Author results

2YXX
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CRYSTAL STRUCTURE ANALYSIS OF DIAMINOPIMELATE DECARBOXYLATE (LYSA)
Descriptor:Diaminopimelate decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Nakamura, Y., Bessho, Y., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-27
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure analysis of Diaminopimelate decarboxylate (lysA)
To be Published
1WG0
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STRUCTURAL COMPARISON OF NAS6P PROTEIN STRUCTURES IN TWO DIFFERENT CRYSTAL FORMS
Descriptor:Probable 26S proteasome regulatory subunit p28
Authors:Nakamura, Y., Umehara, T., Tanaka, A., Horikoshi, M., Yokoyama, S., Padmanabhan, B., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-05-27
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural comparison of Nas6p protein structures in two different crystal forms
To be Published
1X0J
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CRYSTAL STRUCTURE ANALYSIS OF THE N-TERMINAL BROMODOMAIN OF HUMAN BRD2
Descriptor:Bromodomain-containing protein 2, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Nakamura, Y., Umehara, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-03-23
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for acetylated histone H4 recognition by the human Brd2 bromodomain
To be Published
2DZO
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CRYSTAL STRUCTURE ANALYSIS OF YEAST NAS6P COMPLEXED WITH THE PROTEASOME SUBUNIT, RPT3
Descriptor:Probable 26S proteasome regulatory subunit p28, 26S protease regulatory subunit 6B homolog
Authors:Nakamura, Y., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-09-29
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure analysis of yeast Nas6p complexed with the proteasome subunit, rpt3
To be Published
2YYR
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STRUCTURAL ANALYSIS OF PHD DOMAIN OF PYGOPUS COMPLEXED WITH TRIMETHYLATED HISTONE H3 PEPTIDE
Descriptor:Pygopus homolog 1, H3K4Me3 peptide, ZINC ION
Authors:Nakamura, Y., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-01
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of PHD domain of Pygopus complexed with trimethylated histone H3 peptide
To be Published
2DVQ
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CRYSTAL STRUCTURE ANALYSIS OF THE N-TERMINAL BROMODOMAIN OF HUMAN BRD2 COMPLEXED WITH ACETYLATED HISTONE H4 PEPTIDE
Descriptor:Bromodomain-containing protein 2, histone H4
Authors:Nakamura, Y., Umehara, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
2DVR
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CRYSTAL STRUCTURE ANALYSIS OF THE N-TERMINAL BROMODOMAIN OF HUMAN BRD2 COMPLEXED WITH ACETYLATED HISTONE H4 PEPTIDE
Descriptor:bromodomain-containing protein 2, histone H4
Authors:Nakamura, Y., Umehara, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
2DVS
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CRYSTAL STRUCTURE ANALYSIS OF THE N-TERMINAL BROMODOMAIN OF HUMAN BRD2 COMPLEXED WITH ACETYLATED HISTONE H4 PEPTIDE
Descriptor:bromodomain-containing protein 2, histone H4
Authors:Nakamura, Y., Umehara, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
3VQU
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2- YL)AMINO]BENZAMIDE
Descriptor:Dual specificity protein kinase TTK, IODIDE ION, 4-[(4-amino-5-cyano-6-ethoxypyridin-2-yl)amino]benzamide
Authors:Kusakabe, K., Ide, N., Daigo, Y., Itoh, T., Higashino, K., Okano, Y., Tadano, G., Tachibana, Y., Sato, Y., Inoue, M., Wada, T., Iguchi, M., Kanazawa, T., Ishioka, Y., Dohi, K., Tagashira, S., Kido, Y., Sakamoto, S., Yasuo, K., Maeda, M., Yamamoto, T., Higaki, M., Endoh, T., Ueda, K., Shiota, T., Murai, H., Nakamura, Y.
Deposit date:2012-03-30
Release date:2012-06-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation
ACS MED.CHEM.LETT., 2012
3W1F
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 5-(5-ETHOXY-6-(1-METHYL-1H-PYRAZOL-4-YL)-1H-INDAZOL-3-YL)-2-METHYLBENZENESULFONAMIDE
Descriptor:Dual specificity protein kinase TTK, 5-[5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl]-2-methylbenzenesulfonamide
Authors:Kusakabe, K., Ide, N., Daigo, Y., Tachibana, Y., Itoh, T., Yamamoto, T., Hashizume, H., Hato, Y., Higashino, K., Okano, Y., Sato, Y., Inoue, M., Iguchi, M., Kanazawa, T., Ishioka, Y., Dohi, K., Kido, Y., Sakamoto, S., Yasuo, K., Maeda, M., Higaki, M., Ueda, K., Yoshizawa, H., Baba, Y., Shiota, T., Murai, H., Nakamura, Y.
