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3DIF
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BU of 3dif by Molmil
Crystal structure of FabOX117
Descriptor: FabOX117 Heavy Chain Fragment, FabOX117 Light Chain Fragment
Authors:Nettleship, J.E, Ren, J, Owens, R.J, Oxford Protein Production Facility (OPPF)
Deposit date:2008-06-20
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A pipeline for the production of antibody fragments for structural studies using transient expression in HEK 293T cells.
Protein Expr.Purif., 62, 2008
4I2X
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Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, FabOX117 heavy chain, ...
Authors:Nettleship, J.E, Ren, J, Stuart, D.I, Owens, R.J, Oxford Protein Production Facility (OPPF)
Deposit date:2012-11-23
Release date:2013-12-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal structure of signal regulatory protein gamma (SIRP gamma) in complex with an antibody Fab fragment.
Bmc Struct.Biol., 13, 2013
3DGG
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BU of 3dgg by Molmil
Crystal structure of FabOX108
Descriptor: FabOX108 Heavy Chain Fragment, FabOX108 Light Chain Fragment, MAGNESIUM ION
Authors:Ren, J, Nettleship, J.E, Owens, R.J, Oxford Protein Production Facility (OPPF)
Deposit date:2008-06-13
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A pipeline for the production of antibody fragments for structural studies using transient expression in HEK 293T cells.
Protein Expr.Purif., 62, 2008
4KQQ
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid
Descriptor: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J.
Deposit date:2013-05-15
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Acs Chem.Biol., 8, 2013
4KQO
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Crystal structure of penicillin-binding protein 3 from pseudomonas aeruginosa in complex with piperacillin
Descriptor: CHLORIDE ION, GLYCEROL, IMIDAZOLE, ...
Authors:Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J.
Deposit date:2013-05-15
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Acs Chem.Biol., 8, 2013
4KQR
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-Penicilloic Acid
Descriptor: (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Nettleship, J.E, Stuart, D.I, Owens, R.J, Ren, J.
Deposit date:2013-05-15
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Acs Chem.Biol., 8, 2013
4UXH
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Leishmania major Thymidine Kinase in complex with AP5dT
Descriptor: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, THYMIDINE KINASE, ZINC ION
Authors:Timm, J, Bosch-Navarrete, C, Recio, E, Nettleship, J.E, Rada, H, Gonzalez-Pacanowska, D, Wilson, K.S.
Deposit date:2014-08-22
Release date:2015-05-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
Plos Negl Trop Dis, 9, 2015
4UXI
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Leishmania major Thymidine Kinase in complex with thymidine
Descriptor: PHOSPHATE ION, THYMIDINE, THYMIDINE KINASE, ...
Authors:Timm, J, Bosch-Navarrete, C, Recio, E, Nettleship, J.E, Rada, H, Gonzalez-Pacanowska, D, Wilson, K.S.
Deposit date:2014-08-22
Release date:2015-05-27
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
Plos Negl Trop Dis, 9, 2015
4UXJ
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Leishmania major Thymidine Kinase in complex with dTTP
Descriptor: MAGNESIUM ION, THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Timm, J, Bosch-Navarrete, C, Recio, E, Nettleship, J.E, Rada, H, Gonzalez-Pacanowska, D, Wilson, K.S.
Deposit date:2014-08-22
Release date:2015-05-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
Plos Negl Trop Dis, 9, 2015
7OFZ
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BU of 7ofz by Molmil
Nontypeable Haemophillus influenzae SapA in complex with double stranded RNA
Descriptor: ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance, ...
Authors:Lukacik, P, Owen, C.D, Nettleship, J.E, Bird, L.E, Owens, R.J, Walsh, M.A.
Deposit date:2021-05-05
Release date:2021-10-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif.
Plos One, 16, 2021
7OG0
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Nontypeable Haemophillus influenzae SapA in open and closed conformations, in complex with double stranded RNA
Descriptor: ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance, ...
Authors:Lukacik, P, Owen, C.D, Nettleship, J.E, Bird, L.E, Owens, R.J, Walsh, M.A.
Deposit date:2021-05-05
Release date:2021-10-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif.
Plos One, 16, 2021
7OFW
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BU of 7ofw by Molmil
Nontypeable Haemophillus influenzae SapA in complex with heme
Descriptor: ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance, ...
Authors:Lukacik, P, Owen, C.D, Nettleship, J.E, Bird, L.E, Owens, R.J, Walsh, M.A.
Deposit date:2021-05-05
Release date:2021-10-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif.
Plos One, 16, 2021
2A0J
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BU of 2a0j by Molmil
Crystal Structure of Nitrogen Regulatory Protein IIA-Ntr from Neisseria meningitidis
Descriptor: PTS system, nitrogen regulatory IIA protein
Authors:Ren, J, Sainsbury, S, Berrow, N.S, Alderton, D, Nettleship, J.E, Stammers, D.K, Saunders, N.J, Owens, R.J, Oxford Protein Production Facility (OPPF)
Deposit date:2005-06-16
Release date:2005-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of nitrogen regulatory protein IIANtr from Neisseria meningitidis
Bmc Struct.Biol., 5, 2005
3KXA
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BU of 3kxa by Molmil
Crystal Structure of NGO0477 from Neisseria gonorrhoeae
Descriptor: ASPARAGINE, CHLORIDE ION, Putative uncharacterized protein, ...
Authors:Ren, J, Sainsbury, S, Nettleship, J.E, Owens, R.J, Oxford Protein Production Facility (OPPF)
Deposit date:2009-12-02
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of NGO0477 from Neisseria gonorrhoeae reveals a novel protein fold incorporating a helix-turn-helix motif.
