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3DIF
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CRYSTAL STRUCTURE OF FABOX117
Descriptor:FabOX117 Light Chain Fragment, FabOX117 Heavy Chain Fragment
Authors:Nettleship, J.E., Ren, J., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2008-06-20
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A pipeline for the production of antibody fragments for structural studies using transient expression in HEK 293T cells.
Protein Expr.Purif., 62, 2008
4I2X
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CRYSTAL STRUCTURE OF SIGNAL REGULATORY PROTEIN GAMMA (SIRP-GAMMA) IN COMPLEX WITH FABOX117
Descriptor:FabOX117 light chain, FabOX117 heavy chain, Signal-regulatory protein gamma, ...
Authors:Nettleship, J.E., Ren, J., Stuart, D.I., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2012-11-23
Release date:2013-12-18
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal structure of signal regulatory protein gamma (SIRP gamma) in complex with an antibody Fab fragment.
Bmc Struct.Biol., 13, 2013
3DGG
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CRYSTAL STRUCTURE OF FABOX108
Descriptor:FabOX108 Light Chain Fragment, FabOX108 Heavy Chain Fragment, MAGNESIUM ION
Authors:Ren, J., Nettleship, J.E., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2008-06-13
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A pipeline for the production of antibody fragments for structural studies using transient expression in HEK 293T cells.
Protein Expr.Purif., 62, 2008
4KQO
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH PIPERACILLIN
Descriptor:Penicillin-binding protein 3, Piperacillin (Open Form), GLYCEROL, ...
Authors:Nettleship, J.E., Stuart, D.I., Owens, R.J., Ren, J.
Deposit date:2013-05-15
Release date:2013-11-06
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Acs Chem.Biol., 8, 2013
4KQQ
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-PENICILLOIC ACID
Descriptor:Penicillin-binding protein 3, (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, ...
Authors:Nettleship, J.E., Stuart, D.I., Owens, R.J., Ren, J.
Deposit date:2013-05-15
Release date:2013-11-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Acs Chem.Biol., 8, 2013
4KQR
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH (5S)-PENICILLOIC ACID
Descriptor:Penicillin-binding protein 3, (2S,4S)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, ...
Authors:Nettleship, J.E., Stuart, D.I., Owens, R.J., Ren, J.
Deposit date:2013-05-15
Release date:2013-11-06
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
Acs Chem.Biol., 8, 2013
2A0J
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CRYSTAL STRUCTURE OF NITROGEN REGULATORY PROTEIN IIA-NTR FROM NEISSERIA MENINGITIDIS
Descriptor:PTS system, nitrogen regulatory IIA protein
Authors:Ren, J., Sainsbury, S., Berrow, N.S., Alderton, D., Nettleship, J.E., Stammers, D.K., Saunders, N.J., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2005-06-16
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of nitrogen regulatory protein IIANtr from Neisseria meningitidis
Bmc Struct.Biol., 5, 2005
2UVD
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THE CRYSTAL STRUCTURE OF A 3-OXOACYL-(ACYL CARRIER PROTEIN) REDUCTASE FROM BACILLUS ANTHRACIS (BA3989)
Descriptor:3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE
Authors:Zaccai, N.R., Carter, L.G., Berrow, N.S., Sainsbury, S., Nettleship, J.E., Walter, T.S., Harlos, K., Owens, R.J., Wilson, K.S., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2007-03-09
Release date:2007-04-17
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of a 3-Oxoacyl-(Acylcarrier Protein) Reductase (Ba3989) from Bacillus Anthracis at 2.4-A Resolution.
Proteins: Struct., Funct., Bioinf., 70, 2008
2VD8
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THE CRYSTAL STRUCTURE OF ALANINE RACEMASE FROM BACILLUS ANTHRACIS (BA0252)
Descriptor:ALANINE RACEMASE, PYRIDOXAL-5'-PHOSPHATE, MAGNESIUM ION, ...
Authors:Au, K., Ren, J., Walter, T.S., Harlos, K., Nettleship, J.E., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2007-10-01
Release date:2008-05-20
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structures of an Alanine Racemase from Bacillus Anthracis (Ba0252) in the Presence and Absence of (R)-1-Aminoethylphosphonic Acid (L-Ala-P).