Deposit date:2012-11-14
Release date:2013-06-26
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125)
J.Med.Chem., 56, 2013
3WYX
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 6-((3-(CYANOMETHOXY)-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)AMINO)-2-(CYCLOHEXYLAMINO)NICOTINONITRILE
Descriptor:Dual specificity protein kinase TTK, IODIDE ION, 6-{[3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-2-(cyclohexylamino)pyridine-3-carbonitrile
Authors:Kusakabe, K., Ide, N., Daigo, Y., Itoh, T., Yamamoto, T., Kojima, E., Mitsuoka, Y., Tadano, G., Tagashira, S., Higashino, K., Okano, Y., Sato, Y., Inoue, M., Iguchi, M., Kanazawa, T., Ishioka, Y., Dohi, K., Kido, Y., Sakamoto, S., Ando, S., Maeda, M., Higaki, M., Yoshizawa, H., Mura, H., Nakamura, Y.
Deposit date:2014-09-09
Release date:2015-04-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity
Bioorg.Med.Chem., 2015
3WYY
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH (E)-3-(4-((6-(((3S,5S,7S)-ADAMANTAN-1-YL)AMINO)-4-AMINO-5-CYANOPYRIDIN-2-YL)AMINO)-2-(CYANOMETHOXY)PHENYL)-N-(2-METHOXYETHYL)ACRYLAMIDE
Descriptor:Dual specificity protein kinase TTK, (2E)-3-[4-({4-amino-5-cyano-6-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylamino]pyridin-2-yl}amino)-2-(cyanomethoxy)phenyl]-N-(2-methoxyethyl)prop-2-enamide
Authors:Kusakabe, K., Ide, N., Daigo, Y., Itoh, T., Yamamoto, T., Kojima, E., Mitsuoka, Y., Tadano, G., Tagashira, S., Higashino, K., Okano, Y., Sato, Y., Inoue, M., Iguchi, M., Kanazawa, T., Ishioka, Y., Dohi, K., Kido, Y., Sakamoto, S., Ando, S., Maeda, M., Higaki, M., Yoshizawa, H., Murai, H., Nakamura, Y.
Deposit date:2014-09-10
Release date:2015-04-08
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity
Bioorg.Med.Chem., 2015
3WZJ
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-(6-(CYCLOHEXYLAMINO)-8-(((TETRAHYDRO-2H-PYRAN-4-YL)METHYL)AMINO)IMIDAZO[1,2-B]PYRIDAZIN-3-YL)-N-CYCLOPROPYLBENZAMIDE
Descriptor:Dual specificity protein kinase TTK, 4-{6-(cyclohexylamino)-8-[(tetrahydro-2H-pyran-4-ylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}-N-cyclopropylbenzamide
Authors:Kusakabe, K., Ide, N., Daigo, Y., Itoh, T., Yamamoto, T., Kojima, E., Mitsuoka, Y., Tadano, G., Tagashira, S., Higashino, K., Okano, Y., Sato, Y., Inoue, M., Iguchi, M., Kanazawa, T., Ishioka, Y., Dohi, K., Kido, Y., Sakamoto, S., Ando, S., Maeda, M., Higaki, M., Yoshizawa, H., Mura, H., Nakamura, Y.
Deposit date:2014-09-29
Release date:2015-02-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery of Imidazo[1,2-b]pyridazine Derivatives: Selective and Orally Available Mps1 (TTK) Kinase Inhibitors Exhibiting Remarkable Antiproliferative Activity
J.Med.Chem., 2015
3WZK
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH N-CYCLOPROPYL-4-(8-((THIOPHEN-2-YLMETHYL)AMINO)IMIDAZO[1,2-A]PYRAZIN-3-YL)BENZAMIDE
Descriptor:Dual specificity protein kinase TTK, CHLORIDE ION, N-cyclopropyl-4-{8-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]pyrazin-3-yl}benzamide
Authors:Kusakabe, K., Ide, N., Daigo, Y., Itoh, T., Yamamoto, T., Kojima, E., Mitsuoka, Y., Tadano, G., Tagashira, S., Higashino, K., Okano, Y., Sato, Y., Inoue, M., Iguchi, M., Kanazawa, T., Ishioka, Y., Dohi, K., Kido, Y., Sakamoto, S., Ando, S., Maeda, M., Higaki, M., Yoshizawa, H., Mura, H., Nakamura, Y.
Deposit date:2014-09-29
Release date:2015-02-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of Imidazo[1,2-b]pyridazine Derivatives: Selective and Orally Available Mps1 (TTK) Kinase Inhibitors Exhibiting Remarkable Antiproliferative Activity
J.Med.Chem., 2015
2N37
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SOLUTION STRUCTURE OF AVR-PIA
Descriptor:AVR-Pia protein
Authors:Ose, T., Oikawa, A., Nakamura, Y., Maenaka, K., Higuchi, Y., Satoh, Y., Fujiwara, S., Demura, M., Sone, T.
Deposit date:2015-05-25
Release date:2015-10-14
Method:SOLUTION NMR
Cite:Solution structure of an avirulence protein, AVR-Pia, from Magnaporthe oryzae
J.Biomol.Nmr, 63, 2015
2RRC
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SOLUTION STRUCTURE OF RNA APTAMER AGAINST AML1 RUNT DOMAIN
Descriptor:5'-R(P*GP*GP*AP*CP*CP*CP*(AP7)P*CP*CP*AP*CP*GP*GP*CP*GP*AP*GP*GP*UP*CP*CP*A)-3'
Authors:Nomura, Y., Fujiwara, K., Chiba, M., Fukunaga, J., Tanaka, Y., Iibuchi, H., Tanaka, T., Nakamura, Y., Kawai, G., Kozu, T., Sakamoto, T.
