Search by PDB author

Solution structure of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis. Seattle Structural Genomics Center for Infectious Disease target MytuD.01635.a
Descriptor:	Rubredoxin, ZINC ION
Authors:	Buchko, G.W, Hewitt, S.N, Napuli, A.J, Van Voorhis, W.C, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-08-20
Release date:	2009-09-15
Last modified:	2011-09-21
Method:	SOLUTION NMR
Cite:	Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.F, 67, 2011

2KOK

Solution structure of an arsenate reductase (ArsC) related protein from Brucella melitensis. Seattle Structural Genomics Center for Infectious Disease target BrabA.00007.a.
Descriptor:	arsenate reductase
Authors:	Buchko, G.W, Hewitt, S.N, Napuli, A.J, Van Voorhis, W.C, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-09-23
Release date:	2009-10-13
Last modified:	2023-06-14
Method:	SOLUTION NMR
Cite:	Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis, the etiological agent responsible for brucellosis. Acta Crystallogr.,Sect.F, 67, 2011

6UHW

Solution structure of an organic hydroperoxide resistance protein from Burkholderia pseudomallei. Seattle Structural Genomics Center for Infectious Disease target BupsA.00074.a.
Descriptor:	Organic hydroperoxide resistance protein
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2019-09-29
Release date:	2019-10-16
Last modified:	2023-06-14
Method:	SOLUTION NMR
Cite:	Backbone and side chain (1)H, (13)C, and (15)N NMR assignments for the organic hydroperoxide resistance protein (Ohr) from Burkholderia pseudomallei. Biomol.Nmr Assign., 3, 2009

3BJE

Crystal structure of Trypanosoma brucei nucleoside phosphorylase shows uridine phosphorylase activity
Descriptor:	1-O-phosphono-alpha-D-ribofuranose, CALCIUM ION, Nucleoside phosphorylase, ...
Authors:	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-12-03
Release date:	2007-12-18
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.44 Å)
Cite:	The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase J.Mol.Biol., 396, 2010

4WG5

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647
Descriptor:	5-amino-3-[7-(cyclobutyloxy)quinolin-3-yl]-1-cyclohexyl-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-09-17
Release date:	2014-10-15
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647 to be published

4WG3

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610
Descriptor:	3-(7-ethoxynaphthalen-2-yl)-1-(2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-09-17
Release date:	2014-10-15
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610 to be published

4WG4

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613
Descriptor:	3-(7-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-09-17
Release date:	2014-10-15
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613 to be published

4O2D

Crystal structure of aspartyl-tRNA synthetase from Mycobacterium smegmatis with bound aspartic acid
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ASPARTIC ACID, Aspartate--tRNA ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2013-12-17
Release date:	2014-01-22
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4TZR

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1561
Descriptor:	1-{4-amino-3-[2-(cyclopropyloxy)quinolin-6-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-07-10
Release date:	2014-08-27
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. J. Med. Chem., 59, 2016

2KZ0

Solution structure of a BolA protein (ECH_0303) from Ehrlichia chaffeensis. Seattle Structural Genomics Center for Infectious Disease target EhchA.10365.a
Descriptor:	BolA family protein
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2010-06-10
Release date:	2010-06-23
Last modified:	2022-03-16
Method:	SOLUTION NMR
Cite:	Structural characterization of a BolA protein (ECH_0303) from Ehrlichia chaffeensis, the agent responsible for human monocytotropic ehrlichiosis. To be Published

2LPD

Solution structure of a MbtH-like protein from Burkholderia pseudomallei, the etiological agent responsible for melioidosis, Seattle Structural Genomics Center for Infectious Disease target BupsA.13472.b
Descriptor:	Uncharacterized protein
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-02-10
Release date:	2012-02-22
Last modified:	2023-06-14
Method:	SOLUTION NMR
Cite:	Solution structure of a MbtH-like protein from Burkholderia pseudomallei, the etiological agent responsible for melioidosis To be Published