Acta Crystallogr.,Sect.F, 64, 2008
2VD9
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THE CRYSTAL STRUCTURE OF ALANINE RACEMASE FROM BACILLUS ANTHRACIS (BA0252) WITH BOUND L-ALA-P
Descriptor:ALANINE RACEMASE, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Au, K., Ren, J., Walter, T.S., Harlos, K., Nettleship, J.E., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2007-10-01
Release date:2008-05-20
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of an Alanine Racemase from Bacillus Anthracis (Ba0252) in the Presence and Absence of (R)-1-Aminoethylphosphonic Acid (L-Ala-P).
Acta Crystallogr.,Sect.F, 64, 2008
2WO1
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CRYSTAL STRUCTURE OF THE EPHA4 LIGAND BINDING DOMAIN
Descriptor:EPHRIN TYPE-A RECEPTOR, N-PROPANOL
Authors:Bowden, T.A., Aricescu, A.R., Nettleship, J.E., Siebold, C., Rahman-Huq, N., Owens, R.J., Stuart, D.I., Jones, E.Y.
Deposit date:2009-07-21
Release date:2009-10-27
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling
Structure, 17, 2009
2WO2
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CRYSTAL STRUCTURE OF THE EPHA4-EPHRINB2 COMPLEX
Descriptor:EPHRIN TYPE-A RECEPTOR, EPHRIN-B2, N-ACETYL-D-GLUCOSAMINE
Authors:Bowden, T.A., Aricescu, A.R., Nettleship, J.E., Siebold, C., Rahman-Huq, N., Owens, R.J., Stuart, D.I., Jones, E.Y.
Deposit date:2009-07-21
Release date:2009-10-27
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling
Structure, 17, 2009
2WO3
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CRYSTAL STRUCTURE OF THE EPHA4-EPHRINA2 COMPLEX
Descriptor:EPHRIN TYPE-A RECEPTOR, EPHRIN-A2, N-ACETYL-D-GLUCOSAMINE
Authors:Bowden, T.A., Aricescu, A.R., Nettleship, J.E., Siebold, C., Rahman-Huq, N., Owens, R.J., Stuart, D.I., Jones, E.Y.
Deposit date:2009-07-21
Release date:2009-10-27
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling
Structure, 17, 2009
2Y7Q
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THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI
Descriptor:HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA, IG EPSILON CHAIN C REGION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Davies, A.M., Holdom, M.D., Nettleship, J.E., Beavil, A.J., Owens, R.J., Sutton, B.J.
Deposit date:2011-02-01
Release date:2011-04-20
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri
Nat.Struct.Mol.Biol., 18, 2011
3KXA
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CRYSTAL STRUCTURE OF NGO0477 FROM NEISSERIA GONORRHOEAE
Descriptor:Putative uncharacterized protein, ASPARAGINE, CHLORIDE ION, ...
Authors:Ren, J., Sainsbury, S., Nettleship, J.E., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2009-12-02
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of NGO0477 from Neisseria gonorrhoeae reveals a novel protein fold incorporating a helix-turn-helix motif.
Proteins, 78, 2010
4N6T
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ADHIRON: A STABLE AND VERSATILE PEPTIDE DISPLAY SCAFFOLD - FULL LENGTH ADHIRON
Descriptor:Adhiron
Authors:Mcpherson, M., Tomlinson, D., Owen, R.L., Nettleship, J.E., Owens, R.J.
Deposit date:2013-10-14
Release date:2014-04-09
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications.
Protein Eng.Des.Sel., 27, 2014
4N6U
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ADHIRON: A STABLE AND VERSATILE PEPTIDE DISPLAY SCAFFOLD - TRUNCATED ADHIRON
Descriptor:Adhiron
Authors:Mcpherson, M., Tomlinson, D., Owen, R.L., Nettleship, J.E., Owens, R.J.
Deposit date:2013-10-14
Release date:2014-04-09
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications.
