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5EMZ
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BU of 5emz by Molmil
Crystal structure of K48-linked diubiquitin with F45W mutation in the proximal unit
Descriptor: Polyubiquitin-B, SULFATE ION
Authors:Nakasone, M.A, Paukstelis, P.J, Fushman, D.
Deposit date:2015-11-07
Release date:2016-11-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural characterization and practical fluorescence applications of the F45W ubiquitin mutant
To Be Published
7OJX
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BU of 7ojx by Molmil
E2 UBE2K covalently linked to donor Ub, acceptor di-Ub, and RING E3 primed for K48-linked Ub chain synthesis
Descriptor: 1,1'-ethane-1,2-diylbis(1H-pyrrole-2,5-dione), E3 ubiquitin-protein ligase RNF38, Polyubiquitin-B, ...
Authors:Majorek, K.A, Nakasone, M.A, Huang, D.T.
Deposit date:2021-05-17
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension.
Nat.Chem.Biol., 18, 2022
8OV6
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BU of 8ov6 by Molmil
Ternary structure of intramolecular bivalent glue degrader IBG1 bound to BRD4 and DCAF16:DDB1deltaBPB
Descriptor: Bromodomain-containing protein 4, DDB1- and CUL4-associated factor 16, DDB1deltaBPB, ...
Authors:Cowan, A.D, Sundaramoorthy, R, Nakasone, M.A, Ciulli, A.
Deposit date:2023-04-25
Release date:2023-05-17
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Targeted protein degradation via intramolecular bivalent glues.
Nature, 627, 2024
8RX0
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BU of 8rx0 by Molmil
(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub
Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, Elongin-B, ...
Authors:Crowe, C, Nakasone, M.A.
Deposit date:2024-02-05
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub
To Be Published
4OWP
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BU of 4owp by Molmil
Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteasome lid.
Descriptor: 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN8, ZINC ION
Authors:Yu, Z, Mansour, W, Nakasone, M.A, Glickman, M.H, Dvir, H.
Deposit date:2014-02-03
Release date:2015-08-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of rpn11 in a heterodimer complex with rpn8, representing the active portion of the proteasome lid.In preparation.
To Be Published
5O75
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BU of 5o75 by Molmil
Ube4B U-box domain
Descriptor: SULFATE ION, Ubiquitin conjugation factor E4 B
Authors:Gabrielsen, M, Buetow, L, Nakasone, M.A, Huang, D.T.
Deposit date:2017-06-08
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.483 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
8RWZ
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BU of 8rwz by Molmil
Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL
Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Cullin-2, ...
Authors:Ciulli, A, Crowe, C, Nakacone, M.A.
Deposit date:2024-02-05
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL
To Be Published
6Y5N
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BU of 6y5n by Molmil
RING-DTC domain of Deltex1
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase DTX1, ...
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2020-02-25
Release date:2020-09-30
Last modified:2020-10-07
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.
Sci Adv, 6, 2020
6Y5P
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BU of 6y5p by Molmil
RING-DTC domain of Deltex1 bound to NAD
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase DTX1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2020-02-25
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.
Sci Adv, 6, 2020
2MBO
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BU of 2mbo by Molmil
K11-linked Diubiquitin average solution structure at pH 6.8, 0 mM NaCl
Descriptor: Ubiquitin
Authors:Castaneda, C.A, Fushman, D.
Deposit date:2013-08-02
Release date:2013-09-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains.
Structure, 21, 2013
2MBQ
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BU of 2mbq by Molmil
K11-linked Diubiquitin average solution structure at pH 6.8, 150 mM NaCl
Descriptor: Ubiquitin
Authors:Castaneda, C.A, Fushman, D.
Deposit date:2013-08-03
Release date:2013-09-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains.
Structure, 21, 2013
5UJL
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BU of 5ujl by Molmil
Representative 1-conformer ensembles of K27-linked Ub2 from RDC data
Descriptor: Ubiquitin
Authors:Castaneda, C.A, Fushman, D.
Deposit date:2017-01-18
Release date:2017-10-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins.
Structure, 24, 2016
5UJN
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BU of 5ujn by Molmil
Representative 2-conformer ensembles of K27-linked Ub2 from RDC data
Descriptor: Ubiquitin
Authors:Castaneda, C.A, Fushman, D.
Deposit date:2017-01-18
Release date:2018-08-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins.
Structure, 24, 2016
5O76
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BU of 5o76 by Molmil
Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant
Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ...
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2017-06-08
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.473 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O6T
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BU of 5o6t by Molmil
BIRC4 RING in complex with dimeric ubiquitin variant
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase XIAP, Polyubiquitin-B, ...
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2017-06-07
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O6S
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BU of 5o6s by Molmil
UbV.B4R, a dimeric ubiquitin variant binding to BIRC4 RING
Descriptor: Polyubiquitin-B
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2017-06-07
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017

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PDB entries from 2024-03-27

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