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6DH8
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 I50V MUTANT IN COMPLEX WITH UMASS6
分子名称:Protease, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.951 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DH7
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 I50V MUTANT IN COMPLEX WITH UMASS1
分子名称:Protease, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.997 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DH6
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 I50V MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:Protease, SULFATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DH5
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 V82I MUTANT IN COMPLEX WITH UMASS6
分子名称:Protease, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.008 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DH4
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 V82I MUTANT IN COMPLEX WITH UMASS1
分子名称:Protease, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.943 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DH3
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 V82I MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SULFATE ION
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.908 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DH2
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 I84V MUTANT IN COMPLEX WITH UMASS6
分子名称:Protease, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.978 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DH1
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 I84V MUTANT IN COMPLEX WITH UMASS1
分子名称:Protease, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.971 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DH0
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 I84V MUTANT IN COMPLEX WITH DARUNAVIR
分子名称:Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.899 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DGZ
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 WT IN COMPLEX WITH UMASS6
分子名称:Protease, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.994 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DGY
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 WT IN COMPLEX WITH UMASS1
分子名称:Protease, SULFATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.954 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
6DGX
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE NL4-3 WT IN COMPLEX WITH DARUNAVIR
分子名称:Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SULFATE ION
著者Lockbaum, G.J., Schiffer, C.A.
登録日2018-05-18
公開日2018-12-26
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis, 5, 2019
4XXO
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CRYSTAL STRUCTURE OF HUMAN APOBEC3A
分子名称:DNA dC->dU-editing enzyme APOBEC-3A, ZINC ION, CHLORIDE ION
著者Bohn, M.F., Shandilya, S.M.D., Schiffer, C.A.
登録日2015-01-30
公開日2015-04-29
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.843 Å)
主引用文献The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Structure, 23, 2015
4Q1Y
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MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE
分子名称:aspartyl protease, PHOSPHATE ION, ACETATE ION, ...
著者Ragland, D.A., Nalam, M.N.L., Cao, H., Nalivaika, E.A., Cai, Y., Kurt-Yilmaz, N., Schiffer, C.A.
登録日2014-04-04
公開日2015-02-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
J.Am.Chem.Soc., 136, 2014
4Q1X
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MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE
分子名称:ASPARTYL PROTEASE, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, GLYCEROL, ...
著者Ragland, D.A., Nalam, M.N.L., Cao, H., Nalivaika, E.A., Cai, Y., Kurt-Yilmaz, N., Schiffer, C.A.
登録日2014-04-04
公開日2015-02-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
J.Am.Chem.Soc., 136, 2014
4Q1W
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MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE
分子名称:ASPARTYL PROTEASE, PHOSPHATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ...
著者Ragland, D.A., Nalam, M.N.L., Cao, H., Nalivaika, E.A., Cai, Y., Kurt-Yilmaz, N., Schiffer, C.A.
登録日2014-04-04
公開日2015-02-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
J.Am.Chem.Soc., 136, 2014
3OY4
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CRYSTAL STRUCTURE OF HIV-1 L76V PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR DARUNAVIR.
分子名称:HIV-1 PROTEASE, PHOSPHATE ION, ACETATE ION, ...
著者Schiffer, C.A., Nalivaika, E.A., Bandaranayake, R.M.
登録日2010-09-22
公開日2011-02-09
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Crystal Structure of HIV-1 L76V Protease in Complex with the Protease Inhibitor Darunavir.
To be Published
3OXX
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CRYSTAL STRUCTURE OF HIV-1 I50V, A71V PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR ATAZANAVIR
分子名称:HIV-1 PROTEASE, GLYCEROL, 1,2-ETHANEDIOL, ...
著者Schiffer, C.A., Bandaranayake, R.M.
登録日2010-09-22
公開日2011-09-28
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
J.Virol., 87, 2013
3OXW
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CRYSTAL STRUCTURE OF HIV-1 I50V, A71V PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR DARUNAVIR
分子名称:HIV-1 Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ...
著者Mittal, S., Bandaranayake, R.M., Schiffer, C.A.
登録日2010-09-22
公開日2011-09-28
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
J.Virol., 87, 2013
3OXV
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CRYSTAL STRUCTURE OF HIV-1 I50V, A71 PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR AMPRENAVIR.
分子名称:HIV-1 Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, PHOSPHATE ION, ...
著者Schiffer, C.A., Mittal, S., Bandaranayake, R.M.
登録日2010-09-22
公開日2011-09-28
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
J.Virol., 87, 2013
3LZV
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STRUCTURE OF NELFINAVIR-RESISTANT HIV-1 PROTEASE (D30N/N88D) IN COMPLEX WITH DARUNAVIR.
分子名称:HIV-1 Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ...
著者Schiffer, C.A., Kolli, M.
登録日2010-03-01
公開日2010-08-11
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways.
J.Virol., 84, 2010
3LZU
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CRYSTAL STRUCTURE OF A NELFINAVIR RESISTANT HIV-1 CRF01_AE PROTEASE VARIANT (N88S) IN COMPLEX WITH THE PROTEASE INHIBITOR DARUNAVIR.
分子名称:HIV-1 protease, ACETATE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE
著者Schiffer, C.A., Bandaranayake, R.M.
登録日2010-03-01
公開日2010-08-11
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways.
J.Virol., 84, 2010
3LZS
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CRYSTAL STRUCTURE OF HIV-1 CRF01_AE PROTEASE IN COMPLEX WITH DARUNAVIR
分子名称:HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETATE ION
著者Schiffer, C.A., Bandaranayake, R.M.
登録日2010-03-01
公開日2010-08-11
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways.
J.Virol., 84, 2010
3IR2
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CRYSTAL STRUCTURE OF THE APOBEC3G CATALYTIC DOMAIN
分子名称:DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION, CHLORIDE ION, ...
著者Shandilya, S.M.D., Schiffer, C.A.
登録日2009-08-21
公開日2010-01-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces.
Structure, 18, 2010
3EM6
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CRYSTAL STRUCTURE OF I50L/A71V MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR DARUNAVIR
分子名称:Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ...
著者Royer, C.J., King, N.M., Prabu-Jeyabalan, M., Ng, C., Nalivaika, E.A., Schiffer, C.A.
登録日2008-09-23
公開日2009-09-01
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Kinetic and structural studies on atazanavir specific I50L drug-resistant HIV-1 protease mutant.
To be Published
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