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3U9H
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COMPLEX STRUCTURE OF HUMAN TANKYRASE 2 WITH NICOTINAMIDE
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Lehtio, L.
Deposit date:2011-10-19
Release date:2011-11-02
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis of selective inhibition of human tankyrases.
J.Med.Chem., 55, 2012
3U9Y
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 CATALYTIC DOMAIN IN COMPLEX WITH OLAPARIB
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Lehtio, L.
Deposit date:2011-10-20
Release date:2012-01-25
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of selective inhibition of human tankyrases.
J.Med.Chem., 55, 2012
3UA9
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH A SELECTIVE INHIBITOR
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Lehtio, L.
Deposit date:2011-10-21
Release date:2012-01-25
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis of selective inhibition of human tankyrases.
J.Med.Chem., 55, 2012
4AVU
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 6(5H)- PHENANTHRIDINONE
Descriptor:TANKYRASE-2, ZINC ION, SULFATE ION, ...
Authors:Haikarainen, T., Narwal, M., Lehtio, L.
Deposit date:2012-05-29
Release date:2012-06-13
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors
Acs Med.Chem.Lett., 5, 2014
4AVW
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH TIQ-A
Descriptor:TANKYRASE-2, 4H-thieno[2,3-c]isoquinolin-5-one, ZINC ION, ...
Authors:Haikarainen, T., Narwal, M., Lehtio, L.
Deposit date:2012-05-29
Release date:2012-06-13
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors
Acs Med.Chem.Lett., 5, 2014
4HKI
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TANKYRASE 2 IN COMPLEX WITH FLAVONE
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-15
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HKK
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COMPLEX STRUCTURE OF HUMAN TANKYRASE 2 WITH APIGENIN
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-15
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HKN
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COMPLEX STRUCTURE OF HUMAN TANKYRASE 2 WITH LUTEOLIN
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-15
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HL5
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COMPLEX STRUCTURE OF HUMAN TANKYRASE 2 WITH 7-HYDROXY -4'-METHOXYFLAVONE
Descriptor:Tankyrase-2, SULFATE ION, ZINC ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-16
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLF
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CRYSTAL STRUCTURE OF TANKYRASE 2 IN COMPLEX WITH 7,3',4'-TRIHYDROXYFLAVONE
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLG
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CRYSTAL STRUCTURE OF TANKYRASE 2 IN COMPLEX WITH 3'-HYDROXYFLAVONE
Descriptor:Tankyrase-2, SULFATE ION, 2-(3-hydroxyphenyl)-4H-chromen-4-one, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLH
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CRYSTAL STRUCTURE OF TANKYRASE 2 IN COMPLEX WITH 4'-FLUOROFLAVONE
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLK
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CRYSTAL STRUCTURE OF TANKYRASE 2 IN COMPLEX WITH 4'-METHYLFLAVONE
Descriptor:Tankyrase-2, SULFATE ION, 2-(4-methylphenyl)-4H-chromen-4-one, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLM
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CRYSTAL STRUCTURE OF TANKYRASE 2 IN COMPLEX WITH 3',4'-DIHYDROXYFLAVONE
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HMH
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CRYSTAL STRUCTURE OF TANKYRASE 2 IN COMPLEX WITH 7,3-DIHYDROXYFLAVONE
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2012-10-18
Release date:2012-10-31
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4BFP
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH WIKI4
Descriptor:TANKYRASE-2, 2-[3-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propyl]benzo[de]isoquinoline-1,3-dione, SULFATE ION, ...
Authors:Haikarainen, T., Narwal, M., Lehtio, L.
Deposit date:2013-03-21
Release date:2013-06-19
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor Wiki4
Plos One, 8, 2013
4BJ9
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH EB-47
Descriptor:TANKYRASE-2, ZINC ION, SULFATE ION, ...
Authors:Haikarainen, T., Narwal, M., Lehtio, L.
Deposit date:2013-04-17
Release date:2013-12-11
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors
Acs Med.Chem.Lett., 5, 2014
4BJB
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH PJ-34
Descriptor:TANKYRASE-2, SULFATE ION, GLYCEROL, ...
Authors:Haikarainen, T., Narwal, M., Lehtio, L.
Deposit date:2013-04-17
Release date:2013-12-11
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors.
Acs Med.Chem.Lett., 5, 2014
4BJC
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH RUCAPARIB
Descriptor:TANKYRASE-2, Rucaparib, SULFATE ION, ...
Authors:Haikarainen, T., Narwal, M., Lehtio, L.
Deposit date:2013-04-18
Release date:2013-12-11
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors
Acs Med.Chem.Lett., 5, 2014
4KZL
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 4'-FLUORO FLAVONE
Descriptor:Tankyrase-2, 2-(4-fluorophenyl)-4H-chromen-4-one, ZINC ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2013-05-30
Release date:2013-10-30
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4KZQ
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 4' -HYDROXY FLAVONE
Descriptor:Tankyrase-2, 2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE, ZINC ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2013-05-30
Release date:2013-10-30
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4KZU
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 4' -BROMO FLAVONE
Descriptor:Tankyrase-2, 2-(4-bromophenyl)-4H-chromen-4-one, ZINC ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2013-05-30
Release date:2013-10-30
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L09
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CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH 4-(4-OXO-4H-CHROMEN-2-YL)BENZOIC ACID
Descriptor:Tankyrase-2, 4-(4-oxo-4H-chromen-2-yl)benzoic acid, ZINC ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2013-05-31
Release date:2013-10-30
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L0B
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TANKYRASE 2 IN COMPLEX WITH 4'-DIMETHYLAMINO FLAVONE
Descriptor:Tankyrase-2, ZINC ION, SULFATE ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2013-05-31
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L0I
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TANKYRASE 2 CATALYTIC DOMAIN IN COMPLEX WITH ETHYL 4-(4-OXO-4H-CHROMEN-2-YL)BENZOATE
Descriptor:Tankyrase-2, ethyl 4-(4-oxo-4H-chromen-2-yl)benzoate, ZINC ION, ...
Authors:Narwal, M., Haikarainen, T., Lehtio, L.
Deposit date:2013-05-31
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013