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3WUS
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BU of 3wus by Molmil
Crystal Structure of the Vif-Binding Domain of Human APOBEC3F
Descriptor: DNA dC->dU-editing enzyme APOBEC-3F, ZINC ION
Authors:Nakashima, M, Kawamura, T, Ode, H, Watanabe, N, Iwatani, Y.
Deposit date:2014-05-02
Release date:2015-06-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural Insights into HIV-1 Vif-APOBEC3F Interaction.
J.Virol., 90, 2015
5B18
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BU of 5b18 by Molmil
Crystal Structure of a Darunavir Resistant HIV-1 Protease
Descriptor: ACETATE ION, CHLORIDE ION, Protease
Authors:Suzuki, K, Ode, H, Nakashima, M, Sugiura, W, Watanabe, N, Suzuki, A, Iwatani, Y.
Deposit date:2015-11-30
Release date:2016-04-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance
Front Microbiol, 7, 2016
5VP1
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BU of 5vp1 by Molmil
Discovery of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
Descriptor: MAGNESIUM ION, N-{(1S)-2-hydroxy-2-methyl-1-[4-(trifluoromethoxy)phenyl]propyl}-6-methyl-5-(3-methyl-1H-1,2,4-triazol-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, ZINC ION, ...
Authors:Hoffman, I.D.
Deposit date:2017-05-03
Release date:2017-12-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders.
Chem. Pharm. Bull., 65, 2017
3VOW
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BU of 3vow by Molmil
Crystal Structure of the Human APOBEC3C having HIV-1 Vif-binding Interface
Descriptor: CHLORIDE ION, Probable DNA dC->dU-editing enzyme APOBEC-3C, ZINC ION
Authors:Kitamura, S, Suzuki, A, Watanabe, N, Iwatani, Y.
Deposit date:2012-02-22
Release date:2012-10-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The APOBEC3C crystal structure and the interface for HIV-1 Vif binding.
Nat.Struct.Mol.Biol., 19, 2012
3VM8
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BU of 3vm8 by Molmil
Crystal structure of the human APOBEC3C having HIV-1 Vif-binding interface
Descriptor: Probable DNA dC->dU-editing enzyme APOBEC-3C, ZINC ION
Authors:Kitamura, S, Suzuki, A, Watanabe, N, Iwatani, Y.
Deposit date:2011-12-09
Release date:2012-10-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the human APOBEC3C having HIV-1 Vif-binding interface
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