Proteins, 78, 2010
5IOM
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BU of 5iom by Molmil
Crystal Structure of Nucleoside Diphosphate Kinase from Schistosoma mansoni is space group P6322
Descriptor: Nucleoside diphosphate kinase
Authors:Torini, J.R.S, Romanello, L, Bird, L.E, Nettleship, J.E, Owens, R.J, Aller, P, DeMarco, R, Brandao-Neto, J, Pereira, H.M.
Deposit date:2016-03-08
Release date:2017-08-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of a Schistosoma mansoni NDPK expressed in sexual and digestive organs.
Mol.Biochem.Parasitol., 2019
5IOL
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BU of 5iol by Molmil
Crystal structure of Nucleoside Diphosphate Kinase from Schistosoma mansoni
Descriptor: Nucleoside diphosphate kinase
Authors:Torini, J.R.S, Romanello, L, Bird, L.E, Nettleship, J.E, Owens, R.J, Aller, P, DeMarco, R, Brandao-Neto, J, Pereira, H.M.
Deposit date:2016-03-08
Release date:2017-03-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.741 Å)
Cite:Characterization of a Schistosoma mansoni NDPK expressed in sexual and digestive organs.
Mol.Biochem.Parasitol., 2019
6QNA
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BU of 6qna by Molmil
Structure of bovine anti-RSV hybrid Fab B13HC-B4LC
Descriptor: B13 Heavy chain, B4 light chain, GLYCEROL
Authors:Ren, J, Nettleship, J.E, Harris, G, Mwangi, W, Rhaman, N, Grant, C, Kotecha, A, Fry, E, Charleston, B, Stuart, D.I, Hammond, J, Owens, R.J.
Deposit date:2019-02-10
Release date:2019-05-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus.
Mol.Immunol., 112, 2019
6QN9
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BU of 6qn9 by Molmil
Structure of bovine anti-RSV Fab B4
Descriptor: GLYCEROL, Heavy chain, SULFATE ION, ...
Authors:Ren, J, Nettleship, J.E, Harris, G, Mwangi, W, Rhaman, N, Grant, C, Kotecha, A, Fry, E, Charleston, B, Stuart, D.I, Hammond, J, Owens, R.J.
Deposit date:2019-02-10
Release date:2019-05-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus.
Mol.Immunol., 112, 2019
6QN7
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BU of 6qn7 by Molmil
Structure of bovine anti-RSV hybrid Fab B4HC-B13LC
Descriptor: Heavy chain of bovine anti-RSV B4, Light chain of bovine anti-RSV B13
Authors:Ren, J, Nettleship, J.E, Harris, G, Mwangi, W, Rhaman, N, Grant, C, Kotecha, A, Fry, E, Charleston, B, Stuart, D.I, Hammond, J, Owens, R.J.
Deposit date:2019-02-10
Release date:2019-05-29
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus.
Mol.Immunol., 112, 2019
6QN8
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Structure of bovine anti-RSV Fab B13
Descriptor: CHLORIDE ION, Heavy chain of bovine anti-RSV B13 Fab, Light chain of bovine anti-RSV Fab B13
Authors:Ren, J, Nettleship, J.E, Harris, G, Mwangi, W, Rhaman, N, Grant, C, Kotecha, A, Fry, E, Charleston, B, Stuart, D.I, Hammond, J, Owens, R.J.
Deposit date:2019-02-10
Release date:2019-05-29
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus.
Mol.Immunol., 112, 2019
5IPF
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BU of 5ipf by Molmil
Crystal structure of Hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni in complex with IMP
Descriptor: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT), INOSINIC ACID
Authors:Romanello, L, Torini, J.R.S, Bird, L.E, Nettleship, J.E, Owens, R.J, DeMarco, R, Pereira, H.M, Brandao-Neto, J.
Deposit date:2016-03-09
Release date:2017-03-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferases.
Mol. Biochem. Parasitol., 229, 2019
4YU8
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BU of 4yu8 by Molmil
Crystal structure of Neuroblastoma suppressor of tumorigenicity 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Neuroblastoma suppressor of tumorigenicity 1
Authors:Ren, J, Nettleship, J.E, Stammers, D.K, Owens, R.J, Oxford Protein Production Facility (OPPF)
Deposit date:2015-03-18
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of Neuroblastoma suppressor of tumorigenicity 1
To Be Published
5KK8
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Crystal structure of Nucleoside Diphosphate Kinase from Schistosoma mansoni in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase
Authors:Torini, J.R.S, Romanello, L, Bird, L.E, Nettleship, J.E, Owens, R.J, Aller, P, DeMarco, R, Brandao-Neto, J, Pereira, H.M.
Deposit date:2016-06-21
Release date:2017-06-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Characterization of a Schistosoma mansoni NDPK expressed in sexual and digestive organs.
Mol.Biochem.Parasitol., 2019
5ML9
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Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Affimer F4 with specificity for Fc gamma receptor IIIa, CHLORIDE ION, ...
Authors:Robinson, J.I, Tomlinson, D.C, Baxter, E.W, Owen, R.L, Thomsen, M, Win, S.J, Nettleship, J.E, Tiede, C, Foster, R.J, Waterhouse, M.P, Harris, S.A, Owens, R.J, Fishwick, C.W.G, Goldman, A, McPherson, M.J, Morgan, A.W.
Deposit date:2016-12-06
Release date:2017-12-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5MN2
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Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Affimer G3, DI(HYDROXYETHYL)ETHER, ...
Authors:Robinson, J.I, Owen, R.L, Tomlinson, D.C, Baxter, E.W, Nettleship, J.E, Waterhouse, M.P, Harris, S.A, Owens, R.J, McPherson, M.J, Morgan, A.W, Tiede, C, Goldman, A, Thomsen, M.
Deposit date:2016-12-12
Release date:2017-12-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018

 

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