2LXF

Solution NMR structure of a potential acylphosphatase from Giardia lamblia, Seattle Structural Genomics Center for Infectious Disease target GilaA.01396.a
Descriptor:	Uncharacterized protein
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-08-20
Release date:	2012-09-12
Last modified:	2023-06-14
Method:	SOLUTION NMR
Cite:	Solution structure of an acylphosphatase from Giardia lamblia, the etiological agent responsible for giardiasis To be Published

5EJ2

Crystal structure of Carveol dehydrogenase from Mycobacterium avium in complex with NAD
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, Carveol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-10-31
Release date:	2015-12-02
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors. Sci Rep, 7, 2017

3HGB

Crystal structure of glycine cleavage system protein H from Mycobacterium tuberculosis
Descriptor:	Glycine cleavage system H protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-05-13
Release date:	2009-05-26
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source. J.Struct.Funct.Genom., 11, 2010

4YSJ

Calcium-Dependent Protein Kinase from Eimeria tenella in complex with ADP
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin-like domain protein kinase, ...
Authors:	Merritt, E.A.
Deposit date:	2015-03-17
Release date:	2016-04-06
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

4YJN

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1639
Descriptor:	5-amino-1-tert-butyl-3-[2-(cyclobutyloxy)quinolin-6-yl]-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2015-03-03
Release date:	2015-11-25
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. Acs Med.Chem.Lett., 6, 2015

3CXK

1.7 A Crystal structure of methionine-R-sulfoxide reductase from Burkholderia pseudomallei: crystallization in a microfluidic crystal card.
Descriptor:	ACETATE ION, Methionine-R-sulfoxide reductase, ZINC ION
Authors:	Lovell, S, Gerdts, C, Staker, B, Craigen, D, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2008-04-24
Release date:	2008-05-27
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS). Acta Crystallogr.,Sect.D, 64, 2008

3FOC

Tryptophanyl-tRNA synthetase from Giardia lamblia
Descriptor:	GLYCEROL, SULFATE ION, Tryptophanyl-tRNA synthetase
Authors:	Arakaki, T.L, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2008-12-29
Release date:	2009-01-13
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.09 Å)
Cite:	The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. J.Struct.Biol., 171, 2010

3GVC

Crystal structure of probable short-chain dehydrogenase-reductase from Mycobacterium tuberculosis
Descriptor:	Probable short-chain type dehydrogenase/reductase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-03-30
Release date:	2009-04-07
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4GK6

X-ray crystal structure of a hypothetical deoxyuridine 5-triphosphate nucleotidohydrolase from Mycobacterium abscessus
Descriptor:	CHLORIDE ION, Deoxyuridine 5'-triphosphate nucleotidohydrolase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-08-10
Release date:	2012-12-19
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4HDT

Crystal structure of a Carnitinyl-CoA dehydratase from Mycobacterium thermoresistibile
Descriptor:	3-hydroxyisobutyryl-CoA hydrolase, ACETATE ION, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-10-02
Release date:	2012-10-10
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4HR3

Structure of a putative acyl-CoA dehydrogenase from Mycobacterium abscessus
Descriptor:	FLAVIN-ADENINE DINUCLEOTIDE, Putative acyl-CoA dehydrogenase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-10-26
Release date:	2012-11-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4I1Y

The structure of Cysteine synthase from Mycobacterium ulcerans Agy99
Descriptor:	CHLORIDE ION, Cysteine synthase, SULFATE ION
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-11-21
Release date:	2012-12-26
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4IJN

Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to AMP and sulfate
Descriptor:	1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, Acetate kinase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-12-21
Release date:	2013-01-16
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

4IV6

X-ray crystal structure of an isovaleryl-CoA dehydrogenase from Mycobacterium smegmatis
Descriptor:	Acyl-CoA dehydrogenase FadE3, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2013-01-22
Release date:	2013-03-20
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015

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Displayed results:	25
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