Protein Eng.Des.Sel., 27, 2014
4UXH
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LEISHMANIA MAJOR THYMIDINE KINASE IN COMPLEX WITH AP5DT
Descriptor:THYMIDINE KINASE, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, ZINC ION
Authors:Timm, J., Bosch-Navarrete, C., Recio, E., Nettleship, J.E., Rada, H., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2014-08-22
Release date:2015-05-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
Plos Negl Trop Dis, 9, 2015
4UXI
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LEISHMANIA MAJOR THYMIDINE KINASE IN COMPLEX WITH THYMIDINE
Descriptor:THYMIDINE KINASE, PHOSPHATE ION, THYMIDINE, ...
Authors:Timm, J., Bosch-Navarrete, C., Recio, E., Nettleship, J.E., Rada, H., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2014-08-22
Release date:2015-05-27
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
Plos Negl Trop Dis, 9, 2015
4UXJ
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LEISHMANIA MAJOR THYMIDINE KINASE IN COMPLEX WITH DTTP
Descriptor:THYMIDINE KINASE, ZINC ION, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Timm, J., Bosch-Navarrete, C., Recio, E., Nettleship, J.E., Rada, H., Gonzalez-Pacanowska, D., Wilson, K.S.
Deposit date:2014-08-22
Release date:2015-05-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
Plos Negl Trop Dis, 9, 2015
4YU8
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CRYSTAL STRUCTURE OF NEUROBLASTOMA SUPPRESSOR OF TUMORIGENICITY 1
Descriptor:Neuroblastoma suppressor of tumorigenicity 1, GLYCEROL, N-ACETYL-D-GLUCOSAMINE
Authors:Ren, J., Nettleship, J.E., Stammers, D.K., Owens, R.J., Oxford Protein Production Facility (OPPF)
Deposit date:2015-03-18
Release date:2015-03-25
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of Neuroblastoma suppressor of tumorigenicity 1
To Be Published
5ANQ
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INHIBITORS OF JUMONJIC DOMAIN-CONTAINING HISTONE DEMETHYLASES
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, 2-{2-[(pyridin-3-ylmethyl)amino]pyrimidin-4-yl}pyridine-4-carboxylic acid, FE (II) ION, ...
Authors:Roatsch, M., Robaa, D., Pippel, M., Nettleship, J.E., Reddivari, Y., Bird, L.E., Hoffmann, I., Franz, H., Owens, R.J., Schuele, R., Flaig, R., Sippl, W., Jung, M.
Deposit date:2015-09-07
Release date:2016-03-23
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substituted 2-(2-Aminopyrimidin-4-Yl)Pyridine-4-Carboxylates as Potent Inhibitors of Jumonjic Domain-Containing Histone Demethylases.
Fut.Med.Chem., 8, 2016
5DF7
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH AZLOCILLIN
Descriptor:Cell division protein, (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxo-1-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}ethyl]-1,3-thiazolidine-4-carboxylic acid, GLYCEROL, ...
Authors:Ren, J., Nettleship, J.E., Males, A., Stuart, D.I., Owens, R.J.
Deposit date:2015-08-26
Release date:2016-01-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.
Febs Lett., 590, 2016
5DF8
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH CEFOPERAZONE
Descriptor:Cell division protein, (2R,4R,5R)-2-[(1R)-1-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-2-oxoethyl]-5-methyl-1,3-thiazinane-4-carboxylic acid, GLYCEROL, ...
Authors:Ren, J., Nettleship, J.E., Males, A., Stuart, D.I., Owens, R.J.
Deposit date:2015-08-26
Release date:2016-01-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.
Febs Lett., 590, 2016
5DF9
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 IN COMPLEX WITH DEACYLATED PRODUCT OF CEFOPERAZONE
Descriptor:Cell division protein, SULFATE ION, (2R,5R)-2-[(R)-carboxy{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}methyl]-5-methyl-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ...
Authors:Ren, J., Nettleship, J.E., Males, A., Stuart, D.I., Owens, R.J.
Deposit date:2015-08-26
Release date:2016-01-13
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of penicillin-binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms.
Febs Lett., 590, 2016
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