Deposit date:2010-06-23
Release date:2011-06-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A novel high affinity RNA motif that mimics DNA in AML1 Runt domain binding
To be Published
3AGV
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CRYSTAL STRUCTURE OF A HUMAN IGG-APTAMER COMPLEX
Descriptor:Ig gamma-1 chain C region, 5'-R(*GP*GP*AP*GP*GP*(UFT)P*GP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*GP*AP*AP*A*GP*GP*AP*AP*(CFZ)P*(UFT)P*(CFZ)P*(CFZ)P*A)-3', ALPHA-D-MANNOSE, ...
Authors:Nomura, Y., Sugiyama, S., Sakamoto, T., Miyakawa, S., Adachi, H., Takano, K., Murakami, S., Inoue, T., Mori, Y., Nakamura, Y., Matsumura, H.
Deposit date:2010-04-08
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Conformational plasticity of RNA for target recognition as revealed by the 2.15 A crystal structure of a human IgG-aptamer complex
Nucleic Acids Res., 38, 2010
3WXV
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CRYSTAL STRUCTURE OF THE HUMAN ADIPONECTIN RECEPTOR 1
Descriptor:Adiponectin receptor protein 1, V region heavy chain, V region light chain, ...
Authors:Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S.
Deposit date:2014-08-11
Release date:2015-04-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of the human adiponectin receptors
Nature, 520, 2015
3WXW
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CRYSTAL STRUCTURE OF THE HUMAN ADIPONECTIN RECEPTOR 2
Descriptor:Adiponectin receptor protein 2, V region heavy chain, V region light chain, ...
Authors:Tanabe, H., Fujii, Y., Nakamura, Y., Hosaka, T., Okada-Iwabu, M., Iwabu, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T., Yokoyama, S.
Deposit date:2014-08-11
Release date:2015-04-15
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the human adiponectin receptors
Nature, 520, 2015
2YRN
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SOLUTION STRUCTURE OF THE CH DOMAIN FROM HUMAN NEURON NAVIGATOR 2
Descriptor:Neuron navigator 2 isoform 4
Authors:Tomizawa, T., Tochio, N., Koshiba, S., Inoue, M., Nakamura, Y., Furukawa, Y., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-02
Release date:2008-02-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the CH domain from Human Neuron navigator 2
To be Published
2YYT
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CRYSTAL STRUCTURE OF UNCHARACTERIZED CONSERVED PROTEIN FROM GEOBACILLUS KAUSTOPHILUS
Descriptor:Orotidine 5'-phosphate decarboxylase
Authors:Kanagawa, M., Baba, S., Nakamura, Y., Bessho, Y., Kuramitsu, S., Yokoyama, S., Kawai, G., Sampei, G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-02
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus
To be Published
2YYU
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CRYSTAL STRUCTURE OF UNCHARACTERIZED CONSERVED PROTEIN FROM GEOBACILLUS KAUSTOPHILUS
Descriptor:Orotidine 5'-phosphate decarboxylase, CYTIDINE-5'-MONOPHOSPHATE
Authors:Kanagawa, M., Baba, S., Nakamura, Y., Bessho, Y., Kuramitsu, S., Yokoyama, S., Kawai, G., Sampei, G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-02
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of uncharacterized conserved protein from Geobacillus kaustophilus
To be Published
2YYV
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CRYSTAL STRUCTURE OF UNCHARACTERIZED CONSERVED PROTEIN FROM THERMOTOGA MARITIMA
Descriptor:Probable 2-phosphosulfolactate phosphatase
Authors:Nakagawa, N., Nakamura, Y., Bessho, Y., Yokoyama, S., Kuramitsu, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-02
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of uncharacterized conserved protein from Thermotoga maritima
To be Published
2YZO
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CRYSTAL STRUCTURE OF UNCHARACTERIZED CONSERVED PROTEIN FROM THERMOTOGA MARITIMA
Descriptor:Probable 2-phosphosulfolactate phosphatase, D-MALATE
Authors:Nakagawa, N., Nakamura, Y., Bessho, Y., Yokoyama, S., Kuramitsu, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-06
Release date:2007-11-06
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of uncharacterized conserved protein from Thermotoga maritima
To be Published
1IYN
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CRYSTAL STRUCTURE OF CHLOROPLASTIC ASCORBATE PEROXIDASE FROM TOBACCO PLANTS AND STRUCTURAL INSIGHTS FOR ITS INSTABILITY
Descriptor:Chloroplastic ascorbate peroxidase, SODIUM ION, PROTOPORPHYRIN IX CONTAINING FE
Authors:Wada, K., Tada, T., Nakamura, Y.
Deposit date:2002-09-03
Release date:2003-09-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of chloroplastic ascorbate peroxidase from tobacco plants and structural insights into its instability
J.BIOCHEM.(TOKYO), 134, 2003
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