K., Aitkenhead, H., Oppermann, U.C.T., Cho, H.J., Osman, R., Gileadi, O.
Deposit date:2016-01-28
Release date:2016-10-26
Method:X-RAY DIFFRACTION (2.923 Å)
Cite:Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
Plos One, 11, 2016
5LB3
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CRYSTAL STRUCTURE OF HUMAN RECQL5 HELICASE IN COMPLEX WITH ADP/MG.
Descriptor:ATP-dependent DNA helicase Q5, ZINC ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Newman, J.A., Aitkenhead, H., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Nucleic Acids Res., 45, 2017
5LB5
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CRYSTAL STRUCTURE OF HUMAN RECQL5 HELICASE IN COMPLEX WITH ADP/MG (TRICILINC FORM).
Descriptor:ATP-dependent DNA helicase Q5, ZINC ION, DIMETHYL SULFOXIDE, ...
Authors:Newman, J.A., Aitkenhead, H., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Nucleic Acids Res., 45, 2017
5LB8
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CRYSTAL STRUCTURE OF HUMAN RECQL5 HELICASE APO FORM.
Descriptor:ATP-dependent DNA helicase Q5, ZINC ION
Authors:Newman, J.A., Aitkenhead, H., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Nucleic Acids Res., 45, 2017
5LBA
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CRYSTAL STRUCTURE OF HUMAN RECQL5 HELICASE IN COMPLEX WITH DSPL FRAGMENT(1-CYCLOHEXYL-3-(OXOLAN-2-YLMETHYL)UREA, SGC - DIAMOND XCHEM I04-1 FRAGMENT SCREENING.
Descriptor:ATP-dependent DNA helicase Q5, MAGNESIUM ION, ZINC ION, ...
Authors:Newman, J.A., Aitkenhead, H., Talon, R., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O., Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human RECQL5 helicase in complex with 3D fragment (1-cyclohexyl-3-(oxolan-2-ylmethyl)urea)
To be published
5MR1
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CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF INTERACTOR PROTEIN FOR CYTOHESIN EXCHANGE FACTORS 1 (IPCEF1)
Descriptor:Interactor protein for cytohesin exchange factors 1
Authors:Newman, J.A., Aitkenhead, H., Wang, D., Burgess-Brown, N., Williams, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2016-12-21
Release date:2017-01-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of the Pleckstrin homology domain of Interactor protein for cytohesin exchange factors 1 (IPCEF1)
To be published
5NZW
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CRYSTAL STRUCTURE OF DNA CROSS-LINK REPAIR PROTEIN 1A IN COMPLEX WITH CEFTRIAXONE
Descriptor:DNA cross-link repair 1A protein, NICKEL (II) ION, Ceftriaxone
Authors:Newman, J.A., Aitkenhead, H., Kupinska, K., Burgess-Brown, N.A., Talon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2017-06-14
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of DNA cross-link repair protein 1A in complex with ceftriaxone
To Be Published
5NZX
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CRYSTAL STRUCTURE OF DNA CROSS-LINK REPAIR PROTEIN 1A IN COMPLEX WITH CEFTRIAXONE (ALTERNATIVE SITE)
Descriptor:DNA cross-link repair 1A protein, NICKEL (II) ION, Ceftriaxone
Authors:Newman, J.A., Aitkenhead, H., Kupinska, K., Burgess-Brown, N.A., Talon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2017-06-14
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Crystal structure of DNA cross-link repair protein 1A in complex with Ceftriaxone (alternative site)
To Be Published
5NZY
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CRYSTAL STRUCTURE OF DNA CROSS-LINK REPAIR PROTEIN 1A IN COMPLEX WITH CEFOTAXIME
Descriptor:DNA cross-link repair 1A protein, NICKEL (II) ION, (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Authors:Newman, J.A., Aitkenhead, H., Kupinska, K., Burgess-Brown, N.A., Talon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2017-06-14
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:To Be published
To Be Published
5OCN
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CRYSTAL STRUCTURE OF THE FORKHEAD DOMAIN OF HUMAN FOXN1
Descriptor:Forkhead box protein N1, POTASSIUM ION
Authors:Newman, J.A., Aitkenhead, H., Pinkas, D.M., von Delft, F., Arrowsmith, C.H., Edwwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-07-03
Release date:2017-08-02
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the forkhead domain of human FOXN1
To be published
5Q1J
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF DCLRE1A IN COMPLEX WITH FMSOA000341B
Descriptor:DNA cross-link repair 1A protein, MALONATE ION, NICKEL (II) ION, ...
Authors:Newman, J.A., Aitkenhead, H., Lee, S.Y., Kupinska, K., Burgess-Brown, N., Tallon, R., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2017-05-15
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:PanDDA analysis group deposition
To Be Published